Evaluation of bone marrow involvement in extranodal NK/T cell lymphoma by FDG-PET/CT.

Abstract:

:Evaluation of bone marrow involvement (BMI) by conventional bone marrow biopsy (BMB) can generate false-negative results if marrow disease is focal. The sensitivity of 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) in assessing BMI in extranodal NK/T cell lymphoma (ENKL) has not been determined. We retrospectively collected clinical data from a series of 55 patients with newly diagnosed ENKL, who have received both FDG-PET/CT and BMB prior to treatment. BMB results were used as reference standard. Twelve patients (21.8 %) were considered positive lymphomatous infiltration by FDG-PET/CT (PET-CT/BM+), and five patients (9 %) were identified positive by BMB (BMB/BM+). There was a discordant result in seven patients who were PET-CT/BM+ but BMB/BM-. The sensitivity and specificity of FDG-PET/CT for identifying BMI were 100 and 86 %, respectively. Then, we analyzed the overall survival (OS) and progression-free survival (PFS) of patients who were PET-CT/BM+ and PET-CT/BM-. The median follow-up time was 16 months (range, 3 to 43 months). PET-CT/BM+ patients possessed worse 2-year OS than PET-CT/BM- patients (84.8 vs 67.9 %, P < 0.05). The estimated 2-year PFS for PET-CT/BM- and PET-CT/BM+ patients were 72.7 and 41.9 % (P < 0.05), respectively. However, it was hard to conclude that patients who were PET-CT/BM+ had similar survivals to advanced-stage patients due to the low number of patients who were PET-CT/BM+. In conclusion, FDG-PET/CT can complementally detect positive BMI patients missed by BMB in ENKL. The utility of FDG-PET/CT for defining bone marrow status has important prognostic value.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Zhou Z,Chen C,Li X,Li Z,Zhang X,Chang Y,Lu L,Cui Y,Ma Y,Zhang M

doi

10.1007/s00277-014-2289-4

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

963-7

issue

6

eissn

0939-5555

issn

1432-0584

journal_volume

94

pub_type

杂志文章
  • Immune thrombocytopenia: epidemiological and clinical features of 216 patients in northwestern Turkey.

    abstract::We evaluated the clinical features, treatment modalities, treatment responses, and prognosis of our patients with immune thrombocytopenia (ITP). Furthermore, we estimated the frequency of ITP in the Thrace region of Turkey. Two hundred sixteen patients diagnosed with ITP between 2000 and 2012 at our center were retros...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2220-z

    authors: Koylu A,Pamuk GE,Uyanik MS,Demir M,Pamuk ON

    更新日期:2015-03-01 00:00:00

  • Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia.

    abstract::We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concen...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01695696

    authors: Fest T,de Wazières B,Lamy B,Maskani M,Vuitton D,Dupond JL

    更新日期:1994-09-01 00:00:00

  • Autologous transplantation in patients with relapsed or high-grade follicular lymphoma provides long term disease-free survival and best median duration of response.

    abstract::The best treatment option for patients with relapsed or high-grade follicular lymphoma (FL) is unknown. In spite of major advances in the therapy for FL, disease-free survival remains short, and median time to progression is just over a year. Autologous stem cell transplantation in patients with relapsed FL is safe an...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-005-1058-9

    authors: Ganguly S,Divine CL,Deauna-Limayo D,Bodensteiner DC,Cook JD,Lewis JN,Skikne BS

    更新日期:2005-08-01 00:00:00

  • Higher prevalence of anemia among pregnant immigrant women compared to pregnant ethnic Danish women.

    abstract::The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-007-0305-7

    authors: Nybo M,Friis-Hansen L,Felding P,Milman N

    更新日期:2007-09-01 00:00:00

  • Second line azacitidine for elderly or infirmed patients with acute myeloid leukemia (AML) not eligible for allogeneic hematopoietic cell transplantation-a retrospective national multicenter study.

    abstract::Elderly and infirm patients with acute myeloid leukemia (AML) with either induction refractory or relapse disease may benefit from treatment with azacitidine. We retrospectively reviewed the data from five tertiary centers in Israel, treated between 2009 and 2015. Thirty-four patients (median age 74 years) were identi...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-016-2914-5

    authors: Ram R,Gatt M,Merkel D,Helman I,Inbar T,Nagler A,Avivi I,Ofran Y

    更新日期:2017-04-01 00:00:00

  • Severe epidermal necrolysis after treatment with imatinib and consecutive allogeneic hematopoietic stem cell transplantation.

    abstract::Imatinib is a new promising therapeutic option for chronic myeloid leukemia (CML) with efficacy even in the blast phase of the disease. However, most patients treated with imatinib in the blast phase develop progressive disease rapidly. Thus, treatment with imatinib has to be followed by other treatment strategies. Th...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0643-z

    authors: Schaich M,Schäkel K,Illmer T,Ehninger G,Bornhäuser M

    更新日期:2003-05-01 00:00:00

  • New prognostic model for extranodal natural killer/T cell lymphoma, nasal type.

    abstract::Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 pa...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2089-x

    authors: Cai Q,Luo X,Zhang G,Huang H,Huang H,Lin T,Jiang W,Xia Z,Young KH

    更新日期:2014-09-01 00:00:00

  • Trends in quality of non-Hodgkin's lymphoma care: is it getting better?

    abstract::This study outlines trends in quality of delivered non-Hodgkin's lymphoma (NHL) care in the Netherlands between 2007 and 2011 and to what extend this was influenced by the national Visible Care program, which aimed at increasing transparency by providing insight into the quality of healthcare. We analyzed data collect...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00277-015-2340-0

    authors: Stienen JJ,Ottevanger PB,Wennekes L,van de Schans SA,Dekker HM,van der Maazen RW,van Krieken JH,Blijlevens NM,Hermens RP,PEARL study group.

    更新日期:2015-07-01 00:00:00

  • IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.

    abstract::The somatic mutations of isocitrate dehydrogenase genes (IDH1 and IDH2) have been identified in a proportion of hematologic malignancies. We examined IDH1 R132 and IDH2 R140/R172 mutations by high resolution melting analysis and direct sequencing in Chinese patients with different myeloid malignancies including 198 ac...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1352-7

    authors: Lin J,Yao DM,Qian J,Chen Q,Qian W,Li Y,Yang J,Wang CZ,Chai HY,Qian Z,Xiao GF,Xu WR

    更新日期:2012-04-01 00:00:00

  • Transplant outcomes of the triple-negative NPM1/FLT3-ITD/CEBPA mutation subgroup are equivalent to those of the favourable ELN risk group, but significantly better than the intermediate-I risk group after allogeneic transplant in normal-karyotype AML.

    abstract::The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-015-2580-z

    authors: Ahn JS,Kim HJ,Kim YK,Jung SH,Yang DH,Lee JJ,Kim NY,Choi SH,Jung CW,Jang JH,Kim HJ,Moon JH,Sohn SK,Won JH,Kim SH,Kim DD

    更新日期:2016-03-01 00:00:00

  • Relapsing bloodstream infections during treatment of acute leukemia.

    abstract::Acute leukemia (AL) patients may experience more than one episode of bloodstream infection (BSI) caused by the same pathogen during the entire chemotherapy program. In order to identify factors influencing BSI recurrence (R-BSI) during subsequent phases of treatment, we analyzed all BSIs occurring to consecutively tre...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-1965-0

    authors: Cattaneo C,Antoniazzi F,Tumbarello M,Skert C,Borlenghi E,Schieppati F,Cerqui E,Pagani C,Petullà M,Re A,Rossi G

    更新日期:2014-05-01 00:00:00

  • Splenectomy for immune thrombocytopenic purpura: long-term results and treatment of postsplenectomy relapses.

    abstract::Information regarding prognostic determinants of outcome after splenectomy for adult immune thrombocytopenic purpura (ITP) and the management of postsplenectomy relapse is limited. Among 140 adult patients with ITP who had therapeutic splenectomy at our institution, 88% achieved either a complete (platelets > 150 x 10...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-002-0461-8

    authors: Kumar S,Diehn FE,Gertz MA,Tefferi A

    更新日期:2002-06-01 00:00:00

  • Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.

    abstract::Immunoglobulin D (IgD) myeloma is a rare subtype that used to lead to a poor outcome. To investigate the current clinical features, cytogenetic changes and survival of patients with IgD myeloma under novel treatments, we analysed 47 patients with IgD myeloma, 31 men and 16 women, with a median age of 54.5 years. We fo...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-018-3582-4

    authors: Chen L,Fan F,Deng J,Xu J,Xu A,Sun C,Hu Y

    更新日期:2019-04-01 00:00:00

  • Acute lymphoblastic leukemia in elderly: the Polish Adult Leukemia Group (PALG) experience.

    abstract::This is a retrospective, multicenter study to evaluate biological features and outcome of elderly patients diagnosed with acute lymphoblastic leukemia (ALL) during the last 10 years in ten hematological centers in Poland. Eighty-seven patients aged 60 years or older were studied. To our knowledge, this is one of the l...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-003-0808-9

    authors: Robak T,Szmigielska-Kapłon A,Wrzesień-Kuś A,Wierzbowska A,Skotnicki AB,Piatkowska-Jakubas B,Kuliczkowski K,Mazur G,Zduńczyk A,Stella-Hołowiecka B,Hołowiecki J,Dwilewicz-Trojaczek J,Madry K,Dmoszyńska A,Cioch M

    更新日期:2004-04-01 00:00:00

  • Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.

    abstract::A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal a...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0795-x

    authors: Rothe A,Seibold M,Hoppe T,Seifert H,Engert A,Caspar C,Karthaus M,Fätkenheuer G,Bethe U,Tintelnot K,Cornely OA

    更新日期:2004-06-01 00:00:00

  • Stabilization of standard platelet concentrates and minimization of the platelet storage lesion by a prostacyclin analogue.

    abstract::Platelet concentrates were pretreated with a stable synthetic prostacyclin analogue (Iloprost) at two different concentrations before the second centrifugation step (pelleting step) of preparation. This resulted in loss of platelet sensitivity to aggregating agents. To mimic the situation after transfusion and to asse...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01695474

    authors: Elias M,Heethuis A,Weggemans M,Bom V,Blom N,McShine RL,Halie MR,Smit Sibinga CT

    更新日期:1992-06-01 00:00:00

  • Selective expansion of the CD14(+)/CD16(bright) subpopulation of circulating monocytes in patients with hemophagocytic syndrome.

    abstract::Overproduction of proinflammatory cytokines is characteristic of hemophagocytic syndrome (HPS), a highly lethal inflammatory disease. Peripheral blood monocytes include two distinct subpopulations according to surface antigen expression: a major type, CD14(+)/CD16(-) (classical monocytes), and a minor type, CD14(+)/CD...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-007-0332-4

    authors: Takeyama N,Yabuki T,Kumagai T,Takagi S,Takamoto S,Noguchi H

    更新日期:2007-11-01 00:00:00

  • Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus antithymocyte globulin.

    abstract::We investigated the efficacy of an antithymocyte globulin/cyclophosphamide preparative regimen prior to allogeneic stem cell transplantation from HLA-identical siblings in patients with severe aplastic anemia. Since 1990, 21 patients, 6 males and 15 females, with a median age of 25 years (range: 7-43) have been enroll...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-002-0566-0

    authors: Kröger N,Zabelina T,Renges H,Krüger W,Kordes U,Rischewski J,Schrum J,Horstmann M,Ayuk F,Erttmann R,Kabisch H,Zander AR

    更新日期:2002-11-01 00:00:00

  • CT-guided needle biopsy performed with modified coaxial technique in patients with refractory or recurrent lymphomas.

    abstract::The aim of this study was to evaluate the role of computed tomography (CT)-guided core needle biopsy (CNB) performed by modified coaxial technique as an alternative tool to surgical biopsy in patients with refractory or recurrent lymphomas. Between May 2005 and May 2012, 57 CT-guided CNB of deep lesions were performed...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2078-0

    authors: Gaudio F,Pedote P,Ferrante A,Perrone T,Ingravallo G,Ianora AA,Angelelli G,Specchia G

    更新日期:2014-09-01 00:00:00

  • Features of extramedullary myeloma relapse: high proliferation, minimal marrow involvement, adverse cytogenetics: a retrospective single-center study of 24 cases.

    abstract::Extramedullary (e) relapse in multiple myeloma(MM) has an adverse prognosis, but knowledge concerning biological features and preferred treatment is scarce. We screened the myeloma registry of our institution for eMM relapses and identified 24 cases among 357 patients (pts).Only 8% of eMM relapses occurred after initi...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1414-5

    authors: Rasche L,Bernard C,Topp MS,Kapp M,Duell J,Wesemeier C,Haralambieva E,Maeder U,Einsele H,Knop S

    更新日期:2012-07-01 00:00:00

  • A case of congenital leukemia with monosomy 7.

    abstract::A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriam...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01836073

    authors: Shitara T,Suetake N,Yugami S,Sotomatu M,Oshima Y,Ijima H,Kuroume T,Nakazawa S

    更新日期:1992-12-01 00:00:00

  • Central nervous system involvement in adults with haemophagocytic lymphohistiocytosis: a single-center study.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystem disorder characterized by proliferation and diffuse infiltration multiple organs with histiocytes, including the central nervous system (CNS). Neurological manifestations of HLH have been recognized in different studies with children, but they remain relat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-3035-5

    authors: Cai G,Wang Y,Liu X,Han Y,Wang Z

    更新日期:2017-08-01 00:00:00

  • Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125.

    abstract::Expression of long non-coding RNA KIAA0125 has been incorporated in various gene expression signatures for prognostic prediction in acute myeloid leukemia (AML) patients, yet its functions and clinical significance remain unclear. This study aimed to investigate the clinical and biological characteristics of AML beari...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-020-04358-y

    authors: Wang YH,Lin CC,Hsu CL,Hung SY,Yao CY,Lee SH,Tsai CH,Hou HA,Chou WC,Tien HF

    更新日期:2021-02-01 00:00:00

  • Neutropenic enterocolitis: a serious complication during the treatment of acute leukemias.

    abstract::Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-003-0815-x

    authors: Wach M,Dmoszynska A,Wasik-Szczepanek E,Pozarowski A,Drop A,Szczepanek D

    更新日期:2004-08-01 00:00:00

  • Gamma/delta receptor-expressing T-cell clones from a cutaneous T-cell lymphoma suppress hematopoiesis.

    abstract::Recently we described a cutaneous T-cell lymphoma expressing the gamma/delta T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a s...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01695808

    authors: Wilhelm M,Meyer P,Batram C,Tony HP,Dummer R,Nestle F,Burg G,Wilms K

    更新日期:1992-09-01 00:00:00

  • Involvement of Fas and TNF pathways in the induction of apoptosis of T cells by antithymocyte globulin.

    abstract::Antithymocyte globulin (ATG) is the treatment of choice for those aplastic anemia patients who are not suitable for bone marrow transplantation (BMT). ATG is also used for the treatment of rejections in organ transplantation and as a conditioning regimen in BMT. Despite the proven efficacy of ATG in these areas, its m...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0645-x

    authors: Dubey S,Nityanand S

    更新日期:2003-08-01 00:00:00

  • MCNU in the treatment of essential thrombocythemia--a pilot study.

    abstract::The efficacy of a single dose of MCNU 150 mg was evaluated in nine symptomatic patients with essential thrombocythemia (ET). As the platelet counts increased during the following 4 weeks, an extra dose of 100 mg of MCNU was administered to three patients. All patients had thrombotic or hemorrhagic complications. Seven...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01738474

    authors: Murakami H,Tamura J,Sawamura M

    更新日期:1993-05-01 00:00:00

  • Eosinophilia during fludarabine treatment of chronic lymphocytic leukemia.

    abstract::Although eosinophilia has been reported as a side effect of purine analogues, there is no report on fludarabine-induced eosinophilia in chronic lymphocytic leukemia (CLL). During chemotherapy with fludarabine and cyclophosphamide, we observed two cases of significant eosinophilia. A 67-year-old patient with CLL develo...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s002770050602

    authors: Sezer O,Schmid P,Hallek M,Schweigert M,Beinert T,Langelotz C,Mergenthaler HG,Possinger K

    更新日期:1999-10-01 00:00:00

  • Genetic screening for HFE hemochromatosis in 6,020 Danish men: penetrance of C282Y, H63D, and S65C variants.

    abstract::The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0679-1

    authors: Pedersen P,Milman N

    更新日期:2009-08-01 00:00:00

  • Leukemic transformation of essential thrombocythemia without previous cytoreductive treatment.

    abstract::Blastic transformation of essential thrombocythemia (ET) preceded by chemotherapy is occasionally described in the literature. In ET as well as in other myeloproliferative disorders the leukemogenic effect of alkylating agents and (32)P is well established, and recent reports also indicate a certain leukemogenic effec...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050007

    authors: Andersson PO,Ridell B,Wadenvik H,Kutti J

    更新日期:2000-01-01 00:00:00