Abstract：
:It has been suggested that human mesenchymal stem cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC to limit radiation-induced skin lesions. Immunodeficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/min) using a (60)Co source to induce a severe skin lesion. Cultured bone marrow hMSC were delivered intravenously to the mice. The irradiated skin samples were studied for the presence of the human cells, the severity of the lesions and the healing process. Macroscopic analysis and histology results showed that the lesions were evolving to a less severe degree of radiation dermatitis after hMSC transplant when compared to irradiated non-transplanted controls. Clinical scores for the studied skin parameters of treated mice were significantly improved. A faster healing was observed when compared to untreated mouse. Immunohistology and polymerase chain reaction analysis provided evidence that the human cells were found in the irradiated area. These results suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
François S,Mouiseddine M,Mathieu N,Semont A,Monti P,Dudoignon N,Saché A,Boutarfa A,Thierry D,Gourmelon P,Chapel Adoi
10.1007/s00277-006-0166-5subject
Has Abstractpub_date
2007-01-01 00:00:00pages
1-8issue
1eissn
0939-5555issn
1432-0584journal_volume
86pub_type
杂志文章abstract：:In the present study, we questioned whether the cholesterol synthesis inhibitor lovastatin potentiates the cytotoxicity of chemotherapeutic agents in the primitive CD34(+) subpopulation of acute myeloid leukemia (AML) cells. AML mononuclear cells (n = 17) were sorted in CD34(+) and CD34(-) fractions and compared to no...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0633-2
更新日期：2009-06-01 00:00:00
abstract：:A 24-year-old woman with a large cell anaplastic CD 30-positive T-cell non-Hodgkin's lymphoma (NHL) developed downbeat nystagmus, anisocoria, and oscillopsia. Prior to overt cerebral invasion by NHL, she had a thiamine deficiency with very low thiamine concentrations in the CSF, probably caused by protracted vomiting ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050484
更新日期：1999-02-01 00:00:00
abstract：:Establishing reference ranges by multiparametric immunophenotyping of mature B cells in bone marrow of healthy adults is of interest because the detection of bone marrow infiltration and persistence of light chain restriction, as well as discrimination between reactive and malignant lymphocytes are important applicati...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01702647
更新日期：1995-09-01 00:00:00
abstract：:MicroRNAs are short noncoding RNAs, known regulators of several signaling pathways cell differentiation and proliferation, development, and apoptosis, which are deregulated in acute leukemia. Mixed lineage leukemia (MLL) gene encodes a protein with histone methyltransferase activity, which is essential for the fine tu...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-013-1803-4
更新日期：2013-11-01 00:00:00
abstract：:Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-015-2411-2
更新日期：2015-09-01 00:00:00
abstract：:Rituximab induces B-cell depletion; therefore, it has been used in the treatment of immune thrombocytopenic purpura (ITP). The aim of this retrospective study was to evaluate the effectiveness of rituximab in the treatment of 89 patients with chronic ITP refractory to several treatments. All the patients had platelet ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-005-0073-1
更新日期：2006-06-01 00:00:00
abstract：:This study retrospectively analyzed the clinical outcome of 172 children with newly diagnosed severe aplastic anemia (SAA) between January 2008 and April 2018, who received rabbit antithymocyte globulin (ATG) and cyclosporine (CsA) as first-line treatment. The median age at diagnosis was 5 years (range, 1-14). The ove...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04296-9
更新日期：2021-01-01 00:00:00
abstract：:The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-007-0305-7
更新日期：2007-09-01 00:00:00
abstract：:To investigate whether cytokine genetic polymorphisms influence the outcome of diffuse large B cell lymphoma (DLBCL), we tested 337 consecutive DLBCL treated with CHOP or rituximab-CHOP (R-CHOP) from interleukin 10 (IL10), Bcl-2, and tumor necrosis factor (TNF)-α polymorphisms. Patients who carried the IL10 rs1800871 ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2857-x
更新日期：2017-02-01 00:00:00
abstract：:We investigated the efficacy of an antithymocyte globulin/cyclophosphamide preparative regimen prior to allogeneic stem cell transplantation from HLA-identical siblings in patients with severe aplastic anemia. Since 1990, 21 patients, 6 males and 15 females, with a median age of 25 years (range: 7-43) have been enroll...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-002-0566-0
更新日期：2002-11-01 00:00:00
abstract：:Nodal peripheral T cell lymphomas (nPTCL) present aggressive clinical course, and its heterogeneous nature and poor prognosis with current therapeutic strategies make it a target for the development of new prognostic markers. Thus, we investigated tumor-associated macrophages (TAM) according to the number of cells exp...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03731-w
更新日期：2019-09-01 00:00:00
abstract：:We retrospectively analyzed very early chimerism before and ongoing neutrophil engraftment (days 7, 14, 21, 28) and investigated the influence of conditioning regimens and stem cell sources on donor-type chimerism in 59 Japanese patients who had received allogeneic hematopoietic stem cell transplantation. The percenta...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0542-4
更新日期：2008-12-01 00:00:00
abstract：:We discuss possible justifications to split study populations from a biometrical point of view. The existence of prognostic differences between subgroups are neither a sufficient nor a necessary reason to justify a splitting decision. There are essentially two separate types of relevant arguments to justify a split of...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/pl00022792
更新日期：2001-01-01 00:00:00
abstract：:Hydroxyurea is increasingly being used to control myeloproliferative disorders, in part because of its relative lack of side effects. We present a case of life-threatening alveolitis in a patient treated with hydroxyurea for myeloproliferative syndrome. Absence of exposure to other drugs and the clinical course sugges...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01701737
更新日期：1993-09-01 00:00:00
abstract：:We investigated the efficacy and toxicity of the combination of busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP-16) as a preparative regimen prior to autologous hematopoietic stem cell transplantation (ASCT) in patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL). Fifty-three patients with recurren...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-001-0413-8
更新日期：2002-02-01 00:00:00
abstract：:Activation-induced cytidine deaminase (AID) is a mutator enzyme essential for somatic hypermutation (SHM) and class switch recombination (CSR) during effective adaptive immune responses. Its aberrant expression and activity have been detected in lymphomas, leukemias, and solid tumors. In chronic lymphocytic leukemia (...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3520-5
更新日期：2019-02-01 00:00:00
abstract：:We investigated a new protein-C (PC) concentrate in a child with a type-II homozygous deficiency, concerning tolerance and safety. By means of various functional and antigen assays the in vivo recovery and the half-life were determined. In order to compare the results we reduced the measured values to the average half...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01697402
更新日期：1992-03-01 00:00:00
abstract：:Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) ineligible for allogeneic stem cell transplantation. Recently, rabbit ATG with cyclosporine A has been used as a first-line IST regimen in patients with SAA because of unavailability of ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1674-8
更新日期：2013-06-01 00:00:00
abstract：:A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriam...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01836073
更新日期：1992-12-01 00:00:00
abstract：:Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean p...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-006-0091-7
更新日期：2006-05-01 00:00:00
abstract：:In hematopoietic system development, PU.1 and GATA-1 as lineage-specific transcription factors (TF) are expressed in common myeloid progenitors. The cross antagonism between them ascertains gene expression programs of monocytic and erythroid cells, respectively. This concept in transdifferentiation approaches has not ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2583-9
更新日期：2016-03-01 00:00:00
abstract：:We describe three cases of acute promyelocytic leukemia (APL) with long-term disease-free survival who developed congestive heart failure (CHF) requiring cardiac transplantation. All three patients presented late-onset cardiotoxicity. Cardiac failure occurred progressively after 31-month, 32-month, and 14-month interv...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0534-8
更新日期：2002-09-01 00:00:00
abstract：:This paper describes six Indian families in which silent-gene beta-thalassemia was encountered by us in the past 2 years. This stresses the importance of globin-chain synthesis in the diagnosis of beta-thalassemia. Of these six cases, five were diagnosed retrospectively when they had a homozygous beta-thalassemia offs...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01715386
更新日期：1995-01-01 00:00:00
abstract：:Asplenic and hyposplenic patients have an increased risk for overwhelming pneumococcal infections, even several decades after splenectomy. Pneumococcal vaccination and daily oral administration of penicillin V are recommended to prevent such infections, 2-5 years after splenectomy, and for at least 5 years in children...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0779-x
更新日期：2004-01-01 00:00:00
abstract：:Fanconi anemia (FA) is a DNA repair disorder resulting from mutations in genes encoding for FA DNA repair complex components and is characterized by variable congenital abnormalities, bone marrow failure (BMF), and high incidences of malignancies. FA mosaicism arises from reversion or other compensatory mutations in h...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-03954-2
更新日期：2020-05-01 00:00:00
abstract：:We screened for increased osmotic fragility of erythrocytes in 1464 healthy German blood donors. The osmotic fragility was determined by an acidified glycerol lysis test (AGLT) using glycerol-sodium phosphate-buffered NaCl solution. Since the original test described by Zanella et al. [23] showed only low specificity f...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01715351
更新日期：1992-02-01 00:00:00
abstract：:Rituximab was recently described also as first-line therapy of chronic graft-versus-host disease (cGvHD). We retrospectively analyzed the efficacy and safety of all patients receiving rituximab for treatment of cGvHD between 2005 and 2016 at the Regensburg University transplant center with a median follow-up after rit...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03768-x
更新日期：2019-10-01 00:00:00
abstract：:Recent developments in the field of targeted therapy have led to the discovery of a new drug, plerixafor, that is a specific inhibitor of the CXCR4 receptor. Plerixafor acts in concert with granulocyte colony-stimulating factor (G-CSF) to increase the number of stem cells circulating in the peripheral blood (PB). Ther...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-010-1098-7
更新日期：2011-05-01 00:00:00
abstract：:We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombop...
journal_title：Annals of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00277-011-1249-5
更新日期：2012-01-01 00:00:00
abstract：:This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002779900136
更新日期：2000-06-01 00:00:00
