Life-threatening thrombocytopenia associated with acute Epstein-Barr virus infection in an older adult.

abstract：:Patients with malignancy often present with a variety of coagulation abnormalities which may ultimately lead to recurrent arterial and venous thromboses. Recently the presence of antiphospholipid antibodies in cancer patients has been proposed as one of the potential mechanisms promoting hypercoagulability. Here we re...

journal_title：Annals of hematology

authors： Langer F,Eifrig B,Marx G,Stork A,Hegewisch-Becker S,Hossfeld DK

更新日期：2002-12-01 00:00:00

abstract：:Hematopoietic recovery in 115 patients with metastatic breast cancer or metastatic melanoma, enrolled in phase-I studies of recombinant growth factors while undergoing treatment with high-dose chemotherapy with autologous bone marrow support, was examined with assays of bone marrow progenitor cells and peripheral bloo...

journal_title：Annals of hematology

authors： Laughlin MJ,Kirkpatrick G,Sabiston N,Peters W,Kurtzberg J

更新日期：1993-12-01 00:00:00

abstract：:African Americans have two- to three-fold higher incidence of multiple myeloma and MGUS compared to other ethnic groups in the USA. Some physicians often perform diagnostic evaluations for plasma cell disorders (PCD) in African American patients on the basis of hematological abnormalities (thrombocytopenia, leucopenia...

journal_title：Annals of hematology

authors： Tun NM,Joseph G,Soe AM,Ford JG

更新日期：2014-06-01 00:00:00

abstract：:Aplastic anaemia (AA) is a rare bone marrow failure syndrome treated either by immunosuppressive therapy or allogeneic stem cell transplantation (SCT). At present, no randomised clinical trials evaluating both treatment options, and in particular SCT from unrelated donors, are available. We here report the clinical co...

journal_title：Annals of hematology

authors： Buchholz S,Dammann E,Koenecke Ch,Stadler M,Franzke A,Blasczyk R,Bremer M,Krauter J,Hertenstein B,Ganser A,Eder M

更新日期：2008-07-01 00:00:00

abstract：:The clarification of enlarged lymph nodes is a common issue in clinical routine. By now, open surgery with complete lymph node extirpation, followed by histopathology, is considered as standard. We investigated the value of fine needle aspiration (FNA) and core needle biopsy (CNB) when supporting the conventional morp...

journal_title：Annals of hematology

authors： Metzgeroth G,Schneider S,Walz C,Reiter S,Hofmann WK,Marx A,Hastka J

更新日期：2012-09-01 00:00:00

abstract：:The Wilms' tumor 1 (WT1) expression has been recognized in a substantial number of acute myeloid leukemia (AML) patients. Some studies indicated the association of diagnosed WT1 higher expression (WT1(H)) and poor outcome in the AML patients, while other studies had different opinions. Therefore, we performed a meta-a...

journal_title：Annals of hematology

authors： Yi-Ning Y,Xiao-rui W,Chu-xian Z,Chun W,You-wen Q

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to investigate the prognostic role of pre- and/or early post-autologous stem cell transplantation (ASCT) (18)F-flourodeoxyglucose (FDG) positron emission tomography (PET) in patients with relapsed/refractory Hodgkin lymphoma. Forty-three consecutive patients were enrolled in this study...

journal_title：Annals of hematology

authors： Sucak GT,Özkurt ZN,Suyani E,Yaşar DG,Akdemir ÖÜ,Aki Z,Yeğin ZA,Yağci M,Kapucu ÖL

更新日期：2011-11-01 00:00:00

abstract：:Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic M...

journal_title：Annals of hematology

authors： Mussetti A,Pellegrinelli A,Cieri N,Garzone G,Dominoni F,Cabras A,Montefusco V

更新日期：2019-07-01 00:00:00

abstract：:The purpose of this cross-sectional prospective study was to determine the prevalence of anemia among elderly hospitalized patients in Germany and to investigate its association with multidimensional loss of function (MLF). One hundred participants aged 70 years or older from two distinct wards (50 each from an emerge...

journal_title：Annals of hematology

authors： Zilinski J,Zillmann R,Becker I,Benzing T,Schulz RJ,Roehrig G

更新日期：2014-10-01 00:00:00

abstract：:The most common causes of morbidity and mortality in myeloproliferative neoplasms (MPN) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPN, correlates with several clinical and laboratory characteristics even if the relevance of JAK2V617F allele burden in the natural history of...

journal_title：Annals of hematology

authors： Bertozzi I,Bogoni G,Biagetti G,Duner E,Lombardi AM,Fabris F,Randi ML

更新日期：2017-08-01 00:00:00

abstract：:Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Coopera...

journal_title：Annals of hematology

authors： Breccia M,Andriani A,Montanaro M,Abruzzese E,Buccisano F,Cedrone M,Centra A,Villivà N,Celesti F,Trawinska MM,Massaro F,Di Veroli A,Anaclerico B,Colafigli G,Molica M,Spadea A,Petriccione L,Cimino G,Latagliata R

更新日期：2017-03-01 00:00:00

abstract：:To investigate the problem of allogeneic bone marrow transplantation (allo-BMT) for advanced stage patients, we retrospectively analyzed 24 consecutive patients who underwent allo-BMT in the non-remission stage. Twenty-four patients (19 males and 5 females) with acute leukemia, chronic myelogenous leukemia, and malign...

journal_title：Annals of hematology

authors： Tabata M,Satake A,Okura N,Yamazaki Y,Toda A,Nishioka K,Tanaka H,Chin M,Itsukuma T,Yamaguchi M,Misawa M,Kai S,Hara H

更新日期：2002-10-01 00:00:00

abstract：:von Willebrand disease (VWD) is the commonest inherited bleeding disorder, yet it has not been well recognized in Southeast Asia. The aim of this prospective study was to report our experience of VWD diagnosis and to establish the clinical presentations of VWD in Taiwan. From October 2003 to April 2010, 863 patients w...

journal_title：Annals of hematology

authors： Chen YC,Yang L,Cheng SN,Hu SH,Chao TY

更新日期：2011-10-01 00:00:00

abstract：:The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 cente...

journal_title：Annals of hematology

authors： Leclerc M,Suarez F,Noël MP,Vekhoff A,Troussard X,Claisse JF,Thieblemont C,Maloisel F,Beguin Y,Tamburini J,Barbe C,Delmer A

更新日期：2015-01-01 00:00:00

abstract：:Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression t...

journal_title：Annals of hematology

authors： Appelmann I,Kreher S,Parmentier S,Wolf HH,Bisping G,Kirschner M,Bergmann F,Schilling K,Brümmendorf TH,Petrides PE,Tiede A,Matzdorff A,Griesshammer M,Riess H,Koschmieder S

更新日期：2016-04-01 00:00:00

abstract：:Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...

journal_title：Annals of hematology

authors： Cario H

更新日期：2005-03-01 00:00:00

abstract：:The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...

journal_title：Annals of hematology

authors： Kubota M,Sawada M,Watanabe K,Koishi S,Kataoka A,Usami I,Lin YW,Okuda A,Akiyama Y,Furusho K

更新日期：1997-02-01 00:00:00

abstract：:Overproduction of proinflammatory cytokines is characteristic of hemophagocytic syndrome (HPS), a highly lethal inflammatory disease. Peripheral blood monocytes include two distinct subpopulations according to surface antigen expression: a major type, CD14(+)/CD16(-) (classical monocytes), and a minor type, CD14(+)/CD...

journal_title：Annals of hematology

authors： Takeyama N,Yabuki T,Kumagai T,Takagi S,Takamoto S,Noguchi H

更新日期：2007-11-01 00:00:00

abstract：:To elucidate the role of hematopoietic growth factors (HGFs) and other cytokines in the autocrine or paracrine regulation of inducible hematopoiesis we studied cytokine gene expression in the bone marrow (BM) of patients after myelosuppressive treatment. Furthermore, we studied the cytokine gene expression profile in ...

journal_title：Annals of hematology

authors： Cluitmans FH,Esendam BH,Veenhof WF,Landegent JE,Willemze R,Falkenburg JH

更新日期：1997-07-01 00:00:00

abstract：:Telomere shortening represents an established mechanism connecting aging and cancer development. We sequentially analyzed telomere length (TL) of 49 acute myeloid leukemia (AML) patients at diagnosis (n = 24), once they achieved complete cytological remission (CCR) and/or during refractory disease or relapse and after...

journal_title：Annals of hematology

authors： Ventura Ferreira MS,Crysandt M,Ziegler P,Hummel S,Wilop S,Kirschner M,Schemionek M,Jost E,Wagner W,Brümmendorf TH,Beier F

更新日期：2017-09-01 00:00:00

abstract：:This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...

journal_title：Annals of hematology

authors： Brodmann S,Passweg JR,Gratwohl A,Tichelli A,Skoda RC

更新日期：2000-06-01 00:00:00

abstract：:Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP wa...

journal_title：Annals of hematology

authors： Liu WP,Wang XP,Zheng W,Xie Y,Tu MF,Lin NJ,Ping LY,Ying ZT,Zhang C,Deng LJ,Ding N,Wang XG,Song YQ,Zhu J

更新日期：2018-01-01 00:00:00

abstract：:We investigated whether human peripheral blood mononuclear cells (PBMC) express prothrombinase following stimulation with bacterial lipopolysaccharide (LPS). LPS-stimulated PBMC devoid of contaminating platelets failed to activate prothrombin directly. Addition of platelets did not result in expression of prothrombina...

journal_title：Annals of hematology

authors： Pejler G,Geczy CL

更新日期：2001-05-01 00:00:00

abstract：:Indolent follicular lymphomas are diseases which are generally incurable with conventional therapy. Although patients can survive for prolonged periods, the median duration of first remissions is about 2.5 years, and subsequent remissions progressively shorten with time. High-dose therapy with hematopoietic stem cell ...

journal_title：Annals of hematology

authors： Friedberg JW,Freedman AS

更新日期：1999-05-01 00:00:00

abstract：:Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 pa...

journal_title：Annals of hematology

authors： Cai Q,Luo X,Zhang G,Huang H,Huang H,Lin T,Jiang W,Xia Z,Young KH

更新日期：2014-09-01 00:00:00

abstract：:While much has been learned about the basic immunology and clinical characteristics of immune thrombocytopenia, many important questions remain with regard to pathogenesis, disease progression, identification of novel therapeutic targets and approaches, and clinical trials that rationalize and optimize use of existing...

journal_title：Annals of hematology

authors： Zehnder JL,Semple JW,Imbach P,Neufeld EJ,Buchanan GR,Cines DB,ICIS Study Group on Future Research in ITP.

更新日期：2010-07-01 00:00:00

abstract：:The present meta-analysis was undertaken to (1) assess erythroid response rates in myelodysplastic syndromes (MDS) patients treated with epoetin alfa as a monotherapy, (2) gain further insights into predictors of response rates, and (3) compare the erythroid response rates observed with epoetin alfa and darbepoetin al...

journal_title：Annals of hematology

authors： Moyo V,Lefebvre P,Duh MS,Yektashenas B,Mundle S

更新日期：2008-07-01 00:00:00

abstract：:Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma with heterogeneous outcomes. Progression or relapse of FL within 2 years (so-called POD24) after diagnosis is associated with a poor outcome for patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone) in clinica...

journal_title：Annals of hematology

authors： Sortais C,Lok A,Tessoulin B,Gastinne T,Mahé B,Dubruille V,Blin N,Touzeau C,Moreau A,Bossard C,Peterlin P,Garnier A,Guillaume T,Le Bourgeois A,Chevallier P,Moreau P,Leux C,Le Gouill S

更新日期：2020-07-01 00:00:00

abstract：:Since December 2019, a novel coronavirus has spread throughout China and across the world, causing a continuous increase in confirmed cases within a short period of time. Some studies reported cases of thrombocytopenia, but hardly any studies mentioned how the virus causes thrombocytopenia. We propose several mechanis...

journal_title：Annals of hematology

authors： Xu P,Zhou Q,Xu J

更新日期：2020-06-01 00:00:00

abstract：:The main purpose of this report is to focus on the importance of an accurate etiologic diagnosis of gastrointestinal complications during chemotherapy for acute myeloid leukemia, taking into account that a syndrome characterized by bowel wall thickening associated with diarrhea and abdominal pain may have etiologies d...

journal_title：Annals of hematology

authors： Capria S,Vitolo D,Cartoni C,Dessanti L,Micozzi A,Mandelli F,Meloni G

更新日期：2004-03-01 00:00:00