Abstract：
:Elderly and infirm patients with acute myeloid leukemia (AML) with either induction refractory or relapse disease may benefit from treatment with azacitidine. We retrospectively reviewed the data from five tertiary centers in Israel, treated between 2009 and 2015. Thirty-four patients (median age 74 years) were identified. Sixty-two percent of the patients had relapsed disease and 38% had refractory disease. Median time of follow-up was 12.1 months. Out of a total of 327 courses, incidence of infectious episodes was 6%. Eighteen percent experienced major bleeding. Thirty-two percent of the patients achieved morphologic complete remission, and 26% had stabilization of disease during at least three courses. At 12 and 18 months after the first course of azacitidine, 33 and 10% of the patients were progression-free, respectively. Incidences of overall survival at 12 and 24 months were 54.5 and 16%, respectively. Age <75 years was associated with better overall survival. Normal leukocyte count at the first dose of azacitidine and standard doses of azacitidine were both associated with a better progression-free and overall survival. We conclude that azacitidine is feasible in patients who have failed induction chemotherapy and may be associated with prolongation of survival. A prospective trial to validate these results is warranted.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Ram R,Gatt M,Merkel D,Helman I,Inbar T,Nagler A,Avivi I,Ofran Ydoi
10.1007/s00277-016-2914-5subject
Has Abstractpub_date
2017-04-01 00:00:00pages
575-579issue
4eissn
0939-5555issn
1432-0584pii
10.1007/s00277-016-2914-5journal_volume
96pub_type
杂志文章,多中心研究abstract：:The response to intravenous immunoglobulin treatment (IVIG) is thought, in part, to be due to blockade of Fc receptor for IgG in the mononuclear phagocyte system (MPS). We have studied this by measuring splenic clearance of heat-damaged and IgG antibody-coated red cells in immune thrombocytopenic patients receiving IV...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01698483
更新日期：1994-08-01 00:00:00
abstract：:Acquired aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are interrelated ultra-rare diseases. Quality of life (QoL) evaluation tools used in studies for AA and PNH are unspecific and designed for cancer patients (e.g., the European Organization for Research and Treatment of Cancer Quality of Life Q...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2867-8
更新日期：2017-02-01 00:00:00
abstract：:Relapse remains one of the major obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) even after allogeneic hematopoietic stem cell transplantation. The persistence of leukemia-propagating cells (LPCs) may lead to the recurrence of Ph+ALL. Using a xenograft assay, LPCs enrichment in the ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3253-5
更新日期：2018-05-01 00:00:00
abstract：:To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seroposi...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2222-x
更新日期：2015-03-01 00:00:00
abstract：:Primary non-Hodgkin's lymphoma (NHL) of the genital tract is a rare entity. Etiology and pathogenesis of these NHLs are unknown, although there might be a possible association between chronic inflammation and lymphomas. The most common histological subtype is the diffuse large B-cell lymphoma. We report two cases of u...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-009-0741-7
更新日期：2009-12-01 00:00:00
abstract：:In spite of their recognized risk of thrombosis, patients with myeloproliferative neoplasms (MPN) show little or no abnormalities of traditional coagulation tests, perhaps because these are unable to represent the balance between pro- and anticoagulants nor the effect of platelets and blood cells. We investigated whet...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1834-x
更新日期：2013-12-01 00:00:00
abstract：:Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-009-0896-2
更新日期：2010-07-01 00:00:00
abstract：:Thirty-four patients with acute myeloid leukemia (AML) in complete remission (CR), 30 of them aged over 60, received maintenance therapy scheduling four courses of low-dose cytarabine (LDA) 20 mg/m2/day in two subcutaneous injections for 3 weeks every 6 weeks. Each course was stopped when hematologic toxicity occurred...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/BF01698132
更新日期：1992-08-01 00:00:00
abstract：:The B cell surface antigen CD19 is a target for treating B cell malignancies, such as B cell precursor acute lymphoblastic leukemia and B cell non-Hodgkin lymphoma. The BiTE® immuno-oncology platform includes blinatumomab, which is approved for relapsed/refractory B cell precursor acute lymphoblastic leukemia and B ce...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-020-04221-0
更新日期：2020-10-01 00:00:00
abstract：:Expression of long non-coding RNA KIAA0125 has been incorporated in various gene expression signatures for prognostic prediction in acute myeloid leukemia (AML) patients, yet its functions and clinical significance remain unclear. This study aimed to investigate the clinical and biological characteristics of AML beari...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-020-04358-y
更新日期：2021-02-01 00:00:00
abstract：:Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-2943-8
更新日期：2017-05-01 00:00:00
abstract：:Antithymocyte globulin (ATG) is the treatment of choice for those aplastic anemia patients who are not suitable for bone marrow transplantation (BMT). ATG is also used for the treatment of rejections in organ transplantation and as a conditioning regimen in BMT. Despite the proven efficacy of ATG in these areas, its m...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0645-x
更新日期：2003-08-01 00:00:00
abstract：:Information regarding prognostic determinants of outcome after splenectomy for adult immune thrombocytopenic purpura (ITP) and the management of postsplenectomy relapse is limited. Among 140 adult patients with ITP who had therapeutic splenectomy at our institution, 88% achieved either a complete (platelets > 150 x 10...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0461-8
更新日期：2002-06-01 00:00:00
abstract：:In 1989, a prospective randomized multicenter study was initiated in order to determine the safety and efficacy of oral clodronate in myeloma patients. The primary objective of this long-term trial is to evaluate whether supportive clodronate is able to prevent or retard the progression of bone disease and reduce the ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01697625
更新日期：1993-03-01 00:00:00
abstract：:This retrospective single-center analysis studied the impact of the conditioning and the graft-versus-host disease (GVHD) prophylaxis on outcome in unselected patients allografted for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) secondary to documented prior CMML. A total of 44 patients (med...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-03952-4
更新日期：2020-04-01 00:00:00
abstract：:Alterations in hemoglobin oxygen affinity can be detected by exposing blood to different PO2 and recording oxygen saturation, a method termed tonometry. It is the gold standard to measure the PO2 associated with 50 % oxygen saturation, the index used to quantify oxygen affinity (P50Tono). P50Tono is used in the evalua...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1667-z
更新日期：2013-04-01 00:00:00
abstract：:Autologous stem cell transplant (ASCT) is an effective treatment for non-Hodgkin lymphoma (NHL). However, recent supply issues and toxicity of carmustine have necessitated a new conditioning regimen. We conducted a multicenter, phase II study of BEB (busulfan, etoposide, and bendamustine) conditioning regimen for ASCT...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-020-03942-6
更新日期：2020-04-01 00:00:00
abstract：:Less toxic and more active treatments are needed for indolent lymphomas as there is no curative treatment, and patients eventually die due to complications related to their disease. The purpose of the present study was to assess the antitumour activity of the combination of low doses of Enzastaurin and Lenalidomide (R...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1490-6
更新日期：2012-10-01 00:00:00
abstract：:Philadelphia-negative myeloproliferative neoplasms (MPNs) are a diverse group of diseases whose common feature is the presence of V617F mutation of the JAK2 gene. In the era of novel therapeutic strategies in MPNs, such as JAK-inhibitor therapy, there is a growing need for establishing high sensitive quantitative meth...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-018-3451-1
更新日期：2018-12-01 00:00:00
abstract：:To evaluate the outcomes of refractory/relapsed cHL patients after high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) in Beijing Cancer hospital and to identify the prognostic risk factors. We retrospectively analyzed 115 relapsed/refractory cHL patients who accepted HDCT and ASCT in our can...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03812-w
更新日期：2020-03-01 00:00:00
abstract：:Fanconi anemia (FA) is a DNA repair disorder resulting from mutations in genes encoding for FA DNA repair complex components and is characterized by variable congenital abnormalities, bone marrow failure (BMF), and high incidences of malignancies. FA mosaicism arises from reversion or other compensatory mutations in h...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-03954-2
更新日期：2020-05-01 00:00:00
abstract：:To investigate whether cytokine genetic polymorphisms influence the outcome of diffuse large B cell lymphoma (DLBCL), we tested 337 consecutive DLBCL treated with CHOP or rituximab-CHOP (R-CHOP) from interleukin 10 (IL10), Bcl-2, and tumor necrosis factor (TNF)-α polymorphisms. Patients who carried the IL10 rs1800871 ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2857-x
更新日期：2017-02-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder which is clinically characterized by thrombocytopenia, microangiopathic hemolytic anemia, fever, neurologic symptoms, and cardiac and renal involvement. The pathogenic mechanisms of this disease are poorly understood. It is well known that TTP is asso...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01738304
更新日期：1992-05-01 00:00:00
abstract：:We have compared the kinetics of minimal residual disease (MRD) by simultaneous polymerase chain reaction (PCR) monitoring with oligonucleotides for the immunoglobulin heavy chain (IgH) complementarity-determining region 3 (CDR3) and the T-cell receptor gamma chain gene (TCR gamma), as well as clone-specific CDR3 sequ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/BF01910311
更新日期：1995-10-01 00:00:00
abstract：:Many studies have confirmed that overexpressed WT1 exists in leukemic cells, especially in AML. However, the immunophenotypic features of this sort of leukemic cells remain to be unclarified. We retrospectively analyzed the immunophenotype of 283 newly diagnosed AML patients with intermediated and poor cytogenetic ris...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03808-6
更新日期：2020-02-01 00:00:00
abstract：:The best treatment option for patients with relapsed or high-grade follicular lymphoma (FL) is unknown. In spite of major advances in the therapy for FL, disease-free survival remains short, and median time to progression is just over a year. Autologous stem cell transplantation in patients with relapsed FL is safe an...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-005-1058-9
更新日期：2005-08-01 00:00:00
abstract：:We encountered two patients who presented with hypochromic-microcytic anemia and were refractory to iron therapy. The symptoms were suggestive of anemia of chronic disease (ACD); however, there was no evidence of any such disease, either inflammatory or malignant. These patients were reminiscent of patients originally...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770000180
更新日期：2000-08-01 00:00:00
abstract：:von Willebrand disease (VWD) is the commonest inherited bleeding disorder, yet it has not been well recognized in Southeast Asia. The aim of this prospective study was to report our experience of VWD diagnosis and to establish the clinical presentations of VWD in Taiwan. From October 2003 to April 2010, 863 patients w...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1266-4
更新日期：2011-10-01 00:00:00
abstract：:Sickle cell disease (SCD) is a relatively common inherited hemolytic anemia among individuals of African descent. Genetic factors might clarify clinical diversity of the disease and variations in treatment response. Some researchers investigated heme oxygenase-1 (HMOX1) or chemokine receptor 5 (CCR5Δ32) genotypes amon...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03697-9
更新日期：2019-08-01 00:00:00
abstract：:The BCR/ABL1 fusion gene is mainly caused by the t(9; 22)(q34; q11.2) translocation, which results in the Philadelphia (Ph) chromosome. The Ph chromosome is the typical hallmark in chronic myeloid leukemia (CML), but can also be present in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The BCR/AB...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-001-0424-5
更新日期：2002-03-01 00:00:00
