Hematopoietic growth factors and the treatment of tumor-associated anemias.

abstract：:Anaphylactoid reaction to cyclophosphamide administration in a 85-year old woman is described. Symptomatology was restricted to bronchospasm, which regressed within one hour. This incomplete and rapidly regressive symptomatology might be explained by previous administration of methylprednisolone. No anaphylactoid symp...

journal_title：Annals of hematology

authors： Salles G,Vial T,Archimbaud E

更新日期：1991-02-01 00:00:00

abstract：:We analyzed the prognostic factors for a successful mobilization and peripheral blood stem cell collection in a series of 57 consecutive patients with multiple myeloma (MM); a new scoring system to predict an adequate mobilization in this subset of patients was also constructed. A total of 221 aphereses were performed...

journal_title：Annals of hematology

authors： Perea G,Sureda A,Martino R,Altés A,Martínez C,Cabezudo E,Amill B,Martín-Henao GA,González Y,Muñoz L,Peyret M,Brunet S,Sierra J

更新日期：2001-10-01 00:00:00

abstract：:Primary non-Hodgkin's lymphoma of bone (PLB) is a rare entity. We present three new cases and a review of the literature. If PLB is suspected radiologically, the diagnosis must be confirmed by open biopsy. Histopathologically, PLB usually represents diffuse large B-cell lymphoma or lymphoma of the follicular center ty...

journal_title：Annals of hematology

authors： Misgeld E,Wehmeier A,Krömeke O,Gattermann N

更新日期：2003-07-01 00:00:00

abstract：:Imatinib is a new promising therapeutic option for chronic myeloid leukemia (CML) with efficacy even in the blast phase of the disease. However, most patients treated with imatinib in the blast phase develop progressive disease rapidly. Thus, treatment with imatinib has to be followed by other treatment strategies. Th...

journal_title：Annals of hematology

authors： Schaich M,Schäkel K,Illmer T,Ehninger G,Bornhäuser M

更新日期：2003-05-01 00:00:00

abstract：:Bortezomib synergizes with melphalan in preclinical and early clinical studies. Updated data from our phase 1/2 study assessing the safety and efficacy of bortezomib plus melphalan in relapsed/refractory multiple myeloma (MM) are presented. Bortezomib (0.7, 1.0, or 1.3 mg/m(2)) on days 1, 4, 8, and 11 and oral melphal...

journal_title：Annals of hematology

authors： Berenson JR,Yang HH,Vescio RA,Nassir Y,Mapes R,Lee SP,Wilson J,Yellin O,Morrison B,Hilger J,Swift R

更新日期：2008-08-01 00:00:00

abstract：:Cytokines and adhesion molecules play an important role in the pathophysiology of vaso-occlusion in sickle cell disease (SCD), and their in vivo profiles are potential tools for assessing SCD severity. We compared steady-state soluble vascular cell adhesion molecule-1 (sVCAM-1) serum levels to clinical (painful crisis...

journal_title：Annals of hematology

authors： Schnog JB,Rojer RA,Mac Gillavry MR,Ten Cate H,Brandjes DPM,Duits AJ

更新日期：2003-02-01 00:00:00

abstract：:In the attempt to induce graft-vs-host disease (GVHD) in patients undergoing autologous bone marrow transplantation (ABMT) or blood stem cell transplantation (BSCT), 12 consecutive patients received cyclosporin A (CyA) post transplant. CyA was given at a dose of 1.5 mg/kg/day intravenously for 28 days, starting on the...

journal_title：Annals of hematology

authors： Carella AM,Gaozza E,Congiu A,Carlier P,Nati S,Truini M,Castellaneta A,Viale M

更新日期：1991-05-01 00:00:00

abstract：:Alterations in hemoglobin oxygen affinity can be detected by exposing blood to different PO2 and recording oxygen saturation, a method termed tonometry. It is the gold standard to measure the PO2 associated with 50 % oxygen saturation, the index used to quantify oxygen affinity (P50Tono). P50Tono is used in the evalua...

journal_title：Annals of hematology

authors： Huber FL,Latshang TD,Goede JS,Bloch KE

更新日期：2013-04-01 00:00:00

abstract：:Antithymocyte globulin (ATG) is the treatment of choice for those aplastic anemia patients who are not suitable for bone marrow transplantation (BMT). ATG is also used for the treatment of rejections in organ transplantation and as a conditioning regimen in BMT. Despite the proven efficacy of ATG in these areas, its m...

journal_title：Annals of hematology

authors： Dubey S,Nityanand S

更新日期：2003-08-01 00:00:00

abstract：:In Germany, analyses of clinical and laboratory features of patients with acute porphyrias are only available for hereditary coproporphyria (HCP) but not with other acute porphyrias, acute intermittent porphyria (AIP) and variegate porphyria (VP). The aim of the study was to analyze a large cohort of patients with par...

journal_title：Annals of hematology

authors： Bronisch O,Stauch T,Haverkamp T,Beykirch MK,Petrides PE

更新日期：2019-12-01 00:00:00

abstract：:As ethnic variations are known to exist in inherited genetic defects, the clinico-haematological profile of Indian children with thrombophilia may be different from that of Caucasians. The aim of the study was to analyse the phenotypic and genotypic causes of thrombophilia in Indian children. Forty patients with arter...

journal_title：Annals of hematology

authors： Gupta PK,Ahmed RP,Bhattacharyya M,Kannan M,Biswas A,Kalra V,Saxena R

更新日期：2005-02-01 00:00:00

abstract：:Wilms' tumor gene 1 (WT1) is gaining increasing attention as a therapeutic target molecule due to its common expression in acute leukemias and its involvement in cell proliferation. Here, we reported on WT1 messenger RNA expression levels at diagnosis in a series of 238 adult acute lymphoblastic leukemia (ALL) samples...

journal_title：Annals of hematology

authors： Busse A,Gökbuget N,Siehl JM,Hoelzer D,Schwartz S,Rietz A,Thiel E,Keilholz U

更新日期：2009-12-01 00:00:00

abstract：:Recently we described a cutaneous T-cell lymphoma expressing the gamma/delta T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a s...

journal_title：Annals of hematology

authors： Wilhelm M,Meyer P,Batram C,Tony HP,Dummer R,Nestle F,Burg G,Wilms K

更新日期：1992-09-01 00:00:00

abstract：:Early cytomegalovirus (CMV) replication (eCMV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been suggested as an independent factor that reduces leukemia relapse risk. We retrospectively analyzed 74 patients with acute myeloid leukemia (AML) who underwent allo-HSCT between August 2006 and S...

journal_title：Annals of hematology

authors： Jang JE,Kim SJ,Cheong JW,Hyun SY,Kim YD,Kim YR,Kim JS,Min YH

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:The current study was initiated to assess the clinical efficacy and side effects of rituximab in patients with relapsed advanced stage follicular lymphoma. PATIENTS AND METHODS:The study was performed as an open-label non-randomized multicenter phase-II trial and included patients older than 18 years of age wi...

journal_title：Annals of hematology

authors： Feuring-Buske M,Kneba M,Unterhalt M,Engert A,Gramatzki M,Hiller E,Trümper L,Brugger W,Ostermann H,Atzpodien J,Hallek M,Aulitzky E,Hiddemann W

更新日期：2000-09-01 00:00:00

abstract：:Although the outcome of patients with acute myeloid leukemia (AML) has improved by optimized chemotherapy regimens and bone marrow transplantation, leukemia relapse remains one of the most challenging problems during therapy. Sustained existence of AML blasts is a fundamental determinant for the development of leukemi...

journal_title：Annals of hematology

authors： Liu J,Qin YZ,Yang S,Wang Y,Chang YJ,Zhao T,Jiang Q,Huang XJ

更新日期：2017-04-01 00:00:00

abstract：:In multiple myeloma, the polymerase chain reaction (PCR) of the Ig heavy chain with allele-specific oligonucleotide (ASO) primers is a common and well-described method of identifying the tumor clone in peripheral blood (PB), bone marrow (BM) or leukapheresis products (LA). A factor which is crucial to the detection of...

journal_title：Annals of hematology

authors： Draube A,Pfister R,Vockerodt M,Schuster S,Kube D,Diehl V,Tesch H

更新日期：2001-02-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is a highly effective agent in the treatment of acute promyelocytic leukemia (APL), whereas other hematopoietic tumors are less responsive to this agent and mechanisms underlying As2O3,-resistance are poorly understood. To better understand the complex network of GSH-related pathways in As2O3 ...

journal_title：Annals of hematology

authors： Bernardini S,Nuccetelli M,Noguera NI,Bellincampi L,Lunghi P,Bonati A,Mann K,Miller WH Jr,Federici G,Lo Coco F

更新日期：2006-10-01 00:00:00

abstract：:We have studied some of the factors involved in the cytotoxic actions of the anticancer anthracycline antibiotics doxorubicin (DOX) and idarubicin (IDA) towards human B-cell lymphoma cells in vitro. IDA was found to accumulate within cells to a greater degree than the related drug DOX for both short (1 h) and long-ter...

journal_title：Annals of hematology

authors： Smith PJ,Rackstraw C,Cotter F

更新日期：1994-01-01 00:00:00

abstract：:Acute megakaryoblastic leukaemia (AML-M7) is an uncommon disease, composing 0.5-1.2% of newly diagnosed adult acute myeloid leukaemias (AML). It is characterised by higher incidence and complexity of cytogenetic abnormalities. We report a rare case of Philadelphia (Ph) chromosome-positive AML-M7, presenting with extre...

journal_title：Annals of hematology

authors： Balatzenko G,Guenova M,Zechev J,Toshkov S

更新日期：2004-06-01 00:00:00

abstract：:Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...

journal_title：Annals of hematology

authors： Patel K,Kelsey P

更新日期：1997-04-01 00:00:00

abstract：:In this paper we report a rare association of a splenic marginal zone B-cell lymphoma with villous lymphocytes and a T-cell large granular lymphocytic leukemia coexpressing CD4 and CD8 as well as CD56 and CD57 natural killer-associated markers in an asymptomatic patient investigated because of an occasional finding of...

journal_title：Annals of hematology

authors： Lima M,Gonçalves C,Marques L,Martin MC,Teixeira MA,Queirós ML,Santos AH,Balanzategui A,Garcia-Sanz R,Pinto-Ribeiro AC,Justiça B,Orfão A

更新日期：2001-11-01 00:00:00

abstract：:Mixed phenotype acute leukemia (MPAL) is a rare type of leukemia with a limited number of studies conducted to characterize its clinical spectrum and most importantly the best treatment modality. MPAL blasts show more than one phenotype either myeloid/monocytic with T- or B-lymphoid or extremely rare triple lineage as...

journal_title：Annals of hematology

authors： Rasekh EO,Osman R,Ibraheem D,Madney Y,Radwan E,Gameel A,Abdelhafiz A,Kamel A,Elfishawi S

更新日期：2020-11-23 00:00:00

abstract：:Hematopoietic chimerism can be used as a tool for patient management after allogeneic hematopoietic stem cell transplantation (HSCT). An increase in the proportion of recipient cells after transplantation is strongly associated with relapse in chronic myeloid leukemia. However, in acute myeloid leukemia (AML) the sign...

journal_title：Annals of hematology

authors： Waterhouse M,Bertz H,Finke J

更新日期：2014-02-01 00:00:00

abstract：:Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...

journal_title：Annals of hematology

authors： Gupta PK,Charan VD,Saxena R

更新日期：2007-06-01 00:00:00

abstract：:An acute leukemia with an unusual immunophenotype developed in a 17-year-old girl. At the initial presentation, extramedullary involvement was not evident, but with advancing disease, massive splenomegaly and an osteolytic rib tumor developed. The disease was aggressive and refractory to intensive chemotherapeutic reg...

journal_title：Annals of hematology

authors： Ino T,Tsuzuki M,Okamoto M,Shamoto M,Hirano M

更新日期：1999-01-01 00:00:00

abstract：:Iron status, i.e. serum ferritin and haemoglobin (Hb) levels, was assessed in a population survey in 1994 (Dan-Monica 10) comprising 1319 Caucasian Danish women in age cohorts of 40, 50, 60 and 70 years. In the entire series, ferritin levels increased significantly from 40 years to 60 years of age. The prevalence of s...

journal_title：Annals of hematology

authors： Milman N,Byg KE,Ovesen L

更新日期：2000-11-01 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte antigen-4 (CTLA-4) are important risk factors associated with autoimmune diseases and malignancies. This study explored the association of CTLA-4SNPs with the development of myeloma and evaluated the outcome of patients receiving bortezomib-based regimen...

journal_title：Annals of hematology

authors： Qin XY,Lu J,Li GX,Wen L,Liu Y,Xu LP,Chang YJ,Liu KY,Jiang ZF,Huang XJ

更新日期：2018-03-01 00:00:00

abstract：:Because of the widespread use of immunosuppressive drugs, CMV infection is one of the most important causes of morbidity and mortality in patients with haematological malignancies worldwide. The aim of the study was to retrospectively analyse the epidemiology of CMV infection in haematological patients. Between 2008 a...

journal_title：Annals of hematology

authors： Piukovics K,Terhes G,Gurbity-Pálfi T,Bereczki Á,Rárosi F,Deák J,Borbényi Z,Urbán E

更新日期：2017-01-01 00:00:00

abstract：:This study aimed to determine whether dose-dense therapy improves 3-year survival over the standard therapy for untreated aggressive lymphoma. One hundred and fifteen patients with untreated aggressive lymphoma were stratified by center, age, and international prognostic index and randomized to one of two treatment ar...

journal_title：Annals of hematology

authors： Fridrik MA,Hausmaninger H,Lang A,Drach J,Krieger O,Geissler D,Michlmayr G,Ulsperger E,Chott A,Oberaigner W,Greil R

更新日期：2010-03-01 00:00:00