Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.

Abstract:

:A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal amphotericin B 5 mg/kg qd. Preceding monotherapy with amphotericin B deoxycholate 1.0-1.5 mg/kg qd had not stopped the progression of infection. The combination therapy described here represents a novel approach to the treatment of Fusarium spp. in the immunocompromised host in whom Fusarium spp. are known to cause disseminated infection with high mortality.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Rothe A,Seibold M,Hoppe T,Seifert H,Engert A,Caspar C,Karthaus M,Fätkenheuer G,Bethe U,Tintelnot K,Cornely OA

doi

10.1007/s00277-003-0795-x

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

394-7

issue

6

eissn

0939-5555

issn

1432-0584

journal_volume

83

pub_type

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