Clinical heterogeneity of silent-gene b-thalassemia among Indians.

abstract：:It has been suggested that human mesenchymal stem cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC to limit radiation-induced skin lesions. Immunodeficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/min) using a (60)Co source to ind...

journal_title：Annals of hematology

authors： François S,Mouiseddine M,Mathieu N,Semont A,Monti P,Dudoignon N,Saché A,Boutarfa A,Thierry D,Gourmelon P,Chapel A

更新日期：2007-01-01 00:00:00

abstract：:The object of this study was to assess the estimation of 2- and 5-year overall survival and tumor response and the frequency and severity of treatment morbidity with a modified ProMACE-MOPP hybrid protocol in patients with primary CNS lymphoma (PCNSL). Thirty-two immunocompetent patients were treated with a regimen of...

journal_title：Annals of hematology

authors： Yamanaka R,Morii K,Shinbo Y,Takeuchi S,Tamura T,Hondoh H,Takahashi H,Onda K,Takahashi H,Tanaka R

更新日期：2005-07-01 00:00:00

abstract：:The JAK2V617F mutation is part of the major criteria for diagnosis of myeloproliferative neoplasms (MPN). Allele-specific quantitative PCR (qPCR) is the most prevalent method used in laboratories but with the advent of next-generation sequencing (NGS) techniques, we felt necessary to evaluate this approach for JAK2 mu...

journal_title：Annals of hematology

authors： Maslah N,Verger E,Schlageter MH,Miclea JM,Kiladjian JJ,Giraudier S,Chomienne C,Cassinat B

更新日期：2019-01-01 00:00:00

abstract：:The response to intravenous immunoglobulin treatment (IVIG) is thought, in part, to be due to blockade of Fc receptor for IgG in the mononuclear phagocyte system (MPS). We have studied this by measuring splenic clearance of heat-damaged and IgG antibody-coated red cells in immune thrombocytopenic patients receiving IV...

journal_title：Annals of hematology

authors： Newland AC,Macey MG

更新日期：1994-08-01 00:00:00

abstract：:The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively...

journal_title：Annals of hematology

authors： Byun JM,Kim YJ,Yoon HJ,Kim SY,Kim HJ,Yoon J,Min YH,Cheong JW,Park J,Lee JH,Hong DS,Park SK,Kim HJ,Ahn JS,Shin HJ,Chung JS,Lee WS,Lee SM,Park Y,Kim BS,Lee JH,Lee KH,Jung CW,Jang JH,Min WS,Park TS,AML\/M

更新日期：2016-08-01 00:00:00

abstract：:The benefits of intensive post-remission chemotherapy have not been verified in elderly patients with acute myeloid leukemia (AML). To reduce fatal complications caused by intensive post-remission therapy, we performed a prospective phase II multicenter trial of standard induction chemotherapy ('7+3' of cytarabine plu...

journal_title：Annals of hematology

authors： Lee JH,Choi SJ,Lee JH,Park JH,Kim H,Joo YD,Lee WS,Zang DY,Kim HJ,Lee KH,Cooperative Study Group A for Hematology.

更新日期：2006-06-01 00:00:00

abstract：:High-count monoclonal B cell lymphocytosis (MBL) with a chronic lymphocytic leukemia (CLL) phenotype is a well-known entity, featuring 1-4% annual risk of progression towards CLL requiring treatment. Lymphoma-like MBL (L-MBL), on the other hand, remains poorly defined and data regarding outcome are lacking. We retrosp...

journal_title：Annals of hematology

authors： Vander Meeren S,Heyrman B,Renmans W,Bakkus M,Maes B,De Raeve H,Schots R,Jochmans K

更新日期：2018-07-01 00:00:00

abstract：:Children with sickle cell disease (SCD) benefit from newborn screening, because life-threatening complications can be prevented by pre-symptomatic diagnosis. In Germany, the immigration of people from endemic countries is steadily growing. Comprehensive data about the epidemiology and prevalence of SCD in Germany are ...

journal_title：Annals of hematology

authors： Kunz JB,Awad S,Happich M,Muckenthaler L,Lindner M,Gramer G,Okun JG,Hoffmann GF,Bruckner T,Muckenthaler MU,Kulozik AE

更新日期：2016-02-01 00:00:00

abstract：:The Wilms' tumor 1 (WT1) expression has been recognized in a substantial number of acute myeloid leukemia (AML) patients. Some studies indicated the association of diagnosed WT1 higher expression (WT1(H)) and poor outcome in the AML patients, while other studies had different opinions. Therefore, we performed a meta-a...

journal_title：Annals of hematology

authors： Yi-Ning Y,Xiao-rui W,Chu-xian Z,Chun W,You-wen Q

更新日期：2015-06-01 00:00:00

abstract：:Hematopoietic chimerism can be used as a tool for patient management after allogeneic hematopoietic stem cell transplantation (HSCT). An increase in the proportion of recipient cells after transplantation is strongly associated with relapse in chronic myeloid leukemia. However, in acute myeloid leukemia (AML) the sign...

journal_title：Annals of hematology

authors： Waterhouse M,Bertz H,Finke J

更新日期：2014-02-01 00:00:00

abstract：:Indolent follicular lymphomas are diseases which are generally incurable with conventional therapy. Although patients can survive for prolonged periods, the median duration of first remissions is about 2.5 years, and subsequent remissions progressively shorten with time. High-dose therapy with hematopoietic stem cell ...

journal_title：Annals of hematology

authors： Friedberg JW,Freedman AS

更新日期：1999-05-01 00:00:00

abstract：:The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...

journal_title：Annals of hematology

authors： Kubota M,Sawada M,Watanabe K,Koishi S,Kataoka A,Usami I,Lin YW,Okuda A,Akiyama Y,Furusho K

更新日期：1997-02-01 00:00:00

abstract：:Iron status, i.e. serum ferritin and haemoglobin (Hb) levels, was assessed in a population survey in 1994 (Dan-Monica 10) comprising 1319 Caucasian Danish women in age cohorts of 40, 50, 60 and 70 years. In the entire series, ferritin levels increased significantly from 40 years to 60 years of age. The prevalence of s...

journal_title：Annals of hematology

authors： Milman N,Byg KE,Ovesen L

更新日期：2000-11-01 00:00:00

abstract：:We report a factor X (FX)-deficient Chinese family with two novel FX gene (F10) mutations. Two sibling probands had a bleeding tendency since childhood. Both had very low FX:C (<0.01 IU/ml) and FX:Ag (5-6%) levels and were heterozygous for two novel F10 mutations, a 2-bp GC deletion involving nucleotides 33 and 34, le...

journal_title：Annals of hematology

authors： Au WY,Lam CC,Cheung WC,Kwong YL

更新日期：2004-05-01 00:00:00

abstract：:Telomere shortening represents an established mechanism connecting aging and cancer development. We sequentially analyzed telomere length (TL) of 49 acute myeloid leukemia (AML) patients at diagnosis (n = 24), once they achieved complete cytological remission (CCR) and/or during refractory disease or relapse and after...

journal_title：Annals of hematology

authors： Ventura Ferreira MS,Crysandt M,Ziegler P,Hummel S,Wilop S,Kirschner M,Schemionek M,Jost E,Wagner W,Brümmendorf TH,Beier F

更新日期：2017-09-01 00:00:00

abstract：:Expression of long non-coding RNA KIAA0125 has been incorporated in various gene expression signatures for prognostic prediction in acute myeloid leukemia (AML) patients, yet its functions and clinical significance remain unclear. This study aimed to investigate the clinical and biological characteristics of AML beari...

journal_title：Annals of hematology

authors： Wang YH,Lin CC,Hsu CL,Hung SY,Yao CY,Lee SH,Tsai CH,Hou HA,Chou WC,Tien HF

更新日期：2021-02-01 00:00:00

abstract：:Follicular lymphoma (FL) is generally considered an indolent disorder. With modern day treatments, long remissions are often achieved both in the front-line and relapsed setting. However, a subset of patients has a more aggressive course and a worse outcome. Their identification is the main purpose of modern day progn...

journal_title：Annals of hematology

authors： Sorigue M,Sancho JM

更新日期：2018-02-01 00:00:00

abstract：:The possibility that human mesenchymal stromal cells (hMSC) may derive from the malignant clone in hematological malignancies (HM) is a controversial issue. In order to clarify hMSC origin and disclose possible cytogenetic heterogeneity in hMSC belonging to different patients, bone marrow (BM)-derived hMSC samples fro...

journal_title：Annals of hematology

authors： Campioni D,Bardi MA,Cavazzini F,Tammiso E,Pezzolo E,Pregnolato E,Volta E,Cuneo A,Lanza F

更新日期：2012-10-01 00:00:00

abstract：:Monoclonal immunoglobulin, as a marker for monoclonal gammopathy, is evaluated by protein electrophoresis (PEP) and immunofixation electrophoresis (IFE). However, PEP and IFE are not satisfactory in sensitivity, objectivity, and facility. Recently, a highly sensitive, automated immunoassay for measurement of free ligh...

journal_title：Annals of hematology

authors： Kang SY,Suh JT,Lee HJ,Yoon HJ,Lee WI

更新日期：2005-09-01 00:00:00

abstract：:Immunoglobulin D (IgD) myeloma is a rare subtype that used to lead to a poor outcome. To investigate the current clinical features, cytogenetic changes and survival of patients with IgD myeloma under novel treatments, we analysed 47 patients with IgD myeloma, 31 men and 16 women, with a median age of 54.5 years. We fo...

journal_title：Annals of hematology

authors： Chen L,Fan F,Deng J,Xu J,Xu A,Sun C,Hu Y

更新日期：2019-04-01 00:00:00

abstract：:A 72-year-old-man with night sweats and a low-grade fever was found to have bilateral adrenal enlargement associated with incipient adrenal insufficiency. Without any intervention, these adrenal lesions regressed spontaneously, accompanied by disappearance of clinical symptoms. Seven months later, however, the lesions...

journal_title：Annals of hematology

authors： Fujiwara T,Kawamura M,Sasaki A,Asahi H,Sasou S,Itoh S,Hiramori K

更新日期：2001-09-01 00:00:00

abstract：:To elucidate the role of hematopoietic growth factors (HGFs) and other cytokines in the autocrine or paracrine regulation of inducible hematopoiesis we studied cytokine gene expression in the bone marrow (BM) of patients after myelosuppressive treatment. Furthermore, we studied the cytokine gene expression profile in ...

journal_title：Annals of hematology

authors： Cluitmans FH,Esendam BH,Veenhof WF,Landegent JE,Willemze R,Falkenburg JH

更新日期：1997-07-01 00:00:00

abstract：:t(8;16)(p11.2;p13.3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML). We report 15 cases with t(8;16)(p11.2;p13.3). All patients were adult and had AML: 13 women and 2 men, with a median age of 50 years. Ten patients had a history of malignancy and received cytotox...

journal_title：Annals of hematology

authors： Xie W,Hu S,Xu J,Chen Z,Medeiros LJ,Tang G

更新日期：2019-05-01 00:00:00

abstract：:Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon type of cutaneous lymphoma with an aggressive natural history. It generally carries a poor prognosis despite standard anthracycline-based chemotherapy. The optimum therapy is unknown. We report the case of a 66-year-old man with CD4/CD8 double negat...

journal_title：Annals of hematology

authors： Go RS,Gazelka H,Hogan JD,Wester SM

更新日期：2003-04-01 00:00:00

abstract：:Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and non-relapse mortality. The FLAMSA-RIC protocol for high-risk patients with acute myeloid leukemia (AML) and myel...

journal_title：Annals of hematology

authors： Chemnitz JM,von Lilienfeld-Toal M,Holtick U,Theurich S,Shimabukuro-Vornhagen A,Krause A,Brossart P,Hallek M,Scheid C

更新日期：2012-01-01 00:00:00

abstract：:Thirty-four patients with acute myeloid leukemia (AML) in complete remission (CR), 30 of them aged over 60, received maintenance therapy scheduling four courses of low-dose cytarabine (LDA) 20 mg/m2/day in two subcutaneous injections for 3 weeks every 6 weeks. Each course was stopped when hematologic toxicity occurred...

journal_title：Annals of hematology

authors： Archimbaud E,Anglaret B,Thomas X,Jaubert J,Sebban C,Guyotat D,Fiere D

更新日期：1992-08-01 00:00:00

abstract：:Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...

journal_title：Annals of hematology

authors： Patel K,Kelsey P

更新日期：1997-04-01 00:00:00

abstract：:Malignant lymphomas are a heterogenous group of malignancies, belonging to the 10 most frequent types of cancers worldwide. In indolent lymphoma only patients with limited stage I/II (Ann Arbor) can be potentially cured by local irradiation. However, about 85% of cases present with advanced stage; for these patients n...

journal_title：Annals of hematology

authors： Buske C,Dreyling H,Unterhalt M,Hiddemann W

更新日期：2004-01-01 00:00:00

abstract：:Amifostine increases in vitro burst-forming unit-erythroid and colony-forming unit-granulocyte/granulcoyte-macrophage cultured from bone-marrow cells from patients with myelodysplastic syndrome (MDS). Several small clinical studies give divergent informations about the potential of amifostine as single agent to improv...

journal_title：Annals of hematology

authors： Hofmann WK,Seipelt G,Ottmann OG,Kalina U,Koschmieder S,Brücher J,Frickhofen N,Klausmann M,Mitrou PS,Hoelzer D

更新日期：2000-05-01 00:00:00

abstract：:Systemic AL amyloidosis is associated with nearly 15% of cases of multiple myeloma, but data on the frequency and significance of amyloid deposits in the bone marrow of patients affected by multiple myeloma without clinical signs of systemic amyloidosis are scanty. Bone marrow smears of 166 unselected patients affecte...

journal_title：Annals of hematology

authors： Petruzziello F,Zeppa P,Catalano L,Cozzolino I,Gargiulo G,Musto P,D'Auria F,Liso V,Rizzi R,Caruso N,Califano C,Piro E,Musso M,Bonanno V,Pia Falcone A,Tafuto S,Di Raimondo F,De Laurentiis M,Pane F,Palombini L,Rotoli

更新日期：2010-05-01 00:00:00