Mechanism of thrombocytopenia in COVID-19 patients.

abstract：:Rituximab was recently described also as first-line therapy of chronic graft-versus-host disease (cGvHD). We retrospectively analyzed the efficacy and safety of all patients receiving rituximab for treatment of cGvHD between 2005 and 2016 at the Regensburg University transplant center with a median follow-up after rit...

journal_title：Annals of hematology

authors： Klobuch S,Weber D,Holler B,Edinger M,Herr W,Holler E,Wolff D

更新日期：2019-10-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a rare hematologic malignancy in children. Hyperactivation of the Ras pathway from gene mutations is known to be the key culprit in the development of JMML. In this study, we investigated Ras pathway mutations and prognostic implication in Korean patients with JMML. A total o...

journal_title：Annals of hematology

authors： Park HD,Lee SH,Sung KW,Koo HH,Jung NG,Cho B,Kim HK,Park IA,Lee KO,Ki CS,Kim SH,Yoo KH,Kim HJ

更新日期：2012-04-01 00:00:00

abstract：:While inherited X-linked (XL) isolated thrombocytopenia is a mild condition, the Wiskott-Aldrich syndrome (WAS) associates severe thrombocytopenia with an immunodeficiency component and has a poor prognosis. Whether these conditions correspond to separate genetic entities or to different mutations of the same gene(s) ...

journal_title：Annals of hematology

authors： De Saint-Basile G,Schlegel N,Caniglia M,Le Deist F,Kaplan C,Lecompte T,Piller F,Fischer A,Griscelli C

更新日期：1991-08-01 00:00:00

abstract：:The prognosis of patients with stage III/IV NK/T-cell lymphoma (NTCL) is extremely poor. Although L-asparaginase (L-asp) is effective for NTCL, its significance has not been clearly demonstrated. In addition, there are few studies comparing treatment outcomes in stage III/IV NTCL. This study evaluated the efficacy of ...

journal_title：Annals of hematology

authors： Kim M,Kim TM,Kim KH,Keam B,Lee SH,Kim DW,Lee JS,Jeon YK,Kim CW,Heo DS

更新日期：2015-03-01 00:00:00

abstract：:Follicular lymphoma (FL) is a low-grade lymphoma that is usually characterized by generalized lymphadenopathy. Extranodal invasion by FL generally involves the bone marrow, skin, and duodenum; splenic infiltration often occurs in the advanced stages. However, primary splenic FL is very rare. Hence, few studies have be...

journal_title：Annals of hematology

authors： Shimono J,Miyoshi H,Kamimura T,Eto T,Miyagishima T,Sasaki Y,Kurita D,Kawamoto K,Nagafuji K,Seto M,Teshima T,Ohshima K

更新日期：2017-12-01 00:00:00

abstract：:Since July 2017, different generic imatinib formulations have been introduced in Italy for the treatment of patients with chronic myeloid leukemia (CML). We analyzed 168 chronic phase CML patients treated with branded imatinib for a median of 12 years (range 1-16) at a single institution who switched to a single gener...

journal_title：Annals of hematology

authors： Scalzulli E,Colafigli G,Latagliata R,Pepe S,Diverio D,Stocchi F,Di Prima A,Efficace F,Martelli M,Foà R,Breccia M

更新日期：2020-12-01 00:00:00

abstract：:This paper describes six Indian families in which silent-gene beta-thalassemia was encountered by us in the past 2 years. This stresses the importance of globin-chain synthesis in the diagnosis of beta-thalassemia. Of these six cases, five were diagnosed retrospectively when they had a homozygous beta-thalassemia offs...

journal_title：Annals of hematology

authors： Nadkarni A,Pawar A,Mudera VC,Mohanty D,Colah R

更新日期：1995-01-01 00:00:00

abstract：:In this paper we report a rare association of a splenic marginal zone B-cell lymphoma with villous lymphocytes and a T-cell large granular lymphocytic leukemia coexpressing CD4 and CD8 as well as CD56 and CD57 natural killer-associated markers in an asymptomatic patient investigated because of an occasional finding of...

journal_title：Annals of hematology

authors： Lima M,Gonçalves C,Marques L,Martin MC,Teixeira MA,Queirós ML,Santos AH,Balanzategui A,Garcia-Sanz R,Pinto-Ribeiro AC,Justiça B,Orfão A

更新日期：2001-11-01 00:00:00

abstract：:Genes involved in the hemostatic mechanism are logical candidate genes for association studies in prothrombotic conditions such as stroke. Since the underlying etiology in pediatric strokes is different than adults, looking for genetic causes would be the logical thing to do in the pediatric stroke population. Fifty-e...

journal_title：Annals of hematology

authors： Biswas A,Tiwari AK,Ranjan R,Meena A,Akhter MS,Yadav BK,Behari M,Saxena R

更新日期：2009-05-01 00:00:00

abstract：:We have performed a retrospective analysis of all patients with extragastric mucosa-associated lymphoid tissue (MALT) lymphoma treated at our institution to compare the efficacy of first-line therapeutic modalities including surgery, radiation, systemic therapy, and antibiotics. One hundred eighty-five patients with e...

journal_title：Annals of hematology

authors： Wöhrer S,Kiesewetter B,Fischbach J,Müllauer L,Troch M,Lukas J,Mayerhoefer ME,Raderer M

更新日期：2014-08-01 00:00:00

abstract：:Solitary plasmacytoma of bone (SPB) is a rare tumor that represents a minority of patients with plasma cell localized malignancy characterized by a single osteolytic bone lesion. The molecular mechanism underlying the genesis of SPB has remained enigmatic. Signal transducers and activators of transcription-3 (STAT3) i...

journal_title：Annals of hematology

authors： Guo S,Zhi Y,Yang H,Yu Y,Wang Y,Zhang J,Wang G,Zhang L,Sun B,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean p...

journal_title：Annals of hematology

authors： Ceyhan T,Beyan C,Başer I,Kaptan K,Güngör S,Ifran A

更新日期：2006-05-01 00:00:00

abstract：:Multiresistant bacterial infections are a potentially life-threatening condition in acute leukaemia (AL) patients. We aimed to better define the very recent epidemiology and outcome of bloodstream infections (BSIs) in a real-life setting. We prospectively collected all consecutive febrile/infectious episodes occurring...

journal_title：Annals of hematology

authors： Cattaneo C,Zappasodi P,Mancini V,Annaloro C,Pavesi F,Skert C,Ferrario A,Todisco E,Saccà V,Verga L,Passi A,Da Vià M,Ferrari S,Mometto G,Petullà M,Nosari A,Rossi G

更新日期：2016-12-01 00:00:00

abstract：:We have established reference values of peripheral blood lymphocyte subsets in healthy female Wistar rats under highly standardized conditions. Using monoclonal antibodies and flow cytometry, T lymphocytes (OX19+), B lymphocytes (OX6+ and anti-Ig+), T-helper/inducer (W3/25+), and T-suppressor/cytotoxic subsets (OX8+) ...

journal_title：Annals of hematology

authors： Franch A,Castellote C,Pelegrí C,Tolosa E,Castell M

更新日期：1993-09-01 00:00:00

abstract：:Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...

journal_title：Annals of hematology

authors： Awan FT,Jones JA,Maddocks K,Poi M,Grever MR,Johnson A,Byrd JC,Andritsos LA

更新日期：2016-06-01 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte antigen-4 (CTLA-4) are important risk factors associated with autoimmune diseases and malignancies. This study explored the association of CTLA-4SNPs with the development of myeloma and evaluated the outcome of patients receiving bortezomib-based regimen...

journal_title：Annals of hematology

authors： Qin XY,Lu J,Li GX,Wen L,Liu Y,Xu LP,Chang YJ,Liu KY,Jiang ZF,Huang XJ

更新日期：2018-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have emerged as a therapeutic approach in a range of medical fields, including regenerative medicine, cancer, autoimmune diseases, and inflammatory diseases, because of their unique properties of tissue repair and major histocompatibility complex-unmatched immunosuppression. Because both ...

journal_title：Annals of hematology

authors： Kim N,Im KI,Lim JY,Jeon EJ,Nam YS,Kim EJ,Cho SG

更新日期：2013-10-01 00:00:00

abstract：:The optimal treatment strategy for elderly patients with natural killer/T-cell lymphoma (NKTCL) remains to be established. A total of 63 elderly patients with newly diagnosed NKTCL were retrospectively reviewed. Among the patients with stage I-II disease, 58.3 % received radiotherapy (RT) ± chemotherapy, and 41.7 % re...

journal_title：Annals of hematology

authors： Bi XW,Xia Y,Zhang WW,Sun P,Liu PP,Wang Y,Huang JJ,Jiang WQ,Li ZM

更新日期：2015-09-01 00:00:00

abstract：:Umbilical cord blood is capable of hematopoietic stem cell reconstitution in children. However, the major limitation of cord blood is a relatively low content of pluripotent progenitor cells. Thus, safe engraftment for adolescents and for adults is still not predictable and a technology for ex vivo expansion of umbili...

journal_title：Annals of hematology

authors： Schwinger W,Benesch M,Lackner H,Kerbl R,Walcher M,Urban C

更新日期：1999-08-01 00:00:00

abstract：:A 40-year-old patient with low-grade B-NHL developed a generalized macular-papular rash following the first cycle of fludarabine treatment which progressed to a complete epidermal necrolysis following the second cycle. Clinical symptoms and the results of the direct and indirect immunofluorescence were consistent with...

journal_title：Annals of hematology

authors： Braess J,Reich K,Willert S,Strutz F,Neumann C,Hiddemann W,Wörmann B

更新日期：1997-11-01 00:00:00

abstract：:Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...

journal_title：Annals of hematology

authors： Cario H

更新日期：2005-03-01 00:00:00

abstract：:During the last few years, new insights into the biology of mantle cell lymphoma have been obtained. However, with a median survival of only 3 years, mantle cell lymphoma remains the lymphoma subtype with the poorest prognosis. At initial diagnosis most patients present with advanced Ann Arbor stage III or IV and conv...

journal_title：Annals of hematology

authors： Lenz G,Dreyling M,Hiddemann W

更新日期：2004-02-01 00:00:00

abstract：:Despite high-dose chemotherapy and autografting, the outcome for patients with primary refractory Hodgkin's disease (HD) or multiple relapses remains unsatisfactory. Six pediatric patients (median age: 16 years, range: 11-19) received reduced intensity conditioning and allogeneic peripheral blood stem cell transplanta...

journal_title：Annals of hematology

authors： Claviez A,Klingebiel T,Beyer J,Nürnberger W,Ehninger G,Suttorp M,Dreger P,Dörffel W,Schmitz N

更新日期：2004-04-01 00:00:00

abstract：:Azacitidine (AZA) is a DNA hypomethylation agent administered in myeloid neoplasms; however, there is still a lack of established predictors of response. We studied 113 patients with myelodysplastic syndromes (n = 85) or acute myeloid leukemia (n = 28) who received AZA to assess the predictive value on response of cli...

journal_title：Annals of hematology

authors： Martín I,Navarro B,Serrano A,Villamón E,Calabuig M,Solano C,Chaves FJ,Yagüe N,Orts M,Amat P,Fuentes A,Seda E,García F,Hernández-Boluda JC,Tormo M

更新日期：2020-03-01 00:00:00

abstract：:Patients with malignancy often present with a variety of coagulation abnormalities which may ultimately lead to recurrent arterial and venous thromboses. Recently the presence of antiphospholipid antibodies in cancer patients has been proposed as one of the potential mechanisms promoting hypercoagulability. Here we re...

journal_title：Annals of hematology

authors： Langer F,Eifrig B,Marx G,Stork A,Hegewisch-Becker S,Hossfeld DK

更新日期：2002-12-01 00:00:00

abstract：:Steroid-resistant acute graft-versus-host disease (GVHD) of the gastrointestinal tract associates with important morbidity and mortality. While high-dose steroids are the established first-line therapy in GVHD, no second-line therapy is generally accepted. In this analysis of 65 consecutive patients with severe, stero...

journal_title：Annals of hematology

authors： Turki AT,Bayraktar E,Basu O,Benkö T,Yi JH,Kehrmann J,Tzalavras A,Liebregts T,Beelen DW,Steckel NK

更新日期：2019-10-01 00:00:00

abstract：:Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among genetically at risk p...

journal_title：Annals of hematology

authors： Aranda N,Viteri FE,Montserrat C,Arija V

更新日期：2010-08-01 00:00:00

abstract：:Spontaneous splenic rupture is a rare, though life-threatening complication of some hematological malignancies and is even more infrequent as the initial symptom of acute lymphoblastic leukemia. We describe the fourth case, to our knowledge, of acute lymphoblastic leukemia presenting as splenic rupture, and for the fi...

journal_title：Annals of hematology

authors： Altès A,Brunet S,Martinez C,Soler J,Ayats R,Sureda A,López R,Domingo A

更新日期：1994-03-01 00:00:00

abstract：:Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...

journal_title：Annals of hematology

authors： Saultz JN,Wu HM,Cataland S

更新日期：2015-09-01 00:00:00

abstract：:Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and non-relapse mortality. The FLAMSA-RIC protocol for high-risk patients with acute myeloid leukemia (AML) and myel...

journal_title：Annals of hematology

authors： Chemnitz JM,von Lilienfeld-Toal M,Holtick U,Theurich S,Shimabukuro-Vornhagen A,Krause A,Brossart P,Hallek M,Scheid C

更新日期：2012-01-01 00:00:00