Incidence, clinical characteristics, and outcome of interstitial pneumonia in patients with lymphoma.

Abstract:

:Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP was observed in 106 patients. Of these, 23 patients were excluded from the study. Finally, 83 patients with IP were included in this study. The incidence of IP was 3.9% (7/287) in Hodgkin lymphoma and 2.4% (76/1925) in non-Hodgkin lymphoma (P = 0.210). The median number of chemotherapy cycles before IP was 3. The median time from the cessation of chemotherapy to IP was 17 days. Eighty-two (98.8%) patients recovered after the treatment with glucocorticoids. Sixty-six (79.5%) patients had a delay in chemotherapy, and 14 (16.9%) patients had premature termination of chemotherapy. Sixty-nine patients were re-treated with chemotherapy after remission from IP, of which 22 (31.9%) experienced IP recurrence. The incidence of IP recurrence was significantly higher in patients re-treated with a similar regimen than in those re-treated with an alternative regimen (65.4 vs. 11.6%, P < 0.001). In a multivariate Cox regression analysis, B symptoms and a history of drug allergies were identified as risk factors for IP. In conclusion, IP is a life-threatening complication in lymphoma patients. Glucocorticoid therapy with continuous monitoring of chest radiographic changes may be a favourable strategy for treating IP. However, IP may recur, especially in patients re-treated with a similar chemotherapy regimen.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Liu WP,Wang XP,Zheng W,Xie Y,Tu MF,Lin NJ,Ping LY,Ying ZT,Zhang C,Deng LJ,Ding N,Wang XG,Song YQ,Zhu J

doi

10.1007/s00277-017-3157-9

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

133-139

issue

1

eissn

0939-5555

issn

1432-0584

pii

10.1007/s00277-017-3157-9

journal_volume

97

pub_type

杂志文章
  • Myelodysplastic patients with raised percentage of hypochromic red cells have evidence of functional iron deficiency.

    abstract::Raised percentage hypochromic red cells (%HRC) were detected at diagnosis in 10 of 34 consecutive patients with low-risk myelodysplastic syndrome (MDS) [refractory anemia (RA) (4/26) and RA with ring sideroblasts (6/8)], all of whom had normal or increased serum ferritin and bone marrow iron stores. Elevated %HRC has ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-006-0107-3

    authors: Murphy PT,Quinn JP,O'Donghaile D,Swords R,O'Donnell JR

    更新日期:2006-07-01 00:00:00

  • Implication of HMOX1 and CCR5 genotypes on clinical phenotype of Egyptian patients with sickle cell anemia.

    abstract::Sickle cell disease (SCD) is a relatively common inherited hemolytic anemia among individuals of African descent. Genetic factors might clarify clinical diversity of the disease and variations in treatment response. Some researchers investigated heme oxygenase-1 (HMOX1) or chemokine receptor 5 (CCR5Δ32) genotypes amon...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-019-03697-9

    authors: Bakr S,Khorshied M,Talha N,Jaffer KY,Soliman N,Eid K,El-Ghamrawy M

    更新日期:2019-08-01 00:00:00

  • Allogeneic bone marrow transplantation compared to peripheral blood stem cell transplantation for the treatment of hematologic malignancies: a meta-analysis based on time-to-event data from randomized controlled trials.

    abstract::Controversy remains regarding the transplant outcomes of human leukocyte antigen-identical related bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) for the treatment of patients with hematological malignancies. To provide an estimate of the effect of BMT and PBSCT on clinical ou...

    journal_title:Annals of hematology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00277-011-1299-8

    authors: Chang YJ,Weng CL,Sun LX,Zhao YT

    更新日期:2012-03-01 00:00:00

  • Predictors of plasma cell disorders among African American patients: a community practice perspective.

    abstract::African Americans have two- to three-fold higher incidence of multiple myeloma and MGUS compared to other ethnic groups in the USA. Some physicians often perform diagnostic evaluations for plasma cell disorders (PCD) in African American patients on the basis of hematological abnormalities (thrombocytopenia, leucopenia...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-1990-z

    authors: Tun NM,Joseph G,Soe AM,Ford JG

    更新日期:2014-06-01 00:00:00

  • Allogeneic bone marrow transplantation for refractory mantle cell lymphoma.

    abstract::We report about a 28-year-old woman with relapsed mantle cell lymphoma (MCL, centrocytic lymphoma according to the Kiel classification) refractory to salvage chemotherapy. The patient underwent allogeneic bone marrow transplantation from a HLA-identical brother after myeloablative chemotherapy consisting of busulfan, ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770000196

    authors: Kröger N,Hoffknecht M,Krüger W,Zeller W,Renges H,Stute N,Zschaber R,Zander AR

    更新日期:2000-10-01 00:00:00

  • Toxoplasma gondii infection in patients with hematological malignancies.

    abstract::Toxoplasmosis is one of the most common parasitic infections in humans, but in most cases it does not cause serious illness; this protozoan can nevertheless cause devastating disease in immunocompromised hosts such as HIV-positive individuals. Only rarely is toxoplasmosis documented in hematological patients, and amon...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0898-z

    authors: Pagano L,Trapè G,Putzulu R,Caramatti C,Picardi M,Nosari A,Cinieri S,Caira M,Del Favero A,GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto)-Infection Program.

    更新日期:2004-09-01 00:00:00

  • Allogeneic hematopoietic stem cell transplantation for non-Hodgkin's lymphomas: a retrospective analysis of 77 cases.

    abstract::Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect. The main complications are graft-versus-host disease and infections. We performed a retrospec...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-2934-9

    authors: Picleanu AM,Novelli S,Monter A,Garcia-Cadenas I,Caballero AC,Martino R,Esquirol A,Briones J,Sierra J

    更新日期:2017-05-01 00:00:00

  • Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia.

    abstract::Indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells (DCs) can induce or maintain peripheral immune tolerance. Impaired IDO-mediated tryptophan catabolism has been observed in autoimmune diseases. In order to investigate the effects of IDO-mediated tryptophan catabolism and IDO-expressing DCs in immune thro...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1451-0

    authors: Xu SQ,Wang CY,Zhu XJ,Dong XY,Shi Y,Peng J,Qin P,Sun JZ,Guo C,Ni H,Hou M

    更新日期:2012-10-01 00:00:00

  • Chlorambucil-induced pulmonary disease: a case report and review of the literature.

    abstract::A 77-year-old man developed pneumonitis while on chlorambucil therapy for chronic lymphocytic leukemia, with a cumulative dose of 2700 mg. The condition improved promptly with the discontinuation of the drug and initiation of steroids. A case report and review of the literature are presented in this paper. ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s002770050418

    authors: Khong HT,McCarthy J

    更新日期:1998-07-01 00:00:00

  • Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia.

    abstract::Hypermethylation of CpG islands near gene promoter regions is associated with transcriptional inactivation and represents an important mechanism of gene silencing in carcinogenesis. Such epigenetic phenomena can act alongside DNA mutations and deletions to disrupt tumor-suppressor gene function. The methylation status...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-005-0005-0

    authors: Galm O,Wilop S,Lüders C,Jost E,Gehbauer G,Herman JG,Osieka R

    更新日期:2005-12-01 00:00:00

  • The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women.

    abstract::The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01714957

    authors: Milman N,Kirchhoff M

    更新日期:1991-07-01 00:00:00

  • Antibiotic prevention of pneumococcal infections in asplenic hosts: admission of insufficiency.

    abstract::Asplenic and hyposplenic patients have an increased risk for overwhelming pneumococcal infections, even several decades after splenectomy. Pneumococcal vaccination and daily oral administration of penicillin V are recommended to prevent such infections, 2-5 years after splenectomy, and for at least 5 years in children...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0779-x

    authors: de Montalembert M,Lenoir G

    更新日期:2004-01-01 00:00:00

  • B cell-activating factor: its clinical significance in multiple myeloma patients.

    abstract::B cell-activating factor (BAFF) is a cytokine that plays a major role in the maintenance of normal B-cell development and homeostasis. It has been suggested that in multiple myeloma (MM) it might have regulatory effects on the proliferation and viability of malignant plasma cells. The aim of this study was to evaluate...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1470-x

    authors: Fragioudaki M,Boula A,Tsirakis G,Psarakis F,Spanoudakis M,Papadakis IS,Pappa CA,Alexandrakis MG

    更新日期:2012-09-01 00:00:00

  • Correction to: Clinical outcomes in patients with diffuse large B cell lymphoma with a partial response to first-line R-CHOP chemotherapy: prognostic value of secondary International Prognostic Index scores and Deauville scores.

    abstract::An additional affiliation for the first author was not indicated. Hyewon Lee is also affiliated with: Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea. ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00277-019-03868-8

    authors: Lee H,Kim YR,Kim SJ,Park Y,Eom HS,Oh SY,Kim HJ,Kang HJ,Lee WS,Moon JH,Won YW,Kim TS,Kim JS

    更新日期:2020-01-01 00:00:00

  • Novel treatment strategies in follicular lymphoma.

    abstract::Malignant lymphomas are a heterogenous group of malignancies, belonging to the 10 most frequent types of cancers worldwide. In indolent lymphoma only patients with limited stage I/II (Ann Arbor) can be potentially cured by local irradiation. However, about 85% of cases present with advanced stage; for these patients n...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0850-2

    authors: Buske C,Dreyling H,Unterhalt M,Hiddemann W

    更新日期:2004-01-01 00:00:00

  • Platelet activation and function during eltrombopag treatment in immune thrombocytopenia.

    abstract::We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombop...

    journal_title:Annals of hematology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00277-011-1249-5

    authors: Haselboeck J,Pabinger I,Ay C,Koder S,Panzer S

    更新日期:2012-01-01 00:00:00

  • CLIPI: a new prognostic index for indolent cutaneous B cell lymphoma proposed by the International Extranodal Lymphoma Study Group (IELSG 11).

    abstract::Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with di...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-010-1083-1

    authors: Mian M,Marcheselli L,Luminari S,Federico M,Cantonetti M,Sarris AH,Rossi A,Rambaldi A,Frontani M,Devizzi L,Gianni AM,Busetto M,Berti E,Martinelli G,Tsang RW,Ferreri AJ,Pinotti G,Pogliani E,Zucca E,Cortelazzo S

    更新日期:2011-04-01 00:00:00

  • Prediction of thrombosis risk in patients with paroxysmal nocturnal hemoglobinuria.

    abstract::Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disease with thrombosis as a major complication. The mechanism of thrombosis and related risk factors in PNH patients are still not well characterized. We retrospectively enrolled 99 patients with newly diagnosed PNH at our institute from 2011 to 2016....

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-019-03770-3

    authors: Huang Y,Liu X,Chen F,Zhou W,Li H,Long Z,Yang C,Chen M,Han B

    更新日期:2019-10-01 00:00:00

  • Differential plasma proteome profiles of mild versus severe β-thalassemia/Hb E.

    abstract::The severity of thalassemia is currently classified based on clinical manifestations and multiple tests. In the present study, we performed a plasma proteome analysis to identify differentially expressed proteins compared between normal subjects and patients with mild and severe forms of β-thalassemia/hemoglobin E (Hb...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1629-5

    authors: Hatairaktham S,Srisawat C,Siritanaratkul N,Chiangjong W,Fucharoen S,Thongboonkerd V,Kalpravidh RW

    更新日期:2013-03-01 00:00:00

  • Abnormal depolarizing patterns in three patients with filarial infection.

    abstract::Several authors have described a particular potential of automated depolarization analysis in detecting malaria infection as part of the routine full blood count (FBC) performed by the Cell-Dyn 4000 analyzer. In these cases, abnormal depolarizing patterns are due to the presence of leukocyte-associated malaria hemozoi...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0786-y

    authors: Crespo S,Palacios G,Scott S,Lago M,Puente S,Martínez M,Baquero M,Subirats M

    更新日期:2004-05-01 00:00:00

  • Impact of extramedullary plasmacytomas on outcomes according to treatment approach in newly diagnosed symptomatic multiple myeloma.

    abstract::The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone. A total of 275 consecutive patients with newly diagnosed MM were included, a...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2216-8

    authors: Lee SE,Kim JH,Jeon YW,Yoon JH,Shin SH,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Lee JW,Min WS,Park CW,Min CK

    更新日期:2015-03-01 00:00:00

  • Two novel factor X gene mutations in a Chinese family with factor X deficiency.

    abstract::We report a factor X (FX)-deficient Chinese family with two novel FX gene (F10) mutations. Two sibling probands had a bleeding tendency since childhood. Both had very low FX:C (<0.01 IU/ml) and FX:Ag (5-6%) levels and were heterozygous for two novel F10 mutations, a 2-bp GC deletion involving nucleotides 33 and 34, le...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0803-1

    authors: Au WY,Lam CC,Cheung WC,Kwong YL

    更新日期:2004-05-01 00:00:00

  • Improved clinical outcomes for multiple myeloma patients treated at a single specialty clinic.

    abstract::Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong overall survival (OS) and preserve patients' quality of life. We have analyzed data from 264 consecutive MM patients who had their initial visit bet...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2888-3

    authors: Berenson A,Vardanyan S,David M,Wang J,Harutyunyan NM,Gottlieb J,Halleluyan R,Spektor TM,Udd KA,Eshaghian S,Nassir Y,Eades B,Swift R,Berenson JR

    更新日期:2017-03-01 00:00:00

  • 2-Chlorodeoxyadenosine with or without daunorubicin in relapsed or refractory acute myeloid leukemia.

    abstract::2-Chlorodeoxyadenosine (2-CdA) is a purine analogue which has proved to be active in acute myeloid leukemia (AML), especially in children. In adults, results yielded by 2-CdA alone or with ara-C were less encouraging. Here we report on the efficacy of 2-CdA with or without daunorubicin (DNR) in 19 relapsing or refract...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s002770050355

    authors: Van Den Neste E,Martiat P,Mineur P,Delannoy A,Doyen C,Zenebergh A,Michaux JL,Ferrant A

    更新日期:1998-01-01 00:00:00

  • T-cell large granular lymphocyte leukemia: an Asian perspective.

    abstract::To characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most co...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-009-0895-3

    authors: Kwong YL,Au WY,Leung AY,Tse EW

    更新日期:2010-04-01 00:00:00

  • A novel scoring system to predict the incidence of invasive fungal disease in salvage chemotherapies for malignant lymphoma.

    abstract::The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2093-1

    authors: Takaoka K,Nannya Y,Shinohara A,Arai S,Nakamura F,Kurokawa M

    更新日期:2014-10-01 00:00:00

  • Geriatric nutritional risk index as a useful prognostic factor in second allogeneic hematopoietic stem cell transplantation.

    abstract::Second allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a low survival outcome and a high non-relapse mortality (NRM) rate which is a major obstacle to this treatment. We hypothesized that the status of malnourishment after first allo-HSCT as represented by the geriatric nutritional risk index (GNRI)...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04089-0

    authors: Kaito S,Wada A,Adachi H,Konuma R,Kishida Y,Nagata A,Konishi T,Yamada Y,Kumagai T,Yoshifuji K,Mukae J,Akiyama M,Inamoto K,Toya T,Igarashi A,Najima Y,Muto H,Kobayashi T,Kakihana K,Ohashi K,Sakamaki H,Doki N

    更新日期:2020-07-01 00:00:00

  • An unusual case of leukemic non-Hodgkin's lymphoma with blastic transformation.

    abstract::We report on a patient who was diagnosed as having B-cell chronic lymphocytic leukemia (CLL) with atypical morphology. Flow cytometry disclosed CD5, CD19, and CD23 positivity, an immunophenotype seen mostly in B-CLL. Histology of the spleen and bone marrow suggested a diagnosis of small lymphocytic lymphoma. Upon blas...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050582

    authors: Späth-Schwalbe E,Flath B,Kaufmann O,Thiel G,Brinckmann R,Dietel M,Possinger K

    更新日期:2000-04-01 00:00:00

  • Severe epidermal necrolysis after treatment with imatinib and consecutive allogeneic hematopoietic stem cell transplantation.

    abstract::Imatinib is a new promising therapeutic option for chronic myeloid leukemia (CML) with efficacy even in the blast phase of the disease. However, most patients treated with imatinib in the blast phase develop progressive disease rapidly. Thus, treatment with imatinib has to be followed by other treatment strategies. Th...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0643-z

    authors: Schaich M,Schäkel K,Illmer T,Ehninger G,Bornhäuser M

    更新日期:2003-05-01 00:00:00

  • Radiotherapy and PGEMOX/GELOX regimen improved prognosis in elderly patients with early-stage extranodal NK/T-cell lymphoma.

    abstract::The optimal treatment strategy for elderly patients with natural killer/T-cell lymphoma (NKTCL) remains to be established. A total of 63 elderly patients with newly diagnosed NKTCL were retrospectively reviewed. Among the patients with stage I-II disease, 58.3 % received radiotherapy (RT) ± chemotherapy, and 41.7 % re...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-015-2395-y

    authors: Bi XW,Xia Y,Zhang WW,Sun P,Liu PP,Wang Y,Huang JJ,Jiang WQ,Li ZM

    更新日期:2015-09-01 00:00:00