Bloodstream infections with gram-negative organisms and the impact of multidrug resistance in patients with hematological malignancies.

abstract：:In a large proportion of patients with mild bleeding disorders (MBDs) no diagnosis can be established by routine coagulation tests. We investigated whether alterations in plasma clot properties account for MBDs of unknown cause. Ninety-five patients with MBDs of unknown origin and 98 age- and sex-matched healthy contr...

journal_title：Annals of hematology

authors： Gebhart J,Laczkovics C,Posch F,Ay C,Reitter-Pfoertner SE,Haslacher H,Muszbek L,Wolberg AS,Pabinger I

更新日期：2015-08-01 00:00:00

abstract：:The production of erythropoietin (Epo), the glycoprotein hormone which controls red blood cell formation, is regulated by feedback mechanisms sensing tissue oxygenation. The mechanism of the putative oxygen sensor has yet to be elucidated. There is evidence that at least two pathways participate in hypoxia signal tran...

journal_title：Annals of hematology

authors： Daghman NA,Elder GE,Savage GA,Winter PC,Maxwell AP,Lappin TR

更新日期：1999-06-01 00:00:00

abstract：:An improvement in quality of life and survival occurred among thalassemia major (TM) patients: pregnancy in such patients has become a reality. Safe pregnancy and delivery require efforts to ensure the best outcomes. Between 2007 and 2016, 30 TM patients had 37 pregnancies. We analyzed the hematological parameters bef...

journal_title：Annals of hematology

authors： Cassinerio E,Baldini IM,Alameddine RS,Marcon A,Borroni R,Ossola W,Taher A,Cappellini MD

更新日期：2017-06-01 00:00:00

abstract：:Ruxolitinib, a JAK1 and JAK2 inhibitor, has been tested and approved for the treatment of primary and secondary myelofibrosis (MF). Aim of our study is to report safety and efficacy of ruxolitinib in 98 patients affected by MF treated outside clinical trials and collected and treated consecutively by the Lazio Coopera...

journal_title：Annals of hematology

authors： Breccia M,Andriani A,Montanaro M,Abruzzese E,Buccisano F,Cedrone M,Centra A,Villivà N,Celesti F,Trawinska MM,Massaro F,Di Veroli A,Anaclerico B,Colafigli G,Molica M,Spadea A,Petriccione L,Cimino G,Latagliata R

更新日期：2017-03-01 00:00:00

abstract：:Several guidelines and recommendations on the management of chronic myeloid leukemia (CML) have been prepared by several scientific societies. The European LeukemiaNet (ELN) appointed a panel of experts who submitted their recommendations to peer-reviewed scientific journals in 2006, 2009, and 2013. Here, we make a cr...

journal_title：Annals of hematology

authors： Baccarani M,Castagnetti F,Gugliotta G,Rosti G

更新日期：2015-04-01 00:00:00

abstract：:Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few ...

journal_title：Annals of hematology

authors： Wach M,Dmoszynska A,Wasik-Szczepanek E,Pozarowski A,Drop A,Szczepanek D

更新日期：2004-08-01 00:00:00

abstract：:Aberrant promoter methylation of RASSF6 and RASSF10 occurs at a high frequency in acute lymphoblastic leukemia (ALL). Because of the complexity of the current minimal residual disease (MRD) detecting-methods, the DNA methylation status of the RASSF6 and RASSF10 genes could potentially become biomarkers for the assessm...

journal_title：Annals of hematology

authors： Younesian S,Shahkarami S,Ghaffari P,Alizadeh S,Mehrasa R,Ghaffari SH

更新日期：2019-12-01 00:00:00

abstract：:To evaluate the outcomes of refractory/relapsed cHL patients after high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) in Beijing Cancer hospital and to identify the prognostic risk factors. We retrospectively analyzed 115 relapsed/refractory cHL patients who accepted HDCT and ASCT in our can...

journal_title：Annals of hematology

authors： Xie Y,Wang X,Leng X,Zheng W,Ping L,Zhang C,Liu W,Deng L,Wu M,Song Y,Zhu J

更新日期：2020-03-01 00:00:00

abstract：:In view of obscure clinical and biological significance of leukemic cells heterogeneity, we studied the efficacy of apoptosis, proliferation, and expression levels of the Bcl-2, MDR1, LRP, and BCRP genes in sorted CD34+ and CD34- subpopulations of childhood AML leukemic samples. In five out of nine cases, CD34+ cells ...

journal_title：Annals of hematology

authors： Shman TV,Fedasenka UU,Savitski VP,Aleinikova OV

更新日期：2008-05-01 00:00:00

abstract：:Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...

journal_title：Annals of hematology

authors： Saultz JN,Wu HM,Cataland S

更新日期：2015-09-01 00:00:00

abstract：:In multiple myeloma, the polymerase chain reaction (PCR) of the Ig heavy chain with allele-specific oligonucleotide (ASO) primers is a common and well-described method of identifying the tumor clone in peripheral blood (PB), bone marrow (BM) or leukapheresis products (LA). A factor which is crucial to the detection of...

journal_title：Annals of hematology

authors： Draube A,Pfister R,Vockerodt M,Schuster S,Kube D,Diehl V,Tesch H

更新日期：2001-02-01 00:00:00

abstract：:The impact of intraocular involvement (IOL) in primary CNS lymphoma (PCNSL) has not been sufficiently evaluated. Here, we present the analysis of IOL in the only completed randomized phase III trial in PCNSL. The G-PCNSL-SG1 study evaluated the role of whole-brain radiotherapy in primary therapy of PCNSL. Data of the ...

journal_title：Annals of hematology

authors： Kreher S,Strehlow F,Martus P,Roth P,Hertenstein B,Röth A,Birnbaum T,Griesinger F,Rauch M,Kanz L,Thiel E,Weller M,Korfel A

更新日期：2015-03-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a well-recognized complication in pediatric oncology patients. Studies in adult oncology patients have suggested a potential negative association between VTE and survival, but this association has not been examined in pediatric patients yet. The aim of this study was to assess the assoc...

journal_title：Annals of hematology

authors： Forbrigger Z,Kuhle S,Brown MM,Moorehead PC,Digout C,Kulkarni K

更新日期：2018-10-01 00:00:00

abstract：:Malignant lymphomas are a heterogenous group of malignancies, belonging to the 10 most frequent types of cancers worldwide. In indolent lymphoma only patients with limited stage I/II (Ann Arbor) can be potentially cured by local irradiation. However, about 85% of cases present with advanced stage; for these patients n...

journal_title：Annals of hematology

authors： Buske C,Dreyling H,Unterhalt M,Hiddemann W

更新日期：2004-01-01 00:00:00

abstract：:The clarification of enlarged lymph nodes is a common issue in clinical routine. By now, open surgery with complete lymph node extirpation, followed by histopathology, is considered as standard. We investigated the value of fine needle aspiration (FNA) and core needle biopsy (CNB) when supporting the conventional morp...

journal_title：Annals of hematology

authors： Metzgeroth G,Schneider S,Walz C,Reiter S,Hofmann WK,Marx A,Hastka J

更新日期：2012-09-01 00:00:00

abstract：:The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...

journal_title：Annals of hematology

authors： Milman N,Kirchhoff M

更新日期：1991-07-01 00:00:00

abstract：:The general objective of this study was to evaluate the risks of agranulocytosis and aplastic anemia in relation to drug use. Other potential risk factors, including history of infectious mononucleosis, were also evaluated. In an international population-based case-control study, cases of agranulocytosis and aplastic ...

journal_title：Annals of hematology

authors： Levy M,Kelly JP,Kaufman DW,Shapiro S

更新日期：1993-10-01 00:00:00

abstract：:Haplo-identical transplants (Haplo-Tx) are an important alternative for patients with hematological malignancies who lack a HLA-identical donor. Seventy-one T-replete Haplo-Tx were performed in 70 high-risk patients at our center; 22/70 (31%) patients with refractory/relapsed leukemia received sequential salvage thera...

journal_title：Annals of hematology

authors： Brunello L,Passera R,Dellacasa CM,Giaccone L,Audisio E,Ferrero D,D'Ardia S,Allione B,Aydin S,Festuccia M,Lia G,Crisà E,Maffini E,Butera S,Busca A,Bruno B

更新日期：2018-11-01 00:00:00

abstract：:Telomere shortening represents an established mechanism connecting aging and cancer development. We sequentially analyzed telomere length (TL) of 49 acute myeloid leukemia (AML) patients at diagnosis (n = 24), once they achieved complete cytological remission (CCR) and/or during refractory disease or relapse and after...

journal_title：Annals of hematology

authors： Ventura Ferreira MS,Crysandt M,Ziegler P,Hummel S,Wilop S,Kirschner M,Schemionek M,Jost E,Wagner W,Brümmendorf TH,Beier F

更新日期：2017-09-01 00:00:00

abstract：:Spontaneous splenic rupture is a rare, though life-threatening complication of some hematological malignancies and is even more infrequent as the initial symptom of acute lymphoblastic leukemia. We describe the fourth case, to our knowledge, of acute lymphoblastic leukemia presenting as splenic rupture, and for the fi...

journal_title：Annals of hematology

authors： Altès A,Brunet S,Martinez C,Soler J,Ayats R,Sureda A,López R,Domingo A

更新日期：1994-03-01 00:00:00

abstract：:Cells of the macrophage lineage are a major source of various cytokines and hematopoietic growth factors. With regard to the growth factors acting on cells of their own lineage, macrophage colony-stimulating factor (M-CSF) has been proven to be secreted by monocytes (MO) and macrophages (MAC), whereas the production o...

journal_title：Annals of hematology

authors： Krause SW,Kreutz M,Zenke G,Andreesen R

更新日期：1992-04-01 00:00:00

abstract：:Multicentric Castleman's disease (MCD) is a rare systemic lymphoproliferative disorder with too few patient series reported in the literature to have a clear idea about the etiology, outcome and the best treatment available. Systemic reactive amyloidosis is a very rare complication of MCD and its presence worsens the ...

journal_title：Annals of hematology

authors： Gholam D,Vantelon JM,Al-Jijakli A,Bourhis JH

更新日期：2003-12-01 00:00:00

abstract：:Upper aerodigestive tract natural killer (NK)/T-cell lymphoma (UNKTL) is the most common type of extranodal NK/T-cell lymphoma, nasal type. Serum beta2-microglobulin (β2-M) was found to be a predictor in some subtypes of B-cell lymphoma. However, its prognostic significance in NK/T-cell lymphoma has never been explore...

journal_title：Annals of hematology

authors： Li ZM,Zhu YJ,Sun J,Xia Y,Huang JJ,Zou BY,Lin TY,Huang HQ,Jiang WQ

更新日期：2012-08-01 00:00:00

abstract：:We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concen...

journal_title：Annals of hematology

authors： Fest T,de Wazières B,Lamy B,Maskani M,Vuitton D,Dupond JL

更新日期：1994-09-01 00:00:00

abstract：:Iron deficiency anemia is among the most frequent causes of disability. Intravenous iron is the quickest way to correct iron deficiency, bypassing the bottleneck of iron intestinal absorption, the only true mechanism of iron balance regulation in human body. Intravenous iron administration is suggested in patients who...

journal_title：Annals of hematology

authors： Giordano G,Napolitano M,Di Battista V,Lucchesi A

更新日期：2020-12-02 00:00:00

abstract：:Although B chronic lymphocytic leukemia (B-CLL) cells express the alpha chain of the interleukin-2 (IL-2) receptor CD25, little is known about the effect of IL-2 on apoptosis in B-CLL cells. We have shown previously that stimulation of B-CLL cells with a CpG-oligonucleotide induces IL-2 high affinity receptors. In our...

journal_title：Annals of hematology

authors： Decker T,Bogner C,Oelsner M,Peschel C,Ringshausen I

更新日期：2010-11-01 00:00:00

abstract：:To characterize the clinical features, associated disorders, and treatment of necrobiotic xanthogranuloma (NXG), a rare non-Langerhans cell histiocytosis, we conducted a retrospective review of pathologically confirmed NXG at Mayo Clinic Arizona from 1987 to June 2017. Data on clinical findings, laboratory findings, a...

journal_title：Annals of hematology

authors： Hilal T,DiCaudo DJ,Connolly SM,Reeder CB

更新日期：2018-08-01 00:00:00

abstract：:The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...

journal_title：Annals of hematology

authors： Takaoka K,Nannya Y,Shinohara A,Arai S,Nakamura F,Kurokawa M

更新日期：2014-10-01 00:00:00

abstract：:Antithymocyte globulin (ATG) is the treatment of choice for those aplastic anemia patients who are not suitable for bone marrow transplantation (BMT). ATG is also used for the treatment of rejections in organ transplantation and as a conditioning regimen in BMT. Despite the proven efficacy of ATG in these areas, its m...

journal_title：Annals of hematology

authors： Dubey S,Nityanand S

更新日期：2003-08-01 00:00:00

abstract：:Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...

journal_title：Annals of hematology

authors： Gupta PK,Charan VD,Saxena R

更新日期：2007-06-01 00:00:00