Abstract：
:Aplastic anemia is a rare complication of thymoma and is properly documented in only few cases. Here, we report the case of a previously healthy, 65-year-old patient who was found simultaneously to have a spindle-cell thymoma and severe hypoplastic anemia with a mild infiltration of the bone marrow by CD4+ and CD8+ T lymphocytes, CD16+ natural killer cells, and a decrease in blood CD4/CD8 ratio. Cultures of marrow erythroid progenitors demonstrated serum inhibitor. While steroids, cyclophosphamide and antilymphocyte globulin failed to improve hematopoiesis, cyclosporine A (Cy-A) led to a partial, stable remission that was sustained for 4 years. Since Cy-A has been associated with good responses in three cases of thymoma-associated red cell aplasia, we recommend its use in cases of thymoma-associated cytopenias refractory to steroids and cyclophosphamide.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Liozon E,Touati M,Allegraud A,Gachard N,Loustaud V,Vidal E,Bordessoule Ddoi
10.1007/s002770050437subject
Has Abstractpub_date
1998-10-01 00:00:00pages
175-8issue
4eissn
0939-5555issn
1432-0584journal_volume
77pub_type
杂志文章abstract：:A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriam...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01836073
更新日期：1992-12-01 00:00:00
abstract：:The microRNA/miR deregulation in BCR-ABL-negative myelodysplastic-myeloproliferative neoplasms (MDS/MPN) is not known. Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain reaction (PCR) in bone marrow cells of atypical chronic myeloid leukaemia (aCML, n ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-010-1072-4
更新日期：2011-03-01 00:00:00
abstract：:In an effort to overcome bone marrow failure in myelodysplastic syndrome (MDS), we have investigated recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) in phase I-II clinical trials. Although these agents partially increased peripheral blood granulocyte counts, their e...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01709650
更新日期：1991-12-01 00:00:00
abstract：:Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relat...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2779-7
更新日期：2016-10-01 00:00:00
abstract：:The objective of this study was to evaluate retrospectively the clinical characteristics, treatments, and outcomes of patients with primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract. The basic characteristics, treatments, and outcomes of six patients diagnosed with primary DLBCL of the female g...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-2003-y
更新日期：2014-06-01 00:00:00
abstract：:Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with di...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-010-1083-1
更新日期：2011-04-01 00:00:00
abstract：:Haemoglobinopathies are the world's most frequently found monogenic disorders. In the cases with high oxygen affinity, the decrease in the liberation of the oxygen determines a secondary erythrocytosis. In this work, we present 17 unrelated families of Caucasian race and of Spanish origin, with ten variants of haemogl...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0581-x
更新日期：2009-03-01 00:00:00
abstract：:Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean p...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-006-0091-7
更新日期：2006-05-01 00:00:00
abstract：:Treatment of acute lymphoblastic leukemia (ALL) requires the combination of multiple drugs to integrate a complete remission. The different prognostic factors (age, leukocytes, risk, cytogenetic alterations) allow identifying those patients with a high risk of relapse, but there are few described factors that impact t...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04277-y
更新日期：2020-11-01 00:00:00
abstract：:Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-016-2683-1
更新日期：2016-06-01 00:00:00
abstract：:Extreme thrombocytosis (ExT) has been associated with an increased bleeding risk in myeloproliferative neoplasm (MPN) patients and is included in the high risk category in treatment guidelines. Treatment of patients with ExT has not been studied in prospective trials. To study physicians' approaches to ExT, we distrib...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2826-4
更新日期：2017-01-01 00:00:00
abstract：:Despite significant advances in the treatment of complications requiring intensive care unit (ICU) admission, ICU mortality remains high for patients after allogeneic stem cell transplantation. We evaluated the role of thrombocytopenia and poor graft function in allogeneic stem cell recipients receiving ICU treatments...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-018-3538-8
更新日期：2019-02-01 00:00:00
abstract：:Recently we described a cutaneous T-cell lymphoma expressing the gamma/delta T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a s...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01695808
更新日期：1992-09-01 00:00:00
abstract：:The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0679-1
更新日期：2009-08-01 00:00:00
abstract：:Ruxolitinib is a promising option for treating steroid-refractory acute graft-versus-host disease (SR-aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, we describe ruxolitinib treatment for SR-aGVHD in HSCT patients with Epstein-Barr virus-associated hemophagocytic lymphohisti...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03864-y
更新日期：2020-02-01 00:00:00
abstract：:Erythropoietin, alone or in combination with colony-stimulating factors, is a promising agent in the treatment of patients with cancer-related 'anemia of chronic disorders', chemo/radiotherapy-induced anemia, or anemia due to myelodysplastic or myeloproliferative syndromes. In the first two groups, at least half of th...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/BF01700275
更新日期：1994-11-01 00:00:00
abstract：:Multiple myeloma is a malignant B-cell neoplasm that involves the skeleton in approximately 80% of the patients. With an average age of 60 years and a 5-years survival of nearly 45% Brenner et al. (Blood 111:2516-2520,35) the onset is to be classified as occurring still early in life while the disease can be very aggr...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-009-0829-0
更新日期：2009-12-01 00:00:00
abstract：:Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), occurs secondary to a number of hereditary and acquired disorders of hemostasis. A recently recognized polymorphism in Factor V (FV) gene H1299R (also named HR2) has been reported to be a possible risk factor for the deve...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0543-3
更新日期：2008-12-01 00:00:00
abstract：:African Americans have two- to three-fold higher incidence of multiple myeloma and MGUS compared to other ethnic groups in the USA. Some physicians often perform diagnostic evaluations for plasma cell disorders (PCD) in African American patients on the basis of hematological abnormalities (thrombocytopenia, leucopenia...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1990-z
更新日期：2014-06-01 00:00:00
abstract：:Patients with malignancy often present with a variety of coagulation abnormalities which may ultimately lead to recurrent arterial and venous thromboses. Recently the presence of antiphospholipid antibodies in cancer patients has been proposed as one of the potential mechanisms promoting hypercoagulability. Here we re...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-002-0565-1
更新日期：2002-12-01 00:00:00
abstract：:The development of thrombocytopenia following exposure to the platelet glycoprotein (GP) IIb/ IIIa receptor antagonist abciximab (c7E3 Fab, ReoPro) is associated with adverse clinical outcome and excessive bleeding. Pseudothrombocytopenia is an important differential diagnosis in sudden onset of thrombocytopenia in a ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050573
更新日期：2000-03-01 00:00:00
abstract：:Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-2943-8
更新日期：2017-05-01 00:00:00
abstract：:Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative treatment option for myelofibrosis (MF) despite the emergence of novel targeted therapies. To reduce graft rejection and graft-versus-host disease (GvHD), current allo-HCT protocols often include in vivo T lymphocyte depletion using pol...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-016-2758-z
更新日期：2016-10-01 00:00:00
abstract：:This study aimed to systematically review the prognostic value of interim and end-of-treatment (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in follicular lymphoma during and after first-line therapy. The PubMed/MEDLINE database was searched for relevant original studies. Included studies were ...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-015-2553-2
更新日期：2016-01-01 00:00:00
abstract：:Autologous stem cell transplant (ASCT) is standard consolidation therapy in management of multiple myeloma (MM) patients. We reviewed records of all consecutive MM patients who underwent ASCT with high-dose melphalan at our center from year 2002 to 2016. A total of 141 ASCT were conducted (90 males and 51 females) wit...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3370-1
更新日期：2018-10-01 00:00:00
abstract：:A particular case of marginal zone B-cell lymphoma (MZBCL) presenting with leukemic lymphocytes is reported. In the present observation, the leukemic cells not only displayed a remarkable morphological fluctuation but also had an unusual phenotype, changing with time. These phenotypic features, which have been functio...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050274
更新日期：1997-03-01 00:00:00
abstract：:Secondary central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) includes an isolated CNS relapse or CNS involvement with systemic disease progression. This rare but fatal clinical problem still remains a therapeutic dilemma in the management of DLBCL. However, there are limited data about i...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-010-1104-0
更新日期：2011-05-01 00:00:00
abstract：:In Germany, analyses of clinical and laboratory features of patients with acute porphyrias are only available for hereditary coproporphyria (HCP) but not with other acute porphyrias, acute intermittent porphyria (AIP) and variegate porphyria (VP). The aim of the study was to analyze a large cohort of patients with par...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03831-7
更新日期：2019-12-01 00:00:00
abstract：:Early mortality remains a major challenge for the treatment of hemophagocytic lymphohistiocytosis (HLH), which warrants the need for prompt risk stratification in the early phase of the disease. We retrospectively analyzed clinical features of a cohort of pediatric patients managed at a tertiary hospital in southern C...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2727-6
更新日期：2016-09-01 00:00:00
abstract：:The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2580-z
更新日期：2016-03-01 00:00:00
