Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin's lymphoma.

abstract：:Hypermethylation of CpG islands near gene promoter regions is associated with transcriptional inactivation and represents an important mechanism of gene silencing in carcinogenesis. Such epigenetic phenomena can act alongside DNA mutations and deletions to disrupt tumor-suppressor gene function. The methylation status...

journal_title：Annals of hematology

authors： Galm O,Wilop S,Lüders C,Jost E,Gehbauer G,Herman JG,Osieka R

更新日期：2005-12-01 00:00:00

abstract：:Secondary central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) includes an isolated CNS relapse or CNS involvement with systemic disease progression. This rare but fatal clinical problem still remains a therapeutic dilemma in the management of DLBCL. However, there are limited data about i...

journal_title：Annals of hematology

authors： Kim SJ,Oh SY,Kim JS,Kim H,Lee GW,Won JH,Shin HJ,Yang DH,Choi CW,Park J,Kim WS,Suh C

更新日期：2011-05-01 00:00:00

abstract：:The benefits of intensive post-remission chemotherapy have not been verified in elderly patients with acute myeloid leukemia (AML). To reduce fatal complications caused by intensive post-remission therapy, we performed a prospective phase II multicenter trial of standard induction chemotherapy ('7+3' of cytarabine plu...

journal_title：Annals of hematology

authors： Lee JH,Choi SJ,Lee JH,Park JH,Kim H,Joo YD,Lee WS,Zang DY,Kim HJ,Lee KH,Cooperative Study Group A for Hematology.

更新日期：2006-06-01 00:00:00

abstract：:Information regarding prognostic determinants of outcome after splenectomy for adult immune thrombocytopenic purpura (ITP) and the management of postsplenectomy relapse is limited. Among 140 adult patients with ITP who had therapeutic splenectomy at our institution, 88% achieved either a complete (platelets > 150 x 10...

journal_title：Annals of hematology

authors： Kumar S,Diehn FE,Gertz MA,Tefferi A

更新日期：2002-06-01 00:00:00

abstract：:The efficacy of a single dose of MCNU 150 mg was evaluated in nine symptomatic patients with essential thrombocythemia (ET). As the platelet counts increased during the following 4 weeks, an extra dose of 100 mg of MCNU was administered to three patients. All patients had thrombotic or hemorrhagic complications. Seven...

journal_title：Annals of hematology

authors： Murakami H,Tamura J,Sawamura M

更新日期：1993-05-01 00:00:00

abstract：:The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplas...

journal_title：Annals of hematology

authors： Steinmetz HT,Schulz A,Staib P,Scheid C,Glasmacher A,Neufang A,Franklin J,Tesch H,Diehl V,Dias Wickramanayake P

更新日期：1999-09-01 00:00:00

abstract：:We tested two Fc gamma receptor I (Fc gamma RI); six Fc gamma RII; and six Fc gamma RIII-specific monoclonal antibodies (mAb) for their capacity to inhibit monocyte and polymorphonuclear granulocyte (PMN) immune phagocytosis which is mediated by Fc gamma R. We used human red blood cells (rbc) coated with hIgG1 or mIgG...

journal_title：Annals of hematology

authors： Flesch BK,Achtert G,Neppert J

更新日期：1997-01-01 00:00:00

abstract：:Hematopoietic recovery in 115 patients with metastatic breast cancer or metastatic melanoma, enrolled in phase-I studies of recombinant growth factors while undergoing treatment with high-dose chemotherapy with autologous bone marrow support, was examined with assays of bone marrow progenitor cells and peripheral bloo...

journal_title：Annals of hematology

authors： Laughlin MJ,Kirkpatrick G,Sabiston N,Peters W,Kurtzberg J

更新日期：1993-12-01 00:00:00

abstract：:National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...

journal_title：Annals of hematology

authors： Höglund M,Sandin F,Simonsson B

更新日期：2015-04-01 00:00:00

abstract：:The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...

journal_title：Annals of hematology

authors： Pedersen P,Milman N

更新日期：2009-08-01 00:00:00

abstract：:Treatment of acute lymphoblastic leukemia (ALL) requires the combination of multiple drugs to integrate a complete remission. The different prognostic factors (age, leukocytes, risk, cytogenetic alterations) allow identifying those patients with a high risk of relapse, but there are few described factors that impact t...

journal_title：Annals of hematology

authors： Ramos-Peñafiel C,Olarte-Carrillo I,Maldonado RC,de la Cruz Rosas A,Collazo-Jaloma J,Martínez-Tovar A

更新日期：2020-11-01 00:00:00

abstract：:High-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) includes the risk of infectious complications due to neutropenia and therapy-induced immune deviation. In order to understand early immune recovery in this situation, we analyzed the distribution of cell subsets by flow cytometry...

journal_title：Annals of hematology

authors： Krause SW,Rothe G,Gnad M,Reichle A,Andreesen R

更新日期：2003-10-01 00:00:00

abstract：:In this report we show that serum has differentiation-inducing effects on primitive hematopoietic progenitor cells with the CD34++CD38- immunophenotype. Using the pre-colony forming unit (pre-CFU) assay as a model for early myelopoiesis, we compared the effects of serum-containing and serum-free media and evaluated di...

journal_title：Annals of hematology

authors： Willems R,Henckaerts E,Lenjou M,Nijs G,Rodrigus I,Moulijn AC,Slegers H,Berneman ZN,Van Bockstaele DR

更新日期：2001-01-01 00:00:00

abstract：:During the last few years, new insights into the biology of mantle cell lymphoma have been obtained. However, with a median survival of only 3 years, mantle cell lymphoma remains the lymphoma subtype with the poorest prognosis. At initial diagnosis most patients present with advanced Ann Arbor stage III or IV and conv...

journal_title：Annals of hematology

authors： Lenz G,Dreyling M,Hiddemann W

更新日期：2004-02-01 00:00:00

abstract：:Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the "unexplained" decrease in the number of circulating neutrophils. Serum inflammatory cytokines and chemokines are increased in CINA. In addition, cytokines gene polymorphisms are associated with increased levels of respectiv...

journal_title：Annals of hematology

authors： Addas-Carvalho M,de Paula EV,Lima CS,Saad ST

更新日期：2005-10-01 00:00:00

abstract：:Hodgkin lymphoma (HL) can be aggressive and intractable in some cases. Patients who relapse after autologous HCT (auto-HCT) have limited treatment options. City of Hope reports our experience in the use of reduced intensity allogeneic hematopoietic cell transplantation (allo-HCT) in 24 heavily pretreated patients with...

journal_title：Annals of hematology

authors： Chen R,Palmer JM,Popplewell L,Shen J,Smith E,Delioukina M,Kogut N,Rosenthal J,Forman S,Nademanee A

更新日期：2011-07-01 00:00:00

abstract：:The aim of this review is to summarize the current knowledge on the clinical results of biotherapy of chronic myelogenous leukemia (CML) and potential mechanisms of the antitumor action of interferon alpha. IFN alpha treatment induces hematologic and cytogenetic remissions in patients with chronic phase CML. In additi...

journal_title：Annals of hematology

authors： Aulitzky WE,Peschel C,Schneller F,Huber C

更新日期：1995-03-01 00:00:00

abstract：:Although B chronic lymphocytic leukemia (B-CLL) cells express the alpha chain of the interleukin-2 (IL-2) receptor CD25, little is known about the effect of IL-2 on apoptosis in B-CLL cells. We have shown previously that stimulation of B-CLL cells with a CpG-oligonucleotide induces IL-2 high affinity receptors. In our...

journal_title：Annals of hematology

authors： Decker T,Bogner C,Oelsner M,Peschel C,Ringshausen I

更新日期：2010-11-01 00:00:00

abstract：:Several guidelines and recommendations on the management of chronic myeloid leukemia (CML) have been prepared by several scientific societies. The European LeukemiaNet (ELN) appointed a panel of experts who submitted their recommendations to peer-reviewed scientific journals in 2006, 2009, and 2013. Here, we make a cr...

journal_title：Annals of hematology

authors： Baccarani M,Castagnetti F,Gugliotta G,Rosti G

更新日期：2015-04-01 00:00:00

abstract：:t(8;16)(p11.2;p13.3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML). We report 15 cases with t(8;16)(p11.2;p13.3). All patients were adult and had AML: 13 women and 2 men, with a median age of 50 years. Ten patients had a history of malignancy and received cytotox...

journal_title：Annals of hematology

authors： Xie W,Hu S,Xu J,Chen Z,Medeiros LJ,Tang G

更新日期：2019-05-01 00:00:00

abstract：:NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (NUTM1) fuses to bromodomain protein family member 4 gene (BRD4), resulting in the formation of BRD4-NUTM1 transcript. Here, we report ...

journal_title：Annals of hematology

authors： Cheng Z,Luo Y,Zhang Y,Wang Y,Chen Y,Xu Y,Peng H,Zhang G

更新日期：2020-07-01 00:00:00

abstract：:Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal condition with various underlying disorders in adult patients and is diagnosed based on the HLH-2004 criteria, which were established based on experience in pediatric patients. However, few studies have prospectively evaluated the treatment outcome...

journal_title：Annals of hematology

authors： Yoon SE,Eun Y,Huh K,Chung CR,Yoo IY,Cho J,Cho D,Ko YH,Park S,Kim WS,Kim SJ

更新日期：2020-09-01 00:00:00

abstract：:Therapy-induced autoimmunity may mediate the destruction of cancer cells. Previous studies have demonstrated that presence of autoimmune thyroid disorder is associated with favorable outcome in patients with solid cancer. Patients with diffuse large B cell lymphoma (DLBCL) who achieved complete response on positron em...

journal_title：Annals of hematology

authors： Song MK,Chung JS,Kim SJ,Kim SS,Shin HJ

更新日期：2015-06-01 00:00:00

abstract：:An improvement in quality of life and survival occurred among thalassemia major (TM) patients: pregnancy in such patients has become a reality. Safe pregnancy and delivery require efforts to ensure the best outcomes. Between 2007 and 2016, 30 TM patients had 37 pregnancies. We analyzed the hematological parameters bef...

journal_title：Annals of hematology

authors： Cassinerio E,Baldini IM,Alameddine RS,Marcon A,Borroni R,Ossola W,Taher A,Cappellini MD

更新日期：2017-06-01 00:00:00

abstract：:Patients with primary refractory or relapsed acute myeloid leukemia (AML) who undergo intensive salvage chemotherapy carry a high risk of treatment failure due to infectious complications and early relapses. The study presented here assessed the effect of granulocyte colony-stimulating factor (G-CSF) on the duration o...

journal_title：Annals of hematology

authors： Kern W,Aul C,Maschmeyer G,Kuse R,Kerkhoff A,Grote-Metke A,Eimermacher H,Kubica U,Wörmann B,Büchner T,Hiddemann W

更新日期：1998-09-01 00:00:00

abstract：:African Americans have two- to three-fold higher incidence of multiple myeloma and MGUS compared to other ethnic groups in the USA. Some physicians often perform diagnostic evaluations for plasma cell disorders (PCD) in African American patients on the basis of hematological abnormalities (thrombocytopenia, leucopenia...

journal_title：Annals of hematology

authors： Tun NM,Joseph G,Soe AM,Ford JG

更新日期：2014-06-01 00:00:00

abstract：:The objective of this study was to evaluate the efficacy and safety of rituximab in the treatment of patients with idiopathic thrombocytopenic purpura (ITP). A prospective study was performed at Mubarak Al-Kabeer University Hospital involving the use of rituximab in 14 patients who had previously been treated with ste...

journal_title：Annals of hematology

authors： Alasfoor K,Alrasheed M,Alsayegh F,Mousa SA

更新日期：2009-03-01 00:00:00

abstract：:We conducted an investigation to clarify whether or not the levels of total, free, and functional protein S and C4-binding protein (C4bp) in plasma are decreased in systemic lupus erythematosus (SLE) patients, especially those with antiphospholipid antibody (aPL), which is known to be a causative factor of such compli...

journal_title：Annals of hematology

authors： Matsuda J,Gohchi K,Gotoh M,Tsukamoto M,Saitoh N

更新日期：1994-12-01 00:00:00

abstract：:Although eosinophilia has been reported as a side effect of purine analogues, there is no report on fludarabine-induced eosinophilia in chronic lymphocytic leukemia (CLL). During chemotherapy with fludarabine and cyclophosphamide, we observed two cases of significant eosinophilia. A 67-year-old patient with CLL develo...

journal_title：Annals of hematology

authors： Sezer O,Schmid P,Hallek M,Schweigert M,Beinert T,Langelotz C,Mergenthaler HG,Possinger K

更新日期：1999-10-01 00:00:00

abstract：:Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest ...

journal_title：Annals of hematology

authors： Roberts L,O'Driscoll S,Dick MC,Height SE,Deane C,Goss DE,Pohl K,Rees DC

更新日期：2009-10-01 00:00:00