Abstract：
:The objective of this study is to compare and evaluate the diagnostic value of hereditary spherocytosis (HS) by three screening tests, comparing mean spherical corpuscular volume (MSCV) to mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and flow cytometric osmotic fragility test. Peripheral blood was collected from 237 participators diagnosed at the First Affiliated Hospital of Guangxi Medical University, including 56 hereditary spherocytosis patients, 86 thalassemia patients, and 95 healthy people. The samples were examined by three tests, and the three screening tests were evaluated by the sensitivity and specificity of tests. The sensitivity was only 41.07%, and specificity was 94.47% when using MCHC >355 g/L as diagnostic criteria. The sensitivity was 89.28%, and specificity was 96.14% when using MSCV < MCV as the optimum cutoff point. When using the residual red cell percentage <23.6% as the diagnostic threshold in flow cytometric osmotic fragility test, the sensitivity was 85.71% and the specificity was 97.24%. Flow cytometry osmotic fragility test or comparing MSCV to MCV combined with smear examination of peripheral red blood cells morphology can be a simple, practical, and accurate hereditary spherocytosis (HS) laboratory screening method.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Tao YF,Deng ZF,Liao L,Qiu YL,Chen WQ,Lin FQdoi
10.1007/s00277-014-2270-2subject
Has Abstractpub_date
2015-05-01 00:00:00pages
747-51issue
5eissn
0939-5555issn
1432-0584journal_volume
94pub_type
杂志文章abstract：:Over 80% of the α-thalassemia cases in southern China are caused by large deletions involving the α-globin gene cluster on chromosome 16p13.3. Here, we characterized a novel 27.6-kb deletion on the α-globin gene cluster in a Chinese family. Its breakpoints were detected to lie between coordinates 9079 and 36718 of the...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-010-1030-1
更新日期：2011-01-01 00:00:00
abstract：:We evaluated the clinical features, treatment modalities, treatment responses, and prognosis of our patients with immune thrombocytopenia (ITP). Furthermore, we estimated the frequency of ITP in the Thrace region of Turkey. Two hundred sixteen patients diagnosed with ITP between 2000 and 2012 at our center were retros...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2220-z
更新日期：2015-03-01 00:00:00
abstract：:Polo-like kinase 2 (SNK/PLK2), a transcriptional target for wild-type p53 and is hypermethylated in a high percentage of multiple myeloma and B cell lymphomas patients. Given these data, we sought to study the methylation status of the specific gene in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), a...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1193-4
更新日期：2011-09-01 00:00:00
abstract：:The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive. To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed t...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-009-0706-x
更新日期：2009-10-01 00:00:00
abstract：:A patient with a lymphoid blast crisis of a chronic myelogenous leukemia (CML) was treated with vindesine, vincristine and prednisone. Blasts disappeared from the peripheral blood but persisted at a level of 60% in the bone marrow. After 5 weeks of continuous therapy, the patient became thrombopenic, and 2 weeks later...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01715138
更新日期：1994-02-01 00:00:00
abstract：:The purpose of this cross-sectional prospective study was to determine the prevalence of anemia among elderly hospitalized patients in Germany and to investigate its association with multidimensional loss of function (MLF). One hundred participants aged 70 years or older from two distinct wards (50 each from an emerge...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2110-4
更新日期：2014-10-01 00:00:00
abstract：:Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-011-1192-5
更新日期：2011-09-01 00:00:00
abstract：:Renal failure is one of the worst complications occurring in multiple myeloma (MM) patients. It does not affect survival if reverted by a prompt chemotherapy before the damage becomes irreversible; therefore, the early diagnosis of renal dysfunction is crucial. High and low molecular weight urinary proteins have prove...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0699-9
更新日期：2003-08-01 00:00:00
abstract：:It has been suggested that human mesenchymal stem cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC to limit radiation-induced skin lesions. Immunodeficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/min) using a (60)Co source to ind...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-006-0166-5
更新日期：2007-01-01 00:00:00
abstract：:The clarification of enlarged lymph nodes is a common issue in clinical routine. By now, open surgery with complete lymph node extirpation, followed by histopathology, is considered as standard. We investigated the value of fine needle aspiration (FNA) and core needle biopsy (CNB) when supporting the conventional morp...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1476-4
更新日期：2012-09-01 00:00:00
abstract：:Post-transplantation cyclophosphamide (PTCy) demonstrated effectiveness to prevent GVHD after haploidentical hematopoietic cell transplantation (HCT). Reducing toxicities with a maximized efficacy is still challenging in HCT. In this retrospective study, we analyzed the safety and efficacy of transplantation from a 1-...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03673-3
更新日期：2019-06-01 00:00:00
abstract：:To determine the value of aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis (IPA), we initiated a prospective randomized multicenter trial. The scheduled intent-to-treat interim analysis included 115 patients (30%) with prolonged neutropenia after chemotherapy for acute myeloid leuk...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01697981
更新日期：1995-12-01 00:00:00
abstract：:The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplas...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s002770050541
更新日期：1999-09-01 00:00:00
abstract：:This retrospective single-center analysis studied the impact of the conditioning and the graft-versus-host disease (GVHD) prophylaxis on outcome in unselected patients allografted for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) secondary to documented prior CMML. A total of 44 patients (med...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-03952-4
更新日期：2020-04-01 00:00:00
abstract：:The anti-CD38 monoclonal antibody daratumumab is approved as a single agent for the treatment of patients with relapsed and refractory multiple myeloma (RRMM) who have received at least three prior lines of therapy, including a proteasome inhibitor (PI) and an immunomodulatory agent (IMID), or who are double refractor...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03655-5
更新日期：2019-06-01 00:00:00
abstract：:A prospective randomized phase III study was performed to evaluate whether intensified cytarabine would induce a higher response rate and longer event-free interval as compared to low-dose cytarabine in chronic myeloid leukemia (CML). One hundred and eighteen patients with CML in early chronic phase entered the study....
journal_title：Annals of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00277-006-0186-1
更新日期：2007-02-01 00:00:00
abstract：:Patients older than 75 years old with multiple myeloma (MM) have shorter survival and are usually treated differently from what features in clinical trials. In this study, the authors characterized the Portuguese population of MM patients above 75 years old, treated between 2009 and 2016. We compared the outcomes obta...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00277-019-03640-y
更新日期：2019-07-01 00:00:00
abstract：:Eculizumab is indicated for the therapy of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, patients on eculizumab are susceptible to Neisseria meningitidis infections. The two mainstays to reduce the risk of infection are vaccination and antibiotic...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-2924-y
更新日期：2017-04-01 00:00:00
abstract：:Spontaneous splenic rupture is a rare, though life-threatening complication of some hematological malignancies and is even more infrequent as the initial symptom of acute lymphoblastic leukemia. We describe the fourth case, to our knowledge, of acute lymphoblastic leukemia presenting as splenic rupture, and for the fi...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01727419
更新日期：1994-03-01 00:00:00
abstract：:Recent developments in the field of targeted therapy have led to the discovery of a new drug, plerixafor, that is a specific inhibitor of the CXCR4 receptor. Plerixafor acts in concert with granulocyte colony-stimulating factor (G-CSF) to increase the number of stem cells circulating in the peripheral blood (PB). Ther...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-010-1098-7
更新日期：2011-05-01 00:00:00
abstract：PURPOSE AND METHODS:Nowadays more people are becoming older. The median age of a patient with non-Hodgkin's lymphoma (NHL) at diagnosis is over 60 years. The incidence of NHL in elderly has increased in the last decades. Therefore, in the future, NHL will be diagnosed more often in the elderly. Data of all patients in ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770000255
更新日期：2001-03-01 00:00:00
abstract：:Although lenalidomide plus dexamethasone (RD) is a therapeutic option for relapsed/refractory multiple myeloma (RRMM), limited real-world clinical data exist. The purpose of this study was to estimate efficacy and safety of RD in RRMM patients of the clinical practice. Data from patients at 25 university hospitals in ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00277-019-03904-7
更新日期：2020-02-01 00:00:00
abstract：:Two male patients with severe and recurrent bleeding episodes under phenprocoumon therapy are reported. Both patients exhibited a strong decrease of their factor IX activities below 1% of normal, whereas the activities of the vitamin K-dependent factors prothrombin, VII, and X were found to be within or above the expe...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050297
更新日期：1997-06-01 00:00:00
abstract：:This study aimed to determine whether dose-dense therapy improves 3-year survival over the standard therapy for untreated aggressive lymphoma. One hundred and fifteen patients with untreated aggressive lymphoma were stratified by center, age, and international prognostic index and randomized to one of two treatment ar...
journal_title：Annals of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00277-009-0811-x
更新日期：2010-03-01 00:00:00
abstract：:Despite high-dose chemotherapy and autografting, the outcome for patients with primary refractory Hodgkin's disease (HD) or multiple relapses remains unsatisfactory. Six pediatric patients (median age: 16 years, range: 11-19) received reduced intensity conditioning and allogeneic peripheral blood stem cell transplanta...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0814-y
更新日期：2004-04-01 00:00:00
abstract：:t(8;16)(p11.2;p13.3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML). We report 15 cases with t(8;16)(p11.2;p13.3). All patients were adult and had AML: 13 women and 2 men, with a median age of 50 years. Ten patients had a history of malignancy and received cytotox...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03637-7
更新日期：2019-05-01 00:00:00
abstract：:The aim of the present study was to investigate the prognostic role of pre- and/or early post-autologous stem cell transplantation (ASCT) (18)F-flourodeoxyglucose (FDG) positron emission tomography (PET) in patients with relapsed/refractory Hodgkin lymphoma. Forty-three consecutive patients were enrolled in this study...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1209-0
更新日期：2011-11-01 00:00:00
abstract：:The clinical experience of the significant difference in iron metabolism between multiple myeloma and myelodysplasia prompted us to analyse patients according to mutation frequency in the hemochromatosis gene (HFE) known to participate in the regulation of iron metabolism. HFE genotyping results were also evaluated in...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-006-0178-1
更新日期：2006-12-01 00:00:00
abstract：:This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002779900136
更新日期：2000-06-01 00:00:00
abstract：:Evaluation of bone marrow involvement (BMI) by conventional bone marrow biopsy (BMB) can generate false-negative results if marrow disease is focal. The sensitivity of 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) in assessing BMI in extranodal NK/T cell lymphoma (ENKL) h...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2289-4
更新日期：2015-06-01 00:00:00
