Thrombotic thrombocytopenic purpura without any evidence of thrombotic lesions at autopsy.

Abstract:

:Diagnosis of thrombotic thrombocytopenic purpura (TTP) is usually based upon the clinical features, and does not always involve histopathological evidence. We recently had experience with a patient who developed the five signs characteristic for TTP. He had been treated for liver cirrhosis associated with chronic hepatitis B infection, and the hepatic function was severely impaired at admission. Blood levels of vWF (von Willebrand factor) and factor VIII were highly elevated to 506% and 632%, respectively. These findings suggested severe endothelial damage. Thus, the patient was diagnosed as having TTP secondary to severe hepatic damage, and plasma exchanges were initiated immediately. He responded poorly to the treatment, and finally died of pulmonary hemorrhage. At autopsy, hepatocellular carcinoma was identified in the cirrhotic liver, but it was surprising that thorough postmortem examination failed to show any evidence of thrombotic lesions. Our experience suggests that secondary TTP does not always involve pathological evidence of the thrombotic lesions, and that the formation of thrombi causing vessel occlusion might not be essential in the pathogenesis of some secondary TTP.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Hori A,Kami M,Hamaki T,Yamamoto T,Mori M,Miyakoshi S,Takeuchi K

doi

10.1007/s002770100323

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

496-8

issue

8

eissn

0939-5555

issn

1432-0584

journal_volume

80

pub_type

杂志文章
  • Increased expression of T cell immune response cDNA 7 in patients with acute graft-versus-host disease.

    abstract::Acute graft-versus-host disease (aGVHD) has become the important complication post-allogeneic hematopoietic stem cell transplantation. Abnormally activated T cells might play an important role in the pathogenesis of aGVHD. But its exact mechanism remains poorly understood. T cell immune response cDNA 7 (TIRC7) has bee...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-015-2300-8

    authors: Zhu F,Qiao J,Chen W,Pan B,Wu QY,Cao J,Sang W,Yan ZL,Zeng LY,Li ZY,Xu KL

    更新日期:2015-06-01 00:00:00

  • The 6-min walk test: an independent correlate of elevated tricuspid regurgitant jet velocity in children and young adult sickle cell patients.

    abstract::Elevation of echocardiography-determined tricuspid regurgitant jet velocity (TRV) predicts high systolic pulmonary artery pressure. The present study tested the hypotheses that elevated tricuspid regurgitant jet velocity is associated with both hemolysis and hypoxia and abnormal 6-min walk test (6MWT) results. This st...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2030-3

    authors: Agha H,El Tagui M,El Ghamrawy M,Abdel Hady M

    更新日期:2014-07-01 00:00:00

  • Leukemic transformation of essential thrombocythemia without previous cytoreductive treatment.

    abstract::Blastic transformation of essential thrombocythemia (ET) preceded by chemotherapy is occasionally described in the literature. In ET as well as in other myeloproliferative disorders the leukemogenic effect of alkylating agents and (32)P is well established, and recent reports also indicate a certain leukemogenic effec...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050007

    authors: Andersson PO,Ridell B,Wadenvik H,Kutti J

    更新日期:2000-01-01 00:00:00

  • A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction.

    abstract::NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (NUTM1) fuses to bromodomain protein family member 4 gene (BRD4), resulting in the formation of BRD4-NUTM1 transcript. Here, we report ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04000-x

    authors: Cheng Z,Luo Y,Zhang Y,Wang Y,Chen Y,Xu Y,Peng H,Zhang G

    更新日期:2020-07-01 00:00:00

  • Risk for cytomegalovirus infection following reduced intensity allogeneic stem cell transplantation.

    abstract::Preliminary data suggest a faster immune recovery following non-myeloablative stem cell transplantation because of the persistence of recipient T cells, but the real impact on post-transplant infectious complications remains unknown. We retrospectively analysed the incidence of cytomegalovirus (CMV) infection in twent...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0706-1

    authors: Nachbaur D,Larcher C,Kircher B,Eibl G,Nussbaumer W,Gunsilius E,Haun M,Grünewald K,Gastl G

    更新日期:2003-10-01 00:00:00

  • Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia.

    abstract::The microRNA/miR deregulation in BCR-ABL-negative myelodysplastic-myeloproliferative neoplasms (MDS/MPN) is not known. Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain reaction (PCR) in bone marrow cells of atypical chronic myeloid leukaemia (aCML, n ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-010-1072-4

    authors: Hussein K,Büsche G,Muth M,Göhring G,Kreipe H,Bock O

    更新日期:2011-03-01 00:00:00

  • Childhood polycythemias/erythrocytoses: classification, diagnosis, clinical presentation, and treatment.

    abstract::Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-004-0985-1

    authors: Cario H

    更新日期:2005-03-01 00:00:00

  • Differential plasma proteome profiles of mild versus severe β-thalassemia/Hb E.

    abstract::The severity of thalassemia is currently classified based on clinical manifestations and multiple tests. In the present study, we performed a plasma proteome analysis to identify differentially expressed proteins compared between normal subjects and patients with mild and severe forms of β-thalassemia/hemoglobin E (Hb...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1629-5

    authors: Hatairaktham S,Srisawat C,Siritanaratkul N,Chiangjong W,Fucharoen S,Thongboonkerd V,Kalpravidh RW

    更新日期:2013-03-01 00:00:00

  • Presence of a high-grade component in gastric mucosa-associated lymphoid tissue (MALT) lymphoma is not associated with an adverse prognosis.

    abstract::Gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL) show a spectrum of disease characterized by varying proportions of low-grade and high-grade components. While the natural history and optimum treatment for low-grade gastric MALT lymphoma and DLBCL is well established, ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0604-7

    authors: Ang MK,Hee SW,Quek R,Yap SP,Loong S,Tan L,Tao M,Lim ST

    更新日期:2009-05-01 00:00:00

  • Pregnancy in patients with thalassemia major: a cohort study and conclusions for an adequate care management approach.

    abstract::An improvement in quality of life and survival occurred among thalassemia major (TM) patients: pregnancy in such patients has become a reality. Safe pregnancy and delivery require efforts to ensure the best outcomes. Between 2007 and 2016, 30 TM patients had 37 pregnancies. We analyzed the hematological parameters bef...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-2979-9

    authors: Cassinerio E,Baldini IM,Alameddine RS,Marcon A,Borroni R,Ossola W,Taher A,Cappellini MD

    更新日期:2017-06-01 00:00:00

  • Interferon alpha in the treatment of polycythemia vera.

    abstract::Interferon alpha (IFN) inhibits the growth of the abnormal clone in patients with myeloproliferative disorders, leading to a reduction of the clinical and laboratory signs of the pathologic myeloproliferation. The therapeutic efficacy of IFN in polycythemia vera (PV) is demonstrated by the summarized treatment results...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s002770050563

    authors: Lengfelder E,Berger U,Hehlmann R

    更新日期:2000-03-01 00:00:00

  • Platelet activation and function during eltrombopag treatment in immune thrombocytopenia.

    abstract::We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombop...

    journal_title:Annals of hematology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00277-011-1249-5

    authors: Haselboeck J,Pabinger I,Ay C,Koder S,Panzer S

    更新日期:2012-01-01 00:00:00

  • The efficacy of rabbit antithymocyte globulin with cyclosporine in comparison to horse antithymocyte globulin as a first-line treatment in adult patients with severe aplastic anemia: a single-center retrospective study.

    abstract::Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) ineligible for allogeneic stem cell transplantation. Recently, rabbit ATG with cyclosporine A has been used as a first-line IST regimen in patients with SAA because of unavailability of ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-1674-8

    authors: Shin SH,Yoon JH,Yahng SA,Lee SE,Cho BS,Eom KS,Kim YJ,Lee S,Min CK,Kim HJ,Cho SG,Kim DW,Min WS,Park CW,Lee JW

    更新日期:2013-06-01 00:00:00

  • Perinatal management of idiopathic thrombocytopenic purpura in pregnancy: risk factors for passive immune thrombocytopenia.

    abstract::Thirty-nine pregnant women with idiopathic thrombocytopenic purpura (ITP) were studied in order to evaluate the influence of therapies for maternal ITP on fetal passive immune thrombocytopenia (PIT). Neonatal platelet counts were also compared with platelet counts, amount of PAIgG, and presence of circulating antiplat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01695918

    authors: Yamada H,Fujimoto S

    更新日期:1994-01-01 00:00:00

  • Comparison and evaluation of three screening tests of hereditary spherocytosis in Chinese patients.

    abstract::The objective of this study is to compare and evaluate the diagnostic value of hereditary spherocytosis (HS) by three screening tests, comparing mean spherical corpuscular volume (MSCV) to mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and flow cytometric osmotic fragility test. Perip...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2270-2

    authors: Tao YF,Deng ZF,Liao L,Qiu YL,Chen WQ,Lin FQ

    更新日期:2015-05-01 00:00:00

  • Analysis of MTHFR polymorphisms and P16 methylation and their correlation with clinical-biological features of multiple myeloma.

    abstract:BACKGROUND:Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. However, controversial data have been published regarding a protective role of variant alleles of MTHFR on MM. PATIENTS AND METHODS:To inve...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-006-0097-1

    authors: Chiusolo P,Farina G,Putzulu R,Reddiconto G,Fiorini A,De Stefano V,Rossi E,Palladino M,Leone G,Sica S

    更新日期:2006-07-01 00:00:00

  • Acute leukemia with the phenotype of a natural killer/T cell bipotential precursor.

    abstract::An acute leukemia with an unusual immunophenotype developed in a 17-year-old girl. At the initial presentation, extramedullary involvement was not evident, but with advancing disease, massive splenomegaly and an osteolytic rib tumor developed. The disease was aggressive and refractory to intensive chemotherapeutic reg...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050472

    authors: Ino T,Tsuzuki M,Okamoto M,Shamoto M,Hirano M

    更新日期:1999-01-01 00:00:00

  • Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangements.

    abstract::Although the outcome of patients with acute myeloid leukemia (AML) has improved by optimized chemotherapy regimens and bone marrow transplantation, leukemia relapse remains one of the most challenging problems during therapy. Sustained existence of AML blasts is a fundamental determinant for the development of leukemi...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2913-6

    authors: Liu J,Qin YZ,Yang S,Wang Y,Chang YJ,Zhao T,Jiang Q,Huang XJ

    更新日期:2017-04-01 00:00:00

  • High-dose chemotherapy followed by autologous stem cell transplantation for patients with refractory/relapsed classical Hodgkin lymphoma: a single center experience from China.

    abstract::To evaluate the outcomes of refractory/relapsed cHL patients after high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) in Beijing Cancer hospital and to identify the prognostic risk factors. We retrospectively analyzed 115 relapsed/refractory cHL patients who accepted HDCT and ASCT in our can...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-019-03812-w

    authors: Xie Y,Wang X,Leng X,Zheng W,Ping L,Zhang C,Liu W,Deng L,Wu M,Song Y,Zhu J

    更新日期:2020-03-01 00:00:00

  • In vitro megakaryocyte expansion in patients with delayed platelet engraftment after autologous stem cell transplantation.

    abstract::Increasing the number of megakaryocytic cells in stem cell transplants by ex vivo expansion culture may provide an approach to accelerate platelet engraftment after high-dose chemotherapy. However, it is unknown if a relationship exists between the expansion potential of progenitor cells and the time to platelet engra...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-002-0443-x

    authors: Drayer AL,Smit Sibinga CT,Esselink MT,de Wolf JT,Vellenga E

    更新日期:2002-04-01 00:00:00

  • Spectrum of Von Willebrand disease and inherited platelet function disorders amongst Indian bleeders.

    abstract::Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-006-0244-8

    authors: Gupta PK,Charan VD,Saxena R

    更新日期:2007-06-01 00:00:00

  • Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin's lymphoma.

    abstract::The role of 18FDG-PET/CT during follow-up of patients affected by Hodgkin's lymphoma (HL) in complete remission after treatment is not fully elucidated, since a wide use of 18F fluorodeoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) in this setting could be limited by a relative high rate of...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-009-0752-4

    authors: Crocchiolo R,Fallanca F,Giovacchini G,Ferreri AJ,Assanelli A,Verona C,Pescarollo A,Bregni M,Ponzoni M,Gianolli L,Fazio F,Ciceri F

    更新日期:2009-12-01 00:00:00

  • Reduced intensity allogeneic hematopoietic cell transplantation can induce durable remission in heavily pretreated relapsed Hodgkin lymphoma.

    abstract::Hodgkin lymphoma (HL) can be aggressive and intractable in some cases. Patients who relapse after autologous HCT (auto-HCT) have limited treatment options. City of Hope reports our experience in the use of reduced intensity allogeneic hematopoietic cell transplantation (allo-HCT) in 24 heavily pretreated patients with...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-010-1146-3

    authors: Chen R,Palmer JM,Popplewell L,Shen J,Smith E,Delioukina M,Kogut N,Rosenthal J,Forman S,Nademanee A

    更新日期:2011-07-01 00:00:00

  • Successful alemtuzumab retreatment in progressive B-cell chronic lymphocytic leukemia: a multicenter survey in 30 patients.

    abstract::Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-011-1192-5

    authors: Fiegl M,Falkner F,Steurer M,Zojer N,Hopfinger G,Haslbauer F,Winder G,Voskova D,Andel J,Lang A,Brychtova Y,Mayer J,Greil R,Gastl G,Austrian Collaborative Study Group on Alemtuzumab in Chronic Lymphocytic Leukemia.,Czech Leuk

    更新日期:2011-09-01 00:00:00

  • The effect of gamma radiation on the lipid profile of irradiated red blood cells.

    abstract::An investigation into the effects of irradiation and of the storage time on aging and quality are a relevant issue to ensure the safety and the efficiency of irradiation in the prevention of transfusion-associated graft-versus-host disease (TA-GVHD). In this work, the biochemical properties and alterations presented b...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-1944-5

    authors: Maia GA,Renó Cde O,Medina JM,Silveira AB,Mignaco JA,Atella GC,Cortes VF,Barbosa LA,Santos Hde L

    更新日期:2014-05-01 00:00:00

  • Diagnostic value of bronchoscopy in patients with hematologic malignancy and pulmonary infiltrates.

    abstract::Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchosc...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2172-3

    authors: Kim SW,Rhee CK,Kang HS,Lee HY,Kang JY,Kim SJ,Kim SC,Lee SY,Kim YK,Lee JW

    更新日期:2015-01-01 00:00:00

  • Influence of conditioning regimens and stem cell sources on donor-type chimerism early after stem cell transplantation.

    abstract::We retrospectively analyzed very early chimerism before and ongoing neutrophil engraftment (days 7, 14, 21, 28) and investigated the influence of conditioning regimens and stem cell sources on donor-type chimerism in 59 Japanese patients who had received allogeneic hematopoietic stem cell transplantation. The percenta...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0542-4

    authors: Sugita J,Tanaka J,Hashimoto A,Shiratori S,Yasumoto A,Wakasa K,Kikuchi M,Shigematsu A,Miura Y,Tsutsumi Y,Kondo T,Asaka M,Imamura M

    更新日期:2008-12-01 00:00:00

  • Phase IV study evaluating efficacy of escalated dose of imatinib in chronic myeloid leukemia patients showing suboptimal response to standard dose imatinib.

    abstract::The aim of this phase IV study was to (1) to define efficacy of escalating dose imatinib in chronic myeloid leukemia (CML) patients showing suboptimal response to standard dose imatinib and (2) to find markers that predict the response to escalating doses of imatinib. CML patients in chronic phase (CP) who failed to a...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-010-0910-8

    authors: Koh Y,Kim I,Yoon SS,Kim BK,Kim DY,Lee JH,Lee KH,Park E,Kim HJ,Sohn SK,Joo YD,Kim SJ,Chung J,Shin HJ,Kim SH,Kim CS,Song HS,Kim MK,Hyun MS,Ahn JS,Jung CW,Park S,Korean Society of Hematology CML working party.

    更新日期:2010-07-01 00:00:00

  • The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.

    abstract::Nondeletional hereditary persistence of fetal hemoglobin (nd-HPFH), a rare hereditary condition resulting in elevated levels of fetal hemoglobin (Hb F) in adults, is associated with promoter mutations in the human fetal globin (HBG1 and HBG2) genes. In this paper, we report a novel type of nd-HPFH due to a HBG2 gene p...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0643-0

    authors: Chassanidis C,Kalamaras A,Phylactides M,Pourfarzad F,Likousi S,Maroulis V,Papadakis MN,Vamvakopoulos NK,Aleporou-Marinou V,Patrinos GP,Kollia P

    更新日期:2009-06-01 00:00:00

  • Quality of life during maintenance therapy with the anti-CD20 antibody rituximab in patients with B cell non-Hodgkin's lymphoma: results of a prospective randomized controlled trial.

    abstract::The introduction of rituximab into the primary treatment of malignant lymphomas of the B cell lineage has had a major impact on the management of these diseases. In addition, prolonged exposure to rituximab as maintenance therapy has been beneficial in patients with follicular lymphoma and mantle cell lymphoma. For th...

    journal_title:Annals of hematology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00277-008-0560-2

    authors: Witzens-Harig M,Reiz M,Heiss C,Benner A,Hensel M,Neben K,Dreger P,Kraemer A,Ho AD

    更新日期:2009-01-01 00:00:00