Abstract：
:Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage mature bone marrow stromal cells in vitro, but the extent to which marrow mesenchymal stem cells (MSCs) are damaged by HDC in vivo is largely unknown. To address this question, the phenotype and functional properties of marrow MSCs derived from untreated and chemotherapeutically treated patients with hematological malignancy were compared. This study demonstrates a significant reduction in MSC expansion and MSC CD44 expression by MSCs derived from patients receiving HDC regimens, thus implicating potential disadvantages in the use of autologous MSCs in chemotherapeutically pretreated patients for future therapeutic strategies. The clinical importance of these HDC-induced defects we have observed could be determined through prospective randomized trials of the effects of MSC cotransplantation on hematopoietic recovery in the setting of HDC with and without hematopoietic stem cell rescue.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Kemp K,Morse R,Wexler S,Cox C,Mallam E,Hows J,Donaldson Cdoi
10.1007/s00277-009-0896-2subject
Has Abstractpub_date
2010-07-01 00:00:00pages
701-13issue
7eissn
0939-5555issn
1432-0584journal_volume
89pub_type
临床试验,杂志文章abstract：:High-dose chemotherapy (HDT) and stem cell transplantation is a newer treatment option widely applied in poor-risk germ cell tumor patients. Due to the increasing practical clinical experience and the availability of hematopoietic growth factors, this treatment approach has become a relatively safe procedure. Dependin...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s002770050386
更新日期：1998-05-01 00:00:00
abstract：:Haemoglobinopathies are the world's most frequently found monogenic disorders. In the cases with high oxygen affinity, the decrease in the liberation of the oxygen determines a secondary erythrocytosis. In this work, we present 17 unrelated families of Caucasian race and of Spanish origin, with ten variants of haemogl...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0581-x
更新日期：2009-03-01 00:00:00
abstract：:Evaluation of bone marrow involvement (BMI) by conventional bone marrow biopsy (BMB) can generate false-negative results if marrow disease is focal. The sensitivity of 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) in assessing BMI in extranodal NK/T cell lymphoma (ENKL) h...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2289-4
更新日期：2015-06-01 00:00:00
abstract：:The mammalian target of rapamycin (mTOR) is a protein kinase involved in the phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway. It plays a pivotal role in the control of cell proliferation, survival, and angiogenesis with multiple and frequent dysregulations of this pathway in human tumors. Temsirolimus is a...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2570-1
更新日期：2016-02-01 00:00:00
abstract：:The clarification of enlarged lymph nodes is a common issue in clinical routine. By now, open surgery with complete lymph node extirpation, followed by histopathology, is considered as standard. We investigated the value of fine needle aspiration (FNA) and core needle biopsy (CNB) when supporting the conventional morp...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1476-4
更新日期：2012-09-01 00:00:00
abstract：:Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-004-0893-4
更新日期：2005-01-01 00:00:00
abstract：:Multiresistant bacterial infections are a potentially life-threatening condition in acute leukaemia (AL) patients. We aimed to better define the very recent epidemiology and outcome of bloodstream infections (BSIs) in a real-life setting. We prospectively collected all consecutive febrile/infectious episodes occurring...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-016-2815-7
更新日期：2016-12-01 00:00:00
abstract：:Monoclonal immunoglobulin, as a marker for monoclonal gammopathy, is evaluated by protein electrophoresis (PEP) and immunofixation electrophoresis (IFE). However, PEP and IFE are not satisfactory in sensitivity, objectivity, and facility. Recently, a highly sensitive, automated immunoassay for measurement of free ligh...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-005-1047-z
更新日期：2005-09-01 00:00:00
abstract：:Circulating homocysteine is a risk factor of cardiovascular and cerebrovascular events. Hyperhomocysteinemia may be an early indicator for vitamin B12 disorders because cobalamin is a cofactor in the remethylation process of homocysteine. Serum holotranscobalamin (holoTC II) becomes decreased before the development of...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-007-0406-3
更新日期：2008-05-01 00:00:00
abstract：:Acute megakaryoblastic leukaemia (AML-M7) is an uncommon disease, composing 0.5-1.2% of newly diagnosed adult acute myeloid leukaemias (AML). It is characterised by higher incidence and complexity of cytogenetic abnormalities. We report a rare case of Philadelphia (Ph) chromosome-positive AML-M7, presenting with extre...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0783-1
更新日期：2004-06-01 00:00:00
abstract：:The B cell surface antigen CD19 is a target for treating B cell malignancies, such as B cell precursor acute lymphoblastic leukemia and B cell non-Hodgkin lymphoma. The BiTE® immuno-oncology platform includes blinatumomab, which is approved for relapsed/refractory B cell precursor acute lymphoblastic leukemia and B ce...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-020-04221-0
更新日期：2020-10-01 00:00:00
abstract：:The frequency of apoptotic cells in bone marrow trephine biopsies and cytospins of immunomagnetically isolated myeloid progenitor cells was determined in 39 patients with chronic idiopathic neutropenia (CIN) and 12 hematologically normal individuals using the in situ end-labeling (ISEL) apoptosis detection method. We ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0709-y
更新日期：2003-10-01 00:00:00
abstract：:Wilms' tumor gene 1 (WT1) is gaining increasing attention as a therapeutic target molecule due to its common expression in acute leukemias and its involvement in cell proliferation. Here, we reported on WT1 messenger RNA expression levels at diagnosis in a series of 238 adult acute lymphoblastic leukemia (ALL) samples...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-009-0746-2
更新日期：2009-12-01 00:00:00
abstract：:Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has been accepted as a treatment option for aggressive (acute or lymphoma type) adult T cell leukemia/lymphoma (ATLL) patients with a poor prognosis, when a suitable HLA-matched donor is not available. However, haplo-HSCT carries a potential risk of t...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-020-03934-6
更新日期：2020-03-01 00:00:00
abstract：:Neutral red is a vital stain known to be accumulated in the lysosomes of neutrophils and monocytes. It is used mainly to identify and detect the activated state of these cells. We have found that the extracellular application of physiological ceramide, i.e., a product of sphingomyelin hydrolysis and a newly defined in...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050015
更新日期：2000-02-01 00:00:00
abstract：:Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050283
更新日期：1997-04-01 00:00:00
abstract：:Somatic mutations in the SF3B1 gene, a gene encoding the splicing factor 3B subunit 1, were recently reported in myelodysplastic syndromes (MDS), particularly in the presence of ring sideroblasts (RS). The authors investigated the prevalence and clinical significance of SF3B1 mutations in Korean patients with myeloid ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1915-x
更新日期：2014-04-01 00:00:00
abstract：:Burkitt lymphoma (BL) is an aggressive B-cell lymphoma more common in children comprising one third of pediatric non-Hodgkin lymphoma cases. The recent discovery in BL pathogenesis highlighted the activation of PI3K pathway in cooperation with Myc in the development of BL. In this study, we demonstrated that PI3K/Akt ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2021-4
更新日期：2014-06-01 00:00:00
abstract：:Infections by multidrug-resistant (MDR) bacteria are a worrisome phenomenon in hematological patients. Data on the incidence of MDR colonization and related bloodstream infections (BSIs) in haematological patients are scarce. A multicentric prospective observational study was planned in 18 haematological institutions ...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-018-3341-6
更新日期：2018-09-01 00:00:00
abstract：:Azacitidine and decitabine, two hypomethylating agents, are known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who cannot endure intensive cytotoxic chemotherapy or are not eligible for transplantation. However, the treatment response rate is l...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-018-3464-9
更新日期：2018-11-01 00:00:00
abstract：:Eight patients who were carriers of beta-thalassemia induced by the cd121 (G-->T) mutation are described in four nonrelated Dutch families. This mutant, which is considered rare and inherited in a dominant manner, is expressed in a different way among each of the four families and even among carriers of the same famil...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050453
更新日期：1998-12-01 00:00:00
abstract：:Several authors have described a particular potential of automated depolarization analysis in detecting malaria infection as part of the routine full blood count (FBC) performed by the Cell-Dyn 4000 analyzer. In these cases, abnormal depolarizing patterns are due to the presence of leukocyte-associated malaria hemozoi...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0786-y
更新日期：2004-05-01 00:00:00
abstract：:The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0679-1
更新日期：2009-08-01 00:00:00
abstract：:The aim of the study was to investigate the association of leptin with hematological parameters in beta-thalassemia patients in Greece. We measured plasma levels of soluble transferrin receptor (sTfR) and leptin by enzyme-linked immunosorbent assay (ELISA) in 40 beta-thalassemia patients (21 transfusion dependent and ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0499-7
更新日期：2002-09-01 00:00:00
abstract：:An additional affiliation for the first author was not indicated. Hyewon Lee is also affiliated with: Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea. ...
journal_title：Annals of hematology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00277-019-03868-8
更新日期：2020-01-01 00:00:00
abstract：:Erythropoietin, alone or in combination with colony-stimulating factors, is a promising agent in the treatment of patients with cancer-related 'anemia of chronic disorders', chemo/radiotherapy-induced anemia, or anemia due to myelodysplastic or myeloproliferative syndromes. In the first two groups, at least half of th...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/BF01700275
更新日期：1994-11-01 00:00:00
abstract：:Controversy remains regarding the transplant outcomes of human leukocyte antigen-identical related bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) for the treatment of patients with hematological malignancies. To provide an estimate of the effect of BMT and PBSCT on clinical ou...
journal_title：Annals of hematology
pub_type： 杂志文章,meta分析
doi：10.1007/s00277-011-1299-8
更新日期：2012-03-01 00:00:00
abstract：:Although lenalidomide plus dexamethasone (RD) is a therapeutic option for relapsed/refractory multiple myeloma (RRMM), limited real-world clinical data exist. The purpose of this study was to estimate efficacy and safety of RD in RRMM patients of the clinical practice. Data from patients at 25 university hospitals in ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00277-019-03904-7
更新日期：2020-02-01 00:00:00
abstract：:Second-generation azoles may be more effective than first-generation azoles in the prevention of fungal infections in hematology patients. We performed a systematic review with meta-analysis of randomized controlled trials comparing second- with first-generation azoles in hematology patients with respect to proven or ...
journal_title：Annals of hematology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00277-013-1693-5
更新日期：2013-06-01 00:00:00
abstract：:Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), olde...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1785-2
更新日期：2013-11-01 00:00:00
