New prognostic model for extranodal natural killer/T cell lymphoma, nasal type.

Abstract:

:Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 patients who were newly diagnosed with ENKTL. The estimated 5-year overall survival rate was 39.4 %. Independent prognostic factors included total protein (TP) <60 g/L, fasting blood glucose (FBG) >100 mg/dL, and Korean Prognostic Index (KPI) score ≥2. We constructed a new prognostic model by combining these prognostic factors: group 1 (64 cases (41.0 %)), no adverse factors; group 2 (58 cases (37.2 %)), one adverse factor; and group 3 (34 cases (21.8 %)), two or three adverse factors. The 5-year overall survival (OS) rates of these groups were 66.7, 23.0, and 5.9 %, respectively (p < 0.001). Our new prognostic model had a better prognostic value than did the KPI model alone (p < 0.001). Our proposed prognostic model for ENKTL, including the newly identified prognostic indicators, TP and FBG, demonstrated a balanced distribution of patients into different risk groups with better prognostic discrimination compared with the KPI model alone.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Cai Q,Luo X,Zhang G,Huang H,Huang H,Lin T,Jiang W,Xia Z,Young KH

doi

10.1007/s00277-014-2089-x

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1541-9

issue

9

eissn

0939-5555

issn

1432-0584

journal_volume

93

pub_type

杂志文章
  • Clinicopathological characteristics and outcomes of light chain deposition disease: an analysis of 48 patients in a single Chinese center.

    abstract::To explore the clinicopathological characteristics and outcomes of light chain deposition disease (LCDD) in a Chinese population, we retrospectively studied the clinicopathological data, treatment, and outcomes of 48 patients with biopsy-proven LCDD from a single center. Among the patients, there were 29 males and 19 ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2659-1

    authors: Li XM,Rui HC,Liang DD,Xu F,Liang SS,Zhu XD,Huang XH,Liu ZH,Zeng CH

    更新日期:2016-05-01 00:00:00

  • Evaluation of mixed chimerism by two-step polymerase chain reaction amplification of hypervariable region MCT118 after allogeneic bone marrow transplantation.

    abstract::We assessed the origin of peripheral blood cells and bone marrow cells of 92 samples obtained from 19 patients after allo BMT by two-step polymerase chain reaction (PCR) amplification of MCT118, one of the variable number of tandem repeat regions (VNTR) which has a different length in 19 of 32 sibling pairs examined, ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01834365

    authors: Tanaka J,Kasai M,Imamura M,Higa T,Kobayashi S,Hashino S,Sakurada K,Miyazaki T

    更新日期:1994-04-01 00:00:00

  • Automated reticulocyte parameters for hereditary spherocytosis screening.

    abstract::The laboratory diagnosis of hereditary spherocytosis (HS) is based on several screening and confirmatory tests; our algorithm includes clinical features, red blood cell morphology analysis and cryohaemolysis test, and, in case of positive screening, sodium dodecyl sulphate polyacrylamide gel electrophoresis as a diagn...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2127-8

    authors: Lazarova E,Pradier O,Cotton F,Gulbis B

    更新日期:2014-11-01 00:00:00

  • Long-term outcome of follicular low-grade lymphoma. A report of 91 patients.

    abstract::We retrospectively analyzed overall survival and survival after progression in 91 patients with low-grade follicular lymphoma (LGFL). Histological subtype was B in 75 patients and C in 16 patients. Twelve patients with localized disease received involved-field radiotherapy; seven patients without bulky disease had no ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01695972

    authors: Morel P,Dupriez B,Plantier-Colcher I,Gosselin B,Declercq C,Pollet JP,Bauters F

    更新日期:1993-06-01 00:00:00

  • Serologic response to meningococcal vaccination in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with the terminal complement inhibitor eculizumab.

    abstract::Eculizumab is indicated for the therapy of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, patients on eculizumab are susceptible to Neisseria meningitidis infections. The two mainstays to reduce the risk of infection are vaccination and antibiotic...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-2924-y

    authors: Alashkar F,Vance C,Herich-Terhürne D,Preising N,Dührsen U,Röth A

    更新日期:2017-04-01 00:00:00

  • Neutropenic enterocolitis in acute leukemia: diagnostic and therapeutic dilemma.

    abstract::The main purpose of this report is to focus on the importance of an accurate etiologic diagnosis of gastrointestinal complications during chemotherapy for acute myeloid leukemia, taking into account that a syndrome characterized by bowel wall thickening associated with diarrhea and abdominal pain may have etiologies d...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0755-5

    authors: Capria S,Vitolo D,Cartoni C,Dessanti L,Micozzi A,Mandelli F,Meloni G

    更新日期:2004-03-01 00:00:00

  • High-resolution ultrasonography in gastrointestinal graft-versus-host disease.

    abstract::Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0893-4

    authors: Görg C,Wollenberg B,Beyer J,Stolte MS,Neubauer A

    更新日期:2005-01-01 00:00:00

  • Selective expansion of the CD14(+)/CD16(bright) subpopulation of circulating monocytes in patients with hemophagocytic syndrome.

    abstract::Overproduction of proinflammatory cytokines is characteristic of hemophagocytic syndrome (HPS), a highly lethal inflammatory disease. Peripheral blood monocytes include two distinct subpopulations according to surface antigen expression: a major type, CD14(+)/CD16(-) (classical monocytes), and a minor type, CD14(+)/CD...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-007-0332-4

    authors: Takeyama N,Yabuki T,Kumagai T,Takagi S,Takamoto S,Noguchi H

    更新日期:2007-11-01 00:00:00

  • Efficacy of Helicobacter pylori eradication for the 1st line treatment of immune thrombocytopenia patients with moderate thrombocytopenia.

    abstract::The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities of H. pylori eradication ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-014-2268-9

    authors: Kim H,Lee WS,Lee KH,Bae SH,Kim MK,Joo YD,Zang DY,Jo JC,Lee SM,Lee JH,Lee JH,Kim DY,Ryoo HM,Hyun MS,Kim HJ,CoOperative Study Group A for Hematology (COSAH).

    更新日期:2015-05-01 00:00:00

  • A comprehensive analysis of adult patients with secondary hemophagocytic lymphohistiocytosis: a prospective cohort study.

    abstract::Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal condition with various underlying disorders in adult patients and is diagnosed based on the HLH-2004 criteria, which were established based on experience in pediatric patients. However, few studies have prospectively evaluated the treatment outcome...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04083-6

    authors: Yoon SE,Eun Y,Huh K,Chung CR,Yoo IY,Cho J,Cho D,Ko YH,Park S,Kim WS,Kim SJ

    更新日期:2020-09-01 00:00:00

  • A review of the European LeukemiaNet recommendations for the management of CML.

    abstract::Several guidelines and recommendations on the management of chronic myeloid leukemia (CML) have been prepared by several scientific societies. The European LeukemiaNet (ELN) appointed a panel of experts who submitted their recommendations to peer-reviewed scientific journals in 2006, 2009, and 2013. Here, we make a cr...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-015-2322-2

    authors: Baccarani M,Castagnetti F,Gugliotta G,Rosti G

    更新日期:2015-04-01 00:00:00

  • A case of multicentric Castleman's disease associated with advanced systemic amyloidosis treated with chemotherapy and anti-CD20 monoclonal antibody.

    abstract::Multicentric Castleman's disease (MCD) is a rare systemic lymphoproliferative disorder with too few patient series reported in the literature to have a clear idea about the etiology, outcome and the best treatment available. Systemic reactive amyloidosis is a very rare complication of MCD and its presence worsens the ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0718-x

    authors: Gholam D,Vantelon JM,Al-Jijakli A,Bourhis JH

    更新日期:2003-12-01 00:00:00

  • Erythropoiesis-stimulating agents in the treatment of anemia in myelodysplastic syndromes: a meta-analysis.

    abstract::The present meta-analysis was undertaken to (1) assess erythroid response rates in myelodysplastic syndromes (MDS) patients treated with epoetin alfa as a monotherapy, (2) gain further insights into predictors of response rates, and (3) compare the erythroid response rates observed with epoetin alfa and darbepoetin al...

    journal_title:Annals of hematology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00277-008-0450-7

    authors: Moyo V,Lefebvre P,Duh MS,Yektashenas B,Mundle S

    更新日期:2008-07-01 00:00:00

  • Double-faced cell-mediated immunity in beta-thalassemia major: stimulated phenotype versus suppressed activity.

    abstract::In this study, the immunologic abnormalities of Iranian beta-thalassemia major patients were characterized, considering their clinical parameters including splenectomy status and iron overload. Serum samples and peripheral blood mononuclear cells were collected from 28 patients and 30 age- and sex-matched healthy indi...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0564-y

    authors: Gharagozloo M,Karimi M,Amirghofran Z

    更新日期:2009-01-01 00:00:00

  • The effect of gamma radiation on the lipid profile of irradiated red blood cells.

    abstract::An investigation into the effects of irradiation and of the storage time on aging and quality are a relevant issue to ensure the safety and the efficiency of irradiation in the prevention of transfusion-associated graft-versus-host disease (TA-GVHD). In this work, the biochemical properties and alterations presented b...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-1944-5

    authors: Maia GA,Renó Cde O,Medina JM,Silveira AB,Mignaco JA,Atella GC,Cortes VF,Barbosa LA,Santos Hde L

    更新日期:2014-05-01 00:00:00

  • Patients with primary diffuse large B-cell lymphoma of female genital tract have high risk of central nervous system relapse.

    abstract::The objective of this study was to evaluate retrospectively the clinical characteristics, treatments, and outcomes of patients with primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract. The basic characteristics, treatments, and outcomes of six patients diagnosed with primary DLBCL of the female g...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-2003-y

    authors: Cao XX,Li J,Zhang W,Duan MH,Shen T,Zhou DB

    更新日期:2014-06-01 00:00:00

  • An unusual case of leukemic non-Hodgkin's lymphoma with blastic transformation.

    abstract::We report on a patient who was diagnosed as having B-cell chronic lymphocytic leukemia (CLL) with atypical morphology. Flow cytometry disclosed CD5, CD19, and CD23 positivity, an immunophenotype seen mostly in B-CLL. Histology of the spleen and bone marrow suggested a diagnosis of small lymphocytic lymphoma. Upon blas...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050582

    authors: Späth-Schwalbe E,Flath B,Kaufmann O,Thiel G,Brinckmann R,Dietel M,Possinger K

    更新日期:2000-04-01 00:00:00

  • Blood B, T, CD4+ and CD8+ lymphocytes in female Wistar rats.

    abstract::We have established reference values of peripheral blood lymphocyte subsets in healthy female Wistar rats under highly standardized conditions. Using monoclonal antibodies and flow cytometry, T lymphocytes (OX19+), B lymphocytes (OX6+ and anti-Ig+), T-helper/inducer (W3/25+), and T-suppressor/cytotoxic subsets (OX8+) ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01701732

    authors: Franch A,Castellote C,Pelegrí C,Tolosa E,Castell M

    更新日期:1993-09-01 00:00:00

  • Headache prevalence following recovery from TTP and aHUS.

    abstract::Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-015-2411-2

    authors: Saultz JN,Wu HM,Cataland S

    更新日期:2015-09-01 00:00:00

  • Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease.

    abstract::Chronic graft-versus-host disease (cGVHD) is an important complication after allogeneic hematopoietic stem cell transplantation (HSCT). To define the roles of T-cells and B-cells in cGVHD, a murine minor histocompatibility complex-mismatched HSCT model was used. Depletion of donor splenocyte CD4(+) T-cells and B220(+)...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-015-2394-z

    authors: Shao L,Lie AK,Zhang Y,Wong CH,Kwong YL

    更新日期:2015-09-01 00:00:00

  • Activation-induced deaminase and its splice variants associate with trisomy 12 in chronic lymphocytic leukemia.

    abstract::Activation-induced cytidine deaminase (AID) is a mutator enzyme essential for somatic hypermutation (SHM) and class switch recombination (CSR) during effective adaptive immune responses. Its aberrant expression and activity have been detected in lymphomas, leukemias, and solid tumors. In chronic lymphocytic leukemia (...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-018-3520-5

    authors: Zaprazna K,Reblova K,Svobodova V,Radova L,Bystry V,Baloun J,Durechova K,Tom N,Loja T,Buresova M,Stranska K,Oltova A,Doubek M,Atchison ML,Trbusek M,Malcikova J,Pospisilova S

    更新日期:2019-02-01 00:00:00

  • Establishment of serum-free pre-colony forming unit assays for differentiation of primitive hematopoietic progenitors: serum induces early macrophage differentiation and inhibits early erythroid differentiation of CD34++CD38- cells.

    abstract::In this report we show that serum has differentiation-inducing effects on primitive hematopoietic progenitor cells with the CD34++CD38- immunophenotype. Using the pre-colony forming unit (pre-CFU) assay as a model for early myelopoiesis, we compared the effects of serum-containing and serum-free media and evaluated di...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770000227

    authors: Willems R,Henckaerts E,Lenjou M,Nijs G,Rodrigus I,Moulijn AC,Slegers H,Berneman ZN,Van Bockstaele DR

    更新日期:2001-01-01 00:00:00

  • Novel treatment strategies in follicular lymphoma.

    abstract::Malignant lymphomas are a heterogenous group of malignancies, belonging to the 10 most frequent types of cancers worldwide. In indolent lymphoma only patients with limited stage I/II (Ann Arbor) can be potentially cured by local irradiation. However, about 85% of cases present with advanced stage; for these patients n...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0850-2

    authors: Buske C,Dreyling H,Unterhalt M,Hiddemann W

    更新日期:2004-01-01 00:00:00

  • Myelodysplastic patients with raised percentage of hypochromic red cells have evidence of functional iron deficiency.

    abstract::Raised percentage hypochromic red cells (%HRC) were detected at diagnosis in 10 of 34 consecutive patients with low-risk myelodysplastic syndrome (MDS) [refractory anemia (RA) (4/26) and RA with ring sideroblasts (6/8)], all of whom had normal or increased serum ferritin and bone marrow iron stores. Elevated %HRC has ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-006-0107-3

    authors: Murphy PT,Quinn JP,O'Donghaile D,Swords R,O'Donnell JR

    更新日期:2006-07-01 00:00:00

  • Change of paraprotein from IgG lambda to lambda chain in myeloma.

    abstract::We describe a unique case of IgG lambda myeloma in which a plasma cell leukemia developed and the paraprotein changed from IgG lambda to lambda chain, the latter inducing fatal renal failure. In addition, J-chain was detected in the cytoplasm of the plasma cell leukemia cells. ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01703239

    authors: Sawamura M,Murayama K,Tokizawa S,Matsushima T,Tamura J,Murakami H,Naruse T,Tsuchiya J

    更新日期:1993-04-01 00:00:00

  • Quality of life during maintenance therapy with the anti-CD20 antibody rituximab in patients with B cell non-Hodgkin's lymphoma: results of a prospective randomized controlled trial.

    abstract::The introduction of rituximab into the primary treatment of malignant lymphomas of the B cell lineage has had a major impact on the management of these diseases. In addition, prolonged exposure to rituximab as maintenance therapy has been beneficial in patients with follicular lymphoma and mantle cell lymphoma. For th...

    journal_title:Annals of hematology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00277-008-0560-2

    authors: Witzens-Harig M,Reiz M,Heiss C,Benner A,Hensel M,Neben K,Dreger P,Kraemer A,Ho AD

    更新日期:2009-01-01 00:00:00

  • Plasma concentrations of total/free and functional protein S are not decreased in systemic lupus erythematosus patients with lupus anticoagulant and/or antiphospholipid antibodies.

    abstract::We conducted an investigation to clarify whether or not the levels of total, free, and functional protein S and C4-binding protein (C4bp) in plasma are decreased in systemic lupus erythematosus (SLE) patients, especially those with antiphospholipid antibody (aPL), which is known to be a causative factor of such compli...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01696561

    authors: Matsuda J,Gohchi K,Gotoh M,Tsukamoto M,Saitoh N

    更新日期:1994-12-01 00:00:00

  • Rituximab maintenance after autologous stem cell transplantation prolongs response duration in non-naive rituximab follicular lymphoma patients: a single institution experience.

    abstract::We retrospectively evaluated the role of rituximab (R) in maintenance treatment after autologous stem cell transplantation performed in patients with relapsed follicular lymphoma. We compared the outcome of 67 follicular lymphoma (FL) patients according to the use of rituximab maintenance (RM) or not. All patients rec...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2705-z

    authors: Bourcier J,Gastinne T,Leux C,Moreau A,Bossard C,Mahé B,Blin N,Dubruille V,Touzeau C,Voldoire M,Guillaume T,Peterlin P,Gallas P,Garnier A,Maisonneuve H,Moreau P,Juge-Morineau N,Jardel H,Chevallier P,Moreau P,Le Gou

    更新日期:2016-08-01 00:00:00

  • Positron emission tomography in the staging of patients with Hodgkin's lymphoma. A prospective multicentric study by the Intergruppo Italiano Linfomi.

    abstract::In this prospective multicentric study, we investigated the contribution of positron emission tomography (PET) scanning to the staging of Hodgkin's lymphoma (HL) by computed tomography (CT) and attempted to determine whether it has any impact on therapeutic approach. One hundred eighty six consecutive patients with HL...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-007-0356-9

    authors: Rigacci L,Vitolo U,Nassi L,Merli F,Gallamini A,Pregno P,Alvarez I,Salvi F,Sancetta R,Castagnoli A,Versari A,Biggi A,Gregianin M,Pelosi E,Chisesi T,Bosi A,Levis A,Intergruppo Italiano Linfomi.

    更新日期:2007-12-01 00:00:00

  • sIL2R ratio as early marker for response in hairy cell leukemia and the prognostic relevance of IL28B genotype to interferon-α therapy.

    abstract::Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-2943-8

    authors: Jud S,Goede JS,Senn O,Spanaus K,Manz MG,Benz R

    更新日期:2017-05-01 00:00:00