Cyclosporine-induced graft-versus-host disease after autologous bone marrow transplantation in hematological malignancies.

abstract：:We report a factor X (FX)-deficient Chinese family with two novel FX gene (F10) mutations. Two sibling probands had a bleeding tendency since childhood. Both had very low FX:C (<0.01 IU/ml) and FX:Ag (5-6%) levels and were heterozygous for two novel F10 mutations, a 2-bp GC deletion involving nucleotides 33 and 34, le...

journal_title：Annals of hematology

authors： Au WY,Lam CC,Cheung WC,Kwong YL

更新日期：2004-05-01 00:00:00

abstract：:This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...

journal_title：Annals of hematology

authors： Brodmann S,Passweg JR,Gratwohl A,Tichelli A,Skoda RC

更新日期：2000-06-01 00:00:00

abstract：:We conducted a nationwide cohort study of adult Danish patients with primary chronic immune thrombocytopenia (cITP) to examine selected patient and clinical characteristics as predictors for splenectomy. We analyzed data from the Danish National Patient Registry and patient medical records from 1996 to 2007. Using Cox...

journal_title：Annals of hematology

authors： Jensen AO,Nørgaard M,Engebjerg MC,Farkas DK,Fryzek JP,Zhao S,Sørensen HT

更新日期：2011-02-01 00:00:00

abstract：:The introduction of rituximab into the primary treatment of malignant lymphomas of the B cell lineage has had a major impact on the management of these diseases. In addition, prolonged exposure to rituximab as maintenance therapy has been beneficial in patients with follicular lymphoma and mantle cell lymphoma. For th...

journal_title：Annals of hematology

authors： Witzens-Harig M,Reiz M,Heiss C,Benner A,Hensel M,Neben K,Dreger P,Kraemer A,Ho AD

更新日期：2009-01-01 00:00:00

abstract：:Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...

journal_title：Annals of hematology

authors： Patel K,Kelsey P

更新日期：1997-04-01 00:00:00

abstract：:Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by overproduction of red blood cells. We have performed a comprehensive characterization of blood immune cells for expression of naïve and memory receptors as well as β2m-associated and β2m-free MHC class I heavy chains, also known as closed and ope...

journal_title：Annals of hematology

authors： Cardoso EM,Esgalhado AJ,Patrão L,Santos M,Neves VP,Martinez J,Patto MAV,Silva H,Arosa FA

更新日期：2018-09-01 00:00:00

abstract：:The present study attempted to build a single nucleotide polymorphism (SNP)-based risk model for predicting overall survival (OS) and event-free survival (EFS) in patients with core binding factor acute myeloid leukemia (CBF-AML). Adopting genome-wide SNP array using Affymetrix SNP array 6.0, we analyzed 868,157 SNPs ...

journal_title：Annals of hematology

authors： Park S,Choi H,Kim HJ,Ahn JS,Kim HJ,Kim SH,Mun YC,Jung CW,Kim DDH

更新日期：2018-06-01 00:00:00

abstract：:Although the outcome of patients with acute myeloid leukemia (AML) has improved by optimized chemotherapy regimens and bone marrow transplantation, leukemia relapse remains one of the most challenging problems during therapy. Sustained existence of AML blasts is a fundamental determinant for the development of leukemi...

journal_title：Annals of hematology

authors： Liu J,Qin YZ,Yang S,Wang Y,Chang YJ,Zhao T,Jiang Q,Huang XJ

更新日期：2017-04-01 00:00:00

abstract：:Only about one third of all patients with acute myeloid leukemia (AML) will be cured by common chemotherapy regimens. Susceptibility towards chemotherapy either of the leukemic bulk or the leukemic stem cell is considered the major determining parameter for long-term outcome. The purpose of the present study was to in...

journal_title：Annals of hematology

authors： Fiegl M,Zimmermann I,Lorenz I,Hiddemann W,Braess J

更新日期：2008-01-01 00:00:00

abstract：:Diagnosis of thrombotic thrombocytopenic purpura (TTP) is usually based upon the clinical features, and does not always involve histopathological evidence. We recently had experience with a patient who developed the five signs characteristic for TTP. He had been treated for liver cirrhosis associated with chronic hepa...

journal_title：Annals of hematology

authors： Hori A,Kami M,Hamaki T,Yamamoto T,Mori M,Miyakoshi S,Takeuchi K

更新日期：2001-08-01 00:00:00

abstract：:Multiple myeloma is a malignant B-cell neoplasm that involves the skeleton in approximately 80% of the patients. With an average age of 60 years and a 5-years survival of nearly 45% Brenner et al. (Blood 111:2516-2520,35) the onset is to be classified as occurring still early in life while the disease can be very aggr...

journal_title：Annals of hematology

authors： Lütje S,de Rooy JW,Croockewit S,Koedam E,Oyen WJ,Raymakers RA

更新日期：2009-12-01 00:00:00

abstract：:Cryoglobulinemia is uncommon in Southern Chinese in Hong Kong, with tropical climates and low incidence of hepatitis C virus (HCV) infection. Eight positive cases were detected among 481 patients screened for cryoglobulins over a 10-year period. Three HCV carriers (38%) ran benign courses. The others included two carr...

journal_title：Annals of hematology

authors： Au WY,Kwok JS,Chu KM,Ma ES

更新日期：2005-02-01 00:00:00

abstract：:An investigation into the effects of irradiation and of the storage time on aging and quality are a relevant issue to ensure the safety and the efficiency of irradiation in the prevention of transfusion-associated graft-versus-host disease (TA-GVHD). In this work, the biochemical properties and alterations presented b...

journal_title：Annals of hematology

authors： Maia GA,Renó Cde O,Medina JM,Silveira AB,Mignaco JA,Atella GC,Cortes VF,Barbosa LA,Santos Hde L

更新日期：2014-05-01 00:00:00

abstract：:Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...

journal_title：Annals of hematology

authors： Cario H

更新日期：2005-03-01 00:00:00

abstract：:Information regarding prognostic determinants of outcome after splenectomy for adult immune thrombocytopenic purpura (ITP) and the management of postsplenectomy relapse is limited. Among 140 adult patients with ITP who had therapeutic splenectomy at our institution, 88% achieved either a complete (platelets > 150 x 10...

journal_title：Annals of hematology

authors： Kumar S,Diehn FE,Gertz MA,Tefferi A

更新日期：2002-06-01 00:00:00

abstract：:The prognostic value of cytogenetics in adult acute lymphoblastic leukemia (ALL) is not as established as in childhood ALL. We have analyzed the outcome and prognostic value of karyotype in 84 adults diagnosed with Philadelphia-negative ALL from a single institution that received induction chemotherapy and had success...

journal_title：Annals of hematology

authors： Gómez-Seguí I,Cervera J,Such E,Martínez-Cuadrón D,Luna I,Ibáñez M,López-Pavía M,Gascón A,Roig M,Martínez J,Sanz J,Montesinos P,Martín-Aragonés G,Lorenzo I,Senent L,Barragán E,Cordón L,Sempere A,Sanz GF,Sanz MA

更新日期：2012-01-01 00:00:00

abstract：:High-dose chemotherapy (HDT) and stem cell transplantation is a newer treatment option widely applied in poor-risk germ cell tumor patients. Due to the increasing practical clinical experience and the availability of hematopoietic growth factors, this treatment approach has become a relatively safe procedure. Dependin...

journal_title：Annals of hematology

authors： Siegert W,Rick O,Beyer J

更新日期：1998-05-01 00:00:00

abstract：:Multiresistant bacterial infections are a potentially life-threatening condition in acute leukaemia (AL) patients. We aimed to better define the very recent epidemiology and outcome of bloodstream infections (BSIs) in a real-life setting. We prospectively collected all consecutive febrile/infectious episodes occurring...

journal_title：Annals of hematology

authors： Cattaneo C,Zappasodi P,Mancini V,Annaloro C,Pavesi F,Skert C,Ferrario A,Todisco E,Saccà V,Verga L,Passi A,Da Vià M,Ferrari S,Mometto G,Petullà M,Nosari A,Rossi G

更新日期：2016-12-01 00:00:00

abstract：:We investigated a new protein-C (PC) concentrate in a child with a type-II homozygous deficiency, concerning tolerance and safety. By means of various functional and antigen assays the in vivo recovery and the half-life were determined. In order to compare the results we reduced the measured values to the average half...

journal_title：Annals of hematology

authors： Auberger K

更新日期：1992-03-01 00:00:00

abstract：:A particular case of marginal zone B-cell lymphoma (MZBCL) presenting with leukemic lymphocytes is reported. In the present observation, the leukemic cells not only displayed a remarkable morphological fluctuation but also had an unusual phenotype, changing with time. These phenotypic features, which have been functio...

journal_title：Annals of hematology

authors： Dargent JL,Delville JP,Kornreich A,Pradier O,Cochaux P,Velu T,Capel P,Feremans W,Neve P

更新日期：1997-03-01 00:00:00

abstract：:Hydroxyurea is increasingly being used to control myeloproliferative disorders, in part because of its relative lack of side effects. We present a case of life-threatening alveolitis in a patient treated with hydroxyurea for myeloproliferative syndrome. Absence of exposure to other drugs and the clinical course sugges...

journal_title：Annals of hematology

authors： Hennemann B,Bross KJ,Reichle A,Andreesen R

更新日期：1993-09-01 00:00:00

abstract：:A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of L-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone. and there was an intermittent clinical remission of CLL with absence of the monoclo...

journal_title：Annals of hematology

authors： Böhme A,Wolter M,Hoelzer D

更新日期：1998-11-01 00:00:00

abstract：:The objective of this study was to evaluate retrospectively the clinical characteristics, treatments, and outcomes of patients with primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract. The basic characteristics, treatments, and outcomes of six patients diagnosed with primary DLBCL of the female g...

journal_title：Annals of hematology

authors： Cao XX,Li J,Zhang W,Duan MH,Shen T,Zhou DB

更新日期：2014-06-01 00:00:00

abstract：:Patients with non-Hodgkin's lymphoma (NHL) receiving rituximab-containing chemotherapy are at risk of developing respiratory complications, but comprehensive information on these complications and their impact on survival is lacking. We performed a retrospective cohort analysis on 123 NHL patients who received rituxim...

journal_title：Annals of hematology

authors： Keefer K,Bender R,Liao J,Sivik J,Van de Louw A

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. However, controversial data have been published regarding a protective role of variant alleles of MTHFR on MM. PATIENTS AND METHODS:To inve...

journal_title：Annals of hematology

authors： Chiusolo P,Farina G,Putzulu R,Reddiconto G,Fiorini A,De Stefano V,Rossi E,Palladino M,Leone G,Sica S

更新日期：2006-07-01 00:00:00

abstract：:In some instances, because of the lack of mass formation and the absence of prominent lymph node enlargement, diagnosis of lymphoma-associated hemophagocytic syndrome (LAHS) is difficult, which results in the development of progressive disease with unfavorable prognosis. Therefore, in the diagnosis of secondary hemoph...

journal_title：Annals of hematology

authors： Tabata C,Tabata R

更新日期：2012-01-01 00:00:00

abstract：:Telomere shortening represents an established mechanism connecting aging and cancer development. We sequentially analyzed telomere length (TL) of 49 acute myeloid leukemia (AML) patients at diagnosis (n = 24), once they achieved complete cytological remission (CCR) and/or during refractory disease or relapse and after...

journal_title：Annals of hematology

authors： Ventura Ferreira MS,Crysandt M,Ziegler P,Hummel S,Wilop S,Kirschner M,Schemionek M,Jost E,Wagner W,Brümmendorf TH,Beier F

更新日期：2017-09-01 00:00:00

abstract：:An acute leukemia with an unusual immunophenotype developed in a 17-year-old girl. At the initial presentation, extramedullary involvement was not evident, but with advancing disease, massive splenomegaly and an osteolytic rib tumor developed. The disease was aggressive and refractory to intensive chemotherapeutic reg...

journal_title：Annals of hematology

authors： Ino T,Tsuzuki M,Okamoto M,Shamoto M,Hirano M

更新日期：1999-01-01 00:00:00

abstract：:Multiple myeloma (MM) is an incurable disease accompanied by low plasma levels of low-density lipoprotein cholesterol (LDL-c). The significance of altered cholesterol metabolism in the pathophysiology of MM remains elusive. Although it has been hypothesized that myeloma cells depend on exogenous cholesterol for its su...

journal_title：Annals of hematology

authors： Tirado-Vélez JM,Benítez-Rondán A,Cózar-Castellano I,Medina F,Perdomo G

更新日期：2012-01-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a protein kinase involved in the phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway. It plays a pivotal role in the control of cell proliferation, survival, and angiogenesis with multiple and frequent dysregulations of this pathway in human tumors. Temsirolimus is a...

journal_title：Annals of hematology

authors： Zoellner AK,Weiglein T,Hutter G,Zimmermann Y,Cieplik HC,Hess G,Dreyling M

更新日期：2016-02-01 00:00:00