Abstract:
:We describe three cases of acute promyelocytic leukemia (APL) with long-term disease-free survival who developed congestive heart failure (CHF) requiring cardiac transplantation. All three patients presented late-onset cardiotoxicity. Cardiac failure occurred progressively after 31-month, 32-month, and 14-month intervals, respectively, following completion of first anthracycline therapy. Cumulative anthracycline doses were 585 mg of daunorubicin and 64 mg of mitoxantrone in case 1, 1779 mg of daunorubicin in case 2, and 825 mg of daunorubicin in case 3. The questions relating to the pathogenesis of cardiac failure are discussed. We also discuss the prophylactic measures required for such treatment-related side effects.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Thomas X,Le QH,Fiere Ddoi
10.1007/s00277-002-0534-8subject
Has Abstractpub_date
2002-09-01 00:00:00pages
504-7issue
9eissn
0939-5555issn
1432-0584journal_volume
81pub_type
杂志文章abstract::Patients with primary refractory or relapsed acute myeloid leukemia (AML) who undergo intensive salvage chemotherapy carry a high risk of treatment failure due to infectious complications and early relapses. The study presented here assessed the effect of granulocyte colony-stimulating factor (G-CSF) on the duration o...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s002770050425
更新日期:1998-09-01 00:00:00
abstract::Azacitidine and decitabine, two hypomethylating agents, are known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who cannot endure intensive cytotoxic chemotherapy or are not eligible for transplantation. However, the treatment response rate is l...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-018-3464-9
更新日期:2018-11-01 00:00:00
abstract::In view of obscure clinical and biological significance of leukemic cells heterogeneity, we studied the efficacy of apoptosis, proliferation, and expression levels of the Bcl-2, MDR1, LRP, and BCRP genes in sorted CD34+ and CD34- subpopulations of childhood AML leukemic samples. In five out of nine cases, CD34+ cells ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0439-2
更新日期:2008-05-01 00:00:00
abstract::Along with their immunogenic role, dendritic cells (DCs) are also critical in maintaining tolerance to self-antigens by inducing regulatory T cells (Tregs) via the expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In turn, Tregs modulate the maturation and/or function of DCs. In immune th...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-012-1556-5
更新日期:2013-01-01 00:00:00
abstract::Azacitidine (AZA) is a DNA hypomethylation agent administered in myeloid neoplasms; however, there is still a lack of established predictors of response. We studied 113 patients with myelodysplastic syndromes (n = 85) or acute myeloid leukemia (n = 28) who received AZA to assess the predictive value on response of cli...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-020-03932-8
更新日期:2020-03-01 00:00:00
abstract::Natural killer (NK) cell neoplasms are unusual disorders. In this study we compared results of flow cytometric immunophenotype (FCI) with cytomorphology, histopathology and clinical findings in a series of patients with NK cell neoplasms with peripheral blood and/or bone marrow involvement, and the FCI of neoplastic a...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-012-1574-3
更新日期:2013-01-01 00:00:00
abstract::Hypermethylation of CpG islands near gene promoter regions is associated with transcriptional inactivation and represents an important mechanism of gene silencing in carcinogenesis. Such epigenetic phenomena can act alongside DNA mutations and deletions to disrupt tumor-suppressor gene function. The methylation status...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-005-0005-0
更新日期:2005-12-01 00:00:00
abstract::This study retrospectively analyzed the clinical outcome of 172 children with newly diagnosed severe aplastic anemia (SAA) between January 2008 and April 2018, who received rabbit antithymocyte globulin (ATG) and cyclosporine (CsA) as first-line treatment. The median age at diagnosis was 5 years (range, 1-14). The ove...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-04296-9
更新日期:2021-01-01 00:00:00
abstract::Cells of the macrophage lineage are a major source of various cytokines and hematopoietic growth factors. With regard to the growth factors acting on cells of their own lineage, macrophage colony-stimulating factor (M-CSF) has been proven to be secreted by monocytes (MO) and macrophages (MAC), whereas the production o...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01696222
更新日期:1992-04-01 00:00:00
abstract::National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-015-2314-2
更新日期:2015-04-01 00:00:00
abstract::Aberrant promoter methylation of RASSF6 and RASSF10 occurs at a high frequency in acute lymphoblastic leukemia (ALL). Because of the complexity of the current minimal residual disease (MRD) detecting-methods, the DNA methylation status of the RASSF6 and RASSF10 genes could potentially become biomarkers for the assessm...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-019-03775-y
更新日期:2019-12-01 00:00:00
abstract::Antithymocyte globulin (ATG) is the drug of choice for immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) ineligible for allogeneic stem cell transplantation. Recently, rabbit ATG with cyclosporine A has been used as a first-line IST regimen in patients with SAA because of unavailability of ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-013-1674-8
更新日期:2013-06-01 00:00:00
abstract::Three adolescents with central nervous system (CNS) negative acute myeloid leukaemia (AML) refused cranial irradiation for CNS prophylaxis. Instead, these patients received four doses of 50 mg of intrathecal (IT) liposomal cytarabine on day 1, 15, 43 and 71 of maintenance therapy. Corticosteroids were given to prevent...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0521-9
更新日期:2008-11-01 00:00:00
abstract::A 40-year-old patient with low-grade B-NHL developed a generalized macular-papular rash following the first cycle of fludarabine treatment which progressed to a complete epidermal necrolysis following the second cycle. Clinical symptoms and the results of the direct and indirect immunofluorescence were consistent with...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050347
更新日期:1997-11-01 00:00:00
abstract::Aplastic anemia is a rare complication of thymoma and is properly documented in only few cases. Here, we report the case of a previously healthy, 65-year-old patient who was found simultaneously to have a spindle-cell thymoma and severe hypoplastic anemia with a mild infiltration of the bone marrow by CD4+ and CD8+ T ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050437
更新日期:1998-10-01 00:00:00
abstract::We describe a unique case of IgG lambda myeloma in which a plasma cell leukemia developed and the paraprotein changed from IgG lambda to lambda chain, the latter inducing fatal renal failure. In addition, J-chain was detected in the cytoplasm of the plasma cell leukemia cells. ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01703239
更新日期:1993-04-01 00:00:00
abstract::The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate,...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050264
更新日期:1997-02-01 00:00:00
abstract::Defects in central and peripheral tolerance are thought to contribute to life-threatening graft-versus-host disease (GvHD), a severe complication following allogeneic stem cell transplantation (SCT). Recent investigations have demonstrated regulatory T cells (Tregs) to suppress allogeneic immune reactions. Therefore, ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-010-1068-0
更新日期:2011-02-01 00:00:00
abstract::Bleomycin-induced pneumonitis (BIP) has been well described in Hodgkin's lymphoma (HL) patients. The impact of BIP on patients uniformly treated with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) is not clear; previous studies have included patients treated with both ABVD and hybrid regimens. We reviewed ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-010-1032-z
更新日期:2011-01-01 00:00:00
abstract::We have studied some of the factors involved in the cytotoxic actions of the anticancer anthracycline antibiotics doxorubicin (DOX) and idarubicin (IDA) towards human B-cell lymphoma cells in vitro. IDA was found to accumulate within cells to a greater degree than the related drug DOX for both short (1 h) and long-ter...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01757348
更新日期:1994-01-01 00:00:00
abstract::Early cytomegalovirus (CMV) replication (eCMV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been suggested as an independent factor that reduces leukemia relapse risk. We retrospectively analyzed 74 patients with acute myeloid leukemia (AML) who underwent allo-HSCT between August 2006 and S...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2190-1
更新日期:2015-02-01 00:00:00
abstract::Asplenic and hyposplenic patients have an increased risk for overwhelming pneumococcal infections, even several decades after splenectomy. Pneumococcal vaccination and daily oral administration of penicillin V are recommended to prevent such infections, 2-5 years after splenectomy, and for at least 5 years in children...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-003-0779-x
更新日期:2004-01-01 00:00:00
abstract::Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-009-0757-z
更新日期:2009-10-01 00:00:00
abstract::This retrospective study attempts to establish if a correlation exists between osteoporosis and hematopoiesis before and after adjuvant chemotherapy in the context of non-metastatic breast cancer. Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone ma...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-017-3184-6
更新日期:2018-02-01 00:00:00
abstract::The aim of the study was to investigate the association of leptin with hematological parameters in beta-thalassemia patients in Greece. We measured plasma levels of soluble transferrin receptor (sTfR) and leptin by enzyme-linked immunosorbent assay (ELISA) in 40 beta-thalassemia patients (21 transfusion dependent and ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-002-0499-7
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. However, controversial data have been published regarding a protective role of variant alleles of MTHFR on MM. PATIENTS AND METHODS:To inve...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0097-1
更新日期:2006-07-01 00:00:00
abstract::Malignant lymphomas are a heterogenous group of malignancies, belonging to the 10 most frequent types of cancers worldwide. In indolent lymphoma only patients with limited stage I/II (Ann Arbor) can be potentially cured by local irradiation. However, about 85% of cases present with advanced stage; for these patients n...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0850-2
更新日期:2004-01-01 00:00:00
abstract::Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0244-8
更新日期:2007-06-01 00:00:00
abstract::The absence of researches about autophagy in multiple myeloma promoted us to explore the biological characteristics and role of autophagy induced by nutrient depletion in multiple myeloma (MM) cell line RPMI8226 cells. Both autophagic and apoptotic morphology were observed by TUNEL, transmission electron microscopy (T...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-011-1315-z
更新日期:2012-03-01 00:00:00
abstract:PURPOSE AND METHODS:Nowadays more people are becoming older. The median age of a patient with non-Hodgkin's lymphoma (NHL) at diagnosis is over 60 years. The incidence of NHL in elderly has increased in the last decades. Therefore, in the future, NHL will be diagnosed more often in the elderly. Data of all patients in ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000255
更新日期:2001-03-01 00:00:00