Residual methylation of tumor suppressor gene promoters, RASSF6 and RASSF10, as novel biomarkers for minimal residual disease detection in adult acute lymphoblastic leukemia.

abstract：:Hodgkin lymphoma (HL) can be aggressive and intractable in some cases. Patients who relapse after autologous HCT (auto-HCT) have limited treatment options. City of Hope reports our experience in the use of reduced intensity allogeneic hematopoietic cell transplantation (allo-HCT) in 24 heavily pretreated patients with...

journal_title：Annals of hematology

authors： Chen R,Palmer JM,Popplewell L,Shen J,Smith E,Delioukina M,Kogut N,Rosenthal J,Forman S,Nademanee A

更新日期：2011-07-01 00:00:00

abstract：:Immunoglobulin D (IgD) myeloma is a rare subtype that used to lead to a poor outcome. To investigate the current clinical features, cytogenetic changes and survival of patients with IgD myeloma under novel treatments, we analysed 47 patients with IgD myeloma, 31 men and 16 women, with a median age of 54.5 years. We fo...

journal_title：Annals of hematology

authors： Chen L,Fan F,Deng J,Xu J,Xu A,Sun C,Hu Y

更新日期：2019-04-01 00:00:00

abstract：:Organizing pneumonia (OP) is a poorly understood complication of hematopoietic stem cell transplant (HSCT). We identified 15 patients diagnosed with OP following HSCT and described their clinical course. CT chest findings were remarkable for multifocal infiltrates that were predominantly consolidating or ground glass ...

journal_title：Annals of hematology

authors： Brownback KR,Frey JW,Abhyankar S

更新日期：2019-09-01 00:00:00

abstract：:There is little information about cardiovascular adverse event (CV-AE) incidence in chronic myeloid leukemia (CML) patients treated with bosutinib in the real-life practice. We identified 54 consecutive CML patients treated with bosutinib, stratified according to the Systematic Coronary Risk Evaluation (SCORE) assessm...

journal_title：Annals of hematology

authors： Caocci G,Mulas O,Abruzzese E,Iurlo A,Annunziata M,Orlandi EM,Galimberti S,Binotto G,Sgherza N,Luciano L,Martino B,Russo Rossi A,Bonifacio M,Fozza C,Trawinska MM,Cattaneo D,Elena C,Baratè C,De Gregorio F,Molica M,L

更新日期：2019-08-01 00:00:00

abstract：:Transplantation of peripheral blood stem cells (PBSC), positively and/or negatively selected immediately after harvest, has become a widely applied therapeutic option in hematological or oncological patients. The following case of peripheral blood stem cell transplantation represents the first case of successful trans...

journal_title：Annals of hematology

authors： Humpe A,Riggert J,Wolf C,Binder C,Köhler M

更新日期：2001-02-01 00:00:00

abstract：:High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell transplantation (AHSCT) is a promising approach to treatment of multiple sclerosis (MS) patients. In this paper, we present the long-term outcomes of a prospective single-center study with the analysis of the safety and efficacy of HDIT...

journal_title：Annals of hematology

authors： Shevchenko JL,Kuznetsov AN,Ionova TI,Melnichenko VY,Fedorenko DA,Kurbatova KA,Gorodokin GI,Novik AA

更新日期：2015-07-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have emerged as a therapeutic approach in a range of medical fields, including regenerative medicine, cancer, autoimmune diseases, and inflammatory diseases, because of their unique properties of tissue repair and major histocompatibility complex-unmatched immunosuppression. Because both ...

journal_title：Annals of hematology

authors： Kim N,Im KI,Lim JY,Jeon EJ,Nam YS,Kim EJ,Cho SG

更新日期：2013-10-01 00:00:00

abstract：:Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), olde...

journal_title：Annals of hematology

authors： Attarbaschi A,Beishuizen A,Mann G,Rosolen A,Mori T,Uyttebroeck A,Niggli F,Csoka M,Krenova Z,Mellgren K,Kabickova E,Chiang AK,Reiter A,Williams D,Burkhardt B,European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) an

更新日期：2013-11-01 00:00:00

abstract：:Thirty-nine pregnant women with idiopathic thrombocytopenic purpura (ITP) were studied in order to evaluate the influence of therapies for maternal ITP on fetal passive immune thrombocytopenia (PIT). Neonatal platelet counts were also compared with platelet counts, amount of PAIgG, and presence of circulating antiplat...

journal_title：Annals of hematology

authors： Yamada H,Fujimoto S

更新日期：1994-01-01 00:00:00

abstract：:Idarubicin belongs to a group of anthracyclines in which the methoxyl group in position 4 of the D ring in the aglycone moiety is replaced by a hydrogen atom. Lipophilicity is increased compared with other anthracyclines; as a result, idarubicin is the first anthracycline that can be administered orally while at the s...

journal_title：Annals of hematology

authors： Goebel M

更新日期：1993-01-01 00:00:00

abstract：:Approximately 10% of patients with polycythemia vera (PV) transform to acute leukemia (blast phase) at 10 years after initial diagnosis of PV. The bone marrow pathologic, cytogenetic, and molecular features of blast phase have not been well characterized. In this study, we reviewed 422 PV patients over a period of 11 ...

journal_title：Annals of hematology

authors： Hidalgo López JE,Carballo-Zarate A,Verstovsek S,Wang SA,Hu S,Li S,Xu J,Zuo W,Tang Z,Yin CC,Medeiros LJ,Bueso-Ramos CE,Tang G

更新日期：2018-03-01 00:00:00

abstract：:Extensive research in recent years has broadened the functions of nuclear envelope proteins beyond simply stabilizing the nucleus architecture. Particularly, integral nuclear membrane proteins, such as the alternative spliced isoforms of lamina-associated polypeptide 2 (LAP2), have been shown to be important for the i...

journal_title：Annals of hematology

authors： Somech R,Gal-Yam EN,Shaklai S,Geller O,Amariglio N,Rechavi G,Simon AJ

更新日期：2007-06-01 00:00:00

abstract：:The aim of this study was to analyze the ability of an alloantibody from a patient with severe von Willebrand disease (vWD) to interfere with the vWF domain for FVIII, to inhibit factor VIII (FVIII), and to compare it with a rabbit polyclonal antibody. The vWF domain for binding to FVIII was assayed by a method previo...

journal_title：Annals of hematology

authors： Batlle J,Lourés E,Vila P,Hernández MC,Méndez JA,Torea J,Rendal E,Couselo MJ,Filgueira A,López Fernández MF

更新日期：1997-09-01 00:00:00

abstract：:Parenteral human immunoglobulin (IVIG) administration is widely used in low birth weight (LBW) infants for prevention and therapy of neonatal infection. In previous studies, IVIG preparations containing IgG and low IgM concentrations were commonly used. In this study we compare immunoglobulin serum levels in two group...

journal_title：Annals of hematology

authors： Amato M,Markus D,Hüppi P,Imbach P

更新日期：1991-10-01 00:00:00

abstract：:In an effort to overcome bone marrow failure in myelodysplastic syndrome (MDS), we have investigated recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) in phase I-II clinical trials. Although these agents partially increased peripheral blood granulocyte counts, their e...

journal_title：Annals of hematology

authors： Estrov Z,Kurzrock R,Talpaz M,Blake M,Gutterman JU

更新日期：1991-12-01 00:00:00

abstract：:While much has been learned about the basic immunology and clinical characteristics of immune thrombocytopenia, many important questions remain with regard to pathogenesis, disease progression, identification of novel therapeutic targets and approaches, and clinical trials that rationalize and optimize use of existing...

journal_title：Annals of hematology

authors： Zehnder JL,Semple JW,Imbach P,Neufeld EJ,Buchanan GR,Cines DB,ICIS Study Group on Future Research in ITP.

更新日期：2010-07-01 00:00:00

abstract：:Hydroxyurea is increasingly being used to control myeloproliferative disorders, in part because of its relative lack of side effects. We present a case of life-threatening alveolitis in a patient treated with hydroxyurea for myeloproliferative syndrome. Absence of exposure to other drugs and the clinical course sugges...

journal_title：Annals of hematology

authors： Hennemann B,Bross KJ,Reichle A,Andreesen R

更新日期：1993-09-01 00:00:00

abstract：:The hypomethylating agents azacytidine and decitabine are unaffordable for many patients with MDS. The combination of the DNA methyltransferase inhibitor hydralazine and the histone deacetylase inhibitor valproate has shown preliminary efficacy in MDS. The aim of this study is to evaluate the clinical efficacy and saf...

journal_title：Annals of hematology

authors： Candelaria M,Burgos S,Ponce M,Espinoza R,Dueñas-Gonzalez A

更新日期：2017-11-01 00:00:00

abstract：:Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP wa...

journal_title：Annals of hematology

authors： Liu WP,Wang XP,Zheng W,Xie Y,Tu MF,Lin NJ,Ping LY,Ying ZT,Zhang C,Deng LJ,Ding N,Wang XG,Song YQ,Zhu J

更新日期：2018-01-01 00:00:00

abstract：:Eculizumab is indicated for the therapy of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, patients on eculizumab are susceptible to Neisseria meningitidis infections. The two mainstays to reduce the risk of infection are vaccination and antibiotic...

journal_title：Annals of hematology

authors： Alashkar F,Vance C,Herich-Terhürne D,Preising N,Dührsen U,Röth A

更新日期：2017-04-01 00:00:00

abstract：:The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...

journal_title：Annals of hematology

authors： Pedersen P,Milman N

更新日期：2009-08-01 00:00:00

abstract：:A 64-year-old woman with adult T cell leukemia (ATL) was admitted to our hospital with severe hypercalcemia. The serum calcium level was elevated to 14.9 mg/dl. Biochemical parameters for bone formation including serum osteocalcin (bone Gla protein, BGP) and alkaline phosphatase (ALP) were normal. The serum levels of ...

journal_title：Annals of hematology

authors： Hino M,Yamane T,Ohta K,Shioi A,Koyama H,Tahara H,Nishizawa Y,Tatsumi N

更新日期：2001-07-01 00:00:00

abstract：:Along with their immunogenic role, dendritic cells (DCs) are also critical in maintaining tolerance to self-antigens by inducing regulatory T cells (Tregs) via the expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In turn, Tregs modulate the maturation and/or function of DCs. In immune th...

journal_title：Annals of hematology

authors： Catani L,Sollazzo D,Trabanelli S,Curti A,Evangelisti C,Polverelli N,Palandri F,Baccarani M,Vianelli N,Lemoli RM

更新日期：2013-01-01 00:00:00

abstract：:Autoantibody against erythrocytes has occasionally been observed in patients with de novo acute myelocytic leukemia (AML). However, it is not clear whether this autoantibody in AML patients induces frank hemolysis (autoimmune hemolytic anemia, AIHA), as seen in lymphoid neoplasms. We present two de novo AML patients w...

journal_title：Annals of hematology

authors： Tamura H,Ogata K,Yokose N,An E,Kamikubo K,Dan K,Kajii E,Nomura T

更新日期：1996-01-01 00:00:00

abstract：:In follicular lymphoma the t(14;18) might be useful as a tumor marker in predicting the quality of the response to treatment. We investigated whether analyzing numbers of t(14;18)-positive cells in peripheral blood correlated with remission status in individual patients receiving a variety of treatments. Numbers of ci...

journal_title：Annals of hematology

authors： Mandigers CM,Meijerink JP,van 't Veer MB,Mensink EJ,Raemaekers JM

更新日期：2003-12-01 00:00:00

abstract：:We evaluated the clinical features, treatment modalities, treatment responses, and prognosis of our patients with immune thrombocytopenia (ITP). Furthermore, we estimated the frequency of ITP in the Thrace region of Turkey. Two hundred sixteen patients diagnosed with ITP between 2000 and 2012 at our center were retros...

journal_title：Annals of hematology

authors： Koylu A,Pamuk GE,Uyanik MS,Demir M,Pamuk ON

更新日期：2015-03-01 00:00:00

abstract：:Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage ...

journal_title：Annals of hematology

authors： Kemp K,Morse R,Wexler S,Cox C,Mallam E,Hows J,Donaldson C

更新日期：2010-07-01 00:00:00

abstract：:The objective of this study was to evaluate retrospectively the clinical characteristics, treatments, and outcomes of patients with primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract. The basic characteristics, treatments, and outcomes of six patients diagnosed with primary DLBCL of the female g...

journal_title：Annals of hematology

authors： Cao XX,Li J,Zhang W,Duan MH,Shen T,Zhou DB

更新日期：2014-06-01 00:00:00

abstract：:Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic M...

journal_title：Annals of hematology

authors： Mussetti A,Pellegrinelli A,Cieri N,Garzone G,Dominoni F,Cabras A,Montefusco V

更新日期：2019-07-01 00:00:00

abstract：:In vitro studies suggest that haploinsufficiency is involved in the pathogenesis of myelodysplastic syndromes (MDS). In patients with del5q cytogenetic abnormality, RPS-14 and microRNAs (miRNAs) play a major role. In a multicenter phase II single-arm trial with lenalidomide in anemic primary del5q MDS patients with lo...

journal_title：Annals of hematology

authors： Oliva EN,Cuzzola M,Aloe Spiriti MA,Poloni A,Laganà C,Rigolino C,Morabito F,Galimberti S,Ghio R,Cortelezzi A,Palumbo GA,Sanpaolo G,Finelli C,Ricco A,Volpe A,Rodà F,Breccia M,Alimena G,Nobile F,Latagliata R

更新日期：2013-01-01 00:00:00