当前位置： SCI文献检索 > ANNALS OF HEMATOLOGY期刊下所有文献 > Autologous stem cell transplantation in first remission is associated with better progression-free survival in multiple myeloma.

Autologous stem cell transplantation in first remission is associated with better progression-free survival in multiple myeloma.

Abstract：

:Autologous stem cell transplant (ASCT) is standard consolidation therapy in management of multiple myeloma (MM) patients. We reviewed records of all consecutive MM patients who underwent ASCT with high-dose melphalan at our center from year 2002 to 2016. A total of 141 ASCT were conducted (90 males and 51 females) with median age of 55 years (23-68 years). Median time from diagnosis to transplant was 7 months (3-79), with majority of patients underwent transplant in first remission, while 17 (12%) patients received transplant beyond first remission. Eighty-three percent patients obtained CR/VGPR post-ASCT. Transplant-related mortality was 2.1%. At a median follow up of 54 months, mean overall survival (OS) and progression-free survival (PFS) group were 128.3 months (95% C.I. 111.9-144.7 months) and 73.8 months (95% C.I. 57.7-89.9 months), respectively. On univariate analysis, OS was adversely affected by renal insufficiency (p = 0.024), while OS was better with CR/VGPR post-ASCT (p < 0.001) and lenalidomide maintenance therapy (p = 0.009). PFS was affected by CR/VGPR pre-ASCT (p = 0.021), CR/VGPR post-ASCT (p < 0.001), and transplant in first remission (p = 0.034). On multivariate analysis, lenalidomide maintenance (versus thalidomide) (p = 0.007) and CR/VGPR response post-ASCT (p = 0.0003) were found to be predictors for better OS and CR/VGPR response at transplant for better PFS (p = 0.038). Transplant in first remission versus beyond first remission showed a trend for better PFS (p = 0.073). CONCLUSION:Majority of patients obtained CR/VGPR post-ASCT. Longer PFS was seen with patients who were transplanted in first remission.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Aggarwal M,Agrawal N,Yadav N,Verma P,Ahmed R,Mehta P,Kapoor J,Bhurani D

doi

10.1007/s00277-018-3370-1

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1869-1877

issue

10

eissn

0939-5555

issn

1432-0584

pii

10.1007/s00277-018-3370-1

journal_volume

97

pub_type

杂志文章

相关文献

ANNALS OF HEMATOLOGY文献大全
  • Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean patients.

    abstract：:To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seroposi...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2222-x

    authors： Park M,Lee YH,Lee SH,Yoo KH,Sung KW,Koo HH,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Lee JW,Chung NG,Cho B,Kim HK,Koh KN,Im HJ,Seo JJ,Baek HJ,Kook H,Hwang TJ,Lee JM,Hah JO,Lim YJ,Park JE,Lyu CJ,Lim YT,Ch

    更新日期：2015-03-01 00:00:00

  • Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia.

    abstract：:Hypermethylation of CpG islands near gene promoter regions is associated with transcriptional inactivation and represents an important mechanism of gene silencing in carcinogenesis. Such epigenetic phenomena can act alongside DNA mutations and deletions to disrupt tumor-suppressor gene function. The methylation status...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-005-0005-0

    authors： Galm O,Wilop S,Lüders C,Jost E,Gehbauer G,Herman JG,Osieka R

    更新日期：2005-12-01 00:00:00

  • Ixazomib-based regimens for relapsed/refractory multiple myeloma: are real-world data compatible with clinical trial outcomes? A multi-site Israeli registry study.

    abstract：:Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-020-03985-9

    authors： Cohen YC,Magen H,Lavi N,Gatt ME,Chubar E,Horowitz N,Kreiniz N,Tadmor T,Trestman S,Vitkon R,Rouvio O,Shvetz O,Shaulov A,Ziv-Baran T,Avivi I

    更新日期：2020-06-01 00:00:00

  • Ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) plus L-asparaginase as a first-line therapy improves outcomes in stage III/IV NK/T cell-lymphoma, nasal type (NTCL).

    abstract：:The prognosis of patients with stage III/IV NK/T-cell lymphoma (NTCL) is extremely poor. Although L-asparaginase (L-asp) is effective for NTCL, its significance has not been clearly demonstrated. In addition, there are few studies comparing treatment outcomes in stage III/IV NTCL. This study evaluated the efficacy of ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2228-4

    authors： Kim M,Kim TM,Kim KH,Keam B,Lee SH,Kim DW,Lee JS,Jeon YK,Kim CW,Heo DS

    更新日期：2015-03-01 00:00:00

  • Impact of extramedullary plasmacytomas on outcomes according to treatment approach in newly diagnosed symptomatic multiple myeloma.

    abstract：:The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone. A total of 275 consecutive patients with newly diagnosed MM were included, a...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2216-8

    authors： Lee SE,Kim JH,Jeon YW,Yoon JH,Shin SH,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Lee JW,Min WS,Park CW,Min CK

    更新日期：2015-03-01 00:00:00

  • No evidence for neoantigens in human plasma after photochemical virus inactivation.

    abstract：:Photodynamic virus inactivation of human fresh plasma mediated by visible light in the presence of the phenothiazine dyes methylene blue or toluidine blue was investigated to determine whether it influences functional, structural, and immunological properties of plasma proteins. The activities of the coagulation facto...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01703949

    authors： Mohr H,Knüver-Hopf J,Lambrecht B,Scheidecker H,Schmitt H

    更新日期：1992-11-01 00:00:00

  • Current prognostic and predictive factors in follicular lymphoma.

    abstract：:Follicular lymphoma (FL) is generally considered an indolent disorder. With modern day treatments, long remissions are often achieved both in the front-line and relapsed setting. However, a subset of patients has a more aggressive course and a worse outcome. Their identification is the main purpose of modern day progn...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-017-3154-z

    authors： Sorigue M,Sancho JM

    更新日期：2018-02-01 00:00:00

  • Progression of disease within 2 years (POD24) is a clinically relevant endpoint to identify high-risk follicular lymphoma patients in real life.

    abstract：:Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma with heterogeneous outcomes. Progression or relapse of FL within 2 years (so-called POD24) after diagnosis is associated with a poor outcome for patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone) in clinica...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04025-2

    authors： Sortais C,Lok A,Tessoulin B,Gastinne T,Mahé B,Dubruille V,Blin N,Touzeau C,Moreau A,Bossard C,Peterlin P,Garnier A,Guillaume T,Le Bourgeois A,Chevallier P,Moreau P,Leux C,Le Gouill S

    更新日期：2020-07-01 00:00:00

  • Over-representation of bcr3 subtype of PML/RARalpha fusion gene in APL in Indian patients.

    abstract：:Thirty six patients with acute promyelocytic leukemia were studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time PCR. There was concordance between the results achieved by both the methods except in one case, which was negative by RT-PCR but positive by real-time PCR. The prevalence of bcr3...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-005-1095-4

    authors： Sazawal S,Hasan SK,Dutta P,Kumar B,Kumar R,Kumar L,Choudhry VP,Saxena R

    更新日期：2005-11-01 00:00:00

  • The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women.

    abstract：:The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01714957

    authors： Milman N,Kirchhoff M

    更新日期：1991-07-01 00:00:00

  • Failure of combination therapy with recombinant granulocyte colony-stimulating factor and erythropoietin in myelodysplastic syndromes.

    abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) and erythropoietin (rhE-PO) were used to treat ten patients with myelodysplastic syndromes (MDS). None of the patients showed a favorable response in erythrocyte and platelet counts following 10 weeks' treatment, although favorable responses in neutroph...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01834360

    authors： Imamura M,Kobayashi M,Kobayashi S,Yoshida K,Mikuni C,Ishikawa Y,Matsumoto S,Sakamaki S,Niitsu Y,Hinoda Y

    更新日期：1994-04-01 00:00:00

  • Flow cytometric assay of phosphotyrosine levels in Bcr-Abl-positive chronic myelogenous leukemias: a potential prognostic marker.

    abstract：:Assay of phosphotyrosine levels using flow cytometry has been used to identify patients with chronic myelogenous leukemia positive for the Bcr-Abl fusion gene. We hypothesized that clinical monitoring could identify treatment response through reductions in intragranulocyte phosphotyrosine. Initially, we studied cell l...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-008-0563-z

    authors： Sun X,Li J,Chen J,Li D,Chen L,Xu W,Yang Y,Wu Y,Jiang P,Xie W

    更新日期：2009-01-01 00:00:00

  • Good adherence to imatinib therapy among patients with chronic myeloid leukemia--a single-center observational study.

    abstract：:Previous studies have suggested that adherence to imatinib therapy can be an obstacle among patients with chronic myeloid leukemia (CML). We studied adherence to imatinib therapy among CML patients treated at the Sahlgrenska University Hospital. We identified all CML patients that were alive at the 1st of January 2010...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-011-1359-0

    authors： Jönsson S,Olsson B,Söderberg J,Wadenvik H

    更新日期：2012-05-01 00:00:00

  • Role of GSTP1-1 in mediating the effect of As2O3 in the Acute Promyelocytic Leukemia cell line NB4.

    abstract：:Arsenic trioxide (As2O3) is a highly effective agent in the treatment of acute promyelocytic leukemia (APL), whereas other hematopoietic tumors are less responsive to this agent and mechanisms underlying As2O3,-resistance are poorly understood. To better understand the complex network of GSH-related pathways in As2O3 ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-006-0139-8

    authors： Bernardini S,Nuccetelli M,Noguera NI,Bellincampi L,Lunghi P,Bonati A,Mann K,Miller WH Jr,Federici G,Lo Coco F

    更新日期：2006-10-01 00:00:00

  • Biotherapy of chronic myelogenous leukemia.

    abstract：:The aim of this review is to summarize the current knowledge on the clinical results of biotherapy of chronic myelogenous leukemia (CML) and potential mechanisms of the antitumor action of interferon alpha. IFN alpha treatment induces hematologic and cytogenetic remissions in patients with chronic phase CML. In additi...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01682030

    authors： Aulitzky WE,Peschel C,Schneller F,Huber C

    更新日期：1995-03-01 00:00:00

  • Prognostic factors of early outcome in pediatric hemophagocytic lymphohistiocytosis: an analysis of 116 cases.

    abstract：:Early mortality remains a major challenge for the treatment of hemophagocytic lymphohistiocytosis (HLH), which warrants the need for prompt risk stratification in the early phase of the disease. We retrospectively analyzed clinical features of a cohort of pediatric patients managed at a tertiary hospital in southern C...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-016-2727-6

    authors： Bin Q,Gao JH,Luo JM

    更新日期：2016-09-01 00:00:00

  • Anti-thymocyte globulin-induced hyperbilirubinemia in patients with myelofibrosis undergoing allogeneic hematopoietic cell transplantation.

    abstract：:Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative treatment option for myelofibrosis (MF) despite the emergence of novel targeted therapies. To reduce graft rejection and graft-versus-host disease (GvHD), current allo-HCT protocols often include in vivo T lymphocyte depletion using pol...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-016-2758-z

    authors： Ecsedi M,Schmohl J,Zeiser R,Drexler B,Halter J,Medinger M,Duyster J,Kanz L,Passweg J,Finke J,Bethge W,Lengerke C

    更新日期：2016-10-01 00:00:00

  • Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia.

    abstract：:Along with their immunogenic role, dendritic cells (DCs) are also critical in maintaining tolerance to self-antigens by inducing regulatory T cells (Tregs) via the expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In turn, Tregs modulate the maturation and/or function of DCs. In immune th...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-012-1556-5

    authors： Catani L,Sollazzo D,Trabanelli S,Curti A,Evangelisti C,Polverelli N,Palandri F,Baccarani M,Vianelli N,Lemoli RM

    更新日期：2013-01-01 00:00:00

  • Single-agent daratumumab in very advanced relapsed and refractory multiple myeloma patients: a real-life single-center retrospective study.

    abstract：:The anti-CD38 monoclonal antibody daratumumab is approved as a single agent for the treatment of patients with relapsed and refractory multiple myeloma (RRMM) who have received at least three prior lines of therapy, including a proteasome inhibitor (PI) and an immunomodulatory agent (IMID), or who are double refractor...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-019-03655-5

    authors： Jullien M,Trudel S,Tessoulin B,Mahé B,Dubruille V,Blin N,Gastinne T,Bonnet A,Lok A,Lebourgeois A,Peterlin P,Garnier A,Chevalier P,Guillaume T,Thomaré P,Le Gouill S,Moreau P,Touzeau C

    更新日期：2019-06-01 00:00:00

  • Headache prevalence following recovery from TTP and aHUS.

    abstract：:Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-015-2411-2

    authors： Saultz JN,Wu HM,Cataland S

    更新日期：2015-09-01 00:00:00

  • PD-L1, LAG3, and HLA-DR are increasingly expressed during smoldering myeloma progression.

    abstract：:Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic M...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-019-03648-4

    authors： Mussetti A,Pellegrinelli A,Cieri N,Garzone G,Dominoni F,Cabras A,Montefusco V

    更新日期：2019-07-01 00:00:00

  • Geriatric nutritional risk index as a useful prognostic factor in second allogeneic hematopoietic stem cell transplantation.

    abstract：:Second allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a low survival outcome and a high non-relapse mortality (NRM) rate which is a major obstacle to this treatment. We hypothesized that the status of malnourishment after first allo-HSCT as represented by the geriatric nutritional risk index (GNRI)...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04089-0

    authors： Kaito S,Wada A,Adachi H,Konuma R,Kishida Y,Nagata A,Konishi T,Yamada Y,Kumagai T,Yoshifuji K,Mukae J,Akiyama M,Inamoto K,Toya T,Igarashi A,Najima Y,Muto H,Kobayashi T,Kakihana K,Ohashi K,Sakamaki H,Doki N

    更新日期：2020-07-01 00:00:00

  • Maintenance therapy in childhood acute myeloid leukemia.

    abstract：PURPOSE:To determine whether, after very intensive induction and consolidation therapy in childhood AML, further maintenance therapy (MT) confers any advantage. PATIENTS AND METHODS:Three hundred-nine children with previously untreated AML were registered in the LAME 89/91 protocol. This three-cycle intensive regimen ...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00277-004-0850-2

    authors： Perel Y,Auvrignon A,Leblanc T,Michel G,Vannier JP,Dalle JH,Gandemer V,Schmitt C,Mèchinaud F,Lamagnere JP,Piguet Ch,Couillaud G,Pautard B,Baruchel A,Leverger G,Group LAME.,French Society of Pediatric Hematology and Immunol

    更新日期：2004-01-01 00:00:00

  • In vitro cross-resistance to nucleoside analogues and inhibitors of topoisomerase 1 and 2 in acute myeloid leukemia.

    abstract：:Only about one third of all patients with acute myeloid leukemia (AML) will be cured by common chemotherapy regimens. Susceptibility towards chemotherapy either of the leukemic bulk or the leukemic stem cell is considered the major determining parameter for long-term outcome. The purpose of the present study was to in...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-007-0361-z

    authors： Fiegl M,Zimmermann I,Lorenz I,Hiddemann W,Braess J

    更新日期：2008-01-01 00:00:00

  • Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin's lymphoma.

    abstract：:The role of 18FDG-PET/CT during follow-up of patients affected by Hodgkin's lymphoma (HL) in complete remission after treatment is not fully elucidated, since a wide use of 18F fluorodeoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) in this setting could be limited by a relative high rate of...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-009-0752-4

    authors： Crocchiolo R,Fallanca F,Giovacchini G,Ferreri AJ,Assanelli A,Verona C,Pescarollo A,Bregni M,Ponzoni M,Gianolli L,Fazio F,Ciceri F

    更新日期：2009-12-01 00:00:00

  • Evaluation of neutrophil-lymphocyte ratio in patients with early-stage mycosis fungoides.

    abstract：:Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relat...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-016-2779-7

    authors： Eren R,Nizam N,Doğu MH,Mercan S,Erdemir AV,Suyanı E

    更新日期：2016-10-01 00:00:00

  • Pulmonary manifestations of the pre-engraftment syndrome after umbilical cord blood transplantation.

    abstract：:Pre-engraftment syndrome (PES) is a condition occurring after umbilical cord blood transplantation (UCBT) characterized by fever and erythematous skin rash prior to neutrophil engraftment. We sought to determine the incidence and characterize the pulmonary manifestations of PES. A retrospective review of patients who ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-013-1981-0

    authors： Brownback KR,Simpson SQ,McGuirk JP,Lin TL,Abhyankar S,Ganguly S,Aljitawi OS

    更新日期：2014-05-01 00:00:00

  • Prognostic value of cytogenetics in adult patients with Philadelphia-negative acute lymphoblastic leukemia.

    abstract：:The prognostic value of cytogenetics in adult acute lymphoblastic leukemia (ALL) is not as established as in childhood ALL. We have analyzed the outcome and prognostic value of karyotype in 84 adults diagnosed with Philadelphia-negative ALL from a single institution that received induction chemotherapy and had success...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-011-1331-z

    authors： Gómez-Seguí I,Cervera J,Such E,Martínez-Cuadrón D,Luna I,Ibáñez M,López-Pavía M,Gascón A,Roig M,Martínez J,Sanz J,Montesinos P,Martín-Aragonés G,Lorenzo I,Senent L,Barragán E,Cordón L,Sempere A,Sanz GF,Sanz MA

    更新日期：2012-01-01 00:00:00

  • Overview of 321 patients with idiopathic thrombocytopenic purpura. Retrospective analysis of the clinical features and response to therapy.

    abstract：:In this retrospective study, we evaluated the clinical features and the effects of various treatment modalities on the clinical course in patients diagnosed with idiopathic thrombocytopenic purpura (ITP) at our center between 1984-2000. We retrospectively examined the medical records of 321 (229 females, 92 males) ITP...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-002-0488-x

    authors： Pamuk GE,Pamuk ON,Başlar Z,Ongören S,Soysal T,Ferhanoğlu B,Aydin Y,Ulkü B,Aktuğlu G,Akman N

    更新日期：2002-08-01 00:00:00

  • Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial.

    abstract：:Obesity is a well-known risk factor for the development of cancer, but its influence on the course of disease is still controversial. We investigated the influence of body mass index (BMI) on overall survival (OS) in 502 patients with indolent non-Hodgkin's lymphoma or mantle cell lymphoma in a subgroup analysis of th...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-017-3003-0

    authors： Weiss L,Melchardt T,Egle A,Hopfinger G,Hackl H,Greil R,Barth J,Rummel M

    更新日期：2017-07-01 00:00:00