Abstract:
:Organizing pneumonia (OP) is a poorly understood complication of hematopoietic stem cell transplant (HSCT). We identified 15 patients diagnosed with OP following HSCT and described their clinical course. CT chest findings were remarkable for multifocal infiltrates that were predominantly consolidating or ground glass opacities. Bronchoalveolar lavage (BAL) was performed on 14 patients with five having lymphocytosis (> 25% lymphocytes), three with eosinophilia (> 5% eosinophils), three with neutrophilia (> 30% neutrophils), and three with normal cell counts. Flow cytometry was analyzed on BAL fluid in 13 patients with 11 having a CD4/CD8 of < 0.9. Initial treatment with 0.3-1.0 mg/kg prednisone resulted in improvement in symptoms, in radiographic findings, and in pulmonary function testing for the majority of patients. Six patients had recurrence of OP after completing treatment. Eleven patients had evidence of extra-pulmonary graft-versus-host disease prior to diagnosis of OP, and seven patients were diagnosed with an upper respiratory tract infection (URI) within 8 weeks of OP diagnosis. Most patients respond well to prednisone with significant improvement in pulmonary function, but risk of recurrence is high after cessation of steroid treatment. Risk factors for the development of OP may include prior URI.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Brownback KR,Frey JW,Abhyankar Sdoi
10.1007/s00277-019-03746-3subject
Has Abstractpub_date
2019-09-01 00:00:00pages
2187-2195issue
9eissn
0939-5555issn
1432-0584pii
10.1007/s00277-019-03746-3journal_volume
98pub_type
临床试验,杂志文章abstract::The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...
journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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abstract::The intercellular adhesion molecule 1 (ICAM-1) on endothelial cells is involved in the recruitment of leukocytes to inflammatory sites. In contrast to ICAM-1 expression on endothelial cells, little is known about its function in leukocytes in inflammation. Using ICAM-1-directed anti-sense oligodeoxyribonucleotides (OD...
journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0244-8
更新日期:2007-06-01 00:00:00
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journal_title:Annals of hematology
pub_type: 共识发展会议,杂志文章,实务指引,评审
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更新日期:2016-04-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-010-1047-5
更新日期:2011-02-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2042-z
更新日期:2014-08-01 00:00:00
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-018-3260-6
更新日期:2018-06-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050573
更新日期:2000-03-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-012-1483-5
更新日期:2012-09-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2805-9
更新日期:2016-12-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-003-0643-z
更新日期:2003-05-01 00:00:00
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01703239
更新日期:1993-04-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-01-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章,评审
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