Abstract:
:Extensive research in recent years has broadened the functions of nuclear envelope proteins beyond simply stabilizing the nucleus architecture. Particularly, integral nuclear membrane proteins, such as the alternative spliced isoforms of lamina-associated polypeptide 2 (LAP2), have been shown to be important for the initiation of replication and repression of transcription. The latter is regulated by epigenetic changes, induced by the binding of LAP2beta to histone deacetylase-3 (HDAC3), resulting in histone H4 deacetylation. Involvement of nuclear envelope proteins in pathological proliferative conditions, mainly those involving abnormal recruitment and activation of HDACs, is still unknown. In this paper, we show that various nuclear envelope proteins are highly expressed in normal and malignant activated lymphocytes. Specifically, rapidly replicating cells of various hematological malignancies highly express LAP2beta, while slowly proliferating malignant cells of chronic malignant hematological diseases do not. Taking together the elevated expression of LAP2beta in highly proliferative malignant cells with its known ability to modify histones through binding with HDAC3 raises the possibility of its role in hematological malignancies involving aberrant activity of HDAC3. Based on our presented results, we believe that the LAP2-HDAC regulatory pathway should be studied as a new target for rational therapy.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Somech R,Gal-Yam EN,Shaklai S,Geller O,Amariglio N,Rechavi G,Simon AJdoi
10.1007/s00277-007-0275-9subject
Has Abstractpub_date
2007-06-01 00:00:00pages
393-401issue
6eissn
0939-5555issn
1432-0584journal_volume
86pub_type
杂志文章abstract::Systemic AL amyloidosis is associated with nearly 15% of cases of multiple myeloma, but data on the frequency and significance of amyloid deposits in the bone marrow of patients affected by multiple myeloma without clinical signs of systemic amyloidosis are scanty. Bone marrow smears of 166 unselected patients affecte...
journal_title:Annals of hematology
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doi:10.1007/s00277-009-0857-9
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abstract::Chinese Gγ+(Aγδβ)0-thalassemia and SEA-HPFH are the most common types of β-globin gene cluster deletion in Chinese population. The aim of the study was to analyze clinical features of deletional Chinese Gγ+(Aγδβ)0-thalassemia and Southeast Asian hereditary persistence of fetal hemoglobin (SEA-HPFH) in South China. A t...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-04252-7
更新日期:2020-12-01 00:00:00
abstract::We encountered two patients who presented with hypochromic-microcytic anemia and were refractory to iron therapy. The symptoms were suggestive of anemia of chronic disease (ACD); however, there was no evidence of any such disease, either inflammatory or malignant. These patients were reminiscent of patients originally...
journal_title:Annals of hematology
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更新日期:2000-08-01 00:00:00
abstract::We conducted an investigation to clarify whether or not the levels of total, free, and functional protein S and C4-binding protein (C4bp) in plasma are decreased in systemic lupus erythematosus (SLE) patients, especially those with antiphospholipid antibody (aPL), which is known to be a causative factor of such compli...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01696561
更新日期:1994-12-01 00:00:00
abstract::During the last few years, new insights into the biology of mantle cell lymphoma have been obtained. However, with a median survival of only 3 years, mantle cell lymphoma remains the lymphoma subtype with the poorest prognosis. At initial diagnosis most patients present with advanced Ann Arbor stage III or IV and conv...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
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abstract::Assay of phosphotyrosine levels using flow cytometry has been used to identify patients with chronic myelogenous leukemia positive for the Bcr-Abl fusion gene. We hypothesized that clinical monitoring could identify treatment response through reductions in intragranulocyte phosphotyrosine. Initially, we studied cell l...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0563-z
更新日期:2009-01-01 00:00:00
abstract::The present paper summarizes the results of the second German consensus meeting on immunogenetic donor search for allotransplantation of hematopoietic stem cells held in Essen in November 1999 under the auspices of the German Society for Immunogenetics (DGI) and the German Working Party for Blood and Marrow Transplant...
journal_title:Annals of hematology
pub_type: 共识发展会议,杂志文章,评审
doi:10.1007/s00277-001-0384-9
更新日期:2001-12-01 00:00:00
abstract::The benefits of intensive post-remission chemotherapy have not been verified in elderly patients with acute myeloid leukemia (AML). To reduce fatal complications caused by intensive post-remission therapy, we performed a prospective phase II multicenter trial of standard induction chemotherapy ('7+3' of cytarabine plu...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-006-0110-8
更新日期:2006-06-01 00:00:00
abstract::Recently we described a cutaneous T-cell lymphoma expressing the gamma/delta T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a s...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01695808
更新日期:1992-09-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-005-1047-z
更新日期:2005-09-01 00:00:00
abstract::The Wilms' tumor 1 (WT1) expression has been recognized in a substantial number of acute myeloid leukemia (AML) patients. Some studies indicated the association of diagnosed WT1 higher expression (WT1(H)) and poor outcome in the AML patients, while other studies had different opinions. Therefore, we performed a meta-a...
journal_title:Annals of hematology
pub_type: 杂志文章,meta分析
doi:10.1007/s00277-014-2295-6
更新日期:2015-06-01 00:00:00
abstract::Erythropoietin, alone or in combination with colony-stimulating factors, is a promising agent in the treatment of patients with cancer-related 'anemia of chronic disorders', chemo/radiotherapy-induced anemia, or anemia due to myelodysplastic or myeloproliferative syndromes. In the first two groups, at least half of th...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF01700275
更新日期:1994-11-01 00:00:00
abstract::We found increased numbers of CD28-negative T cells in a patient with multicentric Castleman's disease (MCD), who also had significantly decreased interleukin-2 (IL-2) production and impaired T-cell proliferation. The presence of CD28-negative T cells may be indicative of a functional T-cell defect in MCD. ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050228
更新日期:1996-10-01 00:00:00
abstract::Recent studies have demonstrated that direct cell-to-cell interaction is one of the microenvironment factors for transdifferentiation of adult stem cells into cardiomyocytes. We investigated whether transdifferentiation of mesenchymal stem cells (MSCs) into cardiomyocytes was dependent on developmental stages of cocul...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-005-1068-7
更新日期:2005-10-01 00:00:00
abstract::The production of erythropoietin (Epo), the glycoprotein hormone which controls red blood cell formation, is regulated by feedback mechanisms sensing tissue oxygenation. The mechanism of the putative oxygen sensor has yet to be elucidated. There is evidence that at least two pathways participate in hypoxia signal tran...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050514
更新日期:1999-06-01 00:00:00
abstract::The aim of the present study was to investigate the prevalence of chronic idiopathic neutropenia of adults (CINA) among an apparently healthy population born and living on the island of Crete. The study was carried out with 778 subjects, 392 men aged 16-78 years (median 43 years) and 386 women aged 15-79 years (median...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050518
更新日期:1999-07-01 00:00:00
abstract::Controversy remains regarding the transplant outcomes of human leukocyte antigen-identical related bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) for the treatment of patients with hematological malignancies. To provide an estimate of the effect of BMT and PBSCT on clinical ou...
journal_title:Annals of hematology
pub_type: 杂志文章,meta分析
doi:10.1007/s00277-011-1299-8
更新日期:2012-03-01 00:00:00
abstract::Acute graft-versus-host disease (aGVHD) has become the important complication post-allogeneic hematopoietic stem cell transplantation. Abnormally activated T cells might play an important role in the pathogenesis of aGVHD. But its exact mechanism remains poorly understood. T cell immune response cDNA 7 (TIRC7) has bee...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-015-2300-8
更新日期:2015-06-01 00:00:00
abstract::In contrast to adult medicine, specific scoring systems predicting the treatment response for an individual pediatric patient (pt) with chronic myeloid leukemia (CML) have not yet been defined. We evaluated to what extend prognostic scores as described for adults (e.g., Sokal, Hasford, EUTOS score) resulted in compara...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-015-2367-2
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Annals of hematology
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更新日期:2004-01-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000267
更新日期:2001-04-01 00:00:00
abstract::A 57-year-old man with acute myeloid leukemia (AML) French-American-British (FAB) 4 developed disseminated invasive cerebral and pulmonary aspergillosis during postinduction aplasia. According to international consensus, infection was categorized as probable (two host factors: deep neutropenia for >10 days and refract...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-003-0792-0
更新日期:2004-06-01 00:00:00
abstract::Most cases of erythrocytosis occur secondary to chronic tissue hypoxia or as a clonal disease such as polycythemia vera with somatic mutations in the Janus kinase 2 (JAK2) gene. Rarely, erythrocytosis is caused by hereditary gene mutations. This study investigated hereditary gene mutations in 38 unrelated Korean patie...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2006-3
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. However, controversial data have been published regarding a protective role of variant alleles of MTHFR on MM. PATIENTS AND METHODS:To inve...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0097-1
更新日期:2006-07-01 00:00:00
abstract::Hydroxyurea is increasingly being used to control myeloproliferative disorders, in part because of its relative lack of side effects. We present a case of life-threatening alveolitis in a patient treated with hydroxyurea for myeloproliferative syndrome. Absence of exposure to other drugs and the clinical course sugges...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01701737
更新日期:1993-09-01 00:00:00
abstract::The introduction of rituximab into the primary treatment of malignant lymphomas of the B cell lineage has had a major impact on the management of these diseases. In addition, prolonged exposure to rituximab as maintenance therapy has been beneficial in patients with follicular lymphoma and mantle cell lymphoma. For th...
journal_title:Annals of hematology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00277-008-0560-2
更新日期:2009-01-01 00:00:00
abstract::An analysis was conducted in four members of the same family, two of whom had a history of severe bleeding associated with type 2B von Willebrand's disease (VWD) which, although found to be due to the same mutation, nevertheless exhibited different phenotype patterns in the two subjects involved. Von Willebrand's fact...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770100303
更新日期:2001-06-01 00:00:00
abstract::We discuss possible justifications to split study populations from a biometrical point of view. The existence of prognostic differences between subgroups are neither a sufficient nor a necessary reason to justify a splitting decision. There are essentially two separate types of relevant arguments to justify a split of...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/pl00022792
更新日期:2001-01-01 00:00:00
abstract::In this report we show that serum has differentiation-inducing effects on primitive hematopoietic progenitor cells with the CD34++CD38- immunophenotype. Using the pre-colony forming unit (pre-CFU) assay as a model for early myelopoiesis, we compared the effects of serum-containing and serum-free media and evaluated di...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000227
更新日期:2001-01-01 00:00:00