Role of GSTP1-1 in mediating the effect of As2O3 in the Acute Promyelocytic Leukemia cell line NB4.

Abstract:

:Arsenic trioxide (As2O3) is a highly effective agent in the treatment of acute promyelocytic leukemia (APL), whereas other hematopoietic tumors are less responsive to this agent and mechanisms underlying As2O3,-resistance are poorly understood. To better understand the complex network of GSH-related pathways in As2O3 sensitivity, we investigated the role of GSH and GSH-relevant enzymes in an APL cell line sensitive to As2O3 (NB4) and in a resistant subclone (AsR). Cell proliferation, viability, and apoptosis were investigated in NB4 cells before and after treatment with 1 muM As2O3 and in AsR cells. In these experimental cell models, GSTP1-1, JNK1 and JNK2 proteins were analyzed by immunoblotting, and a kinase assay for JNK1 was performed. GSH levels as well as the activities of the enzymes glutathione peroxidase, glutathione transferase, gamma-Glutamylcysteynilsinthetase and superoxide dismutase were measured. NB4 cells treated with As2O3 showed a high level of oxidative stress and an increase of GSH levels. GSTP1-1 polymerization and JNK1 activation were detectable after 24 h and were followed by an increase of the apoptotic rate starting at 72 h. Neither GSTP1-1 polymerization nor JNK activation was found in AsR cells that showed a very low apoptotic rate. Our results suggest that APL sensitivity to As2O3 might be, at least in part, mediated by the balance between association and dissociation of JNK from GSTP1-1, depending on the redox status of the cell. Further investigation is warranted to find a way to interfere with this balance, whenever it might represent a mechanism of drug resistance.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Bernardini S,Nuccetelli M,Noguera NI,Bellincampi L,Lunghi P,Bonati A,Mann K,Miller WH Jr,Federici G,Lo Coco F

doi

10.1007/s00277-006-0139-8

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

681-7

issue

10

eissn

0939-5555

issn

1432-0584

journal_volume

85

pub_type

杂志文章
  • Cytotoxicity of adriamycin, idarubicin, and vincristine in acute myeloid leukemia: chemosensitization by verapamil in relation to P-glycoprotein expression.

    abstract::A 4-day colorimetric tetrazolium dye (MTT) assay was used to assess the cytotoxicity of adriamycin (ADM), vincristine (VCR), and idarubicin (IDA) in blasts isolated from 37 patients with newly diagnosed and pretreated acute myeloid leukemia (AML). The effect of verapamil (VRP) as a chemosensitizer was studied in relat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01703946

    authors: Müller MR,Lennartz K,Boogen C,Nowrousian MR,Rajewsky MF,Seeber S

    更新日期:1992-11-01 00:00:00

  • Cyclosporine-induced graft-versus-host disease after autologous bone marrow transplantation in hematological malignancies.

    abstract::In the attempt to induce graft-vs-host disease (GVHD) in patients undergoing autologous bone marrow transplantation (ABMT) or blood stem cell transplantation (BSCT), 12 consecutive patients received cyclosporin A (CyA) post transplant. CyA was given at a dose of 1.5 mg/kg/day intravenously for 28 days, starting on the...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01703140

    authors: Carella AM,Gaozza E,Congiu A,Carlier P,Nati S,Truini M,Castellaneta A,Viale M

    更新日期:1991-05-01 00:00:00

  • Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients.

    abstract::Despite significant advances in the treatment of complications requiring intensive care unit (ICU) admission, ICU mortality remains high for patients after allogeneic stem cell transplantation. We evaluated the role of thrombocytopenia and poor graft function in allogeneic stem cell recipients receiving ICU treatments...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-018-3538-8

    authors: Turki AT,Lamm W,Schmitt C,Bayraktar E,Alashkar F,Metzenmacher M,Wohlfarth P,Beelen DW,Liebregts T

    更新日期:2019-02-01 00:00:00

  • Cytomegalovirus infection in patients with haematological diseases and after autologous stem cell transplantation as consolidation: a single-centre study.

    abstract::Because of the widespread use of immunosuppressive drugs, CMV infection is one of the most important causes of morbidity and mortality in patients with haematological malignancies worldwide. The aim of the study was to retrospectively analyse the epidemiology of CMV infection in haematological patients. Between 2008 a...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2831-7

    authors: Piukovics K,Terhes G,Gurbity-Pálfi T,Bereczki Á,Rárosi F,Deák J,Borbényi Z,Urbán E

    更新日期:2017-01-01 00:00:00

  • MicroRNAs mark in the MLL-rearranged leukemia.

    abstract::MicroRNAs are short noncoding RNAs, known regulators of several signaling pathways cell differentiation and proliferation, development, and apoptosis, which are deregulated in acute leukemia. Mixed lineage leukemia (MLL) gene encodes a protein with histone methyltransferase activity, which is essential for the fine tu...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-013-1803-4

    authors: Benetatos L,Vartholomatos G

    更新日期:2013-11-01 00:00:00

  • Phenotype variability of the dominant beta-thalassemia induced in four Dutch families by the rare cd121 (G-->T) mutation.

    abstract::Eight patients who were carriers of beta-thalassemia induced by the cd121 (G-->T) mutation are described in four nonrelated Dutch families. This mutant, which is considered rare and inherited in a dominant manner, is expressed in a different way among each of the four families and even among carriers of the same famil...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050453

    authors: Giordano PC,Harteveld CL,Michiels JJ,Terpstra W,Schelfhout LJ,Appel IM,Batelaan D,van Delft P,Plug RJ,Bernini LF

    更新日期:1998-12-01 00:00:00

  • Transdifferentiation of mesenchymal stem cells into cardiomyocytes by direct cell-to-cell contact with neonatal cardiomyocyte but not adult cardiomyocytes.

    abstract::Recent studies have demonstrated that direct cell-to-cell interaction is one of the microenvironment factors for transdifferentiation of adult stem cells into cardiomyocytes. We investigated whether transdifferentiation of mesenchymal stem cells (MSCs) into cardiomyocytes was dependent on developmental stages of cocul...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-005-1068-7

    authors: Yoon J,Shim WJ,Ro YM,Lim DS

    更新日期:2005-10-01 00:00:00

  • Headache prevalence following recovery from TTP and aHUS.

    abstract::Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-015-2411-2

    authors: Saultz JN,Wu HM,Cataland S

    更新日期:2015-09-01 00:00:00

  • Low-density lipoprotein cholesterol suppresses apoptosis in human multiple myeloma cells.

    abstract::Multiple myeloma (MM) is an incurable disease accompanied by low plasma levels of low-density lipoprotein cholesterol (LDL-c). The significance of altered cholesterol metabolism in the pathophysiology of MM remains elusive. Although it has been hypothesized that myeloma cells depend on exogenous cholesterol for its su...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1246-8

    authors: Tirado-Vélez JM,Benítez-Rondán A,Cózar-Castellano I,Medina F,Perdomo G

    更新日期:2012-01-01 00:00:00

  • Second line azacitidine for elderly or infirmed patients with acute myeloid leukemia (AML) not eligible for allogeneic hematopoietic cell transplantation-a retrospective national multicenter study.

    abstract::Elderly and infirm patients with acute myeloid leukemia (AML) with either induction refractory or relapse disease may benefit from treatment with azacitidine. We retrospectively reviewed the data from five tertiary centers in Israel, treated between 2009 and 2015. Thirty-four patients (median age 74 years) were identi...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-016-2914-5

    authors: Ram R,Gatt M,Merkel D,Helman I,Inbar T,Nagler A,Avivi I,Ofran Y

    更新日期:2017-04-01 00:00:00

  • The prognostic value of serum erythropoietin in patients with lower-risk myelodysplastic syndromes: a review of the literature and expert opinion.

    abstract::Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies associated with an erythroid maturation defect, resulting in anemia. Treatments for MDS include erythropoiesis-stimulating agents (ESAs). The identification of prognostic markers is important to help predict response and improve outcomes. Various...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-019-03799-4

    authors: Park S,Kelaidi C,Meunier M,Casadevall N,Gerds AT,Platzbecker U

    更新日期:2020-01-01 00:00:00

  • Chronic myelogenous leukemia in blast crisis: retrospective analysis of prognostic factors in 90 patients.

    abstract::Ninety patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis were reviewed to identify significant prognostic associations. At diagnosis of blast crisis the main clinical, laboratory, and cytogenetic data were recorded and evaluated for prognostic significance. At the time of the ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050233

    authors: Griesshammer M,Heinze B,Hellmann A,Popp C,Anger B,Heil G,Bangerter M,Heimpel H

    更新日期:1996-11-01 00:00:00

  • Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia.

    abstract::Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and non-relapse mortality. The FLAMSA-RIC protocol for high-risk patients with acute myeloid leukemia (AML) and myel...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1253-9

    authors: Chemnitz JM,von Lilienfeld-Toal M,Holtick U,Theurich S,Shimabukuro-Vornhagen A,Krause A,Brossart P,Hallek M,Scheid C

    更新日期:2012-01-01 00:00:00

  • Meningeal and cerebral involvement in multiple myeloma patients.

    abstract::Cerebral involvement is an unusual complication in multiple myeloma: herein four patients who presented myelomatous meningitis with multiple intraparenchymal lesions or a localized cerebral plasmacytoma are described. Two of these patients relapsed with meningeal involvement and a very limited disease outside the cent...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-001-0387-6

    authors: Patriarca F,Zaja F,Silvestri F,Sperotto A,Scalise A,Gigli G,Fanin R

    更新日期:2001-12-01 00:00:00

  • Genotyping of 22 blood group antigen polymorphisms and establishing a national recipient registry in the Korean population.

    abstract::It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewp...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2645-7

    authors: Hong YJ,Chung Y,Hwang SM,Park JS,Kwon JR,Choi YS,Kim JN,Lee DH,Kwon SY,Cho NS,Song EY,Park KU,Song J,Han KS

    更新日期:2016-05-01 00:00:00

  • Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.

    abstract::A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal a...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0795-x

    authors: Rothe A,Seibold M,Hoppe T,Seifert H,Engert A,Caspar C,Karthaus M,Fätkenheuer G,Bethe U,Tintelnot K,Cornely OA

    更新日期:2004-06-01 00:00:00

  • Epidemiology of chronic myeloid leukaemia: an update.

    abstract::National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-015-2314-2

    authors: Höglund M,Sandin F,Simonsson B

    更新日期:2015-04-01 00:00:00

  • Refractory thrombocytopenia with chromosome 11q23 abnormality.

    abstract::Although cytopenia is a common manifestation of myelodysplastic syndrome (MDS), isolated thrombocytopenia is rare. The term "refractory thrombocytopenia" (RTC) has been proposed as a counterpart of refractory anemia. We describe here a case of RTC associated with chromosome abnormality on 11q23. A 59-year-old man was ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050209

    authors: Imoto S,Hayashi Y,Matsui T,Murayama T,Iwata N,Matsuoka H,Nagata A,Itoh H,Chihara K

    更新日期:1996-08-01 00:00:00

  • Early post-transplantation positron emission tomography in patients with Hodgkin lymphoma is an independent prognostic factor with an impact on overall survival.

    abstract::The aim of the present study was to investigate the prognostic role of pre- and/or early post-autologous stem cell transplantation (ASCT) (18)F-flourodeoxyglucose (FDG) positron emission tomography (PET) in patients with relapsed/refractory Hodgkin lymphoma. Forty-three consecutive patients were enrolled in this study...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1209-0

    authors: Sucak GT,Özkurt ZN,Suyani E,Yaşar DG,Akdemir ÖÜ,Aki Z,Yeğin ZA,Yağci M,Kapucu ÖL

    更新日期:2011-11-01 00:00:00

  • Alloantibody from a patient with severe von Willebrand disease inhibits von Willebrand factor-FVIII interaction.

    abstract::The aim of this study was to analyze the ability of an alloantibody from a patient with severe von Willebrand disease (vWD) to interfere with the vWF domain for FVIII, to inhibit factor VIII (FVIII), and to compare it with a rabbit polyclonal antibody. The vWF domain for binding to FVIII was assayed by a method previo...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050323

    authors: Batlle J,Lourés E,Vila P,Hernández MC,Méndez JA,Torea J,Rendal E,Couselo MJ,Filgueira A,López Fernández MF

    更新日期:1997-09-01 00:00:00

  • Downbeat nystagmus caused by thiamine deficiency: an unusual presentation of CNS localization of large cell anaplastic CD 30-positive non-Hodgkin's lymphoma.

    abstract::A 24-year-old woman with a large cell anaplastic CD 30-positive T-cell non-Hodgkin's lymphoma (NHL) developed downbeat nystagmus, anisocoria, and oscillopsia. Prior to overt cerebral invasion by NHL, she had a thiamine deficiency with very low thiamine concentrations in the CSF, probably caused by protracted vomiting ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050484

    authors: Mulder AH,Raemaekers JM,Boerman RH,Mattijssen V

    更新日期:1999-02-01 00:00:00

  • The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion.

    abstract::The absence of researches about autophagy in multiple myeloma promoted us to explore the biological characteristics and role of autophagy induced by nutrient depletion in multiple myeloma (MM) cell line RPMI8226 cells. Both autophagic and apoptotic morphology were observed by TUNEL, transmission electron microscopy (T...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1315-z

    authors: Zeng R,He J,Peng J,Chen Y,Yi S,Zhao F,Cui G

    更新日期:2012-03-01 00:00:00

  • Phase-II trial of idarubicin, fludarabine, cytosine arabinoside, and filgrastim (Ida-FLAG) for treatment of refractory, relapsed, and secondary AML.

    abstract::The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplas...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s002770050541

    authors: Steinmetz HT,Schulz A,Staib P,Scheid C,Glasmacher A,Neufang A,Franklin J,Tesch H,Diehl V,Dias Wickramanayake P

    更新日期:1999-09-01 00:00:00

  • Does mRNA level of microsomal carnitine palmitoyltransferase predict yield of peripheral blood stem cell apheresis?

    abstract::Transplantation of autologous hematopoietic stem cells is a well established therapeutic procedure. Despite advances in efficacy of the stem cell mobilization and apheresis process until now a predictive factor for the expected stem cell yield before initiation of mobilization therapy could not be identified. The main...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-005-0074-0

    authors: Fillitz M,Karlic H,Tüchler H,Zeibig J,Spiegel W,Wihlidal P,Varga F,Pittermann E,Pfeilstöcker M

    更新日期:2006-06-01 00:00:00

  • Quality-adjusted survival analysis shows differences in outcome after immunosuppression or bone marrow transplantation in aplastic anemia.

    abstract::Bone marrow transplantation (BMT) and immunosuppression (IS) have improved the prognosis of aplastic anemia; both treatments have specific advantages and drawbacks but similar survival rates. Analysis of additional endpoints may help in treatment decisions. In a single-center study, patients with aplastic anemia treat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0930-3

    authors: Viollier R,Passweg J,Gregor M,Favre G,Kühne T,Nissen C,Gratwohl A,Tichelli A

    更新日期:2005-01-01 00:00:00

  • Evaluation of a new protein-C concentrate and comparison of protein-C assays in a child with congenital protein-C deficiency.

    abstract::We investigated a new protein-C (PC) concentrate in a child with a type-II homozygous deficiency, concerning tolerance and safety. By means of various functional and antigen assays the in vivo recovery and the half-life were determined. In order to compare the results we reduced the measured values to the average half...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01697402

    authors: Auberger K

    更新日期:1992-03-01 00:00:00

  • Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis

    abstract::Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression t...

    journal_title:Annals of hematology

    pub_type: 共识发展会议,杂志文章,实务指引,评审

    doi:10.1007/s00277-016-2621-2

    authors: Appelmann I,Kreher S,Parmentier S,Wolf HH,Bisping G,Kirschner M,Bergmann F,Schilling K,Brümmendorf TH,Petrides PE,Tiede A,Matzdorff A,Griesshammer M,Riess H,Koschmieder S

    更新日期:2016-04-01 00:00:00

  • JAK2V617F and calreticulin mutations in recurrent venous thromboembolism: results from the EDITH prospective cohort.

    abstract::Cancer incidence in patients with recurrent unprovoked venous thromboembolism (VTE) is much higher than after a first event, but the incidence of myeloproliferative neoplasms (MPN) in this situation is still unknown. We tested for JAK2V617F and calreticulin mutants, 372 DNA samples of patients treated for (VTR). Among...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2853-1

    authors: Ianotto JC,Chauveau A,Mottier D,Ugo V,Berthou C,Lippert E,Delluc A

    更新日期:2017-03-01 00:00:00

  • Modified BEAM with triple autologous stem cell transplantation for patients with relapsed aggressive non-Hodgkin lymphoma.

    abstract::Treatment of relapse and primary progression in aggressive lymphoma remains unsatisfactory; outcome is still poor. Better treatment strategies are much needed for this patient population. The R1 study is a prospective multi-center phase I/II study evaluating a dose finding approach with a triple transplant regimen in ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-016-2671-5

    authors: Hohloch K,Zeynalova S,Chapuy B,Pfreundschuh M,Loeffler M,Ziepert M,Feller AC,Trümper L,Hasenclever D,Wulf G,Schmitz N

    更新日期:2016-06-01 00:00:00

  • Familial hematological malignancies: new IDH2 mutation.

    abstract::Isocitrate dehydrogenase IDH 1 and IDH 2 mutations were reported in several cancer forms, especially in hematological malignancies, but were never been investigated in familial aggregation. The aim of this study is to determine whether germline isocitrate dehydrogenase genes mutations are involved.We targeted IDH1 and...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2813-9

    authors: Hamadou WS,Bourdon V,Létard S,Brenet F,Laarif S,Besbes S,Paci A,David M,Penard-Lacronique V,Youssef YB,Laatiri MA,Eisinger F,Mari V,Gesta P,Dreyfus H,Bonadona V,Dugast C,Zattara H,Faivre L,Noguchi T,Khélif A,Sal

    更新日期:2016-12-01 00:00:00