Abstract:
:Telomere shortening represents an established mechanism connecting aging and cancer development. We sequentially analyzed telomere length (TL) of 49 acute myeloid leukemia (AML) patients at diagnosis (n = 24), once they achieved complete cytological remission (CCR) and/or during refractory disease or relapse and after 1-year follow-up, with all patients having at least two sequential samples. TL was analyzed by monochrome multiplex quantitative polymerase chain reaction. We have observed substantially shortened TL in the cells of patients at diagnosis compared to age-adjusted controls. In patients reaching CCR after chemotherapy, telomere shortening was less pronounced than in persistence or relapse but still significantly shortened compared to controls. We estimate patients harboring approximately 20 years of premature telomere loss compared to healthy aged-matched subjects at the time of AML onset. Our data indicate a pre-existing telomere deficit in non-clonal hematopoiesis of AML patients providing a link between age and AML development.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Ventura Ferreira MS,Crysandt M,Ziegler P,Hummel S,Wilop S,Kirschner M,Schemionek M,Jost E,Wagner W,Brümmendorf TH,Beier Fdoi
10.1007/s00277-017-3049-zsubject
Has Abstractpub_date
2017-09-01 00:00:00pages
1457-1461issue
9eissn
0939-5555issn
1432-0584pii
10.1007/s00277-017-3049-zjournal_volume
96pub_type
杂志文章abstract::The B cell surface antigen CD19 is a target for treating B cell malignancies, such as B cell precursor acute lymphoblastic leukemia and B cell non-Hodgkin lymphoma. The BiTE® immuno-oncology platform includes blinatumomab, which is approved for relapsed/refractory B cell precursor acute lymphoblastic leukemia and B ce...
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