Abstract：
:Information regarding prognostic determinants of outcome after splenectomy for adult immune thrombocytopenic purpura (ITP) and the management of postsplenectomy relapse is limited. Among 140 adult patients with ITP who had therapeutic splenectomy at our institution, 88% achieved either a complete (platelets > 150 x 10(9)/l) or a partial (platelets > or = 50 x 10(9)/l) response that was sustained for at least 1 month. At 3, 6, and 12 months after splenectomy, time-adjusted complete response rates were 77%, 71%, and 74%, respectively. The 5-year relapse-free survival was 75%; all but three relapses occurred within 2 years of splenectomy. In multivariate analysis, younger age and higher peak postsplenectomy platelet counts were significantly associated with a favorable response to splenectomy. None of several preoperative or perioperative variables was predictive of a relapse after an initial response to splenectomy. Corticosteroids, danazol, vincristine, and cyclophosphamide were often effective in the treatment of patients who were either refractory to or had a relapse after splenectomy. One patient responded to rituximab after not responding to corticosteroids, azathioprine, and vincristine. After a median follow-up of 37.5 months (range: 0-183) from splenectomy, there were 25 deaths, including 2 from postoperative complications, 1 from gastrointestinal bleeding related to thrombocytopenia, and 1 from overwhelming sepsis related to the splenectomized state. The current study provides additional data on both the long-term outcome of splenectomy in adults with ITP and the management of postsplenectomy relapse.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Kumar S,Diehn FE,Gertz MA,Tefferi Adoi
10.1007/s00277-002-0461-8subject
Has Abstractpub_date
2002-06-01 00:00:00pages
312-9issue
6eissn
0939-5555issn
1432-0584journal_volume
81pub_type
杂志文章abstract：:The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-007-0305-7
更新日期：2007-09-01 00:00:00
abstract：:The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0679-1
更新日期：2009-08-01 00:00:00
abstract：:We retrospectively analyzed overall survival and survival after progression in 91 patients with low-grade follicular lymphoma (LGFL). Histological subtype was B in 75 patients and C in 16 patients. Twelve patients with localized disease received involved-field radiotherapy; seven patients without bulky disease had no ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01695972
更新日期：1993-06-01 00:00:00
abstract：:Chronic hepatitis C (CHC) and iron overload are the main causes of liver disease in β-thalassemia major (βTM). There is limited data regarding the course of CHC in this population. All patients (n=144) from the thalassemia centre of the University Hospital of Patras were evaluated (January 1981 to June 2012). Patients...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1692-6
更新日期：2013-06-01 00:00:00
abstract：:Treatment of acute lymphoblastic leukemia (ALL) requires the combination of multiple drugs to integrate a complete remission. The different prognostic factors (age, leukocytes, risk, cytogenetic alterations) allow identifying those patients with a high risk of relapse, but there are few described factors that impact t...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04277-y
更新日期：2020-11-01 00:00:00
abstract：:The present paper summarizes the results of the second German consensus meeting on immunogenetic donor search for allotransplantation of hematopoietic stem cells held in Essen in November 1999 under the auspices of the German Society for Immunogenetics (DGI) and the German Working Party for Blood and Marrow Transplant...
journal_title：Annals of hematology
pub_type： 共识发展会议,杂志文章,评审
doi：10.1007/s00277-001-0384-9
更新日期：2001-12-01 00:00:00
abstract：:Recent developments in the field of targeted therapy have led to the discovery of a new drug, plerixafor, that is a specific inhibitor of the CXCR4 receptor. Plerixafor acts in concert with granulocyte colony-stimulating factor (G-CSF) to increase the number of stem cells circulating in the peripheral blood (PB). Ther...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-010-1098-7
更新日期：2011-05-01 00:00:00
abstract：:In this retrospective study, we evaluated the clinical features and the effects of various treatment modalities on the clinical course in patients diagnosed with idiopathic thrombocytopenic purpura (ITP) at our center between 1984-2000. We retrospectively examined the medical records of 321 (229 females, 92 males) ITP...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0488-x
更新日期：2002-08-01 00:00:00
abstract：:Only about one third of all patients with acute myeloid leukemia (AML) will be cured by common chemotherapy regimens. Susceptibility towards chemotherapy either of the leukemic bulk or the leukemic stem cell is considered the major determining parameter for long-term outcome. The purpose of the present study was to in...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-007-0361-z
更新日期：2008-01-01 00:00:00
abstract：:A prospective randomized phase III study was performed to evaluate whether intensified cytarabine would induce a higher response rate and longer event-free interval as compared to low-dose cytarabine in chronic myeloid leukemia (CML). One hundred and eighteen patients with CML in early chronic phase entered the study....
journal_title：Annals of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00277-006-0186-1
更新日期：2007-02-01 00:00:00
abstract：:Paul Kaznelson is credited with describing the first case of pure red cell aplasia. He was also known for his contribution to the discovery of the therapeutic role of splenectomy in idiopathic thrombocytopenic purpura. Most of his academic works appeared in 1910s and 1920s, when he used to work in Karl-Ferdinand Unive...
journal_title：Annals of hematology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s00277-008-0553-1
更新日期：2008-11-01 00:00:00
abstract：:Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Coopera...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-016-2884-7
更新日期：2017-03-01 00:00:00
abstract：:To investigate whether cytokine genetic polymorphisms influence the outcome of diffuse large B cell lymphoma (DLBCL), we tested 337 consecutive DLBCL treated with CHOP or rituximab-CHOP (R-CHOP) from interleukin 10 (IL10), Bcl-2, and tumor necrosis factor (TNF)-α polymorphisms. Patients who carried the IL10 rs1800871 ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2857-x
更新日期：2017-02-01 00:00:00
abstract：:The aim of this review is to summarize the current knowledge on the clinical results of biotherapy of chronic myelogenous leukemia (CML) and potential mechanisms of the antitumor action of interferon alpha. IFN alpha treatment induces hematologic and cytogenetic remissions in patients with chronic phase CML. In additi...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/BF01682030
更新日期：1995-03-01 00:00:00
abstract：:Preliminary data suggest a faster immune recovery following non-myeloablative stem cell transplantation because of the persistence of recipient T cells, but the real impact on post-transplant infectious complications remains unknown. We retrospectively analysed the incidence of cytomegalovirus (CMV) infection in twent...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0706-1
更新日期：2003-10-01 00:00:00
abstract：:Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) ineligible for allogeneic stem cell transplantation. Recently, rabbit ATG with cyclosporine A has been used as a first-line IST regimen in patients with SAA because of unavailability of ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1674-8
更新日期：2013-06-01 00:00:00
abstract：:In some instances, because of the lack of mass formation and the absence of prominent lymph node enlargement, diagnosis of lymphoma-associated hemophagocytic syndrome (LAHS) is difficult, which results in the development of progressive disease with unfavorable prognosis. Therefore, in the diagnosis of secondary hemoph...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1239-7
更新日期：2012-01-01 00:00:00
abstract：:Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), olde...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1785-2
更新日期：2013-11-01 00:00:00
abstract：:Venous thromboembolism (VTE) is a well-recognized complication in pediatric oncology patients. Studies in adult oncology patients have suggested a potential negative association between VTE and survival, but this association has not been examined in pediatric patients yet. The aim of this study was to assess the assoc...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-018-3371-0
更新日期：2018-10-01 00:00:00
abstract：:In the present study, we questioned whether the cholesterol synthesis inhibitor lovastatin potentiates the cytotoxicity of chemotherapeutic agents in the primitive CD34(+) subpopulation of acute myeloid leukemia (AML) cells. AML mononuclear cells (n = 17) were sorted in CD34(+) and CD34(-) fractions and compared to no...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0633-2
更新日期：2009-06-01 00:00:00
abstract：:Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets accompanied by an increased risk of bleeding, which can have a significant negative impact on patients' health-related quality of life. The condition has long been associated with an increased rate of immune-mediated plat...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-010-0953-x
更新日期：2010-07-01 00:00:00
abstract：:The aim of this phase IV study was to (1) to define efficacy of escalating dose imatinib in chronic myeloid leukemia (CML) patients showing suboptimal response to standard dose imatinib and (2) to find markers that predict the response to escalating doses of imatinib. CML patients in chronic phase (CP) who failed to a...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-010-0910-8
更新日期：2010-07-01 00:00:00
abstract：:The somatic mutations of isocitrate dehydrogenase genes (IDH1 and IDH2) have been identified in a proportion of hematologic malignancies. We examined IDH1 R132 and IDH2 R140/R172 mutations by high resolution melting analysis and direct sequencing in Chinese patients with different myeloid malignancies including 198 ac...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1352-7
更新日期：2012-04-01 00:00:00
abstract：:Gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL) show a spectrum of disease characterized by varying proportions of low-grade and high-grade components. While the natural history and optimum treatment for low-grade gastric MALT lymphoma and DLBCL is well established, ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0604-7
更新日期：2009-05-01 00:00:00
abstract：:Currently, the diagnosis of acute graft-versus-host disease (aGVHD) is mainly based on clinical symptoms and biopsy results. This study was designed to further explore new no noninvasive biomarkers for aGVHD prediction/diagnosis. We profiled miRNAs in serum pools from patients with aGVHD (grades II-IV) (n = 9) and non...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-016-2781-0
更新日期：2016-10-01 00:00:00
abstract：:Anaphylactoid reaction to cyclophosphamide administration in a 85-year old woman is described. Symptomatology was restricted to bronchospasm, which regressed within one hour. This incomplete and rapidly regressive symptomatology might be explained by previous administration of methylprednisolone. No anaphylactoid symp...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01714904
更新日期：1991-02-01 00:00:00
abstract：:Cryoglobulinemia is uncommon in Southern Chinese in Hong Kong, with tropical climates and low incidence of hepatitis C virus (HCV) infection. Eight positive cases were detected among 481 patients screened for cryoglobulins over a 10-year period. Three HCV carriers (38%) ran benign courses. The others included two carr...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-004-0955-7
更新日期：2005-02-01 00:00:00
abstract：:Second allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a low survival outcome and a high non-relapse mortality (NRM) rate which is a major obstacle to this treatment. We hypothesized that the status of malnourishment after first allo-HSCT as represented by the geriatric nutritional risk index (GNRI)...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04089-0
更新日期：2020-07-01 00:00:00
abstract：:Hydroxyurea is a drug widely used to control myeloproliferative disorders, due in part to its relative lack of severe side effects. We present a case of acute interstitial pneumonitis in a patient who was treated with hydroxyurea for essential thrombocythemia. The clinical course suggests that the interstitial pneumon...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050498
更新日期：1999-04-01 00:00:00
abstract：:A 40-year-old patient with low-grade B-NHL developed a generalized macular-papular rash following the first cycle of fludarabine treatment which progressed to a complete epidermal necrolysis following the second cycle. Clinical symptoms and the results of the direct and indirect immunofluorescence were consistent with...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050347
更新日期：1997-11-01 00:00:00
