A case of congenital leukemia with monosomy 7.

abstract：:Infections and especially blood stream infections (BSI) with gram-negative bacteria (GNB) represent a major threat for patients with hematological diseases undergoing chemotherapy and mainly contribute to morbidity and mortality. In this retrospective single-center study, we analyzed the impact of BSI with different g...

journal_title：Annals of hematology

authors： Scheich S,Weber S,Reinheimer C,Wichelhaus TA,Hogardt M,Kempf VAJ,Kessel J,Serve H,Steffen B

更新日期：2018-11-01 00:00:00

abstract：:The laboratory diagnosis of hereditary spherocytosis (HS) is based on several screening and confirmatory tests; our algorithm includes clinical features, red blood cell morphology analysis and cryohaemolysis test, and, in case of positive screening, sodium dodecyl sulphate polyacrylamide gel electrophoresis as a diagn...

journal_title：Annals of hematology

authors： Lazarova E,Pradier O,Cotton F,Gulbis B

更新日期：2014-11-01 00:00:00

abstract：:The matricellular protein SPARC (secreted protein acidic and rich in cysteine)/osteonectin was determined in patients with multiple myeloma and related disease to assess the hypothesized role of SPARC as a possible marker of tumor burden and disease progression. Soluble SPARC was measured by competitive enzyme-linked ...

journal_title：Annals of hematology

authors： Turk N,Kusec R,Jaksic B,Turk Z

更新日期：2005-05-01 00:00:00

abstract：:Repeated courses of HD IVIg are reported to induce stable remission in a significant proportion of adults with chronic refractory ITP. We have treated 14 such patients obtaining a remission rate quite comparable to the 5-10% of spontaneous remission. ...

journal_title：Annals of hematology

authors： Schiavotto C,Ruggeri M,Rodeghiero F

更新日期：1995-02-01 00:00:00

abstract：:Ninety patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis were reviewed to identify significant prognostic associations. At diagnosis of blast crisis the main clinical, laboratory, and cytogenetic data were recorded and evaluated for prognostic significance. At the time of the ...

journal_title：Annals of hematology

authors： Griesshammer M,Heinze B,Hellmann A,Popp C,Anger B,Heil G,Bangerter M,Heimpel H

更新日期：1996-11-01 00:00:00

abstract：:A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of L-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone. and there was an intermittent clinical remission of CLL with absence of the monoclo...

journal_title：Annals of hematology

authors： Böhme A,Wolter M,Hoelzer D

更新日期：1998-11-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies associated with an erythroid maturation defect, resulting in anemia. Treatments for MDS include erythropoiesis-stimulating agents (ESAs). The identification of prognostic markers is important to help predict response and improve outcomes. Various...

journal_title：Annals of hematology

authors： Park S,Kelaidi C,Meunier M,Casadevall N,Gerds AT,Platzbecker U

更新日期：2020-01-01 00:00:00

abstract：:Photodynamic virus inactivation of human fresh plasma mediated by visible light in the presence of the phenothiazine dyes methylene blue or toluidine blue was investigated to determine whether it influences functional, structural, and immunological properties of plasma proteins. The activities of the coagulation facto...

journal_title：Annals of hematology

authors： Mohr H,Knüver-Hopf J,Lambrecht B,Scheidecker H,Schmitt H

更新日期：1992-11-01 00:00:00

abstract：:Azacitidine (AZA) is a DNA hypomethylation agent administered in myeloid neoplasms; however, there is still a lack of established predictors of response. We studied 113 patients with myelodysplastic syndromes (n = 85) or acute myeloid leukemia (n = 28) who received AZA to assess the predictive value on response of cli...

journal_title：Annals of hematology

authors： Martín I,Navarro B,Serrano A,Villamón E,Calabuig M,Solano C,Chaves FJ,Yagüe N,Orts M,Amat P,Fuentes A,Seda E,García F,Hernández-Boluda JC,Tormo M

更新日期：2020-03-01 00:00:00

abstract：:High-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) includes the risk of infectious complications due to neutropenia and therapy-induced immune deviation. In order to understand early immune recovery in this situation, we analyzed the distribution of cell subsets by flow cytometry...

journal_title：Annals of hematology

authors： Krause SW,Rothe G,Gnad M,Reichle A,Andreesen R

更新日期：2003-10-01 00:00:00

abstract：:Eighteen patients with myeloproliferative syndrome (14 with chronic myeloid leukemia, four with essential thrombocytosis) were investigated for modulation of HLA antigens on peripheral blood lymphocytes, monocytes, and hematopoietic precursors during IFN alpha therapy as a sign of potentially increased immune recognit...

journal_title：Annals of hematology

authors： Müller CA,Walz J,Zinser R,Bühring HJ,Steinke B,Schmidt H

更新日期：1991-11-01 00:00:00

abstract：:In vitro studies suggest that haploinsufficiency is involved in the pathogenesis of myelodysplastic syndromes (MDS). In patients with del5q cytogenetic abnormality, RPS-14 and microRNAs (miRNAs) play a major role. In a multicenter phase II single-arm trial with lenalidomide in anemic primary del5q MDS patients with lo...

journal_title：Annals of hematology

authors： Oliva EN,Cuzzola M,Aloe Spiriti MA,Poloni A,Laganà C,Rigolino C,Morabito F,Galimberti S,Ghio R,Cortelezzi A,Palumbo GA,Sanpaolo G,Finelli C,Ricco A,Volpe A,Rodà F,Breccia M,Alimena G,Nobile F,Latagliata R

更新日期：2013-01-01 00:00:00

abstract：:We assessed the origin of peripheral blood cells and bone marrow cells of 92 samples obtained from 19 patients after allo BMT by two-step polymerase chain reaction (PCR) amplification of MCT118, one of the variable number of tandem repeat regions (VNTR) which has a different length in 19 of 32 sibling pairs examined, ...

journal_title：Annals of hematology

authors： Tanaka J,Kasai M,Imamura M,Higa T,Kobayashi S,Hashino S,Sakurada K,Miyazaki T

更新日期：1994-04-01 00:00:00

abstract：:In the context of discussions on the reproducibility of clinical studies, we reanalyzed a prospective randomized study on the role of splenic irradiation as adjunct to the conditioning for hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML). Between 1986 and 1989, a total of 229 patients ...

journal_title：Annals of hematology

authors： Gratwohl A,Iacobelli S,Bootsman N,van Biezen A,Baldomero H,Arcese W,Arnold R,Bron D,Cordonnier C,Ernst P,Ferrant A,Frassoni F,Gahrton G,Richard C,Kolb HJ,Link H,Niederwieser D,Ruutu T,Schattenberg A,Schmitz N,Torr

更新日期：2016-05-01 00:00:00

abstract：:A patient with painful peripheral neuropathy is presented, whose symptoms were thought to result from an infection with Borrelia burgdorferi sensu lato. Investigations of the cerebrospinal fluid for signs of inflammation and borrelial antibodies were negative, and the patient did not benefit from repeated antibiotic t...

journal_title：Annals of hematology

authors： Behringer D,Spyridonidis A,Fetscher S,Schmitt-Gräff A,Högerle S,Kaiser R

更新日期：2001-04-01 00:00:00

abstract：:Although B chronic lymphocytic leukemia (B-CLL) cells express the alpha chain of the interleukin-2 (IL-2) receptor CD25, little is known about the effect of IL-2 on apoptosis in B-CLL cells. We have shown previously that stimulation of B-CLL cells with a CpG-oligonucleotide induces IL-2 high affinity receptors. In our...

journal_title：Annals of hematology

authors： Decker T,Bogner C,Oelsner M,Peschel C,Ringshausen I

更新日期：2010-11-01 00:00:00

abstract：:B cell-activating factor (BAFF) is a cytokine that plays a major role in the maintenance of normal B-cell development and homeostasis. It has been suggested that in multiple myeloma (MM) it might have regulatory effects on the proliferation and viability of malignant plasma cells. The aim of this study was to evaluate...

journal_title：Annals of hematology

authors： Fragioudaki M,Boula A,Tsirakis G,Psarakis F,Spanoudakis M,Papadakis IS,Pappa CA,Alexandrakis MG

更新日期：2012-09-01 00:00:00

abstract：:We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombop...

journal_title：Annals of hematology

authors： Haselboeck J,Pabinger I,Ay C,Koder S,Panzer S

更新日期：2012-01-01 00:00:00

abstract：:Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic M...

journal_title：Annals of hematology

authors： Mussetti A,Pellegrinelli A,Cieri N,Garzone G,Dominoni F,Cabras A,Montefusco V

更新日期：2019-07-01 00:00:00

abstract：:Hydroxyurea is increasingly being used to control myeloproliferative disorders, in part because of its relative lack of side effects. We present a case of life-threatening alveolitis in a patient treated with hydroxyurea for myeloproliferative syndrome. Absence of exposure to other drugs and the clinical course sugges...

journal_title：Annals of hematology

authors： Hennemann B,Bross KJ,Reichle A,Andreesen R

更新日期：1993-09-01 00:00:00

abstract：:Patients with Philadelphia chromosome-positive (Ph+) and/or BCR-ABL+ acute lymphoblastic leukemia (ALL) have extremely poor prognoses. Most of these patients have additional, heterogenous karyotype abnormalities, the majority of which have uncertain clinical significance. In this study we analyzed the clinical charact...

journal_title：Annals of hematology

authors： Wrzesień-Kuś A,Robak T,Pluta A,Zwolińska M,Wawrzyniak E,Wierzbowska A,Skotnicki A,Jakubas B,Hołowiecki J,Nowak K,Kuliczkowski K,Mazur G,Haus O,Dmoszyńska A,Adamczyk-Cioch M,Jedrzejczak WW,Paluszewska M,Konopka L,Pałyn

更新日期：2006-06-01 00:00:00

abstract：:Elderly and infirm patients with acute myeloid leukemia (AML) with either induction refractory or relapse disease may benefit from treatment with azacitidine. We retrospectively reviewed the data from five tertiary centers in Israel, treated between 2009 and 2015. Thirty-four patients (median age 74 years) were identi...

journal_title：Annals of hematology

authors： Ram R,Gatt M,Merkel D,Helman I,Inbar T,Nagler A,Avivi I,Ofran Y

更新日期：2017-04-01 00:00:00

abstract：:Eculizumab is indicated for the therapy of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, patients on eculizumab are susceptible to Neisseria meningitidis infections. The two mainstays to reduce the risk of infection are vaccination and antibiotic...

journal_title：Annals of hematology

authors： Alashkar F,Vance C,Herich-Terhürne D,Preising N,Dührsen U,Röth A

更新日期：2017-04-01 00:00:00

abstract：:Treatment of acute lymphoblastic leukemia (ALL) requires the combination of multiple drugs to integrate a complete remission. The different prognostic factors (age, leukocytes, risk, cytogenetic alterations) allow identifying those patients with a high risk of relapse, but there are few described factors that impact t...

journal_title：Annals of hematology

authors： Ramos-Peñafiel C,Olarte-Carrillo I,Maldonado RC,de la Cruz Rosas A,Collazo-Jaloma J,Martínez-Tovar A

更新日期：2020-11-01 00:00:00

abstract：:Antithymocyte globulin (ATG) is the treatment of choice for those aplastic anemia patients who are not suitable for bone marrow transplantation (BMT). ATG is also used for the treatment of rejections in organ transplantation and as a conditioning regimen in BMT. Despite the proven efficacy of ATG in these areas, its m...

journal_title：Annals of hematology

authors： Dubey S,Nityanand S

更新日期：2003-08-01 00:00:00

abstract：:Hodgkin lymphoma (HL) in resource-poor population shows an early childhood peak with predominance of mixed cellularity (MCHL) and high Epstein-Barr virus (EBV) association, whereas HL in resource-rich population has a peak in ages 15-29 years with the predominance of nodular sclerosis (NSHL) and low EBV association. W...

journal_title：Annals of hematology

authors： Koh YW,Kang HJ,Yoon DH,Suh C,Kim JE,Kim CW,Huh J

更新日期：2013-12-01 00:00:00

abstract：:Therapy-induced autoimmunity may mediate the destruction of cancer cells. Previous studies have demonstrated that presence of autoimmune thyroid disorder is associated with favorable outcome in patients with solid cancer. Patients with diffuse large B cell lymphoma (DLBCL) who achieved complete response on positron em...

journal_title：Annals of hematology

authors： Song MK,Chung JS,Kim SJ,Kim SS,Shin HJ

更新日期：2015-06-01 00:00:00

abstract：:Imatinib is a new promising therapeutic option for chronic myeloid leukemia (CML) with efficacy even in the blast phase of the disease. However, most patients treated with imatinib in the blast phase develop progressive disease rapidly. Thus, treatment with imatinib has to be followed by other treatment strategies. Th...

journal_title：Annals of hematology

authors： Schaich M,Schäkel K,Illmer T,Ehninger G,Bornhäuser M

更新日期：2003-05-01 00:00:00

abstract：:We analyzed the prognostic factors for a successful mobilization and peripheral blood stem cell collection in a series of 57 consecutive patients with multiple myeloma (MM); a new scoring system to predict an adequate mobilization in this subset of patients was also constructed. A total of 221 aphereses were performed...

journal_title：Annals of hematology

authors： Perea G,Sureda A,Martino R,Altés A,Martínez C,Cabezudo E,Amill B,Martín-Henao GA,González Y,Muñoz L,Peyret M,Brunet S,Sierra J

更新日期：2001-10-01 00:00:00

abstract：:Extranodal natural killer (NK)/T cell lymphoma-associated hemophagocytic syndrome (HPS) (NK/T-LAHS) is a heterogeneous and life-threatening disease, which warrants investigation of its risk factors and clinical features. We retrospectively analyzed the clinical records of 202 patients with extranodal NK/T cell lymphom...

journal_title：Annals of hematology

authors： Jia J,Song Y,Lin N,Liu W,Ping L,Zheng W,Wang X,Xie Y,Tu M,Zhang C,Ying Z,Deng L,Ding N,Zhu J

更新日期：2016-12-01 00:00:00