Leukemia-propagating cells demonstrate distinctive gene expression profiles compared with other cell fractions from patients with de novo Philadelphia chromosome-positive ALL.

abstract：:Recently we described a cutaneous T-cell lymphoma expressing the gamma/delta T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a s...

journal_title：Annals of hematology

authors： Wilhelm M,Meyer P,Batram C,Tony HP,Dummer R,Nestle F,Burg G,Wilms K

更新日期：1992-09-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) has become the important complication post-allogeneic hematopoietic stem cell transplantation. Abnormally activated T cells might play an important role in the pathogenesis of aGVHD. But its exact mechanism remains poorly understood. T cell immune response cDNA 7 (TIRC7) has bee...

journal_title：Annals of hematology

authors： Zhu F,Qiao J,Chen W,Pan B,Wu QY,Cao J,Sang W,Yan ZL,Zeng LY,Li ZY,Xu KL

更新日期：2015-06-01 00:00:00

abstract：:This study retrospectively analyzed the clinical outcome of 172 children with newly diagnosed severe aplastic anemia (SAA) between January 2008 and April 2018, who received rabbit antithymocyte globulin (ATG) and cyclosporine (CsA) as first-line treatment. The median age at diagnosis was 5 years (range, 1-14). The ove...

journal_title：Annals of hematology

authors： Lan Y,Chang L,Yi M,Cai Y,Feng J,Ren Y,Liu C,Chen X,Wang S,Guo Y,Zhang A,Liu L,Zhang J,Zhu X

更新日期：2021-01-01 00:00:00

abstract：:The presenting features of 356 previously untreated multiple myeloma (MM) patients grouped according to age were analyzed in order (a) to elucidate the possible differences in initial clinical and laboratory features between patients younger than 50 years and the older ones and (b) to statistically assess the prognost...

journal_title：Annals of hematology

authors： Corso A,Klersy C,Lazzarino M,Bernasconi C

更新日期：1998-02-01 00:00:00

abstract：:Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is an atypical lympho-proliferative disorder with borderline features that often constitute a diagnostic challenge for the hematopathologist and a therapeutic dilemma for the treating clinician. Morphologically, the involved lymph nodes in this disorder are...

journal_title：Annals of hematology

authors： Sallah AS,Bernard S

更新日期：1996-12-01 00:00:00

abstract：:Autosomal recessive "malignant" osteopetrosis is a rare congenital disorder relating to bone resorption abnormalities. It is believed to arise due to the failure of osteoclasts to resorb immature bone. This leads to abnormal bone marrow cavity formation and, clinically, to the signs and symptoms of bone marrow failure...

journal_title：Annals of hematology

authors： Chen CJ,Lee MY,Hsu ML,Lien SH,Cheng SN

更新日期：2003-01-01 00:00:00

abstract：:Co-inheritance of triplicated α-genes can alter the clinical and hematological phenotypes of β-thalassemias. We evaluated the phenotypic diversity and transfusion requirements in β-thalassemia heterozygotes, homozygotes, and normal individuals with associated α-gene triplication. Clinical and hematological evaluation ...

journal_title：Annals of hematology

authors： Mehta PR,Upadhye DS,Sawant PM,Gorivale MS,Nadkarni AH,Shanmukhaiah C,Ghosh K,Colah RB

更新日期：2015-12-01 00:00:00

abstract：:Second-generation azoles may be more effective than first-generation azoles in the prevention of fungal infections in hematology patients. We performed a systematic review with meta-analysis of randomized controlled trials comparing second- with first-generation azoles in hematology patients with respect to proven or ...

journal_title：Annals of hematology

authors： Ping B,Zhu Y,Gao Y,Yue C,Wu B

更新日期：2013-06-01 00:00:00

abstract：:To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seroposi...

journal_title：Annals of hematology

authors： Park M,Lee YH,Lee SH,Yoo KH,Sung KW,Koo HH,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Lee JW,Chung NG,Cho B,Kim HK,Koh KN,Im HJ,Seo JJ,Baek HJ,Kook H,Hwang TJ,Lee JM,Hah JO,Lim YJ,Park JE,Lyu CJ,Lim YT,Ch

更新日期：2015-03-01 00:00:00

abstract：:The incidence of multiple myeloma (MM) has increased in the last 20 years, particularly in middle and low-middle income countries. Access to diagnostic and prognostic tests and the availability of effective care is highly variable globally. Latin America represents 10% of the world population, distributed in countries...

journal_title：Annals of hematology

authors： Riva E,Schütz N,Peña C,Ruiz-Argüelles G,Hopkins CR,Bove V,Villano F,Andino L,Suárez L,Martínez H,Navarro J,López-Vidal H,Da Costa O,Pineda MR,Rubio Y,Ramirez J,Choque J,Fantl D

更新日期：2020-05-01 00:00:00

abstract：:Gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL) show a spectrum of disease characterized by varying proportions of low-grade and high-grade components. While the natural history and optimum treatment for low-grade gastric MALT lymphoma and DLBCL is well established, ...

journal_title：Annals of hematology

authors： Ang MK,Hee SW,Quek R,Yap SP,Loong S,Tan L,Tao M,Lim ST

更新日期：2009-05-01 00:00:00

abstract：:In the present study, we questioned whether the cholesterol synthesis inhibitor lovastatin potentiates the cytotoxicity of chemotherapeutic agents in the primitive CD34(+) subpopulation of acute myeloid leukemia (AML) cells. AML mononuclear cells (n = 17) were sorted in CD34(+) and CD34(-) fractions and compared to no...

journal_title：Annals of hematology

authors： de Jonge-Peeters SD,van der Weide K,Kuipers F,Sluiter WJ,de Vries EG,Vellenga E

更新日期：2009-06-01 00:00:00

abstract：:The intercellular adhesion molecule 1 (ICAM-1) on endothelial cells is involved in the recruitment of leukocytes to inflammatory sites. In contrast to ICAM-1 expression on endothelial cells, little is known about its function in leukocytes in inflammation. Using ICAM-1-directed anti-sense oligodeoxyribonucleotides (OD...

journal_title：Annals of hematology

authors： Steidl U,Haas R,Kronenwett R

更新日期：2000-08-01 00:00:00

abstract：:Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentat...

journal_title：Annals of hematology

authors： Laurentino MR,Parente Filho SLA,Parente LLC,da Silva Júnior GB,Daher EF,Lemes RPG

更新日期：2019-12-01 00:00:00

abstract：:To characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most co...

journal_title：Annals of hematology

authors： Kwong YL,Au WY,Leung AY,Tse EW

更新日期：2010-04-01 00:00:00

abstract：:Despite significant advances in the treatment of complications requiring intensive care unit (ICU) admission, ICU mortality remains high for patients after allogeneic stem cell transplantation. We evaluated the role of thrombocytopenia and poor graft function in allogeneic stem cell recipients receiving ICU treatments...

journal_title：Annals of hematology

authors： Turki AT,Lamm W,Schmitt C,Bayraktar E,Alashkar F,Metzenmacher M,Wohlfarth P,Beelen DW,Liebregts T

更新日期：2019-02-01 00:00:00

abstract：:Early mortality remains a major challenge for the treatment of hemophagocytic lymphohistiocytosis (HLH), which warrants the need for prompt risk stratification in the early phase of the disease. We retrospectively analyzed clinical features of a cohort of pediatric patients managed at a tertiary hospital in southern C...

journal_title：Annals of hematology

authors： Bin Q,Gao JH,Luo JM

更新日期：2016-09-01 00:00:00

abstract：:Although lenalidomide plus dexamethasone (RD) is a therapeutic option for relapsed/refractory multiple myeloma (RRMM), limited real-world clinical data exist. The purpose of this study was to estimate efficacy and safety of RD in RRMM patients of the clinical practice. Data from patients at 25 university hospitals in ...

journal_title：Annals of hematology

authors： Jo JC,Lee HS,Kim K,Lee JJ,Yoon SS,Bang SM,Kim JS,Eom HS,Yoon DH,Lee Y,Shin HJ,Park Y,Lee WS,Do YR,Mun YC,Lee MH,Kim HJ,Kim SH,Kim MK,Lim SN,Cho SH,Park SK,Yi JH,Lee JH,Kim J,Min CK,Korean Multiple Myel

更新日期：2020-02-01 00:00:00

abstract：:Recently, the combination of rituximab and bendamustine (R-Benda) has been defined as highly active in patients with follicular lymphomas, but little is known about the efficacy of R-Benda in mucosa-associated lymphoid tissue (MALT) lymphoma. In a retrospective analysis, we have defined 14 patients with MALT lymphoma ...

journal_title：Annals of hematology

authors： Kiesewetter B,Mayerhoefer ME,Lukas J,Zielinski CC,Müllauer L,Raderer M

更新日期：2014-02-01 00:00:00

abstract：:The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplas...

journal_title：Annals of hematology

authors： Steinmetz HT,Schulz A,Staib P,Scheid C,Glasmacher A,Neufang A,Franklin J,Tesch H,Diehl V,Dias Wickramanayake P

更新日期：1999-09-01 00:00:00

abstract：:Children with sickle cell disease (SCD) benefit from newborn screening, because life-threatening complications can be prevented by pre-symptomatic diagnosis. In Germany, the immigration of people from endemic countries is steadily growing. Comprehensive data about the epidemiology and prevalence of SCD in Germany are ...

journal_title：Annals of hematology

authors： Kunz JB,Awad S,Happich M,Muckenthaler L,Lindner M,Gramer G,Okun JG,Hoffmann GF,Bruckner T,Muckenthaler MU,Kulozik AE

更新日期：2016-02-01 00:00:00

abstract：:Recent studies in iron-depleted women have challenged the current approach of treating iron-deficiency anemia (IDA) with oral iron in divided daily doses. Alternate day dosing leads to more fractional absorption of iron. In this randomized controlled trial, we looked at the efficacy and safety of alternate-day (AD) ve...

journal_title：Annals of hematology

authors： Kaundal R,Bhatia P,Jain A,Jain A,Nampoothiri RV,Mishra K,Jandial A,Goni D,Sandal R,Jindal N,Meshram A,Sharma R,Khaire N,Singh C,Khadwal A,Prakash G,Das R,Varma N,Varma S,Malhotra P,Lad DP

更新日期：2020-01-01 00:00:00

abstract：:Follicular lymphoma (FL) is generally considered an indolent disorder. With modern day treatments, long remissions are often achieved both in the front-line and relapsed setting. However, a subset of patients has a more aggressive course and a worse outcome. Their identification is the main purpose of modern day progn...

journal_title：Annals of hematology

authors： Sorigue M,Sancho JM

更新日期：2018-02-01 00:00:00

abstract：:Hematopoietic chimerism can be used as a tool for patient management after allogeneic hematopoietic stem cell transplantation (HSCT). An increase in the proportion of recipient cells after transplantation is strongly associated with relapse in chronic myeloid leukemia. However, in acute myeloid leukemia (AML) the sign...

journal_title：Annals of hematology

authors： Waterhouse M,Bertz H,Finke J

更新日期：2014-02-01 00:00:00

abstract：:A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriam...

journal_title：Annals of hematology

authors： Shitara T,Suetake N,Yugami S,Sotomatu M,Oshima Y,Ijima H,Kuroume T,Nakazawa S

更新日期：1992-12-01 00:00:00

abstract：:Alemtuzumab, a humanized anti-CD52 monoclonal antibody, is used in patients with refractory chronic lymphocytic leukaemia (CLL). We report results in health care with alemtuzumab on consecutive, advanced-stage patients from a well-defined geographical region. Records from 1,301 patients (Stockholm-Cancer-Registry 1991...

journal_title：Annals of hematology

authors： Eketorp Sylvan S,Lundin J,Ipek M,Palma M,Karlsson C,Hansson L

更新日期：2014-10-01 00:00:00

abstract：:Amifostine increases in vitro burst-forming unit-erythroid and colony-forming unit-granulocyte/granulcoyte-macrophage cultured from bone-marrow cells from patients with myelodysplastic syndrome (MDS). Several small clinical studies give divergent informations about the potential of amifostine as single agent to improv...

journal_title：Annals of hematology

authors： Hofmann WK,Seipelt G,Ottmann OG,Kalina U,Koschmieder S,Brücher J,Frickhofen N,Klausmann M,Mitrou PS,Hoelzer D

更新日期：2000-05-01 00:00:00

abstract：:Reactive oxygen intermediates (ROI) generated in the respiratory burst reaction are crucial for the killing of bacteria and fungi in phagocytes. The key enzyme for the respiratory burst reaction is the NADPH oxidase. Reactive oxygen intermediates have additionally been proposed to be of general importance for the expr...

journal_title：Annals of hematology

authors： v Bernuth H,Kulka C,Roesler J,Gahr M,Rösen-Wolff A

更新日期：2004-04-01 00:00:00

abstract：:We investigated whether human peripheral blood mononuclear cells (PBMC) express prothrombinase following stimulation with bacterial lipopolysaccharide (LPS). LPS-stimulated PBMC devoid of contaminating platelets failed to activate prothrombin directly. Addition of platelets did not result in expression of prothrombina...

journal_title：Annals of hematology

authors： Pejler G,Geczy CL

更新日期：2001-05-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a protein kinase involved in the phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway. It plays a pivotal role in the control of cell proliferation, survival, and angiogenesis with multiple and frequent dysregulations of this pathway in human tumors. Temsirolimus is a...

journal_title：Annals of hematology

authors： Zoellner AK,Weiglein T,Hutter G,Zimmermann Y,Cieplik HC,Hess G,Dreyling M

更新日期：2016-02-01 00:00:00