Abstract:
:Previous studies exploring associations between statin use and risk of multiple myeloma (MM) showed inconsistent results. We searched for articles published in English in databases (PubMed, Web of Science, EMBASE, Medline, and Google Scholar) before October 2019. The multivariate odds ratio (OR)/relative risk (RR) and 95% confidence intervals (CI) were computed to explore associations between statin use and risk of MM. The study indicated that statin users showed significantly lower risks of MM with a random effects model (OR/RR = 0.77, 95% CI 0.63 to 0.95, I2 = 63.1%, p for Q test = 0.001). Subgroup analyses showed that statin users showed significantly lower risks of MM in Caucasian populations with a fixed effects model (OR/RR = 0.72, 95% CI 0.59 to 0.88, I2 = 43.5%, p for Q test = 0.060), whereas no significant association was shown between statin use and risks of MM in Asian populations with a random effects model. Additionally, Subgroup analyses showed that statin users showed significantly lower risks of MM in cohort studies with a fixed effects model (RR = 0.83, 95% CI 0.74 to 0.93, I2 = 0.0%, p for Q test = 0.429), whereas no significant association was shown between statin use and risks of MM in case-control studies with a random effects model. In conclusion, the present study indicated that statin use might be a protective factor for MM incidence. However, the relationship between statin use and MM risk requires repeated and large prospective studies to be verified.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Zhang P,Liu Bdoi
10.1007/s00277-020-04157-5subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1805-1812issue
8eissn
0939-5555issn
1432-0584pii
10.1007/s00277-020-04157-5journal_volume
99pub_type
杂志文章,meta分析abstract::Primary non-Hodgkin's lymphoma of bone (PLB) is a rare entity. We present three new cases and a review of the literature. If PLB is suspected radiologically, the diagnosis must be confirmed by open biopsy. Histopathologically, PLB usually represents diffuse large B-cell lymphoma or lymphoma of the follicular center ty...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-003-0674-5
更新日期:2003-07-01 00:00:00
abstract::Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is an atypical lympho-proliferative disorder with borderline features that often constitute a diagnostic challenge for the hematopathologist and a therapeutic dilemma for the treating clinician. Morphologically, the involved lymph nodes in this disorder are...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050244
更新日期:1996-12-01 00:00:00
abstract::Circulating homocysteine is a risk factor of cardiovascular and cerebrovascular events. Hyperhomocysteinemia may be an early indicator for vitamin B12 disorders because cobalamin is a cofactor in the remethylation process of homocysteine. Serum holotranscobalamin (holoTC II) becomes decreased before the development of...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-007-0406-3
更新日期:2008-05-01 00:00:00
abstract::During the last few years, new insights into the biology of mantle cell lymphoma have been obtained. However, with a median survival of only 3 years, mantle cell lymphoma remains the lymphoma subtype with the poorest prognosis. At initial diagnosis most patients present with advanced Ann Arbor stage III or IV and conv...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-003-0774-2
更新日期:2004-02-01 00:00:00
abstract::Sickle cell anaemia (SCA; HbSS) is characterised by its clinical variability, which is only partly explained by known genetic factors. Environmental factors are known to contribute to acute problems but their importance in chronic complications has not been analysed. We have studied 93 children with SCA in a single in...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0598-1
更新日期:2009-06-01 00:00:00
abstract::We evaluated the clinical features, treatment modalities, treatment responses, and prognosis of our patients with immune thrombocytopenia (ITP). Furthermore, we estimated the frequency of ITP in the Thrace region of Turkey. Two hundred sixteen patients diagnosed with ITP between 2000 and 2012 at our center were retros...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2220-z
更新日期:2015-03-01 00:00:00
abstract::Repeated courses of HD IVIg are reported to induce stable remission in a significant proportion of adults with chronic refractory ITP. We have treated 14 such patients obtaining a remission rate quite comparable to the 5-10% of spontaneous remission. ...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01834386
更新日期:1995-02-01 00:00:00
abstract::The most common causes of morbidity and mortality in myeloproliferative neoplasms (MPN) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPN, correlates with several clinical and laboratory characteristics even if the relevance of JAK2V617F allele burden in the natural history of...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-017-3040-8
更新日期:2017-08-01 00:00:00
abstract::The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-007-0305-7
更新日期:2007-09-01 00:00:00
abstract::Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050283
更新日期:1997-04-01 00:00:00
abstract::Hodgkin lymphoma (HL), a disease of mostly young patients, also peaks in the elderly. Despite the profound improvement in the outcome of young patients, in the elderly, 5-year progression-free survival (PFS) rates are under 70%. Interim PET-CT (iPET) is known to be highly predictive for PFS in young HL patients, but i...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00277-019-03686-y
更新日期:2019-07-01 00:00:00
abstract::Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by overproduction of red blood cells. We have performed a comprehensive characterization of blood immune cells for expression of naïve and memory receptors as well as β2m-associated and β2m-free MHC class I heavy chains, also known as closed and ope...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-018-3332-7
更新日期:2018-09-01 00:00:00
abstract::Recently we described a cutaneous T-cell lymphoma expressing the gamma/delta T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a s...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01695808
更新日期:1992-09-01 00:00:00
abstract::In this retrospective study, we evaluated the clinical features and the effects of various treatment modalities on the clinical course in patients diagnosed with idiopathic thrombocytopenic purpura (ITP) at our center between 1984-2000. We retrospectively examined the medical records of 321 (229 females, 92 males) ITP...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-002-0488-x
更新日期:2002-08-01 00:00:00
abstract::Post-transplantation cyclophosphamide (PTCy) demonstrated effectiveness to prevent GVHD after haploidentical hematopoietic cell transplantation (HCT). Reducing toxicities with a maximized efficacy is still challenging in HCT. In this retrospective study, we analyzed the safety and efficacy of transplantation from a 1-...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-019-03673-3
更新日期:2019-06-01 00:00:00
abstract::Steroid-resistant acute graft-versus-host disease (GVHD) of the gastrointestinal tract associates with important morbidity and mortality. While high-dose steroids are the established first-line therapy in GVHD, no second-line therapy is generally accepted. In this analysis of 65 consecutive patients with severe, stero...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-019-03754-3
更新日期:2019-10-01 00:00:00
abstract::Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative treatment option for myelofibrosis (MF) despite the emergence of novel targeted therapies. To reduce graft rejection and graft-versus-host disease (GvHD), current allo-HCT protocols often include in vivo T lymphocyte depletion using pol...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-016-2758-z
更新日期:2016-10-01 00:00:00
abstract::Somatic mutations in the SF3B1 gene, a gene encoding the splicing factor 3B subunit 1, were recently reported in myelodysplastic syndromes (MDS), particularly in the presence of ring sideroblasts (RS). The authors investigated the prevalence and clinical significance of SF3B1 mutations in Korean patients with myeloid ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-013-1915-x
更新日期:2014-04-01 00:00:00
abstract::Transplantation of autologous hematopoietic stem cells is a well established therapeutic procedure. Despite advances in efficacy of the stem cell mobilization and apheresis process until now a predictive factor for the expected stem cell yield before initiation of mobilization therapy could not be identified. The main...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-005-0074-0
更新日期:2006-06-01 00:00:00
abstract::Spontaneous splenic rupture is a rare, though life-threatening complication of some hematological malignancies and is even more infrequent as the initial symptom of acute lymphoblastic leukemia. We describe the fourth case, to our knowledge, of acute lymphoblastic leukemia presenting as splenic rupture, and for the fi...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01727419
更新日期:1994-03-01 00:00:00
abstract::Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma with heterogeneous outcomes. Progression or relapse of FL within 2 years (so-called POD24) after diagnosis is associated with a poor outcome for patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone) in clinica...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-04025-2
更新日期:2020-07-01 00:00:00
abstract::Sickle cell disease (SCD) is a relatively common inherited hemolytic anemia among individuals of African descent. Genetic factors might clarify clinical diversity of the disease and variations in treatment response. Some researchers investigated heme oxygenase-1 (HMOX1) or chemokine receptor 5 (CCR5Δ32) genotypes amon...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-019-03697-9
更新日期:2019-08-01 00:00:00
abstract::Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with di...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-010-1083-1
更新日期:2011-04-01 00:00:00
abstract::HbE/Beta thalassemia (HbE/β-thalassemia) is one of the common genetic disorders in South East Asia. It is heterogeneous in its clinical presentation and molecular defects. There are genetic modifiers which have been reported to influence the disease severity of this disorder. The aim of this study was to determine the...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-03927-5
更新日期:2020-04-01 00:00:00
abstract::Blastic transformation of essential thrombocythemia (ET) preceded by chemotherapy is occasionally described in the literature. In ET as well as in other myeloproliferative disorders the leukemogenic effect of alkylating agents and (32)P is well established, and recent reports also indicate a certain leukemogenic effec...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050007
更新日期:2000-01-01 00:00:00
abstract::Hodgkin lymphoma (HL) in resource-poor population shows an early childhood peak with predominance of mixed cellularity (MCHL) and high Epstein-Barr virus (EBV) association, whereas HL in resource-rich population has a peak in ages 15-29 years with the predominance of nodular sclerosis (NSHL) and low EBV association. W...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究,评审
doi:10.1007/s00277-013-1837-7
更新日期:2013-12-01 00:00:00
abstract::The aim of the study was to investigate the association of leptin with hematological parameters in beta-thalassemia patients in Greece. We measured plasma levels of soluble transferrin receptor (sTfR) and leptin by enzyme-linked immunosorbent assay (ELISA) in 40 beta-thalassemia patients (21 transfusion dependent and ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-002-0499-7
更新日期:2002-09-01 00:00:00
abstract::Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression t...
journal_title:Annals of hematology
pub_type: 共识发展会议,杂志文章,实务指引,评审
doi:10.1007/s00277-016-2621-2
更新日期:2016-04-01 00:00:00
abstract::Interferon alpha (IFN) inhibits the growth of the abnormal clone in patients with myeloproliferative disorders, leading to a reduction of the clinical and laboratory signs of the pathologic myeloproliferation. The therapeutic efficacy of IFN in polycythemia vera (PV) is demonstrated by the summarized treatment results...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s002770050563
更新日期:2000-03-01 00:00:00
abstract::Primary non-Hodgkin's lymphoma (NHL) of the genital tract is a rare entity. Etiology and pathogenesis of these NHLs are unknown, although there might be a possible association between chronic inflammation and lymphomas. The most common histological subtype is the diffuse large B-cell lymphoma. We report two cases of u...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-009-0741-7
更新日期:2009-12-01 00:00:00