Abstract:
:Acute graft-versus-host disease (aGVHD) has become the important complication post-allogeneic hematopoietic stem cell transplantation. Abnormally activated T cells might play an important role in the pathogenesis of aGVHD. But its exact mechanism remains poorly understood. T cell immune response cDNA 7 (TIRC7) has been identified to be essential in T cell activation; however, the role of TIRC7 in aGVHD remains unclear. The purpose of this study was to measure the expression of TIRC7 and T helper (Th) cells in patients with aGVHD before and after treatment. We showed that TIRC7 levels in aGVHD patients were higher than those of healthy controls and markedly declined after treatment. The levels of IFN-γ (Th1), IL-17 (Th17), and IL-22 (Th22) were in accordance with the grade of aGVHD. In addition, TIRC7 levels were also associated with the severity of aGVHD. In conclusion, TIRC7 might be involved in the pathogenesis of aGVHD and TIRC7 level might be an indicator to evaluate the response of patients with aGVHD to treatment.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Zhu F,Qiao J,Chen W,Pan B,Wu QY,Cao J,Sang W,Yan ZL,Zeng LY,Li ZY,Xu KLdoi
10.1007/s00277-015-2300-8subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1025-32issue
6eissn
0939-5555issn
1432-0584journal_volume
94pub_type
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