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Single-agent daratumumab in very advanced relapsed and refractory multiple myeloma patients: a real-life single-center retrospective study.

Abstract：

:The anti-CD38 monoclonal antibody daratumumab is approved as a single agent for the treatment of patients with relapsed and refractory multiple myeloma (RRMM) who have received at least three prior lines of therapy, including a proteasome inhibitor (PI) and an immunomodulatory agent (IMID), or who are double refractory to a PI and an IMID. To date, no real-life data on the efficacy and tolerance of daratumumab in this setting are available. We report here the results of a single-center series of 41 RRMM patients treated with single-agent daratumumab outside clinical trials. Patients received a median number of 4 prior therapies. All patients were previously exposed to PI and IMID and all patients were refractory to the last line of therapy. Most patients presented with high-risk characteristics, including 24% adverse cytogenetics (del17p/t(4,14)), 31% extramedullary disease and 12% circulating plasmacytosis at time of daratumumab therapy. The overall response rate was 24%, including 5% very good partial response or better. After a median follow-up of 6.5 months, all patients experienced disease relapse. The median progression-free survival was 1.9 months. At the time of disease progression, 44% of patients did not receive subsequent therapy. The median overall survival was 6.5 months. No new safety signal was identified. These real-life results revealed modest efficacy of single-agent daratumumab in advanced patients with RRMM in comparison with data from clinical trials.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Jullien M,Trudel S,Tessoulin B,Mahé B,Dubruille V,Blin N,Gastinne T,Bonnet A,Lok A,Lebourgeois A,Peterlin P,Garnier A,Chevalier P,Guillaume T,Thomaré P,Le Gouill S,Moreau P,Touzeau C

doi

10.1007/s00277-019-03655-5

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1435-1440

issue

6

eissn

0939-5555

issn

1432-0584

pii

10.1007/s00277-019-03655-5

journal_volume

98

pub_type

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