Fine needle aspiration and core needle biopsy in the diagnosis of lymphadenopathy of unknown aetiology.

Abstract:

:The clarification of enlarged lymph nodes is a common issue in clinical routine. By now, open surgery with complete lymph node extirpation, followed by histopathology, is considered as standard. We investigated the value of fine needle aspiration (FNA) and core needle biopsy (CNB) when supporting the conventional morphology by immunotyping. In total, 101 lymph nodes (reactive, n = 19; lymphoma, n = 46; metastatic, n = 36) were examined. CNB specimens were sufficient for unequivocal diagnosis by histopathology in 95 %. The FNA cytology allowed a correct diagnosis in 49 %. When supported by immunocytology, the success rate improved to 72 %. By accepting "suspicious of" as correct diagnosis, the ratio increased to 91 %. Additional use of flow cytometry in 46 samples minimized the "suspicious of" diagnoses and increased the proportion of unequivocal diagnoses in FNA specimens to 87 %. Flow cytometry allowed a correct subtyping in 20 of 21 B cell lymphoma but recognised only one of five Hodgkin lymphoma. All eight reactive samples were correctly diagnosed by flow cytometry. In summary, CNB allows a reliable clarification of an unclear lymphadenopathy. FNA is a powerful first diagnostic approach, especially if cytology is supported by immunocytology. The most substantial contribution of flow cytometry in FNA is the discrimination between reactive lymphadenopathy and B cell lymphoma.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Metzgeroth G,Schneider S,Walz C,Reiter S,Hofmann WK,Marx A,Hastka J

doi

10.1007/s00277-012-1476-4

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1477-84

issue

9

eissn

0939-5555

issn

1432-0584

journal_volume

91

pub_type

杂志文章
  • Progression of disease within 2 years (POD24) is a clinically relevant endpoint to identify high-risk follicular lymphoma patients in real life.

    abstract::Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma with heterogeneous outcomes. Progression or relapse of FL within 2 years (so-called POD24) after diagnosis is associated with a poor outcome for patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone) in clinica...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04025-2

    authors: Sortais C,Lok A,Tessoulin B,Gastinne T,Mahé B,Dubruille V,Blin N,Touzeau C,Moreau A,Bossard C,Peterlin P,Garnier A,Guillaume T,Le Bourgeois A,Chevallier P,Moreau P,Leux C,Le Gouill S

    更新日期:2020-07-01 00:00:00

  • Blood B, T, CD4+ and CD8+ lymphocytes in female Wistar rats.

    abstract::We have established reference values of peripheral blood lymphocyte subsets in healthy female Wistar rats under highly standardized conditions. Using monoclonal antibodies and flow cytometry, T lymphocytes (OX19+), B lymphocytes (OX6+ and anti-Ig+), T-helper/inducer (W3/25+), and T-suppressor/cytotoxic subsets (OX8+) ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01701732

    authors: Franch A,Castellote C,Pelegrí C,Tolosa E,Castell M

    更新日期:1993-09-01 00:00:00

  • Bortezomib, doxorubicin, and dexamethasone combination therapy followed by thalidomide and dexamethasone consolidation as a salvage treatment for relapsed or refractory multiple myeloma: analysis of efficacy and safety.

    abstract::We conducted a phase 2 study with bortezomib, doxorubicin, and dexamethasone (PAD) followed by thalidomide and dexamethasone (TD) in patients with relapsed multiple myeloma (MM). Forty patients were enrolled between November 2005 and October 2007, with follow-up continuing until January 2009. Efficacy could be assesse...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-010-0943-z

    authors: Lee SS,Suh C,Kim BS,Chung J,Joo YD,Ryoo HM,Do YR,Jin JY,Kang HJ,Lee GW,Lee MH,Shim H,Kim K,Yoon SS,Bang SM,Kim HY,Lee JJ,Park J,Lee DS,Lee JH,Korean Multiple Myeloma Working Party.

    更新日期:2010-09-01 00:00:00

  • Improved clinical outcomes for multiple myeloma patients treated at a single specialty clinic.

    abstract::Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong overall survival (OS) and preserve patients' quality of life. We have analyzed data from 264 consecutive MM patients who had their initial visit bet...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2888-3

    authors: Berenson A,Vardanyan S,David M,Wang J,Harutyunyan NM,Gottlieb J,Halleluyan R,Spektor TM,Udd KA,Eshaghian S,Nassir Y,Eades B,Swift R,Berenson JR

    更新日期:2017-03-01 00:00:00

  • Allogeneic stem cell transplantation from related and unrelated donors for aplastic anaemia in adults--a single-centre experience.

    abstract::Aplastic anaemia (AA) is a rare bone marrow failure syndrome treated either by immunosuppressive therapy or allogeneic stem cell transplantation (SCT). At present, no randomised clinical trials evaluating both treatment options, and in particular SCT from unrelated donors, are available. We here report the clinical co...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0466-z

    authors: Buchholz S,Dammann E,Koenecke Ch,Stadler M,Franzke A,Blasczyk R,Bremer M,Krauter J,Hertenstein B,Ganser A,Eder M

    更新日期:2008-07-01 00:00:00

  • Different clinical importance of FLT3 internal tandem duplications in AML according to FAB classification: possible existence of distinct leukemogenesis involving monocyte differentiation pathway.

    abstract::Impact of FLT3 receptor tyrosine kinase activation via internal tandem duplication (ITD) of the juxtamembrane region on outcome of acute myeloid leukemia (AML) is still controversial. Recent researches reveal a role of FLT3 in monocyte differentiation in hematopoiesis. We analyzed the clinical impact of FLT3 alteratio...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-009-0733-7

    authors: Koh Y,Park J,Ahn KS,Kim I,Bang SM,Lee JH,Yoon SS,Soon Lee D,Yiul Lee Y,Park S,Kim BK

    更新日期:2009-11-01 00:00:00

  • Complete remission of generalized relapsed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type of the gastrointestinal tract after high-dose chemotherapy and autologous peripheral stem cell transplantation.

    abstract::Due to their homing properties, extranodal marginal zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue (MALT) type remain localized for long periods of time, and therefore have an excellent prognosis. However, if generalization and/or transformation into a diffuse large-cell lymphoma occurs, the prognosi...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770000203

    authors: Neumeister P,Hoefler G,Beham-Schmid C,Sill H,Linkesch W

    更新日期:2000-12-01 00:00:00

  • Acute alveolitis induced by hydroxyurea in a patient with myeloproliferative syndrome.

    abstract::Hydroxyurea is increasingly being used to control myeloproliferative disorders, in part because of its relative lack of side effects. We present a case of life-threatening alveolitis in a patient treated with hydroxyurea for myeloproliferative syndrome. Absence of exposure to other drugs and the clinical course sugges...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01701737

    authors: Hennemann B,Bross KJ,Reichle A,Andreesen R

    更新日期:1993-09-01 00:00:00

  • Successful alemtuzumab retreatment in progressive B-cell chronic lymphocytic leukemia: a multicenter survey in 30 patients.

    abstract::Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-011-1192-5

    authors: Fiegl M,Falkner F,Steurer M,Zojer N,Hopfinger G,Haslbauer F,Winder G,Voskova D,Andel J,Lang A,Brychtova Y,Mayer J,Greil R,Gastl G,Austrian Collaborative Study Group on Alemtuzumab in Chronic Lymphocytic Leukemia.,Czech Leuk

    更新日期:2011-09-01 00:00:00

  • High-dose therapy and stem cell transplantation in follicular lymphoma.

    abstract::Indolent follicular lymphomas are diseases which are generally incurable with conventional therapy. Although patients can survive for prolonged periods, the median duration of first remissions is about 2.5 years, and subsequent remissions progressively shorten with time. High-dose therapy with hematopoietic stem cell ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s002770050503

    authors: Friedberg JW,Freedman AS

    更新日期:1999-05-01 00:00:00

  • Reduced dose of post-transplantation cyclophosphamide compared to ATG for graft-versus-host disease prophylaxis in recipients of mismatched unrelated donor hematopoietic cell transplantation: a single-center study.

    abstract::Post-transplantation cyclophosphamide (PTCy) demonstrated effectiveness to prevent GVHD after haploidentical hematopoietic cell transplantation (HCT). Reducing toxicities with a maximized efficacy is still challenging in HCT. In this retrospective study, we analyzed the safety and efficacy of transplantation from a 1-...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-019-03673-3

    authors: Soltermann Y,Heim D,Medinger M,Baldomero H,Halter JP,Gerull S,Arranto C,Passweg JR,Kleber M

    更新日期:2019-06-01 00:00:00

  • Retrospective comparison of the effectiveness of various treatment modalities of extragastric MALT lymphoma: a single-center analysis.

    abstract::We have performed a retrospective analysis of all patients with extragastric mucosa-associated lymphoid tissue (MALT) lymphoma treated at our institution to compare the efficacy of first-line therapeutic modalities including surgery, radiation, systemic therapy, and antibiotics. One hundred eighty-five patients with e...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2042-z

    authors: Wöhrer S,Kiesewetter B,Fischbach J,Müllauer L,Troch M,Lukas J,Mayerhoefer ME,Raderer M

    更新日期:2014-08-01 00:00:00

  • Treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: the role of corticosteroids.

    abstract::We aimed to evaluate the treatments, particularly the role of corticosteroids, in patients with late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). One hundred and sixty-three consecutive patients who underwent non-T-cell-depleted allo-HSCT and met the criterion...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-018-3290-0

    authors: Mo XD,Zhang XH,Xu LP,Wang Y,Yan CH,Chen H,Chen YH,Han W,Wang FR,Wang JZ,Liu KY,Huang XJ

    更新日期:2018-07-01 00:00:00

  • Single-agent daratumumab in very advanced relapsed and refractory multiple myeloma patients: a real-life single-center retrospective study.

    abstract::The anti-CD38 monoclonal antibody daratumumab is approved as a single agent for the treatment of patients with relapsed and refractory multiple myeloma (RRMM) who have received at least three prior lines of therapy, including a proteasome inhibitor (PI) and an immunomodulatory agent (IMID), or who are double refractor...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-019-03655-5

    authors: Jullien M,Trudel S,Tessoulin B,Mahé B,Dubruille V,Blin N,Gastinne T,Bonnet A,Lok A,Lebourgeois A,Peterlin P,Garnier A,Chevalier P,Guillaume T,Thomaré P,Le Gouill S,Moreau P,Touzeau C

    更新日期:2019-06-01 00:00:00

  • Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin's lymphoma.

    abstract::The role of 18FDG-PET/CT during follow-up of patients affected by Hodgkin's lymphoma (HL) in complete remission after treatment is not fully elucidated, since a wide use of 18F fluorodeoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) in this setting could be limited by a relative high rate of...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-009-0752-4

    authors: Crocchiolo R,Fallanca F,Giovacchini G,Ferreri AJ,Assanelli A,Verona C,Pescarollo A,Bregni M,Ponzoni M,Gianolli L,Fazio F,Ciceri F

    更新日期:2009-12-01 00:00:00

  • Increased expression of T cell immune response cDNA 7 in patients with acute graft-versus-host disease.

    abstract::Acute graft-versus-host disease (aGVHD) has become the important complication post-allogeneic hematopoietic stem cell transplantation. Abnormally activated T cells might play an important role in the pathogenesis of aGVHD. But its exact mechanism remains poorly understood. T cell immune response cDNA 7 (TIRC7) has bee...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-015-2300-8

    authors: Zhu F,Qiao J,Chen W,Pan B,Wu QY,Cao J,Sang W,Yan ZL,Zeng LY,Li ZY,Xu KL

    更新日期:2015-06-01 00:00:00

  • Can prognostic scoring systems for chronic myeloid leukemia as established in adults be applied to pediatric patients?

    abstract::In contrast to adult medicine, specific scoring systems predicting the treatment response for an individual pediatric patient (pt) with chronic myeloid leukemia (CML) have not yet been defined. We evaluated to what extend prognostic scores as described for adults (e.g., Sokal, Hasford, EUTOS score) resulted in compara...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-015-2367-2

    authors: Gurrea Salas D,Glauche I,Tauer JT,Thiede C,Suttorp M

    更新日期:2015-08-01 00:00:00

  • Residual methylation of tumor suppressor gene promoters, RASSF6 and RASSF10, as novel biomarkers for minimal residual disease detection in adult acute lymphoblastic leukemia.

    abstract::Aberrant promoter methylation of RASSF6 and RASSF10 occurs at a high frequency in acute lymphoblastic leukemia (ALL). Because of the complexity of the current minimal residual disease (MRD) detecting-methods, the DNA methylation status of the RASSF6 and RASSF10 genes could potentially become biomarkers for the assessm...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-019-03775-y

    authors: Younesian S,Shahkarami S,Ghaffari P,Alizadeh S,Mehrasa R,Ghaffari SH

    更新日期:2019-12-01 00:00:00

  • Absolute monocyte count is a predictor of overall survival and progression-free survival in nodal peripheral T cell lymphoma.

    abstract::Nodal peripheral T cell lymphomas (nPTCL) present aggressive clinical course, and its heterogeneous nature and poor prognosis with current therapeutic strategies make it a target for the development of new prognostic markers. Thus, we investigated tumor-associated macrophages (TAM) according to the number of cells exp...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-019-03731-w

    authors: de Pádua Covas Lage LA,Hamasaki DT,Moreira FR,Rocha V,Zerbini MCN,Pereira J

    更新日期:2019-09-01 00:00:00

  • Myelodysplastic syndrome presenting as third malignancy after non-Hodgkin's lymphoma and osteosarcoma.

    abstract::The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050264

    authors: Kubota M,Sawada M,Watanabe K,Koishi S,Kataoka A,Usami I,Lin YW,Okuda A,Akiyama Y,Furusho K

    更新日期:1997-02-01 00:00:00

  • Multiple myeloma in elderly patients-a Portuguese multicentric real-life study.

    abstract::Patients older than 75 years old with multiple myeloma (MM) have shorter survival and are usually treated differently from what features in clinical trials. In this study, the authors characterized the Portuguese population of MM patients above 75 years old, treated between 2009 and 2016. We compared the outcomes obta...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s00277-019-03640-y

    authors: João C,Bergantim R,Neves M,Chacim S,Afonso C,Barradas J,Bernardo M,Coelho H,Esteves G,Fraga C,Geraldes C,Gonçalves C,Jorge A,Macedo A,Mendonça T,Moreira A,Roque A,Sarmento AB,Trigo F,Vitória H,Esteves S,Lúcio P

    更新日期:2019-07-01 00:00:00

  • Immunodeficiency risk score for prediction of mortality by parainfluenza virus infection in patients with hematologic malignancy.

    abstract::Parainfluenza virus (PIV) infection is a significant cause of morbidity and mortality, especially in hematologic malignancy patients including hematopoietic stem cell transplantation (HCT) recipients. However, limited information is available for risk stratification in PIV-infected patients with hematologic malignancy...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-03996-6

    authors: Lee J,Jung J,Kim MJ,Chong YP,Lee SO,Choi SH,Kim YS,Woo JH,Choi EJ,Park HS,Lee JH,Lee JH,Lee KH,Kim SH

    更新日期:2020-06-01 00:00:00

  • No evidence for neoantigens in human plasma after photochemical virus inactivation.

    abstract::Photodynamic virus inactivation of human fresh plasma mediated by visible light in the presence of the phenothiazine dyes methylene blue or toluidine blue was investigated to determine whether it influences functional, structural, and immunological properties of plasma proteins. The activities of the coagulation facto...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01703949

    authors: Mohr H,Knüver-Hopf J,Lambrecht B,Scheidecker H,Schmitt H

    更新日期:1992-11-01 00:00:00

  • Comparison of different cytomegalovirus diseases following haploidentical hematopoietic stem cell transplantation.

    abstract::Cytomegalovirus (CMV) can cause end-organ diseases including pneumonia, gastroenteritis, retinitis, and encephalitis in hematopoietic stem cell transplantation recipients. Potential differences among different CMV diseases remain uncertain. This study aimed to compare the clinical characteristics, risk factors, and mo...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-020-04201-4

    authors: Meng XY,Fu HX,Zhu XL,Wang JZ,Liu X,Yan CH,Zhang YY,Mo XD,Wang Y,Han W,Chen YH,Chen DB,Liu HX,Chang YJ,Xu LP,Liu KY,Huang XJ,Zhang XH

    更新日期:2020-11-01 00:00:00

  • PD-L1, LAG3, and HLA-DR are increasingly expressed during smoldering myeloma progression.

    abstract::Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic M...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-019-03648-4

    authors: Mussetti A,Pellegrinelli A,Cieri N,Garzone G,Dominoni F,Cabras A,Montefusco V

    更新日期:2019-07-01 00:00:00

  • Over-representation of bcr3 subtype of PML/RARalpha fusion gene in APL in Indian patients.

    abstract::Thirty six patients with acute promyelocytic leukemia were studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time PCR. There was concordance between the results achieved by both the methods except in one case, which was negative by RT-PCR but positive by real-time PCR. The prevalence of bcr3...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-005-1095-4

    authors: Sazawal S,Hasan SK,Dutta P,Kumar B,Kumar R,Kumar L,Choudhry VP,Saxena R

    更新日期:2005-11-01 00:00:00

  • Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean patients.

    abstract::To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seroposi...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2222-x

    authors: Park M,Lee YH,Lee SH,Yoo KH,Sung KW,Koo HH,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Lee JW,Chung NG,Cho B,Kim HK,Koh KN,Im HJ,Seo JJ,Baek HJ,Kook H,Hwang TJ,Lee JM,Hah JO,Lim YJ,Park JE,Lyu CJ,Lim YT,Ch

    更新日期:2015-03-01 00:00:00

  • Predictive factors for a successful mobilization of peripheral blood CD34+ cells in multiple myeloma.

    abstract::We analyzed the prognostic factors for a successful mobilization and peripheral blood stem cell collection in a series of 57 consecutive patients with multiple myeloma (MM); a new scoring system to predict an adequate mobilization in this subset of patients was also constructed. A total of 221 aphereses were performed...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770100351

    authors: Perea G,Sureda A,Martino R,Altés A,Martínez C,Cabezudo E,Amill B,Martín-Henao GA,González Y,Muñoz L,Peyret M,Brunet S,Sierra J

    更新日期:2001-10-01 00:00:00

  • Trends in quality of non-Hodgkin's lymphoma care: is it getting better?

    abstract::This study outlines trends in quality of delivered non-Hodgkin's lymphoma (NHL) care in the Netherlands between 2007 and 2011 and to what extend this was influenced by the national Visible Care program, which aimed at increasing transparency by providing insight into the quality of healthcare. We analyzed data collect...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00277-015-2340-0

    authors: Stienen JJ,Ottevanger PB,Wennekes L,van de Schans SA,Dekker HM,van der Maazen RW,van Krieken JH,Blijlevens NM,Hermens RP,PEARL study group.

    更新日期:2015-07-01 00:00:00

  • von Willebrand disease: a clinical and laboratory study of sixty-five patients.

    abstract::von Willebrand disease (VWD) is the commonest inherited bleeding disorder, yet it has not been well recognized in Southeast Asia. The aim of this prospective study was to report our experience of VWD diagnosis and to establish the clinical presentations of VWD in Taiwan. From October 2003 to April 2010, 863 patients w...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1266-4

    authors: Chen YC,Yang L,Cheng SN,Hu SH,Chao TY

    更新日期:2011-10-01 00:00:00