Abstract：
:Primary non-Hodgkin's lymphoma of bone (PLB) is a rare entity. We present three new cases and a review of the literature. If PLB is suspected radiologically, the diagnosis must be confirmed by open biopsy. Histopathologically, PLB usually represents diffuse large B-cell lymphoma or lymphoma of the follicular center type. The extent of local disease manifestation, additional skeletal involvement, and the presence or absence of lymphadenopathy is assessed by radiological examination. Localized stages of the disease require involved-field radiotherapy (45-50 Gy) to the entire bone that is affected. Regional lymphatics must also be irradiated. Radiotherapy may be required immediately to prevent pathological fractures. In the few cases of more widespread skeletal or extraskeletal involvement, radiotherapy of the major site of manifestation may be followed by a "watch-and-wait" strategy until progression of the disease becomes apparent. In cases of intermediate or high-grade lymphoma of bone, combined radiochemotherapy is the treatment of choice for all stages. Six to eight cycles of chemotherapy (usually the CHOP regimen) are recommended for remission induction. This is followed by involved-field radiotherapy with 45-50 Gy. High-dose chemotherapy with autologous stem cell support is an option if there is no satisfactory response to conventional chemotherapy, or if early relapse occurs.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Misgeld E,Wehmeier A,Krömeke O,Gattermann Ndoi
10.1007/s00277-003-0674-5subject
Has Abstractpub_date
2003-07-01 00:00:00pages
440-3issue
7eissn
0939-5555issn
1432-0584journal_volume
82pub_type
杂志文章,评审abstract：:Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-020-03985-9
更新日期：2020-06-01 00:00:00
abstract：:We encountered two patients who presented with hypochromic-microcytic anemia and were refractory to iron therapy. The symptoms were suggestive of anemia of chronic disease (ACD); however, there was no evidence of any such disease, either inflammatory or malignant. These patients were reminiscent of patients originally...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770000180
更新日期：2000-08-01 00:00:00
abstract：:Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-006-0244-8
更新日期：2007-06-01 00:00:00
abstract：:The aims of this study are to determine the replacement rate of damaged hepatocytes by donor-derived cells in sex-mismatched recipient patients with thalassemia major and to determine whether co-transplantation of mesenchymal stem cells and hematopoietic stem cells (HSCs) can alleviate liver fibrosis. Ten sex-mismatch...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-3181-9
更新日期：2018-02-01 00:00:00
abstract：:Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relat...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2779-7
更新日期：2016-10-01 00:00:00
abstract：:Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) ineligible for allogeneic stem cell transplantation. Recently, rabbit ATG with cyclosporine A has been used as a first-line IST regimen in patients with SAA because of unavailability of ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1674-8
更新日期：2013-06-01 00:00:00
abstract：:Chronic hepatitis C (CHC) and iron overload are the main causes of liver disease in β-thalassemia major (βTM). There is limited data regarding the course of CHC in this population. All patients (n=144) from the thalassemia centre of the University Hospital of Patras were evaluated (January 1981 to June 2012). Patients...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1692-6
更新日期：2013-06-01 00:00:00
abstract：:Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by overproduction of red blood cells. We have performed a comprehensive characterization of blood immune cells for expression of naïve and memory receptors as well as β2m-associated and β2m-free MHC class I heavy chains, also known as closed and ope...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3332-7
更新日期：2018-09-01 00:00:00
abstract：:Alterations in hemoglobin oxygen affinity can be detected by exposing blood to different PO2 and recording oxygen saturation, a method termed tonometry. It is the gold standard to measure the PO2 associated with 50 % oxygen saturation, the index used to quantify oxygen affinity (P50Tono). P50Tono is used in the evalua...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1667-z
更新日期：2013-04-01 00:00:00
abstract：:Amifostine increases in vitro burst-forming unit-erythroid and colony-forming unit-granulocyte/granulcoyte-macrophage cultured from bone-marrow cells from patients with myelodysplastic syndrome (MDS). Several small clinical studies give divergent informations about the potential of amifostine as single agent to improv...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050589
更新日期：2000-05-01 00:00:00
abstract：:Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentat...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-019-03813-9
更新日期：2019-12-01 00:00:00
abstract：:A retrospective study of 120 patients with the clinically and histologically established diagnosis of idiopathic (primary) myelofibrosis (IMF) was performed to determine prognostic factors of predictive value, including parameters characterizing the dynamics of hematopoietic cell kinetics. In contrast to previous stud...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050474
更新日期：1999-02-01 00:00:00
abstract：:Patients with malignancy often present with a variety of coagulation abnormalities which may ultimately lead to recurrent arterial and venous thromboses. Recently the presence of antiphospholipid antibodies in cancer patients has been proposed as one of the potential mechanisms promoting hypercoagulability. Here we re...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0565-1
更新日期：2002-12-01 00:00:00
abstract：:Ruxolitinib is a promising option for treating steroid-refractory acute graft-versus-host disease (SR-aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, we describe ruxolitinib treatment for SR-aGVHD in HSCT patients with Epstein-Barr virus-associated hemophagocytic lymphohisti...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03864-y
更新日期：2020-02-01 00:00:00
abstract：:Second-generation azoles may be more effective than first-generation azoles in the prevention of fungal infections in hematology patients. We performed a systematic review with meta-analysis of randomized controlled trials comparing second- with first-generation azoles in hematology patients with respect to proven or ...
journal_title：Annals of hematology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00277-013-1693-5
更新日期：2013-06-01 00:00:00
abstract：:B cell-activating factor (BAFF) is a cytokine that plays a major role in the maintenance of normal B-cell development and homeostasis. It has been suggested that in multiple myeloma (MM) it might have regulatory effects on the proliferation and viability of malignant plasma cells. The aim of this study was to evaluate...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1470-x
更新日期：2012-09-01 00:00:00
abstract：:In some instances, because of the lack of mass formation and the absence of prominent lymph node enlargement, diagnosis of lymphoma-associated hemophagocytic syndrome (LAHS) is difficult, which results in the development of progressive disease with unfavorable prognosis. Therefore, in the diagnosis of secondary hemoph...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1239-7
更新日期：2012-01-01 00:00:00
abstract：:Among 13,525 haemoglobin analyses performed in our laboratory we detected 21 cases of haemoglobin D (Hb D) disease. Investigation of a family affected with this abnormal haemoglobin revealed two cases of Hb D/beta-(0) thalassaemia for the first time among Saudi Arabs. The two patients were diagnosed as having chronic ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770100376
更新日期：2001-11-01 00:00:00
abstract：:The object of this study was to assess the estimation of 2- and 5-year overall survival and tumor response and the frequency and severity of treatment morbidity with a modified ProMACE-MOPP hybrid protocol in patients with primary CNS lymphoma (PCNSL). Thirty-two immunocompetent patients were treated with a regimen of...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-005-1005-9
更新日期：2005-07-01 00:00:00
abstract：:Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), olde...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1785-2
更新日期：2013-11-01 00:00:00
abstract：:Umbilical cord blood is capable of hematopoietic stem cell reconstitution in children. However, the major limitation of cord blood is a relatively low content of pluripotent progenitor cells. Thus, safe engraftment for adolescents and for adults is still not predictable and a technology for ex vivo expansion of umbili...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050530
更新日期：1999-08-01 00:00:00
abstract：:The purpose of this report is to provide long-term follow-up of 38 patients diagnosed of post-transplant lymphoproliferative disease (PTLD) included in a phase 2 clinical trial of first line therapy with rituximab and to evaluate the same therapy in a real world cohort of 21 consecutive patients treated once the trial...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04056-9
更新日期：2020-05-04 00:00:00
abstract：:The introduction of rituximab into the primary treatment of malignant lymphomas of the B cell lineage has had a major impact on the management of these diseases. In addition, prolonged exposure to rituximab as maintenance therapy has been beneficial in patients with follicular lymphoma and mantle cell lymphoma. For th...
journal_title：Annals of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00277-008-0560-2
更新日期：2009-01-01 00:00:00
abstract：:Organizing pneumonia (OP) is a poorly understood complication of hematopoietic stem cell transplant (HSCT). We identified 15 patients diagnosed with OP following HSCT and described their clinical course. CT chest findings were remarkable for multifocal infiltrates that were predominantly consolidating or ground glass ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03746-3
更新日期：2019-09-01 00:00:00
abstract：:Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-009-0896-2
更新日期：2010-07-01 00:00:00
abstract：:Impact of FLT3 receptor tyrosine kinase activation via internal tandem duplication (ITD) of the juxtamembrane region on outcome of acute myeloid leukemia (AML) is still controversial. Recent researches reveal a role of FLT3 in monocyte differentiation in hematopoiesis. We analyzed the clinical impact of FLT3 alteratio...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-009-0733-7
更新日期：2009-11-01 00:00:00
abstract：:High-dose chemotherapy (HDT) and stem cell transplantation is a newer treatment option widely applied in poor-risk germ cell tumor patients. Due to the increasing practical clinical experience and the availability of hematopoietic growth factors, this treatment approach has become a relatively safe procedure. Dependin...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s002770050386
更新日期：1998-05-01 00:00:00
abstract：:The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050264
更新日期：1997-02-01 00:00:00
abstract：:Early mortality remains a major challenge for the treatment of hemophagocytic lymphohistiocytosis (HLH), which warrants the need for prompt risk stratification in the early phase of the disease. We retrospectively analyzed clinical features of a cohort of pediatric patients managed at a tertiary hospital in southern C...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2727-6
更新日期：2016-09-01 00:00:00
abstract：:Philadelphia-negative myeloproliferative neoplasms (MPNs) are a diverse group of diseases whose common feature is the presence of V617F mutation of the JAK2 gene. In the era of novel therapeutic strategies in MPNs, such as JAK-inhibitor therapy, there is a growing need for establishing high sensitive quantitative meth...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-018-3451-1
更新日期：2018-12-01 00:00:00
