Evidence for a pre-existing telomere deficit in non-clonal hematopoietic stem cells in patients with acute myeloid leukemia.

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect. The main complications are graft-versus-host disease and infections. We performed a retrospec...

journal_title：Annals of hematology

authors： Picleanu AM,Novelli S,Monter A,Garcia-Cadenas I,Caballero AC,Martino R,Esquirol A,Briones J,Sierra J

更新日期：2017-05-01 00:00:00

abstract：:The clinical impact of KIT mutations in core binding factor acute myeloid leukemia (CBF-AML) is still unclear. In the present study, we analyzed the prognostic significance of each KIT mutation (D816, N822K, and other mutations) in Japanese patients with CBF-AML. We retrospectively analyzed 136 cases of CBF-AML that h...

journal_title：Annals of hematology

authors： Yui S,Kurosawa S,Yamaguchi H,Kanamori H,Ueki T,Uoshima N,Mizuno I,Shono K,Usuki K,Chiba S,Nakamura Y,Yanada M,Kanda J,Tajika K,Gomi S,Fukunaga K,Wakita S,Ryotokuji T,Fukuda T,Inokuchi K

更新日期：2017-10-01 00:00:00

abstract：:Several guidelines and recommendations on the management of chronic myeloid leukemia (CML) have been prepared by several scientific societies. The European LeukemiaNet (ELN) appointed a panel of experts who submitted their recommendations to peer-reviewed scientific journals in 2006, 2009, and 2013. Here, we make a cr...

journal_title：Annals of hematology

authors： Baccarani M,Castagnetti F,Gugliotta G,Rosti G

更新日期：2015-04-01 00:00:00

abstract：:Steroid-resistant acute graft-versus-host disease (GVHD) of the gastrointestinal tract associates with important morbidity and mortality. While high-dose steroids are the established first-line therapy in GVHD, no second-line therapy is generally accepted. In this analysis of 65 consecutive patients with severe, stero...

journal_title：Annals of hematology

authors： Turki AT,Bayraktar E,Basu O,Benkö T,Yi JH,Kehrmann J,Tzalavras A,Liebregts T,Beelen DW,Steckel NK

更新日期：2019-10-01 00:00:00

abstract：:The B cell surface antigen CD19 is a target for treating B cell malignancies, such as B cell precursor acute lymphoblastic leukemia and B cell non-Hodgkin lymphoma. The BiTE® immuno-oncology platform includes blinatumomab, which is approved for relapsed/refractory B cell precursor acute lymphoblastic leukemia and B ce...

journal_title：Annals of hematology

authors： Viardot A,Locatelli F,Stieglmaier J,Zaman F,Jabbour E

更新日期：2020-10-01 00:00:00

abstract：:Cytokines and adhesion molecules play an important role in the pathophysiology of vaso-occlusion in sickle cell disease (SCD), and their in vivo profiles are potential tools for assessing SCD severity. We compared steady-state soluble vascular cell adhesion molecule-1 (sVCAM-1) serum levels to clinical (painful crisis...

journal_title：Annals of hematology

authors： Schnog JB,Rojer RA,Mac Gillavry MR,Ten Cate H,Brandjes DPM,Duits AJ

更新日期：2003-02-01 00:00:00

abstract：:The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive. To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed t...

journal_title：Annals of hematology

authors： Caramazza D,Caracciolo C,Barone R,Malato A,Saccullo G,Cigna V,Berretta S,Schinocca L,Quintini G,Abbadessa V,Di Raimondo F,Siragusa S

更新日期：2009-10-01 00:00:00

abstract：:Patients older than 75 years old with multiple myeloma (MM) have shorter survival and are usually treated differently from what features in clinical trials. In this study, the authors characterized the Portuguese population of MM patients above 75 years old, treated between 2009 and 2016. We compared the outcomes obta...

journal_title：Annals of hematology

authors： João C,Bergantim R,Neves M,Chacim S,Afonso C,Barradas J,Bernardo M,Coelho H,Esteves G,Fraga C,Geraldes C,Gonçalves C,Jorge A,Macedo A,Mendonça T,Moreira A,Roque A,Sarmento AB,Trigo F,Vitória H,Esteves S,Lúcio P

更新日期：2019-07-01 00:00:00

abstract：:Acquired aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are interrelated ultra-rare diseases. Quality of life (QoL) evaluation tools used in studies for AA and PNH are unspecific and designed for cancer patients (e.g., the European Organization for Research and Treatment of Cancer Quality of Life Q...

journal_title：Annals of hematology

authors： Groth M,Singer S,Niedeggen C,Petermann-Meyer A,Röth A,Schrezenmeier H,Höchsmann B,Brümmendorf TH,Panse J

更新日期：2017-02-01 00:00:00

abstract：:Along with their immunogenic role, dendritic cells (DCs) are also critical in maintaining tolerance to self-antigens by inducing regulatory T cells (Tregs) via the expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In turn, Tregs modulate the maturation and/or function of DCs. In immune th...

journal_title：Annals of hematology

authors： Catani L,Sollazzo D,Trabanelli S,Curti A,Evangelisti C,Polverelli N,Palandri F,Baccarani M,Vianelli N,Lemoli RM

更新日期：2013-01-01 00:00:00

abstract：:High-count monoclonal B cell lymphocytosis (MBL) with a chronic lymphocytic leukemia (CLL) phenotype is a well-known entity, featuring 1-4% annual risk of progression towards CLL requiring treatment. Lymphoma-like MBL (L-MBL), on the other hand, remains poorly defined and data regarding outcome are lacking. We retrosp...

journal_title：Annals of hematology

authors： Vander Meeren S,Heyrman B,Renmans W,Bakkus M,Maes B,De Raeve H,Schots R,Jochmans K

更新日期：2018-07-01 00:00:00

abstract：:Abnormal blood coagulation often occurs in critically ill patients, which seriously affects their prognosis. This retrospective study investigated the implications of changes in blood coagulation in patients with coronavirus disease 2019 (COVID-19). Records were reviewed for patients admitted with COVID-19 between Feb...

journal_title：Annals of hematology

authors： Luo HC,You CY,Lu SW,Fu YQ

更新日期：2021-01-01 00:00:00

abstract：:Early cytomegalovirus (CMV) replication (eCMV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been suggested as an independent factor that reduces leukemia relapse risk. We retrospectively analyzed 74 patients with acute myeloid leukemia (AML) who underwent allo-HSCT between August 2006 and S...

journal_title：Annals of hematology

authors： Jang JE,Kim SJ,Cheong JW,Hyun SY,Kim YD,Kim YR,Kim JS,Min YH

更新日期：2015-02-01 00:00:00

abstract：:Nodal peripheral T cell lymphomas (nPTCL) present aggressive clinical course, and its heterogeneous nature and poor prognosis with current therapeutic strategies make it a target for the development of new prognostic markers. Thus, we investigated tumor-associated macrophages (TAM) according to the number of cells exp...

journal_title：Annals of hematology

authors： de Pádua Covas Lage LA,Hamasaki DT,Moreira FR,Rocha V,Zerbini MCN,Pereira J

更新日期：2019-09-01 00:00:00

abstract：:Aberrant promoter methylation of RASSF6 and RASSF10 occurs at a high frequency in acute lymphoblastic leukemia (ALL). Because of the complexity of the current minimal residual disease (MRD) detecting-methods, the DNA methylation status of the RASSF6 and RASSF10 genes could potentially become biomarkers for the assessm...

journal_title：Annals of hematology

authors： Younesian S,Shahkarami S,Ghaffari P,Alizadeh S,Mehrasa R,Ghaffari SH

更新日期：2019-12-01 00:00:00

abstract：:Ruxolitinib is a promising option for treating steroid-refractory acute graft-versus-host disease (SR-aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, we describe ruxolitinib treatment for SR-aGVHD in HSCT patients with Epstein-Barr virus-associated hemophagocytic lymphohisti...

journal_title：Annals of hematology

authors： Meng G,Wang J,Wang X,Wang Y,Wang Z

更新日期：2020-02-01 00:00:00

abstract：:Neutral red is a vital stain known to be accumulated in the lysosomes of neutrophils and monocytes. It is used mainly to identify and detect the activated state of these cells. We have found that the extracellular application of physiological ceramide, i.e., a product of sphingomyelin hydrolysis and a newly defined in...

journal_title：Annals of hematology

authors： Sipka S,Antal-Szalmás P,Szöllösi I,Csipö I,Lakos G,Szegedi G

更新日期：2000-02-01 00:00:00

abstract：:The frequency of apoptotic cells in bone marrow trephine biopsies and cytospins of immunomagnetically isolated myeloid progenitor cells was determined in 39 patients with chronic idiopathic neutropenia (CIN) and 12 hematologically normal individuals using the in situ end-labeling (ISEL) apoptosis detection method. We ...

journal_title：Annals of hematology

authors： Koumaki V,Papadaki HA,Stefanaki K,Damianaki A,Gemetzi C,Katonis P,Vrentzos G,Eliopoulos GD

更新日期：2003-10-01 00:00:00

abstract：:Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...

journal_title：Annals of hematology

authors： Görg C,Wollenberg B,Beyer J,Stolte MS,Neubauer A

更新日期：2005-01-01 00:00:00

abstract：:Raised percentage hypochromic red cells (%HRC) were detected at diagnosis in 10 of 34 consecutive patients with low-risk myelodysplastic syndrome (MDS) [refractory anemia (RA) (4/26) and RA with ring sideroblasts (6/8)], all of whom had normal or increased serum ferritin and bone marrow iron stores. Elevated %HRC has ...

journal_title：Annals of hematology

authors： Murphy PT,Quinn JP,O'Donghaile D,Swords R,O'Donnell JR

更新日期：2006-07-01 00:00:00

abstract：:Previous studies exploring associations between statin use and risk of multiple myeloma (MM) showed inconsistent results. We searched for articles published in English in databases (PubMed, Web of Science, EMBASE, Medline, and Google Scholar) before October 2019. The multivariate odds ratio (OR)/relative risk (RR) and...

journal_title：Annals of hematology

authors： Zhang P,Liu B

更新日期：2020-08-01 00:00:00

abstract：:Sickle cell anaemia (SCA; HbSS) is characterised by its clinical variability, which is only partly explained by known genetic factors. Environmental factors are known to contribute to acute problems but their importance in chronic complications has not been analysed. We have studied 93 children with SCA in a single in...

journal_title：Annals of hematology

authors： Mittal H,Roberts L,Fuller GW,O'Driscoll S,Dick MC,Height SE,Thein SL,Rees DC

更新日期：2009-06-01 00:00:00

abstract：:Hemoglobin (Hb) Korle-Bu (beta73; Asp-Asn) is the most frequent of the rare beta-chain variants in the population of West Africa whereas Hb E (beta26; Glu-Lys) is common among the Southeast Asian population. We report a hitherto undescribed condition in which these two beta-chain variants co-segregate. The proband was...

journal_title：Annals of hematology

authors： Changtrakun Y,Fucharoen S,Ayukarn K,Siriratmanawong N,Fucharoen G,Sanchaisuriya K

更新日期：2002-07-01 00:00:00

abstract：:The intercellular adhesion molecule 1 (ICAM-1) on endothelial cells is involved in the recruitment of leukocytes to inflammatory sites. In contrast to ICAM-1 expression on endothelial cells, little is known about its function in leukocytes in inflammation. Using ICAM-1-directed anti-sense oligodeoxyribonucleotides (OD...

journal_title：Annals of hematology

authors： Steidl U,Haas R,Kronenwett R

更新日期：2000-08-01 00:00:00

abstract：:The microRNA/miR deregulation in BCR-ABL-negative myelodysplastic-myeloproliferative neoplasms (MDS/MPN) is not known. Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain reaction (PCR) in bone marrow cells of atypical chronic myeloid leukaemia (aCML, n ...

journal_title：Annals of hematology

authors： Hussein K,Büsche G,Muth M,Göhring G,Kreipe H,Bock O

更新日期：2011-03-01 00:00:00

abstract：:While much has been learned about the basic immunology and clinical characteristics of immune thrombocytopenia, many important questions remain with regard to pathogenesis, disease progression, identification of novel therapeutic targets and approaches, and clinical trials that rationalize and optimize use of existing...

journal_title：Annals of hematology

authors： Zehnder JL,Semple JW,Imbach P,Neufeld EJ,Buchanan GR,Cines DB,ICIS Study Group on Future Research in ITP.

更新日期：2010-07-01 00:00:00

abstract：:To elucidate the role of hematopoietic growth factors (HGFs) and other cytokines in the autocrine or paracrine regulation of inducible hematopoiesis we studied cytokine gene expression in the bone marrow (BM) of patients after myelosuppressive treatment. Furthermore, we studied the cytokine gene expression profile in ...

journal_title：Annals of hematology

authors： Cluitmans FH,Esendam BH,Veenhof WF,Landegent JE,Willemze R,Falkenburg JH

更新日期：1997-07-01 00:00:00

abstract：:We report the case of a 23-year-old female with severe neurologic dysfunction without a clear cause at the time of initial presentation. The search for an underlying malignancy revealed a slightly enlarged cervical lymph node with Hodgkin's disease (HD). There was no evidence of a brain tumor despite nonspecific brigh...

journal_title：Annals of hematology

authors： Kalinka E,Robak T,Wrzesien-Kus A,Krykowski E,Warzocha K

更新日期：2002-05-01 00:00:00

abstract：:The main purpose of this report is to focus on the importance of an accurate etiologic diagnosis of gastrointestinal complications during chemotherapy for acute myeloid leukemia, taking into account that a syndrome characterized by bowel wall thickening associated with diarrhea and abdominal pain may have etiologies d...

journal_title：Annals of hematology

authors： Capria S,Vitolo D,Cartoni C,Dessanti L,Micozzi A,Mandelli F,Meloni G

更新日期：2004-03-01 00:00:00

abstract：:The objective of this study was to evaluate retrospectively the clinical characteristics, treatments, and outcomes of patients with primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract. The basic characteristics, treatments, and outcomes of six patients diagnosed with primary DLBCL of the female g...

journal_title：Annals of hematology

authors： Cao XX,Li J,Zhang W,Duan MH,Shen T,Zhou DB

更新日期：2014-06-01 00:00:00