Abstract:
:Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), occurs secondary to a number of hereditary and acquired disorders of hemostasis. A recently recognized polymorphism in Factor V (FV) gene H1299R (also named HR2) has been reported to be a possible risk factor for the development of VTE. The aim of this study is to evaluate the role of HR2 polymorphism in VTE in a group of Lebanese patients. Seventy-three VTE patients and 125 healthy subjects were examined for HR2. The average ages for the patients and controls were 45.0+/-19.1 years and 35.4+/-18.6 years, respectively. Sixty patients (82.2%) had DVT, eight patients (11%) had PE, and five patients (6.8%) had both. There was significant association between FV Leiden and VTE (p<0.001). HR2 haplotype had a prevalence of 16.4% in patients. VTE patients with normal FV were 2.7 times more likely to have the HR2 haplotype as compared to controls with normal FV (p=0.036, 95% CI=1.04-7.06). We conclude that the FV HR2 haplotype significantly affects the risk of VTE in subjects with normal FV. This finding entails that screening for the HR2 haplotype should be done in VTE patients with normal FV Leiden results.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Otrock ZK,Taher AT,Shamseddeen WA,Zaatari G,Bazarbachi A,Mahfouz RAdoi
10.1007/s00277-008-0543-3subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1013-6issue
12eissn
0939-5555issn
1432-0584journal_volume
87pub_type
杂志文章abstract::Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean p...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0091-7
更新日期:2006-05-01 00:00:00
abstract::Patients older than 75 years old with multiple myeloma (MM) have shorter survival and are usually treated differently from what features in clinical trials. In this study, the authors characterized the Portuguese population of MM patients above 75 years old, treated between 2009 and 2016. We compared the outcomes obta...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00277-019-03640-y
更新日期:2019-07-01 00:00:00
abstract::Since July 2017, different generic imatinib formulations have been introduced in Italy for the treatment of patients with chronic myeloid leukemia (CML). We analyzed 168 chronic phase CML patients treated with branded imatinib for a median of 12 years (range 1-16) at a single institution who switched to a single gener...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-04096-1
更新日期:2020-12-01 00:00:00
abstract::During the last few years, new insights into the biology of mantle cell lymphoma have been obtained. However, with a median survival of only 3 years, mantle cell lymphoma remains the lymphoma subtype with the poorest prognosis. At initial diagnosis most patients present with advanced Ann Arbor stage III or IV and conv...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-003-0774-2
更新日期:2004-02-01 00:00:00
abstract::Several guidelines and recommendations on the management of chronic myeloid leukemia (CML) have been prepared by several scientific societies. The European LeukemiaNet (ELN) appointed a panel of experts who submitted their recommendations to peer-reviewed scientific journals in 2006, 2009, and 2013. Here, we make a cr...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-015-2322-2
更新日期:2015-04-01 00:00:00
abstract::In this paper we report a rare association of a splenic marginal zone B-cell lymphoma with villous lymphocytes and a T-cell large granular lymphocytic leukemia coexpressing CD4 and CD8 as well as CD56 and CD57 natural killer-associated markers in an asymptomatic patient investigated because of an occasional finding of...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770100369
更新日期:2001-11-01 00:00:00
abstract::The objective of this study was to evaluate the efficacy and safety of rituximab in the treatment of patients with idiopathic thrombocytopenic purpura (ITP). A prospective study was performed at Mubarak Al-Kabeer University Hospital involving the use of rituximab in 14 patients who had previously been treated with ste...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0574-9
更新日期:2009-03-01 00:00:00
abstract::Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP wa...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-017-3157-9
更新日期:2018-01-01 00:00:00
abstract::The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplas...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002770050541
更新日期:1999-09-01 00:00:00
abstract::In some instances, because of the lack of mass formation and the absence of prominent lymph node enlargement, diagnosis of lymphoma-associated hemophagocytic syndrome (LAHS) is difficult, which results in the development of progressive disease with unfavorable prognosis. Therefore, in the diagnosis of secondary hemoph...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-011-1239-7
更新日期:2012-01-01 00:00:00
abstract::Data are limited in developing countries regarding the clinicopathologic features and response to therapy of chronic myeloid leukemia (CML) in the era of imatinib (IM). The objective of this study is to report on the clinicoepidemiologic features of CML in Tunisia, to evaluate the long-term outcome of patients in chro...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-017-3224-2
更新日期:2018-04-01 00:00:00
abstract::Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-020-03985-9
更新日期:2020-06-01 00:00:00
abstract::We aimed to evaluate the treatments, particularly the role of corticosteroids, in patients with late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). One hundred and sixty-three consecutive patients who underwent non-T-cell-depleted allo-HSCT and met the criterion...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-018-3290-0
更新日期:2018-07-01 00:00:00
abstract::The prognostic value of cytogenetics in adult acute lymphoblastic leukemia (ALL) is not as established as in childhood ALL. We have analyzed the outcome and prognostic value of karyotype in 84 adults diagnosed with Philadelphia-negative ALL from a single institution that received induction chemotherapy and had success...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-011-1331-z
更新日期:2012-01-01 00:00:00
abstract::Pharmacological agents such as hydroxyurea (HU) have been known to cause induction of fetal hemoglobin and possibly may alleviate the symptoms in thalassemia intermedia patients. Thirty-seven patients with beta-thalassemia intermedia were enrolled to assess response to HU therapy. Major response was defined as transfu...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-005-1026-4
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:The current study was initiated to assess the clinical efficacy and side effects of rituximab in patients with relapsed advanced stage follicular lymphoma. PATIENTS AND METHODS:The study was performed as an open-label non-randomized multicenter phase-II trial and included patients older than 18 years of age wi...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s002770000163
更新日期:2000-09-01 00:00:00
abstract::Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0244-8
更新日期:2007-06-01 00:00:00
abstract::We report about a 28-year-old woman with relapsed mantle cell lymphoma (MCL, centrocytic lymphoma according to the Kiel classification) refractory to salvage chemotherapy. The patient underwent allogeneic bone marrow transplantation from a HLA-identical brother after myeloablative chemotherapy consisting of busulfan, ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000196
更新日期:2000-10-01 00:00:00
abstract::The clinical experience of the significant difference in iron metabolism between multiple myeloma and myelodysplasia prompted us to analyse patients according to mutation frequency in the hemochromatosis gene (HFE) known to participate in the regulation of iron metabolism. HFE genotyping results were also evaluated in...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0178-1
更新日期:2006-12-01 00:00:00
abstract::Alemtuzumab, a humanized anti-CD52 monoclonal antibody, is used in patients with refractory chronic lymphocytic leukaemia (CLL). We report results in health care with alemtuzumab on consecutive, advanced-stage patients from a well-defined geographical region. Records from 1,301 patients (Stockholm-Cancer-Registry 1991...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2105-1
更新日期:2014-10-01 00:00:00
abstract::We encountered two patients who presented with hypochromic-microcytic anemia and were refractory to iron therapy. The symptoms were suggestive of anemia of chronic disease (ACD); however, there was no evidence of any such disease, either inflammatory or malignant. These patients were reminiscent of patients originally...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000180
更新日期:2000-08-01 00:00:00
abstract::This is a retrospective, multicenter study to evaluate biological features and outcome of elderly patients diagnosed with acute lymphoblastic leukemia (ALL) during the last 10 years in ten hematological centers in Poland. Eighty-seven patients aged 60 years or older were studied. To our knowledge, this is one of the l...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-003-0808-9
更新日期:2004-04-01 00:00:00
abstract::Patients with malignancy often present with a variety of coagulation abnormalities which may ultimately lead to recurrent arterial and venous thromboses. Recently the presence of antiphospholipid antibodies in cancer patients has been proposed as one of the potential mechanisms promoting hypercoagulability. Here we re...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-002-0565-1
更新日期:2002-12-01 00:00:00
abstract::Recent studies have demonstrated that direct cell-to-cell interaction is one of the microenvironment factors for transdifferentiation of adult stem cells into cardiomyocytes. We investigated whether transdifferentiation of mesenchymal stem cells (MSCs) into cardiomyocytes was dependent on developmental stages of cocul...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-005-1068-7
更新日期:2005-10-01 00:00:00
abstract::Autoantibody against erythrocytes has occasionally been observed in patients with de novo acute myelocytic leukemia (AML). However, it is not clear whether this autoantibody in AML patients induces frank hemolysis (autoimmune hemolytic anemia, AIHA), as seen in lymphoid neoplasms. We present two de novo AML patients w...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF00663016
更新日期:1996-01-01 00:00:00
abstract::Repeated courses of HD IVIg are reported to induce stable remission in a significant proportion of adults with chronic refractory ITP. We have treated 14 such patients obtaining a remission rate quite comparable to the 5-10% of spontaneous remission. ...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01834386
更新日期:1995-02-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for relapsed, advanced, and otherwise incurable non-Hodgkin's lymphomas (NHL) suggested by the existence of a graft-versus-lymphoma effect. The main complications are graft-versus-host disease and infections. We performed a retrospec...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-017-2934-9
更新日期:2017-05-01 00:00:00
abstract::The prognostic value of peripheral blasts (PB) is not well-studied in patients with myelodysplastic syndromes (MDS). We evaluated the impact of PB on overall survival (OS) and transformation to acute myeloid leukemia (AML) in a large cohort. The MDS database at the Moffitt Cancer Center was retrospectively reviewed to...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-017-3186-4
更新日期:2018-02-01 00:00:00
abstract::The intercellular adhesion molecule 1 (ICAM-1) on endothelial cells is involved in the recruitment of leukocytes to inflammatory sites. In contrast to ICAM-1 expression on endothelial cells, little is known about its function in leukocytes in inflammation. Using ICAM-1-directed anti-sense oligodeoxyribonucleotides (OD...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000168
更新日期:2000-08-01 00:00:00
abstract::Recent studies in iron-depleted women have challenged the current approach of treating iron-deficiency anemia (IDA) with oral iron in divided daily doses. Alternate day dosing leads to more fractional absorption of iron. In this randomized controlled trial, we looked at the efficacy and safety of alternate-day (AD) ve...
journal_title:Annals of hematology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00277-019-03871-z
更新日期:2020-01-01 00:00:00