High-dose therapy and stem cell transplantation in follicular lymphoma.

Abstract:

:Indolent follicular lymphomas are diseases which are generally incurable with conventional therapy. Although patients can survive for prolonged periods, the median duration of first remissions is about 2.5 years, and subsequent remissions progressively shorten with time. High-dose therapy with hematopoietic stem cell support leads to prolonged disease-free and overall survival in a subset of patients with aggressive non-Hodgkin's lymphoma. Mounting evidence suggests similar findings for selected patients with indolent follicular non-Hodgkin's lymphoma. It is still unclear as to when this approach should be used; however, inferior results have been seen in heavily pretreated patients. In contrast, encouraging results are being reported in patients undergoing such treatment early in the course of their disease. Despite these data, many patients continue to relapse, and investigations are now focused on eradication of minimal residual disease, allogeneic transplantation, novel ablative regimens, and improvements in stem cell purging.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Friedberg JW,Freedman AS

doi

10.1007/s002770050503

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

203-11

issue

5

eissn

0939-5555

issn

1432-0584

journal_volume

78

pub_type

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