Combination of low doses of enzastaurin and lenalidomide has synergistic activity in B-non-Hodgkin lymphoma cell lines.

abstract：:t(8;16)(p11.2;p13.3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML). We report 15 cases with t(8;16)(p11.2;p13.3). All patients were adult and had AML: 13 women and 2 men, with a median age of 50 years. Ten patients had a history of malignancy and received cytotox...

journal_title：Annals of hematology

authors： Xie W,Hu S,Xu J,Chen Z,Medeiros LJ,Tang G

更新日期：2019-05-01 00:00:00

abstract：:Because of the widespread use of immunosuppressive drugs, CMV infection is one of the most important causes of morbidity and mortality in patients with haematological malignancies worldwide. The aim of the study was to retrospectively analyse the epidemiology of CMV infection in haematological patients. Between 2008 a...

journal_title：Annals of hematology

authors： Piukovics K,Terhes G,Gurbity-Pálfi T,Bereczki Á,Rárosi F,Deák J,Borbényi Z,Urbán E

更新日期：2017-01-01 00:00:00

abstract：:The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...

journal_title：Annals of hematology

authors： Takaoka K,Nannya Y,Shinohara A,Arai S,Nakamura F,Kurokawa M

更新日期：2014-10-01 00:00:00

abstract：:Umbilical cord blood is capable of hematopoietic stem cell reconstitution in children. However, the major limitation of cord blood is a relatively low content of pluripotent progenitor cells. Thus, safe engraftment for adolescents and for adults is still not predictable and a technology for ex vivo expansion of umbili...

journal_title：Annals of hematology

authors： Schwinger W,Benesch M,Lackner H,Kerbl R,Walcher M,Urban C

更新日期：1999-08-01 00:00:00

abstract：:Co-inheritance of triplicated α-genes can alter the clinical and hematological phenotypes of β-thalassemias. We evaluated the phenotypic diversity and transfusion requirements in β-thalassemia heterozygotes, homozygotes, and normal individuals with associated α-gene triplication. Clinical and hematological evaluation ...

journal_title：Annals of hematology

authors： Mehta PR,Upadhye DS,Sawant PM,Gorivale MS,Nadkarni AH,Shanmukhaiah C,Ghosh K,Colah RB

更新日期：2015-12-01 00:00:00

abstract：:The microRNA/miR deregulation in BCR-ABL-negative myelodysplastic-myeloproliferative neoplasms (MDS/MPN) is not known. Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain reaction (PCR) in bone marrow cells of atypical chronic myeloid leukaemia (aCML, n ...

journal_title：Annals of hematology

authors： Hussein K,Büsche G,Muth M,Göhring G,Kreipe H,Bock O

更新日期：2011-03-01 00:00:00

abstract：:Pre-engraftment syndrome (PES) is a condition occurring after umbilical cord blood transplantation (UCBT) characterized by fever and erythematous skin rash prior to neutrophil engraftment. We sought to determine the incidence and characterize the pulmonary manifestations of PES. A retrospective review of patients who ...

journal_title：Annals of hematology

authors： Brownback KR,Simpson SQ,McGuirk JP,Lin TL,Abhyankar S,Ganguly S,Aljitawi OS

更新日期：2014-05-01 00:00:00

abstract：:Patients with primary refractory or relapsed acute myeloid leukemia (AML) who undergo intensive salvage chemotherapy carry a high risk of treatment failure due to infectious complications and early relapses. The study presented here assessed the effect of granulocyte colony-stimulating factor (G-CSF) on the duration o...

journal_title：Annals of hematology

authors： Kern W,Aul C,Maschmeyer G,Kuse R,Kerkhoff A,Grote-Metke A,Eimermacher H,Kubica U,Wörmann B,Büchner T,Hiddemann W

更新日期：1998-09-01 00:00:00

abstract：:To assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Co...

journal_title：Annals of hematology

authors： Ma SY,Tian XP,Cai J,Zhong GZ,Chen X,Huang HQ,Lin TY,Li ZM,Cai QQ

更新日期：2020-06-01 00:00:00

abstract：:Establishing reference ranges by multiparametric immunophenotyping of mature B cells in bone marrow of healthy adults is of interest because the detection of bone marrow infiltration and persistence of light chain restriction, as well as discrimination between reactive and malignant lymphocytes are important applicati...

journal_title：Annals of hematology

authors： Höffkes HG,Schmidtke G,Schmücker U,Uppenkamp M,Brittinger G

更新日期：1995-09-01 00:00:00

abstract：:Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...

journal_title：Annals of hematology

authors： Patel K,Kelsey P

更新日期：1997-04-01 00:00:00

abstract：:The general objective of this study was to evaluate the risks of agranulocytosis and aplastic anemia in relation to drug use. Other potential risk factors, including history of infectious mononucleosis, were also evaluated. In an international population-based case-control study, cases of agranulocytosis and aplastic ...

journal_title：Annals of hematology

authors： Levy M,Kelly JP,Kaufman DW,Shapiro S

更新日期：1993-10-01 00:00:00

abstract：:Among 13,525 haemoglobin analyses performed in our laboratory we detected 21 cases of haemoglobin D (Hb D) disease. Investigation of a family affected with this abnormal haemoglobin revealed two cases of Hb D/beta-(0) thalassaemia for the first time among Saudi Arabs. The two patients were diagnosed as having chronic ...

journal_title：Annals of hematology

authors： Ahmed M,Stuhrmann M,Bashawri L,Kühnau W,El-Harith EH

更新日期：2001-11-01 00:00:00

abstract：:A particular case of marginal zone B-cell lymphoma (MZBCL) presenting with leukemic lymphocytes is reported. In the present observation, the leukemic cells not only displayed a remarkable morphological fluctuation but also had an unusual phenotype, changing with time. These phenotypic features, which have been functio...

journal_title：Annals of hematology

authors： Dargent JL,Delville JP,Kornreich A,Pradier O,Cochaux P,Velu T,Capel P,Feremans W,Neve P

更新日期：1997-03-01 00:00:00

abstract：:Cryoglobulinemia is uncommon in Southern Chinese in Hong Kong, with tropical climates and low incidence of hepatitis C virus (HCV) infection. Eight positive cases were detected among 481 patients screened for cryoglobulins over a 10-year period. Three HCV carriers (38%) ran benign courses. The others included two carr...

journal_title：Annals of hematology

authors： Au WY,Kwok JS,Chu KM,Ma ES

更新日期：2005-02-01 00:00:00

abstract：:Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchosc...

journal_title：Annals of hematology

authors： Kim SW,Rhee CK,Kang HS,Lee HY,Kang JY,Kim SJ,Kim SC,Lee SY,Kim YK,Lee JW

更新日期：2015-01-01 00:00:00

abstract：:Two male patients with severe and recurrent bleeding episodes under phenprocoumon therapy are reported. Both patients exhibited a strong decrease of their factor IX activities below 1% of normal, whereas the activities of the vitamin K-dependent factors prothrombin, VII, and X were found to be within or above the expe...

journal_title：Annals of hematology

authors： Quenzel EM,Hertfelder HJ,Oldenburg J

更新日期：1997-06-01 00:00:00

abstract：:Despite high-dose chemotherapy and autografting, the outcome for patients with primary refractory Hodgkin's disease (HD) or multiple relapses remains unsatisfactory. Six pediatric patients (median age: 16 years, range: 11-19) received reduced intensity conditioning and allogeneic peripheral blood stem cell transplanta...

journal_title：Annals of hematology

authors： Claviez A,Klingebiel T,Beyer J,Nürnberger W,Ehninger G,Suttorp M,Dreger P,Dörffel W,Schmitz N

更新日期：2004-04-01 00:00:00

abstract：:Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic M...

journal_title：Annals of hematology

authors： Mussetti A,Pellegrinelli A,Cieri N,Garzone G,Dominoni F,Cabras A,Montefusco V

更新日期：2019-07-01 00:00:00

abstract：:Monoclonal immunoglobulin, as a marker for monoclonal gammopathy, is evaluated by protein electrophoresis (PEP) and immunofixation electrophoresis (IFE). However, PEP and IFE are not satisfactory in sensitivity, objectivity, and facility. Recently, a highly sensitive, automated immunoassay for measurement of free ligh...

journal_title：Annals of hematology

authors： Kang SY,Suh JT,Lee HJ,Yoon HJ,Lee WI

更新日期：2005-09-01 00:00:00

abstract：:The best treatment option for patients with relapsed or high-grade follicular lymphoma (FL) is unknown. In spite of major advances in the therapy for FL, disease-free survival remains short, and median time to progression is just over a year. Autologous stem cell transplantation in patients with relapsed FL is safe an...

journal_title：Annals of hematology

authors： Ganguly S,Divine CL,Deauna-Limayo D,Bodensteiner DC,Cook JD,Lewis JN,Skikne BS

更新日期：2005-08-01 00:00:00

abstract：:The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...

journal_title：Annals of hematology

authors： Kubota M,Sawada M,Watanabe K,Koishi S,Kataoka A,Usami I,Lin YW,Okuda A,Akiyama Y,Furusho K

更新日期：1997-02-01 00:00:00

abstract：:Diagnosis of thrombotic thrombocytopenic purpura (TTP) is usually based upon the clinical features, and does not always involve histopathological evidence. We recently had experience with a patient who developed the five signs characteristic for TTP. He had been treated for liver cirrhosis associated with chronic hepa...

journal_title：Annals of hematology

authors： Hori A,Kami M,Hamaki T,Yamamoto T,Mori M,Miyakoshi S,Takeuchi K

更新日期：2001-08-01 00:00:00

abstract：:It has been suggested that human mesenchymal stem cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC to limit radiation-induced skin lesions. Immunodeficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/min) using a (60)Co source to ind...

journal_title：Annals of hematology

authors： François S,Mouiseddine M,Mathieu N,Semont A,Monti P,Dudoignon N,Saché A,Boutarfa A,Thierry D,Gourmelon P,Chapel A

更新日期：2007-01-01 00:00:00

abstract：:Standard conditioning for allogeneic bone marrow transplantation induces high transplant-related mortality (TRM) in patients with a poor performance status. Less intensive regimens have been tested to reduce the TRM; our purpose was to evaluate the feasibility and tolerability of a new combination: thiotepa and fludar...

journal_title：Annals of hematology

authors： Alessandrino EP,Bernasconi P,Colombo AA,Caldera D,Bonfichi M,Pagnucco G,Malcovati L,Varettoni M,Lazzarino M,Bernasconi C

更新日期：2001-09-01 00:00:00

abstract：:Pharmacological agents such as hydroxyurea (HU) have been known to cause induction of fetal hemoglobin and possibly may alleviate the symptoms in thalassemia intermedia patients. Thirty-seven patients with beta-thalassemia intermedia were enrolled to assess response to HU therapy. Major response was defined as transfu...

journal_title：Annals of hematology

authors： Dixit A,Chatterjee TC,Mishra P,Choudhry DR,Mahapatra M,Tyagi S,Kabra M,Saxena R,Choudhry VP

更新日期：2005-07-01 00:00:00

abstract：:In hematopoietic system development, PU.1 and GATA-1 as lineage-specific transcription factors (TF) are expressed in common myeloid progenitors. The cross antagonism between them ascertains gene expression programs of monocytic and erythroid cells, respectively. This concept in transdifferentiation approaches has not ...

journal_title：Annals of hematology

authors： Nouri M,Deezagi A,Ebrahimi M

更新日期：2016-03-01 00:00:00

abstract：:We aimed to evaluate the treatments, particularly the role of corticosteroids, in patients with late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). One hundred and sixty-three consecutive patients who underwent non-T-cell-depleted allo-HSCT and met the criterion...

journal_title：Annals of hematology

authors： Mo XD,Zhang XH,Xu LP,Wang Y,Yan CH,Chen H,Chen YH,Han W,Wang FR,Wang JZ,Liu KY,Huang XJ

更新日期：2018-07-01 00:00:00

abstract：:Established risk factors for thrombosis in essential thrombocythemia (ET) include age (≥ 60 years) and previous vascular events. Recently, also leukocytosis has been proposed in risk stratification of ET patients. We report a retrospective study on 532 ET patients followed for a median of 7.6 years. Sixty-four patient...

journal_title：Annals of hematology

authors： Palandri F,Polverelli N,Catani L,Ottaviani E,Baccarani M,Vianelli N

更新日期：2011-08-01 00:00:00

abstract：:Autologous stem cell transplant (ASCT) is an effective treatment for non-Hodgkin lymphoma (NHL). However, recent supply issues and toxicity of carmustine have necessitated a new conditioning regimen. We conducted a multicenter, phase II study of BEB (busulfan, etoposide, and bendamustine) conditioning regimen for ASCT...

journal_title：Annals of hematology

authors： Kim DY,Chung JS,Jo JC,Cho SH,Shin HJ

更新日期：2020-04-01 00:00:00