Abstract:
:We designed a study to describe the incidence of intracranial hemorrhage according to severity and duration of thrombocytopenia and to quantify the associations of platelet transfusions with intracranial hemorrhage in patients with acute leukemia. In this case-control study nested in a cohort of 859 leukemia patients, cases (n = 17) were patients diagnosed with intracranial hemorrhage who were matched with control patients (n = 55). We documented platelet counts and transfusions for seven days before the intracranial hemorrhage in cases and in a "matched" week for control patients. Three measures of platelet count exposure were assessed in four potentially important time periods before hemorrhage. Among these leukemia patients, we observed the cumulative incidence of intracranial hemorrhage of 3.5%. Low platelet counts were, especially in the three to seven days preceding intracranial hemorrhage, associated with the incidence of intracranial hemorrhage, although with wide confidence intervals. Platelet transfusions during the week preceding the hemorrhage were associated with higher incidences of intracranial hemorrhage; rate ratios (95% confidence interval) for one or two platelet transfusions and for more than two transfusions compared with none were 4.04 (0.73 to 22.27) and 8.91 (1.53 to 51.73) respectively. Thus, among acute leukemia patients, the risk of intracranial hemorrhage was higher among patients with low platelet counts and after receiving more platelet transfusions. Especially, the latter is likely due to clinical factors leading to increased transfusion needs.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Cornelissen LL,Kreuger AL,Caram-Deelder C,Middelburg RA,Kerkhoffs JLH,von dem Borne PA,Beckers EAM,de Vooght KMK,Kuball J,Zwaginga JJ,van der Bom JGdoi
10.1007/s00277-020-04298-7subject
Has Abstractpub_date
2021-01-01 00:00:00pages
261-271issue
1eissn
0939-5555issn
1432-0584pii
10.1007/s00277-020-04298-7journal_volume
100pub_type
杂志文章,多中心研究abstract::Asplenic and hyposplenic patients have an increased risk for overwhelming pneumococcal infections, even several decades after splenectomy. Pneumococcal vaccination and daily oral administration of penicillin V are recommended to prevent such infections, 2-5 years after splenectomy, and for at least 5 years in children...
journal_title:Annals of hematology
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journal_title:Annals of hematology
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