Abstract:
:Secondary central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) includes an isolated CNS relapse or CNS involvement with systemic disease progression. This rare but fatal clinical problem still remains a therapeutic dilemma in the management of DLBCL. However, there are limited data about its treatment outcome. In this study, we gathered 73 cases with secondary CNS involvement of DLBCL from 11 hospitals in Korea. The data were retrospectively compared according to the status of systemic disease (isolated vs. combined CNS involvement) and the use of high-dose methotrexate treatment (HD MTX). Twenty-nine patients showed isolated CNS involvement while 44 had combined CNS involvement with systemic relapse or progression. Thirty-three cases (45.2%) occurred within 6 months from the initial diagnosis, and the majority of these were associated with systemic disease relapse or progression (n = 27). In isolated CNS involvement, HD MTX resulted in fewer treatment failures (3/11) than the other treatments such as other salvage chemotherapy and/or radiotherapy/intraventricular chemotherapy (14/15). However, neither HD MTX nor other treatments were effective at reducing the treatment failure rate in combined CNS involvement (8/10 and 23/30, respectively). Thus, isolated CNS involvement had a better survival than combined involvement (P = 0.008), but systemic disease progression was the main cause of death in combined as well as isolated CNS involvement. In conclusion, the prognosis of secondary CNS involvement was dismal even after intensive chemotherapy using HD MTX. Further research focusing on the development of an optimal treatment strategy is warranted.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Kim SJ,Oh SY,Kim JS,Kim H,Lee GW,Won JH,Shin HJ,Yang DH,Choi CW,Park J,Kim WS,Suh Cdoi
10.1007/s00277-010-1104-0subject
Has Abstractpub_date
2011-05-01 00:00:00pages
539-46issue
5eissn
0939-5555issn
1432-0584journal_volume
90pub_type
杂志文章abstract::Cells of the macrophage lineage are a major source of various cytokines and hematopoietic growth factors. With regard to the growth factors acting on cells of their own lineage, macrophage colony-stimulating factor (M-CSF) has been proven to be secreted by monocytes (MO) and macrophages (MAC), whereas the production o...
journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章,meta分析,评审
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更新日期:2008-07-01 00:00:00
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journal_title:Annals of hematology
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更新日期:2014-06-01 00:00:00
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journal_title:Annals of hematology
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更新日期:2000-07-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Annals of hematology
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更新日期:2005-01-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,评审
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abstract::Fanconi anemia (FA) is a DNA repair disorder resulting from mutations in genes encoding for FA DNA repair complex components and is characterized by variable congenital abnormalities, bone marrow failure (BMF), and high incidences of malignancies. FA mosaicism arises from reversion or other compensatory mutations in h...
journal_title:Annals of hematology
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journal_title:Annals of hematology
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更新日期:2014-05-01 00:00:00
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002770050355
更新日期:1998-01-01 00:00:00
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-01-01 00:00:00
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
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