Abstract：
:In some instances, because of the lack of mass formation and the absence of prominent lymph node enlargement, diagnosis of lymphoma-associated hemophagocytic syndrome (LAHS) is difficult, which results in the development of progressive disease with unfavorable prognosis. Therefore, in the diagnosis of secondary hemophagocytic syndrome (HPS), markers for underlying malignant lymphoma are required. We reviewed 110 Japanese patients, including 57 LAHS cases and 53 benign disease-associated HPS cases, and demonstrated that the values of the serum sIL-2R level and sIL-2R/ferritin ratio in LAHS patients were both statistically higher than those of patients with benign disease-associated HPS. Most LAHS patients showed high values of both indices. The positive predictive value of patients showing high values of both indices for LAHS was 95.6%. On the other hand, the predictive value of patients showing low values of both indices for benign disease-associated HPS was 92.1%. We propose serum sIL-2R/ferritin ratio as a novel useful marker for predicting underlying malignant lymphoma in HPS patients.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Tabata C,Tabata Rdoi
10.1007/s00277-011-1239-7subject
Has Abstractpub_date
2012-01-01 00:00:00pages
63-71issue
1eissn
0939-5555issn
1432-0584journal_volume
91pub_type
杂志文章abstract：:The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2093-1
更新日期：2014-10-01 00:00:00
abstract：:We conducted a phase 2 study with bortezomib, doxorubicin, and dexamethasone (PAD) followed by thalidomide and dexamethasone (TD) in patients with relapsed multiple myeloma (MM). Forty patients were enrolled between November 2005 and October 2007, with follow-up continuing until January 2009. Efficacy could be assesse...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-010-0943-z
更新日期：2010-09-01 00:00:00
abstract：:We describe three cases of acute promyelocytic leukemia (APL) with long-term disease-free survival who developed congestive heart failure (CHF) requiring cardiac transplantation. All three patients presented late-onset cardiotoxicity. Cardiac failure occurred progressively after 31-month, 32-month, and 14-month interv...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0534-8
更新日期：2002-09-01 00:00:00
abstract：:A combination of chromosomal translocations associated with bcl-2 re-arrangement (t(14;18)) and c-myc re-arrangement (t(8;14), t(8;22), or t(2;8)) is a rare event. We describe the first cell line exhibiting t(14;18) and t(8;22), which will enable us to study the interactions of bcl-2 and c-myc systematically. Cell cul...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-007-0313-7
更新日期：2007-11-01 00:00:00
abstract：:Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon type of cutaneous lymphoma with an aggressive natural history. It generally carries a poor prognosis despite standard anthracycline-based chemotherapy. The optimum therapy is unknown. We report the case of a 66-year-old man with CD4/CD8 double negat...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0638-9
更新日期：2003-04-01 00:00:00
abstract：:Transplantation of autologous hematopoietic stem cells is a well established therapeutic procedure. Despite advances in efficacy of the stem cell mobilization and apheresis process until now a predictive factor for the expected stem cell yield before initiation of mobilization therapy could not be identified. The main...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-005-0074-0
更新日期：2006-06-01 00:00:00
abstract：:Upper aerodigestive tract natural killer (NK)/T-cell lymphoma (UNKTL) is the most common type of extranodal NK/T-cell lymphoma, nasal type. Serum beta2-microglobulin (β2-M) was found to be a predictor in some subtypes of B-cell lymphoma. However, its prognostic significance in NK/T-cell lymphoma has never been explore...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1434-1
更新日期：2012-08-01 00:00:00
abstract：:The lymphoplasmocytoid immunocytoma (Waldenström's disease) is a non-Hodgkin's lymphoma of low malignancy. The disease is defined by the production of monoclonal IgM-globulins in the bone marrow. These macroglobulins affect the aggregation of thrombocytes and bind the coagulation factors, which leads not only to hemor...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050195
更新日期：1996-07-01 00:00:00
abstract：:Fusion proteins encoded by several types of chromosomal translocations in promyelocytic leukemia can serve as aberrant transcriptional repressors relying on recruitment of histonedeacetylases (HDACs) into DNA-associated multi-protein complexes. Thus, inappropriate modulation of chromatin structure by HDACs and subsequ...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-004-0850-2
更新日期：2004-01-01 00:00:00
abstract：:Venous thromboembolism (VTE) is a well-recognized complication in pediatric oncology patients. Studies in adult oncology patients have suggested a potential negative association between VTE and survival, but this association has not been examined in pediatric patients yet. The aim of this study was to assess the assoc...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-018-3371-0
更新日期：2018-10-01 00:00:00
abstract：:Early mortality remains a major challenge for the treatment of hemophagocytic lymphohistiocytosis (HLH), which warrants the need for prompt risk stratification in the early phase of the disease. We retrospectively analyzed clinical features of a cohort of pediatric patients managed at a tertiary hospital in southern C...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2727-6
更新日期：2016-09-01 00:00:00
abstract：:Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is an atypical lympho-proliferative disorder with borderline features that often constitute a diagnostic challenge for the hematopathologist and a therapeutic dilemma for the treating clinician. Morphologically, the involved lymph nodes in this disorder are...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050244
更新日期：1996-12-01 00:00:00
abstract：:To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seroposi...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2222-x
更新日期：2015-03-01 00:00:00
abstract：:Acute megakaryoblastic leukaemia (AML-M7) is an uncommon disease, composing 0.5-1.2% of newly diagnosed adult acute myeloid leukaemias (AML). It is characterised by higher incidence and complexity of cytogenetic abnormalities. We report a rare case of Philadelphia (Ph) chromosome-positive AML-M7, presenting with extre...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0783-1
更新日期：2004-06-01 00:00:00
abstract：:We report on a patient who was diagnosed as having B-cell chronic lymphocytic leukemia (CLL) with atypical morphology. Flow cytometry disclosed CD5, CD19, and CD23 positivity, an immunophenotype seen mostly in B-CLL. Histology of the spleen and bone marrow suggested a diagnosis of small lymphocytic lymphoma. Upon blas...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050582
更新日期：2000-04-01 00:00:00
abstract：:Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-004-0985-1
更新日期：2005-03-01 00:00:00
abstract：:Philadelphia-negative myeloproliferative neoplasms (MPNs) are a diverse group of diseases whose common feature is the presence of V617F mutation of the JAK2 gene. In the era of novel therapeutic strategies in MPNs, such as JAK-inhibitor therapy, there is a growing need for establishing high sensitive quantitative meth...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-018-3451-1
更新日期：2018-12-01 00:00:00
abstract：:Recently, the combination of rituximab and bendamustine (R-Benda) has been defined as highly active in patients with follicular lymphomas, but little is known about the efficacy of R-Benda in mucosa-associated lymphoid tissue (MALT) lymphoma. In a retrospective analysis, we have defined 14 patients with MALT lymphoma ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1865-3
更新日期：2014-02-01 00:00:00
abstract：:Lymphoma-associated hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disease. Differences between B cell and T cell lymphoma-associated HLH remain unclear, specifically clinical characteristics and survival. We retrospectively analyzed 30 lymphoma-associated HLH patients from July 2004 to October 2012. Pat...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1784-3
更新日期：2013-11-01 00:00:00
abstract：:Thirty-nine pregnant women with idiopathic thrombocytopenic purpura (ITP) were studied in order to evaluate the influence of therapies for maternal ITP on fetal passive immune thrombocytopenia (PIT). Neonatal platelet counts were also compared with platelet counts, amount of PAIgG, and presence of circulating antiplat...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01695918
更新日期：1994-01-01 00:00:00
abstract：:A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal a...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0795-x
更新日期：2004-06-01 00:00:00
abstract：:The present study attempted to build a single nucleotide polymorphism (SNP)-based risk model for predicting overall survival (OS) and event-free survival (EFS) in patients with core binding factor acute myeloid leukemia (CBF-AML). Adopting genome-wide SNP array using Affymetrix SNP array 6.0, we analyzed 868,157 SNPs ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3260-6
更新日期：2018-06-01 00:00:00
abstract：:t(8;16)(p11.2;p13.3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML). We report 15 cases with t(8;16)(p11.2;p13.3). All patients were adult and had AML: 13 women and 2 men, with a median age of 50 years. Ten patients had a history of malignancy and received cytotox...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03637-7
更新日期：2019-05-01 00:00:00
abstract：:Recently we described a cutaneous T-cell lymphoma expressing the gamma/delta T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a s...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01695808
更新日期：1992-09-01 00:00:00
abstract：:The aim of this phase IV study was to (1) to define efficacy of escalating dose imatinib in chronic myeloid leukemia (CML) patients showing suboptimal response to standard dose imatinib and (2) to find markers that predict the response to escalating doses of imatinib. CML patients in chronic phase (CP) who failed to a...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-010-0910-8
更新日期：2010-07-01 00:00:00
abstract：:Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchosc...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2172-3
更新日期：2015-01-01 00:00:00
abstract：:Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-020-03985-9
更新日期：2020-06-01 00:00:00
abstract：:The impact of intraocular involvement (IOL) in primary CNS lymphoma (PCNSL) has not been sufficiently evaluated. Here, we present the analysis of IOL in the only completed randomized phase III trial in PCNSL. The G-PCNSL-SG1 study evaluated the role of whole-brain radiotherapy in primary therapy of PCNSL. Data of the ...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00277-014-2212-z
更新日期：2015-03-01 00:00:00
abstract：:The rarity of severe complications of this disease in children makes randomized clinical trials in immune thrombocytopenia (ITP) unfeasible. Therefore, the current management recommendations for ITP are largely dependent on clinical expertise and observations. As part of its discussions during the Intercontinental Coo...
journal_title：Annals of hematology
pub_type： 共识发展会议,杂志文章
doi：10.1007/s00277-010-0941-1
更新日期：2010-07-01 00:00:00
abstract：:Multicentric Castleman's disease (MCD) is a rare systemic lymphoproliferative disorder with too few patient series reported in the literature to have a clear idea about the etiology, outcome and the best treatment available. Systemic reactive amyloidosis is a very rare complication of MCD and its presence worsens the ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0718-x
更新日期：2003-12-01 00:00:00
