Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia.

abstract：:Ninety patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis were reviewed to identify significant prognostic associations. At diagnosis of blast crisis the main clinical, laboratory, and cytogenetic data were recorded and evaluated for prognostic significance. At the time of the ...

journal_title：Annals of hematology

authors： Griesshammer M,Heinze B,Hellmann A,Popp C,Anger B,Heil G,Bangerter M,Heimpel H

更新日期：1996-11-01 00:00:00

abstract：:Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...

journal_title：Annals of hematology

authors： Fiegl M,Falkner F,Steurer M,Zojer N,Hopfinger G,Haslbauer F,Winder G,Voskova D,Andel J,Lang A,Brychtova Y,Mayer J,Greil R,Gastl G,Austrian Collaborative Study Group on Alemtuzumab in Chronic Lymphocytic Leukemia.,Czech Leuk

更新日期：2011-09-01 00:00:00

abstract：:Since December 2019, a novel coronavirus has spread throughout China and across the world, causing a continuous increase in confirmed cases within a short period of time. Some studies reported cases of thrombocytopenia, but hardly any studies mentioned how the virus causes thrombocytopenia. We propose several mechanis...

journal_title：Annals of hematology

authors： Xu P,Zhou Q,Xu J

更新日期：2020-06-01 00:00:00

abstract：:In follicular lymphoma the t(14;18) might be useful as a tumor marker in predicting the quality of the response to treatment. We investigated whether analyzing numbers of t(14;18)-positive cells in peripheral blood correlated with remission status in individual patients receiving a variety of treatments. Numbers of ci...

journal_title：Annals of hematology

authors： Mandigers CM,Meijerink JP,van 't Veer MB,Mensink EJ,Raemaekers JM

更新日期：2003-12-01 00:00:00

abstract：:Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few ...

journal_title：Annals of hematology

authors： Wach M,Dmoszynska A,Wasik-Szczepanek E,Pozarowski A,Drop A,Szczepanek D

更新日期：2004-08-01 00:00:00

abstract：:The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...

journal_title：Annals of hematology

authors： Takaoka K,Nannya Y,Shinohara A,Arai S,Nakamura F,Kurokawa M

更新日期：2014-10-01 00:00:00

abstract：:To assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Co...

journal_title：Annals of hematology

authors： Ma SY,Tian XP,Cai J,Zhong GZ,Chen X,Huang HQ,Lin TY,Li ZM,Cai QQ

更新日期：2020-06-01 00:00:00

abstract：:It is often difficult for standard blood banks in Korea to supply adequate amounts of blood for patients with rare phenotype. Moreover, the definition of a blood in need is ambiguous, and much remains to be learned. In this study, we determined the prevalence of various red blood cell (RBC) antigens from a donor viewp...

journal_title：Annals of hematology

authors： Hong YJ,Chung Y,Hwang SM,Park JS,Kwon JR,Choi YS,Kim JN,Lee DH,Kwon SY,Cho NS,Song EY,Park KU,Song J,Han KS

更新日期：2016-05-01 00:00:00

abstract：:Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Coopera...

journal_title：Annals of hematology

authors： Breccia M,Andriani A,Montanaro M,Abruzzese E,Buccisano F,Cedrone M,Centra A,Villivà N,Celesti F,Trawinska MM,Massaro F,Di Veroli A,Anaclerico B,Colafigli G,Molica M,Spadea A,Petriccione L,Cimino G,Latagliata R

更新日期：2017-03-01 00:00:00

abstract：:Increasing the number of megakaryocytic cells in stem cell transplants by ex vivo expansion culture may provide an approach to accelerate platelet engraftment after high-dose chemotherapy. However, it is unknown if a relationship exists between the expansion potential of progenitor cells and the time to platelet engra...

journal_title：Annals of hematology

authors： Drayer AL,Smit Sibinga CT,Esselink MT,de Wolf JT,Vellenga E

更新日期：2002-04-01 00:00:00

abstract：:FLT3 and its ligand (FL) are one of the regulators of normal hematopoiesis. Ligand-independent activation of FLT3 occurs in about 30% of acute myeloid leukemia cases and is one goal for selectively targeted therapies. However, the function of FLT3/FL in the regulation of non-malignant immature hematopoietic cells is p...

journal_title：Annals of hematology

authors： Weisel KC,Yildirim S,Schweikle E,Kanz L,Möhle R

更新日期：2009-03-01 00:00:00

abstract：:Pre-engraftment syndrome (PES) is a condition occurring after umbilical cord blood transplantation (UCBT) characterized by fever and erythematous skin rash prior to neutrophil engraftment. We sought to determine the incidence and characterize the pulmonary manifestations of PES. A retrospective review of patients who ...

journal_title：Annals of hematology

authors： Brownback KR,Simpson SQ,McGuirk JP,Lin TL,Abhyankar S,Ganguly S,Aljitawi OS

更新日期：2014-05-01 00:00:00

abstract：:Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...

journal_title：Annals of hematology

authors： Cohen YC,Magen H,Lavi N,Gatt ME,Chubar E,Horowitz N,Kreiniz N,Tadmor T,Trestman S,Vitkon R,Rouvio O,Shvetz O,Shaulov A,Ziv-Baran T,Avivi I

更新日期：2020-06-01 00:00:00

abstract：:In Germany, analyses of clinical and laboratory features of patients with acute porphyrias are only available for hereditary coproporphyria (HCP) but not with other acute porphyrias, acute intermittent porphyria (AIP) and variegate porphyria (VP). The aim of the study was to analyze a large cohort of patients with par...

journal_title：Annals of hematology

authors： Bronisch O,Stauch T,Haverkamp T,Beykirch MK,Petrides PE

更新日期：2019-12-01 00:00:00

abstract：:Many studies have confirmed that overexpressed WT1 exists in leukemic cells, especially in AML. However, the immunophenotypic features of this sort of leukemic cells remain to be unclarified. We retrospectively analyzed the immunophenotype of 283 newly diagnosed AML patients with intermediated and poor cytogenetic ris...

journal_title：Annals of hematology

authors： Wang XR,Chang Y,Yuan XY,Wang YZ,Qin YZ,Ruan GR,Lai YY,Liu YR

更新日期：2020-02-01 00:00:00

abstract：:The clinical experience of the significant difference in iron metabolism between multiple myeloma and myelodysplasia prompted us to analyse patients according to mutation frequency in the hemochromatosis gene (HFE) known to participate in the regulation of iron metabolism. HFE genotyping results were also evaluated in...

journal_title：Annals of hematology

authors： Várkonyi J,Demeter J,Tordai A,Andrikovics H

更新日期：2006-12-01 00:00:00

abstract：:Delayed platelet engraftment (DPE) is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This phenomenon is also a predictor of increased treatment-related mortality and poor survival. Therefore, therapies that promote platelet engraftment to prevent DPE are needed. This pr...

journal_title：Annals of hematology

authors： Han TT,Xu LP,Liu DH,Liu KY,Wang FR,Wang Y,Yan CH,Chen YH,Sun YQ,Ji Y,Wang JZ,Zhang XH,Huang XJ

更新日期：2015-01-01 00:00:00

abstract：:The incidence of multiple myeloma (MM) has increased in the last 20 years, particularly in middle and low-middle income countries. Access to diagnostic and prognostic tests and the availability of effective care is highly variable globally. Latin America represents 10% of the world population, distributed in countries...

journal_title：Annals of hematology

authors： Riva E,Schütz N,Peña C,Ruiz-Argüelles G,Hopkins CR,Bove V,Villano F,Andino L,Suárez L,Martínez H,Navarro J,López-Vidal H,Da Costa O,Pineda MR,Rubio Y,Ramirez J,Choque J,Fantl D

更新日期：2020-05-01 00:00:00

abstract：:Azacitidine (AZA) is a DNA hypomethylation agent administered in myeloid neoplasms; however, there is still a lack of established predictors of response. We studied 113 patients with myelodysplastic syndromes (n = 85) or acute myeloid leukemia (n = 28) who received AZA to assess the predictive value on response of cli...

journal_title：Annals of hematology

authors： Martín I,Navarro B,Serrano A,Villamón E,Calabuig M,Solano C,Chaves FJ,Yagüe N,Orts M,Amat P,Fuentes A,Seda E,García F,Hernández-Boluda JC,Tormo M

更新日期：2020-03-01 00:00:00

abstract：:The prognostic value of peripheral blasts (PB) is not well-studied in patients with myelodysplastic syndromes (MDS). We evaluated the impact of PB on overall survival (OS) and transformation to acute myeloid leukemia (AML) in a large cohort. The MDS database at the Moffitt Cancer Center was retrospectively reviewed to...

journal_title：Annals of hematology

authors： Duong VH,Padron E,Al Ali NH,Lancet JE,Hall J,Kwok B,Zhang L,Epling-Burnette PK,List AF,Komrokji RS

更新日期：2018-02-01 00:00:00

abstract：:Primary myelofibrosis (PMF)-associated pruritus is often severe and requires treatment. Fifty-one patients with bone marrow-proven PMF with associated pruritus were identified from a primary cohort of patients with PMF (n = 566) seen at our institution. We conducted a retrospective review of the clinical characteristi...

journal_title：Annals of hematology

authors： Vaa BE,Tefferi A,Gangat N,Pardanani A,Lasho TL,Finke CM,Wolanskyj AP

更新日期：2016-06-01 00:00:00

abstract：:We have studied the effects of recombinant human thrombopoietin (TPO, mpl ligand) on the megakaryocyte colony formation from control human bone marrow cells, human leukemia cells at diagnosis, and human bone marrow cells after induction chemotherapy for acute leukemias. In the control human bone marrow cells from four...

journal_title：Annals of hematology

authors： Liang DC,Shih LY,Kuo MC,Chen SH,Liu HC,Shimosaka A

更新日期：1998-07-01 00:00:00

abstract：:This is a retrospective, multicenter study to evaluate biological features and outcome of elderly patients diagnosed with acute lymphoblastic leukemia (ALL) during the last 10 years in ten hematological centers in Poland. Eighty-seven patients aged 60 years or older were studied. To our knowledge, this is one of the l...

journal_title：Annals of hematology

authors： Robak T,Szmigielska-Kapłon A,Wrzesień-Kuś A,Wierzbowska A,Skotnicki AB,Piatkowska-Jakubas B,Kuliczkowski K,Mazur G,Zduńczyk A,Stella-Hołowiecka B,Hołowiecki J,Dwilewicz-Trojaczek J,Madry K,Dmoszyńska A,Cioch M

更新日期：2004-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) can cause end-organ diseases including pneumonia, gastroenteritis, retinitis, and encephalitis in hematopoietic stem cell transplantation recipients. Potential differences among different CMV diseases remain uncertain. This study aimed to compare the clinical characteristics, risk factors, and mo...

journal_title：Annals of hematology

authors： Meng XY,Fu HX,Zhu XL,Wang JZ,Liu X,Yan CH,Zhang YY,Mo XD,Wang Y,Han W,Chen YH,Chen DB,Liu HX,Chang YJ,Xu LP,Liu KY,Huang XJ,Zhang XH

更新日期：2020-11-01 00:00:00

abstract：:Impact of FLT3 receptor tyrosine kinase activation via internal tandem duplication (ITD) of the juxtamembrane region on outcome of acute myeloid leukemia (AML) is still controversial. Recent researches reveal a role of FLT3 in monocyte differentiation in hematopoiesis. We analyzed the clinical impact of FLT3 alteratio...

journal_title：Annals of hematology

authors： Koh Y,Park J,Ahn KS,Kim I,Bang SM,Lee JH,Yoon SS,Soon Lee D,Yiul Lee Y,Park S,Kim BK

更新日期：2009-11-01 00:00:00

abstract：:We describe three cases of acute promyelocytic leukemia (APL) with long-term disease-free survival who developed congestive heart failure (CHF) requiring cardiac transplantation. All three patients presented late-onset cardiotoxicity. Cardiac failure occurred progressively after 31-month, 32-month, and 14-month interv...

journal_title：Annals of hematology

authors： Thomas X,Le QH,Fiere D

更新日期：2002-09-01 00:00:00

abstract：:The laboratory diagnosis of hereditary spherocytosis (HS) is based on several screening and confirmatory tests; our algorithm includes clinical features, red blood cell morphology analysis and cryohaemolysis test, and, in case of positive screening, sodium dodecyl sulphate polyacrylamide gel electrophoresis as a diagn...

journal_title：Annals of hematology

authors： Lazarova E,Pradier O,Cotton F,Gulbis B

更新日期：2014-11-01 00:00:00

abstract：:Haplo-identical transplants (Haplo-Tx) are an important alternative for patients with hematological malignancies who lack a HLA-identical donor. Seventy-one T-replete Haplo-Tx were performed in 70 high-risk patients at our center; 22/70 (31%) patients with refractory/relapsed leukemia received sequential salvage thera...

journal_title：Annals of hematology

authors： Brunello L,Passera R,Dellacasa CM,Giaccone L,Audisio E,Ferrero D,D'Ardia S,Allione B,Aydin S,Festuccia M,Lia G,Crisà E,Maffini E,Butera S,Busca A,Bruno B

更新日期：2018-11-01 00:00:00

abstract：:To characterize the clinical features, associated disorders, and treatment of necrobiotic xanthogranuloma (NXG), a rare non-Langerhans cell histiocytosis, we conducted a retrospective review of pathologically confirmed NXG at Mayo Clinic Arizona from 1987 to June 2017. Data on clinical findings, laboratory findings, a...

journal_title：Annals of hematology

authors： Hilal T,DiCaudo DJ,Connolly SM,Reeder CB

更新日期：2018-08-01 00:00:00

abstract：:Solitary plasmacytoma of bone (SPB) is a rare tumor that represents a minority of patients with plasma cell localized malignancy characterized by a single osteolytic bone lesion. The molecular mechanism underlying the genesis of SPB has remained enigmatic. Signal transducers and activators of transcription-3 (STAT3) i...

journal_title：Annals of hematology

authors： Guo S,Zhi Y,Yang H,Yu Y,Wang Y,Zhang J,Wang G,Zhang L,Sun B,Zhang Y

更新日期：2014-03-01 00:00:00