In vitro cross-resistance to nucleoside analogues and inhibitors of topoisomerase 1 and 2 in acute myeloid leukemia.

abstract：:Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODN...

journal_title：Annals of hematology

authors： Albrecht T,Schwab R,Peschel C,Engels HJ,Fischer T,Huber C,Aulitzky WE

更新日期：1996-02-01 00:00:00

abstract：:Overproduction of proinflammatory cytokines is characteristic of hemophagocytic syndrome (HPS), a highly lethal inflammatory disease. Peripheral blood monocytes include two distinct subpopulations according to surface antigen expression: a major type, CD14(+)/CD16(-) (classical monocytes), and a minor type, CD14(+)/CD...

journal_title：Annals of hematology

authors： Takeyama N,Yabuki T,Kumagai T,Takagi S,Takamoto S,Noguchi H

更新日期：2007-11-01 00:00:00

abstract：:Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...

journal_title：Annals of hematology

authors： Görg C,Wollenberg B,Beyer J,Stolte MS,Neubauer A

更新日期：2005-01-01 00:00:00

abstract：:This study outlines trends in quality of delivered non-Hodgkin's lymphoma (NHL) care in the Netherlands between 2007 and 2011 and to what extend this was influenced by the national Visible Care program, which aimed at increasing transparency by providing insight into the quality of healthcare. We analyzed data collect...

journal_title：Annals of hematology

authors： Stienen JJ,Ottevanger PB,Wennekes L,van de Schans SA,Dekker HM,van der Maazen RW,van Krieken JH,Blijlevens NM,Hermens RP,PEARL study group.

更新日期：2015-07-01 00:00:00

abstract：:Gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL) show a spectrum of disease characterized by varying proportions of low-grade and high-grade components. While the natural history and optimum treatment for low-grade gastric MALT lymphoma and DLBCL is well established, ...

journal_title：Annals of hematology

authors： Ang MK,Hee SW,Quek R,Yap SP,Loong S,Tan L,Tao M,Lim ST

更新日期：2009-05-01 00:00:00

abstract：:To characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most co...

journal_title：Annals of hematology

authors： Kwong YL,Au WY,Leung AY,Tse EW

更新日期：2010-04-01 00:00:00

abstract：:Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchosc...

journal_title：Annals of hematology

authors： Kim SW,Rhee CK,Kang HS,Lee HY,Kang JY,Kim SJ,Kim SC,Lee SY,Kim YK,Lee JW

更新日期：2015-01-01 00:00:00

abstract：:The development of thrombocytopenia following exposure to the platelet glycoprotein (GP) IIb/ IIIa receptor antagonist abciximab (c7E3 Fab, ReoPro) is associated with adverse clinical outcome and excessive bleeding. Pseudothrombocytopenia is an important differential diagnosis in sudden onset of thrombocytopenia in a ...

journal_title：Annals of hematology

authors： Stiegler H,Fischer Y,Steiner S,Strauer BE,Reinauer H

更新日期：2000-03-01 00:00:00

abstract：:Somatic mutations in the SF3B1 gene, a gene encoding the splicing factor 3B subunit 1, were recently reported in myelodysplastic syndromes (MDS), particularly in the presence of ring sideroblasts (RS). The authors investigated the prevalence and clinical significance of SF3B1 mutations in Korean patients with myeloid ...

journal_title：Annals of hematology

authors： Seo JY,Lee KO,Kim SH,Kim K,Jung CW,Jang JH,Kim HJ

更新日期：2014-04-01 00:00:00

abstract：:Hodgkin lymphoma (HL) in resource-poor population shows an early childhood peak with predominance of mixed cellularity (MCHL) and high Epstein-Barr virus (EBV) association, whereas HL in resource-rich population has a peak in ages 15-29 years with the predominance of nodular sclerosis (NSHL) and low EBV association. W...

journal_title：Annals of hematology

authors： Koh YW,Kang HJ,Yoon DH,Suh C,Kim JE,Kim CW,Huh J

更新日期：2013-12-01 00:00:00

abstract：:B cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy with limited treatment strategies. Histone deacetylases inhibitors (HDACis) are promising novel tools for cancer therapy, whose anti-tumor effects and the underlying mechanisms on B-ALL remain to be elucidated. Recently, Notch1 signali...

journal_title：Annals of hematology

authors： Shao N,Ma D,Wang J,Lu T,Guo Y,Ji C

更新日期：2013-01-01 00:00:00

abstract：:Sickle cell disease (SCD) is a relatively common inherited hemolytic anemia among individuals of African descent. Genetic factors might clarify clinical diversity of the disease and variations in treatment response. Some researchers investigated heme oxygenase-1 (HMOX1) or chemokine receptor 5 (CCR5Δ32) genotypes amon...

journal_title：Annals of hematology

authors： Bakr S,Khorshied M,Talha N,Jaffer KY,Soliman N,Eid K,El-Ghamrawy M

更新日期：2019-08-01 00:00:00

abstract：:Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with di...

journal_title：Annals of hematology

authors： Mian M,Marcheselli L,Luminari S,Federico M,Cantonetti M,Sarris AH,Rossi A,Rambaldi A,Frontani M,Devizzi L,Gianni AM,Busetto M,Berti E,Martinelli G,Tsang RW,Ferreri AJ,Pinotti G,Pogliani E,Zucca E,Cortelazzo S

更新日期：2011-04-01 00:00:00

abstract：:Organizing pneumonia (OP) is a poorly understood complication of hematopoietic stem cell transplant (HSCT). We identified 15 patients diagnosed with OP following HSCT and described their clinical course. CT chest findings were remarkable for multifocal infiltrates that were predominantly consolidating or ground glass ...

journal_title：Annals of hematology

authors： Brownback KR,Frey JW,Abhyankar S

更新日期：2019-09-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells (DCs) can induce or maintain peripheral immune tolerance. Impaired IDO-mediated tryptophan catabolism has been observed in autoimmune diseases. In order to investigate the effects of IDO-mediated tryptophan catabolism and IDO-expressing DCs in immune thro...

journal_title：Annals of hematology

authors： Xu SQ,Wang CY,Zhu XJ,Dong XY,Shi Y,Peng J,Qin P,Sun JZ,Guo C,Ni H,Hou M

更新日期：2012-10-01 00:00:00

abstract：:We designed a study to describe the incidence of intracranial hemorrhage according to severity and duration of thrombocytopenia and to quantify the associations of platelet transfusions with intracranial hemorrhage in patients with acute leukemia. In this case-control study nested in a cohort of 859 leukemia patients,...

journal_title：Annals of hematology

authors： Cornelissen LL,Kreuger AL,Caram-Deelder C,Middelburg RA,Kerkhoffs JLH,von dem Borne PA,Beckers EAM,de Vooght KMK,Kuball J,Zwaginga JJ,van der Bom JG

更新日期：2021-01-01 00:00:00

abstract：:Stored red blood cells become deficient in nitric oxide that limits their ability to transfer oxygen to tissues that need it. The aims of this study are to assess the endogenous nitric oxide metabolites (NOx) and arginase I levels in transfusion-dependent β-thalassemic patients; to compare these levels in patients tra...

journal_title：Annals of hematology

authors： El-Hady SB,Farahat MH,Atfy M,Elhady MA

更新日期：2012-08-01 00:00:00

abstract：:The prognostic impact of extramedullary plasmacytomas (EMPs) on newly diagnosed symptomatic multiple myeloma (MM) was evaluated in the context of treatment approach including autologous stem cell transplantation (ASCT) and chemotherapy alone. A total of 275 consecutive patients with newly diagnosed MM were included, a...

journal_title：Annals of hematology

authors： Lee SE,Kim JH,Jeon YW,Yoon JH,Shin SH,Eom KS,Kim YJ,Kim HJ,Lee S,Cho SG,Lee JW,Min WS,Park CW,Min CK

更新日期：2015-03-01 00:00:00

abstract：:This paper describes six Indian families in which silent-gene beta-thalassemia was encountered by us in the past 2 years. This stresses the importance of globin-chain synthesis in the diagnosis of beta-thalassemia. Of these six cases, five were diagnosed retrospectively when they had a homozygous beta-thalassemia offs...

journal_title：Annals of hematology

authors： Nadkarni A,Pawar A,Mudera VC,Mohanty D,Colah R

更新日期：1995-01-01 00:00:00

abstract：:We describe a unique case of IgG lambda myeloma in which a plasma cell leukemia developed and the paraprotein changed from IgG lambda to lambda chain, the latter inducing fatal renal failure. In addition, J-chain was detected in the cytoplasm of the plasma cell leukemia cells. ...

journal_title：Annals of hematology

authors： Sawamura M,Murayama K,Tokizawa S,Matsushima T,Tamura J,Murakami H,Naruse T,Tsuchiya J

更新日期：1993-04-01 00:00:00

abstract：:Approximately 10% of patients with polycythemia vera (PV) transform to acute leukemia (blast phase) at 10 years after initial diagnosis of PV. The bone marrow pathologic, cytogenetic, and molecular features of blast phase have not been well characterized. In this study, we reviewed 422 PV patients over a period of 11 ...

journal_title：Annals of hematology

authors： Hidalgo López JE,Carballo-Zarate A,Verstovsek S,Wang SA,Hu S,Li S,Xu J,Zuo W,Tang Z,Yin CC,Medeiros LJ,Bueso-Ramos CE,Tang G

更新日期：2018-03-01 00:00:00

abstract：:In a large proportion of patients with mild bleeding disorders (MBDs) no diagnosis can be established by routine coagulation tests. We investigated whether alterations in plasma clot properties account for MBDs of unknown cause. Ninety-five patients with MBDs of unknown origin and 98 age- and sex-matched healthy contr...

journal_title：Annals of hematology

authors： Gebhart J,Laczkovics C,Posch F,Ay C,Reitter-Pfoertner SE,Haslacher H,Muszbek L,Wolberg AS,Pabinger I

更新日期：2015-08-01 00:00:00

abstract：:Assay of phosphotyrosine levels using flow cytometry has been used to identify patients with chronic myelogenous leukemia positive for the Bcr-Abl fusion gene. We hypothesized that clinical monitoring could identify treatment response through reductions in intragranulocyte phosphotyrosine. Initially, we studied cell l...

journal_title：Annals of hematology

authors： Sun X,Li J,Chen J,Li D,Chen L,Xu W,Yang Y,Wu Y,Jiang P,Xie W

更新日期：2009-01-01 00:00:00

abstract：:To characterize the clinical features, associated disorders, and treatment of necrobiotic xanthogranuloma (NXG), a rare non-Langerhans cell histiocytosis, we conducted a retrospective review of pathologically confirmed NXG at Mayo Clinic Arizona from 1987 to June 2017. Data on clinical findings, laboratory findings, a...

journal_title：Annals of hematology

authors： Hilal T,DiCaudo DJ,Connolly SM,Reeder CB

更新日期：2018-08-01 00:00:00

abstract：:A prospective randomized phase III study was performed to evaluate whether intensified cytarabine would induce a higher response rate and longer event-free interval as compared to low-dose cytarabine in chronic myeloid leukemia (CML). One hundred and eighteen patients with CML in early chronic phase entered the study....

journal_title：Annals of hematology

authors： Deenik W,van der Holt B,Verhoef GE,Schattenberg AV,Verdonck LF,Daenen SM,Zachée P,Westveer PH,Smit WM,Wittebol S,Schouten HC,Löwenberg B,Ossenkoppele GJ,Cornelissen JJ

更新日期：2007-02-01 00:00:00

abstract：:In hematopoietic system development, PU.1 and GATA-1 as lineage-specific transcription factors (TF) are expressed in common myeloid progenitors. The cross antagonism between them ascertains gene expression programs of monocytic and erythroid cells, respectively. This concept in transdifferentiation approaches has not ...

journal_title：Annals of hematology

authors： Nouri M,Deezagi A,Ebrahimi M

更新日期：2016-03-01 00:00:00

abstract：:The prognostic value of peripheral blasts (PB) is not well-studied in patients with myelodysplastic syndromes (MDS). We evaluated the impact of PB on overall survival (OS) and transformation to acute myeloid leukemia (AML) in a large cohort. The MDS database at the Moffitt Cancer Center was retrospectively reviewed to...

journal_title：Annals of hematology

authors： Duong VH,Padron E,Al Ali NH,Lancet JE,Hall J,Kwok B,Zhang L,Epling-Burnette PK,List AF,Komrokji RS

更新日期：2018-02-01 00:00:00

abstract：:A combination of chromosomal translocations associated with bcl-2 re-arrangement (t(14;18)) and c-myc re-arrangement (t(8;14), t(8;22), or t(2;8)) is a rare event. We describe the first cell line exhibiting t(14;18) and t(8;22), which will enable us to study the interactions of bcl-2 and c-myc systematically. Cell cul...

journal_title：Annals of hematology

authors： Kiefer T,Schüler F,Knopp A,Wimmer M,Hirt C,Schaefer HE,Dölken G

更新日期：2007-11-01 00:00:00

abstract：:A retrospective study of 120 patients with the clinically and histologically established diagnosis of idiopathic (primary) myelofibrosis (IMF) was performed to determine prognostic factors of predictive value, including parameters characterizing the dynamics of hematopoietic cell kinetics. In contrast to previous stud...

journal_title：Annals of hematology

authors： Kvasnicka HM,Thiele J,Regn C,Zankovich R,Diehl V,Fischer R

更新日期：1999-02-01 00:00:00

abstract：:We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concen...

journal_title：Annals of hematology

authors： Fest T,de Wazières B,Lamy B,Maskani M,Vuitton D,Dupond JL

更新日期：1994-09-01 00:00:00