Increased expression of T cell immune response cDNA 7 in patients with acute graft-versus-host disease.

Abstract:

:Acute graft-versus-host disease (aGVHD) has become the important complication post-allogeneic hematopoietic stem cell transplantation. Abnormally activated T cells might play an important role in the pathogenesis of aGVHD. But its exact mechanism remains poorly understood. T cell immune response cDNA 7 (TIRC7) has been identified to be essential in T cell activation; however, the role of TIRC7 in aGVHD remains unclear. The purpose of this study was to measure the expression of TIRC7 and T helper (Th) cells in patients with aGVHD before and after treatment. We showed that TIRC7 levels in aGVHD patients were higher than those of healthy controls and markedly declined after treatment. The levels of IFN-γ (Th1), IL-17 (Th17), and IL-22 (Th22) were in accordance with the grade of aGVHD. In addition, TIRC7 levels were also associated with the severity of aGVHD. In conclusion, TIRC7 might be involved in the pathogenesis of aGVHD and TIRC7 level might be an indicator to evaluate the response of patients with aGVHD to treatment.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Zhu F,Qiao J,Chen W,Pan B,Wu QY,Cao J,Sang W,Yan ZL,Zeng LY,Li ZY,Xu KL

doi

10.1007/s00277-015-2300-8

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

1025-32

issue

6

eissn

0939-5555

issn

1432-0584

journal_volume

94

pub_type

杂志文章
  • Compound heterozygosity for Hb Korle-Bu (beta(73); Asp-Asn) and Hb E (beta(26); Glu-Lys) with a 3.7-kb deletional alpha-thalassemia in Thai patients.

    abstract::Hemoglobin (Hb) Korle-Bu (beta73; Asp-Asn) is the most frequent of the rare beta-chain variants in the population of West Africa whereas Hb E (beta26; Glu-Lys) is common among the Southeast Asian population. We report a hitherto undescribed condition in which these two beta-chain variants co-segregate. The proband was...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-002-0485-0

    authors: Changtrakun Y,Fucharoen S,Ayukarn K,Siriratmanawong N,Fucharoen G,Sanchaisuriya K

    更新日期:2002-07-01 00:00:00

  • Prognostic value of cytogenetics in adult patients with Philadelphia-negative acute lymphoblastic leukemia.

    abstract::The prognostic value of cytogenetics in adult acute lymphoblastic leukemia (ALL) is not as established as in childhood ALL. We have analyzed the outcome and prognostic value of karyotype in 84 adults diagnosed with Philadelphia-negative ALL from a single institution that received induction chemotherapy and had success...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1331-z

    authors: Gómez-Seguí I,Cervera J,Such E,Martínez-Cuadrón D,Luna I,Ibáñez M,López-Pavía M,Gascón A,Roig M,Martínez J,Sanz J,Montesinos P,Martín-Aragonés G,Lorenzo I,Senent L,Barragán E,Cordón L,Sempere A,Sanz GF,Sanz MA

    更新日期:2012-01-01 00:00:00

  • The association of venous thromboembolism with survival in pediatric cancer patients: a population-based cohort study.

    abstract::Venous thromboembolism (VTE) is a well-recognized complication in pediatric oncology patients. Studies in adult oncology patients have suggested a potential negative association between VTE and survival, but this association has not been examined in pediatric patients yet. The aim of this study was to assess the assoc...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-018-3371-0

    authors: Forbrigger Z,Kuhle S,Brown MM,Moorehead PC,Digout C,Kulkarni K

    更新日期:2018-10-01 00:00:00

  • Ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) plus L-asparaginase as a first-line therapy improves outcomes in stage III/IV NK/T cell-lymphoma, nasal type (NTCL).

    abstract::The prognosis of patients with stage III/IV NK/T-cell lymphoma (NTCL) is extremely poor. Although L-asparaginase (L-asp) is effective for NTCL, its significance has not been clearly demonstrated. In addition, there are few studies comparing treatment outcomes in stage III/IV NTCL. This study evaluated the efficacy of ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2228-4

    authors: Kim M,Kim TM,Kim KH,Keam B,Lee SH,Kim DW,Lee JS,Jeon YK,Kim CW,Heo DS

    更新日期:2015-03-01 00:00:00

  • Acute porphyrias: a German monocentric study of the biochemical, molecular genetic, and clinical data of 62 families.

    abstract::In Germany, analyses of clinical and laboratory features of patients with acute porphyrias are only available for hereditary coproporphyria (HCP) but not with other acute porphyrias, acute intermittent porphyria (AIP) and variegate porphyria (VP). The aim of the study was to analyze a large cohort of patients with par...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-019-03831-7

    authors: Bronisch O,Stauch T,Haverkamp T,Beykirch MK,Petrides PE

    更新日期:2019-12-01 00:00:00

  • The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women.

    abstract::The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01714957

    authors: Milman N,Kirchhoff M

    更新日期:1991-07-01 00:00:00

  • Predictors of plasma cell disorders among African American patients: a community practice perspective.

    abstract::African Americans have two- to three-fold higher incidence of multiple myeloma and MGUS compared to other ethnic groups in the USA. Some physicians often perform diagnostic evaluations for plasma cell disorders (PCD) in African American patients on the basis of hematological abnormalities (thrombocytopenia, leucopenia...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-1990-z

    authors: Tun NM,Joseph G,Soe AM,Ford JG

    更新日期:2014-06-01 00:00:00

  • Bcl-2 expression is associated with poor prognosis of solitary plasmacytoma of bone.

    abstract::Solitary plasmacytoma of bone (SPB) is a rare tumor that represents a minority of patients with plasma cell localized malignancy characterized by a single osteolytic bone lesion. The molecular mechanism underlying the genesis of SPB has remained enigmatic. Signal transducers and activators of transcription-3 (STAT3) i...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-1897-8

    authors: Guo S,Zhi Y,Yang H,Yu Y,Wang Y,Zhang J,Wang G,Zhang L,Sun B,Zhang Y

    更新日期:2014-03-01 00:00:00

  • Characteristics of pulmonary complications in non-Hodgkin's lymphoma patients treated with rituximab-containing chemotherapy and impact on survival.

    abstract::Patients with non-Hodgkin's lymphoma (NHL) receiving rituximab-containing chemotherapy are at risk of developing respiratory complications, but comprehensive information on these complications and their impact on survival is lacking. We performed a retrospective cohort analysis on 123 NHL patients who received rituxim...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-018-3448-9

    authors: Keefer K,Bender R,Liao J,Sivik J,Van de Louw A

    更新日期:2018-12-01 00:00:00

  • Perinatal management of idiopathic thrombocytopenic purpura in pregnancy: risk factors for passive immune thrombocytopenia.

    abstract::Thirty-nine pregnant women with idiopathic thrombocytopenic purpura (ITP) were studied in order to evaluate the influence of therapies for maternal ITP on fetal passive immune thrombocytopenia (PIT). Neonatal platelet counts were also compared with platelet counts, amount of PAIgG, and presence of circulating antiplat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01695918

    authors: Yamada H,Fujimoto S

    更新日期:1994-01-01 00:00:00

  • Leukemia-propagating cells demonstrate distinctive gene expression profiles compared with other cell fractions from patients with de novo Philadelphia chromosome-positive ALL.

    abstract::Relapse remains one of the major obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) even after allogeneic hematopoietic stem cell transplantation. The persistence of leukemia-propagating cells (LPCs) may lead to the recurrence of Ph+ALL. Using a xenograft assay, LPCs enrichment in the ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-018-3253-5

    authors: Zhao HY,Song Y,Cao XN,Qin YZ,Lai YY,Jiang H,Jiang Q,Huang XJ,Kong Y

    更新日期:2018-05-01 00:00:00

  • Clinical significance of metabolic tumor volume by PET/CT in stages II and III of diffuse large B cell lymphoma without extranodal site involvement.

    abstract::The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL). We evaluated 169 patients with nodal stages II and III DLBCL...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1357-2

    authors: Song MK,Chung JS,Shin HJ,Lee SM,Lee SE,Lee HS,Lee GW,Kim SJ,Lee SM,Chung DS

    更新日期:2012-05-01 00:00:00

  • DNA fragmentation as a consequence of cell cycle traverse in doxorubicin- and idarubicin-treated human lymphoma cells.

    abstract::We have studied some of the factors involved in the cytotoxic actions of the anticancer anthracycline antibiotics doxorubicin (DOX) and idarubicin (IDA) towards human B-cell lymphoma cells in vitro. IDA was found to accumulate within cells to a greater degree than the related drug DOX for both short (1 h) and long-ter...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01757348

    authors: Smith PJ,Rackstraw C,Cotter F

    更新日期:1994-01-01 00:00:00

  • Kinetics of minimal residual disease during induction/consolidation therapy in standard-risk adult B-lineage acute lymphoblastic leukemia.

    abstract::We have compared the kinetics of minimal residual disease (MRD) by simultaneous polymerase chain reaction (PCR) monitoring with oligonucleotides for the immunoglobulin heavy chain (IgH) complementarity-determining region 3 (CDR3) and the T-cell receptor gamma chain gene (TCR gamma), as well as clone-specific CDR3 sequ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01910311

    authors: Scholten C,Födinger M,Mitterbauer M,Laczika K,Mitterbauer G,Haas OA,Knöbl P,Schwarzinger I,Thalhammer R,Purtscher B

    更新日期:1995-10-01 00:00:00

  • Factor V HR2 haplotype: a risk factor for venous thromboembolism in individuals with absence of Factor V Leiden.

    abstract::Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), occurs secondary to a number of hereditary and acquired disorders of hemostasis. A recently recognized polymorphism in Factor V (FV) gene H1299R (also named HR2) has been reported to be a possible risk factor for the deve...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0543-3

    authors: Otrock ZK,Taher AT,Shamseddeen WA,Zaatari G,Bazarbachi A,Mahfouz RA

    更新日期:2008-12-01 00:00:00

  • CT-guided needle biopsy performed with modified coaxial technique in patients with refractory or recurrent lymphomas.

    abstract::The aim of this study was to evaluate the role of computed tomography (CT)-guided core needle biopsy (CNB) performed by modified coaxial technique as an alternative tool to surgical biopsy in patients with refractory or recurrent lymphomas. Between May 2005 and May 2012, 57 CT-guided CNB of deep lesions were performed...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2078-0

    authors: Gaudio F,Pedote P,Ferrante A,Perrone T,Ingravallo G,Ianora AA,Angelelli G,Specchia G

    更新日期:2014-09-01 00:00:00

  • MicroRNAs: pivotal regulators in acute myeloid leukemia.

    abstract::MicroRNAs are a class of small non-coding RNAs that are 19-22 nucleotides in length and regulate a variety of biological processes at the post-transcriptional level. MicroRNA dysregulation disrupts normal biological processes, resulting in tumorigenesis. Acute myeloid leukemia is an invasive hematological malignancy c...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-019-03887-5

    authors: Li M,Cui X,Guan H

    更新日期:2020-03-01 00:00:00

  • Comparison and evaluation of three screening tests of hereditary spherocytosis in Chinese patients.

    abstract::The objective of this study is to compare and evaluate the diagnostic value of hereditary spherocytosis (HS) by three screening tests, comparing mean spherical corpuscular volume (MSCV) to mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and flow cytometric osmotic fragility test. Perip...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2270-2

    authors: Tao YF,Deng ZF,Liao L,Qiu YL,Chen WQ,Lin FQ

    更新日期:2015-05-01 00:00:00

  • Rituximab maintenance after autologous stem cell transplantation prolongs response duration in non-naive rituximab follicular lymphoma patients: a single institution experience.

    abstract::We retrospectively evaluated the role of rituximab (R) in maintenance treatment after autologous stem cell transplantation performed in patients with relapsed follicular lymphoma. We compared the outcome of 67 follicular lymphoma (FL) patients according to the use of rituximab maintenance (RM) or not. All patients rec...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2705-z

    authors: Bourcier J,Gastinne T,Leux C,Moreau A,Bossard C,Mahé B,Blin N,Dubruille V,Touzeau C,Voldoire M,Guillaume T,Peterlin P,Gallas P,Garnier A,Maisonneuve H,Moreau P,Juge-Morineau N,Jardel H,Chevallier P,Moreau P,Le Gou

    更新日期:2016-08-01 00:00:00

  • Two novel factor X gene mutations in a Chinese family with factor X deficiency.

    abstract::We report a factor X (FX)-deficient Chinese family with two novel FX gene (F10) mutations. Two sibling probands had a bleeding tendency since childhood. Both had very low FX:C (<0.01 IU/ml) and FX:Ag (5-6%) levels and were heterozygous for two novel F10 mutations, a 2-bp GC deletion involving nucleotides 33 and 34, le...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0803-1

    authors: Au WY,Lam CC,Cheung WC,Kwong YL

    更新日期:2004-05-01 00:00:00

  • Headache prevalence following recovery from TTP and aHUS.

    abstract::Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-015-2411-2

    authors: Saultz JN,Wu HM,Cataland S

    更新日期:2015-09-01 00:00:00

  • Low infectious morbidity in patients with heavily pretreated hematological malignancies receiving autologous peripheral blood stem cell transplantation without antimicrobial prophylaxis.

    abstract::The use of prophylactic antimicrobials during autologous peripheral blood stem cell transplantation (APBSCT) remains controversial. A prospective study was therefore conducted to examine whether the use of prophylactic antimicrobials is necessary. In this study, all the antimicrobials were given therapeutically rather...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-002-0567-z

    authors: Yeh SP,Chiu CF,Lo WJ,Lin CL,Hsueh CT,Liao YM,Shen YC

    更新日期:2003-01-01 00:00:00

  • Successful transplantation and engraftment of peripheral blood stem cells after cryopreservation, positive and negative purging procedures, and a second cryopreservation cycle.

    abstract::Transplantation of peripheral blood stem cells (PBSC), positively and/or negatively selected immediately after harvest, has become a widely applied therapeutic option in hematological or oncological patients. The following case of peripheral blood stem cell transplantation represents the first case of successful trans...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770000243

    authors: Humpe A,Riggert J,Wolf C,Binder C,Köhler M

    更新日期:2001-02-01 00:00:00

  • Thromboembolic events as an emerging adverse effect during high-dose intravenous immunoglobulin therapy in elderly patients: a case report and discussion of the relevant literature.

    abstract::A case of an 82-year-old man who suffered an acute ST-elevation myocardial infarction while receiving treatment with intravenous immunoglobulin (IVIg) for thrombocytopenia is discussed. A total of 29 other cases of thromboembolism related to IVIg therapy have been reported, and the incidence seems to be especially hig...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-004-0895-2

    authors: Hefer D,Jaloudi M

    更新日期:2004-10-01 00:00:00

  • Blood B, T, CD4+ and CD8+ lymphocytes in female Wistar rats.

    abstract::We have established reference values of peripheral blood lymphocyte subsets in healthy female Wistar rats under highly standardized conditions. Using monoclonal antibodies and flow cytometry, T lymphocytes (OX19+), B lymphocytes (OX6+ and anti-Ig+), T-helper/inducer (W3/25+), and T-suppressor/cytotoxic subsets (OX8+) ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01701732

    authors: Franch A,Castellote C,Pelegrí C,Tolosa E,Castell M

    更新日期:1993-09-01 00:00:00

  • Acute myeloid leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults.

    abstract::t(8;16)(p11.2;p13.3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML). We report 15 cases with t(8;16)(p11.2;p13.3). All patients were adult and had AML: 13 women and 2 men, with a median age of 50 years. Ten patients had a history of malignancy and received cytotox...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-019-03637-7

    authors: Xie W,Hu S,Xu J,Chen Z,Medeiros LJ,Tang G

    更新日期:2019-05-01 00:00:00

  • Long-term follow-up of a prospective phase 2 clinical trial of extended treatment with rituximab in patients with B cell post-transplant lymphoproliferative disease and validation in real world patients.

    abstract::The purpose of this report is to provide long-term follow-up of 38 patients diagnosed of post-transplant lymphoproliferative disease (PTLD) included in a phase 2 clinical trial of first line therapy with rituximab and to evaluate the same therapy in a real world cohort of 21 consecutive patients treated once the trial...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04056-9

    authors: González-Barca E,Capote FJ,Gómez-Codina J,Panizo C,Salar A,Sancho JM,López A,Briones J,Muñoz A,Encuentra M,Mercadal S,Domingo-Domenech E,de Sevilla AF,GELTAMO (Spanish Lymphoma Group) and GOTEL (Group of Oncology for Therapy an

    更新日期:2020-05-04 00:00:00

  • A novel scoring system to predict the incidence of invasive fungal disease in salvage chemotherapies for malignant lymphoma.

    abstract::The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2093-1

    authors: Takaoka K,Nannya Y,Shinohara A,Arai S,Nakamura F,Kurokawa M

    更新日期:2014-10-01 00:00:00

  • Bone resorption associated with uncoupling of osteoclastic and osteoblastic activities in adult T cell leukemia with hypercalcemia: case report.

    abstract::A 64-year-old woman with adult T cell leukemia (ATL) was admitted to our hospital with severe hypercalcemia. The serum calcium level was elevated to 14.9 mg/dl. Biochemical parameters for bone formation including serum osteocalcin (bone Gla protein, BGP) and alkaline phosphatase (ALP) were normal. The serum levels of ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770100305

    authors: Hino M,Yamane T,Ohta K,Shioi A,Koyama H,Tahara H,Nishizawa Y,Tatsumi N

    更新日期:2001-07-01 00:00:00

  • Implication of HMOX1 and CCR5 genotypes on clinical phenotype of Egyptian patients with sickle cell anemia.

    abstract::Sickle cell disease (SCD) is a relatively common inherited hemolytic anemia among individuals of African descent. Genetic factors might clarify clinical diversity of the disease and variations in treatment response. Some researchers investigated heme oxygenase-1 (HMOX1) or chemokine receptor 5 (CCR5Δ32) genotypes amon...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-019-03697-9

    authors: Bakr S,Khorshied M,Talha N,Jaffer KY,Soliman N,Eid K,El-Ghamrawy M

    更新日期:2019-08-01 00:00:00