Abstract:
:A case of an 82-year-old man who suffered an acute ST-elevation myocardial infarction while receiving treatment with intravenous immunoglobulin (IVIg) for thrombocytopenia is discussed. A total of 29 other cases of thromboembolism related to IVIg therapy have been reported, and the incidence seems to be especially high in elderly patients with cerebrovascular risk factors and also in patients with paraproteinemias. Possible mechanisms to account for this complication may include some of the following: platelet activation, increased blood viscosity, contamination of IVIg with activated coagulation factors, induced arterial vasospasm, production of vasoconstrictive cytokines, and vasculitis. Ten patients out of the 29 reported patients died from this serious complication. In our patient, spontaneous reperfusion occurred without any treatment and he had an uneventful outcome.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Hefer D,Jaloudi Mdoi
10.1007/s00277-004-0895-2subject
Has Abstractpub_date
2004-10-01 00:00:00pages
661-5issue
10eissn
0939-5555issn
1432-0584journal_volume
83pub_type
杂志文章,评审abstract::Anthracyclines are a major component in the therapy of non-Hodgkin's lymphoma. However, due to their cardiac toxicity potential, curative and palliative treatment is often limited in patients with preexisting cardiac dysfunction. Liposomal doxorubicin formulations have been described to be less cardiotoxic than conven...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-011-1308-y
更新日期:2012-03-01 00:00:00
abstract::Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-006-0244-8
更新日期:2007-06-01 00:00:00
abstract::Monoclonal immunoglobulin, as a marker for monoclonal gammopathy, is evaluated by protein electrophoresis (PEP) and immunofixation electrophoresis (IFE). However, PEP and IFE are not satisfactory in sensitivity, objectivity, and facility. Recently, a highly sensitive, automated immunoassay for measurement of free ligh...
journal_title:Annals of hematology
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doi:10.1007/s00277-005-1047-z
更新日期:2005-09-01 00:00:00
abstract::A retrospective study of 120 patients with the clinically and histologically established diagnosis of idiopathic (primary) myelofibrosis (IMF) was performed to determine prognostic factors of predictive value, including parameters characterizing the dynamics of hematopoietic cell kinetics. In contrast to previous stud...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050474
更新日期:1999-02-01 00:00:00
abstract::Reactive oxygen intermediates (ROI) generated in the respiratory burst reaction are crucial for the killing of bacteria and fungi in phagocytes. The key enzyme for the respiratory burst reaction is the NADPH oxidase. Reactive oxygen intermediates have additionally been proposed to be of general importance for the expr...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-003-0837-4
更新日期:2004-04-01 00:00:00
abstract::Currently, the diagnosis of acute graft-versus-host disease (aGVHD) is mainly based on clinical symptoms and biopsy results. This study was designed to further explore new no noninvasive biomarkers for aGVHD prediction/diagnosis. We profiled miRNAs in serum pools from patients with aGVHD (grades II-IV) (n = 9) and non...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-016-2781-0
更新日期:2016-10-01 00:00:00
abstract::Acute leukemia (AL) patients may experience more than one episode of bloodstream infection (BSI) caused by the same pathogen during the entire chemotherapy program. In order to identify factors influencing BSI recurrence (R-BSI) during subsequent phases of treatment, we analyzed all BSIs occurring to consecutively tre...
journal_title:Annals of hematology
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更新日期:2014-05-01 00:00:00
abstract::The aim of the present study was to investigate the prevalence of chronic idiopathic neutropenia of adults (CINA) among an apparently healthy population born and living on the island of Crete. The study was carried out with 778 subjects, 392 men aged 16-78 years (median 43 years) and 386 women aged 15-79 years (median...
journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
abstract::Nodal peripheral T cell lymphomas (nPTCL) present aggressive clinical course, and its heterogeneous nature and poor prognosis with current therapeutic strategies make it a target for the development of new prognostic markers. Thus, we investigated tumor-associated macrophages (TAM) according to the number of cells exp...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
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更新日期:2019-09-01 00:00:00
abstract::Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...
journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00277-020-03985-9
更新日期:2020-06-01 00:00:00
abstract::Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchosc...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2172-3
更新日期:2015-01-01 00:00:00
abstract::Stem cell factor (SCF), also termed mast cell growth factor or c-kit ligand, plays a central role in the regulation of hematopoiesis and maintenance of viability of hematopoietic cells. We used a new murine monoclonal antibody (MAb) specific for canine SCF to further dissect the role of SCF in vitro and in vivo. This ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050168
更新日期:1996-04-01 00:00:00
abstract::Polo-like kinase 2 (SNK/PLK2), a transcriptional target for wild-type p53 and is hypermethylated in a high percentage of multiple myeloma and B cell lymphomas patients. Given these data, we sought to study the methylation status of the specific gene in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), a...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-011-1193-4
更新日期:2011-09-01 00:00:00
abstract::Overproduction of proinflammatory cytokines is characteristic of hemophagocytic syndrome (HPS), a highly lethal inflammatory disease. Peripheral blood monocytes include two distinct subpopulations according to surface antigen expression: a major type, CD14(+)/CD16(-) (classical monocytes), and a minor type, CD14(+)/CD...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-007-0332-4
更新日期:2007-11-01 00:00:00
abstract::Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disease with thrombosis as a major complication. The mechanism of thrombosis and related risk factors in PNH patients are still not well characterized. We retrospectively enrolled 99 patients with newly diagnosed PNH at our institute from 2011 to 2016....
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-019-03770-3
更新日期:2019-10-01 00:00:00
abstract::Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystem disorder characterized by proliferation and diffuse infiltration multiple organs with histiocytes, including the central nervous system (CNS). Neurological manifestations of HLH have been recognized in different studies with children, but they remain relat...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-017-3035-5
更新日期:2017-08-01 00:00:00
abstract::Transplantation of peripheral blood stem cells (PBSC), positively and/or negatively selected immediately after harvest, has become a widely applied therapeutic option in hematological or oncological patients. The following case of peripheral blood stem cell transplantation represents the first case of successful trans...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000243
更新日期:2001-02-01 00:00:00
abstract::The aim of this epidemiologic population survey was to assess the penetrance of the most frequent hemochromatosis (HFE) gene variants in ethnic Danish men. A cohort of 6,020 men aged 30-53 years was screened for HFE C282Y, H63D, and S65C variants by restriction fragment length polymorphism analysis. Subsequently, iron...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0679-1
更新日期:2009-08-01 00:00:00
abstract::Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean p...
journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-008-0521-9
更新日期:2008-11-01 00:00:00
abstract::Bernard-Soulier syndrome (BSS) is a rare autosomal recessive genetic disorder characterized by thrombocytopenia, circulating giant platelets, and prolonged bleeding time. BSS is explained by a defect in primary hemostasis owing to quantitative or qualitative defect in the GPIb-IX-V complex, composed of four subunits: ...
journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
abstract::Iron deficiency anemia is among the most frequent causes of disability. Intravenous iron is the quickest way to correct iron deficiency, bypassing the bottleneck of iron intestinal absorption, the only true mechanism of iron balance regulation in human body. Intravenous iron administration is suggested in patients who...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-020-04361-3
更新日期:2020-12-02 00:00:00
abstract::Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few ...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-003-0815-x
更新日期:2004-08-01 00:00:00
abstract::Autoantibody against erythrocytes has occasionally been observed in patients with de novo acute myelocytic leukemia (AML). However, it is not clear whether this autoantibody in AML patients induces frank hemolysis (autoimmune hemolytic anemia, AIHA), as seen in lymphoid neoplasms. We present two de novo AML patients w...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF00663016
更新日期:1996-01-01 00:00:00
abstract::Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies associated with an erythroid maturation defect, resulting in anemia. Treatments for MDS include erythropoiesis-stimulating agents (ESAs). The identification of prognostic markers is important to help predict response and improve outcomes. Various...
journal_title:Annals of hematology
pub_type: 杂志文章,评审
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abstract::Burkitt lymphoma (BL) is an aggressive B-cell lymphoma more common in children comprising one third of pediatric non-Hodgkin lymphoma cases. The recent discovery in BL pathogenesis highlighted the activation of PI3K pathway in cooperation with Myc in the development of BL. In this study, we demonstrated that PI3K/Akt ...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2021-4
更新日期:2014-06-01 00:00:00
abstract::Less toxic and more active treatments are needed for indolent lymphomas as there is no curative treatment, and patients eventually die due to complications related to their disease. The purpose of the present study was to assess the antitumour activity of the combination of low doses of Enzastaurin and Lenalidomide (R...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-012-1490-6
更新日期:2012-10-01 00:00:00
abstract::Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and non-relapse mortality. The FLAMSA-RIC protocol for high-risk patients with acute myeloid leukemia (AML) and myel...
journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
abstract::The main purpose of this report is to focus on the importance of an accurate etiologic diagnosis of gastrointestinal complications during chemotherapy for acute myeloid leukemia, taking into account that a syndrome characterized by bowel wall thickening associated with diarrhea and abdominal pain may have etiologies d...
journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-003-0755-5
更新日期:2004-03-01 00:00:00
abstract::Pharmacological agents such as hydroxyurea (HU) have been known to cause induction of fetal hemoglobin and possibly may alleviate the symptoms in thalassemia intermedia patients. Thirty-seven patients with beta-thalassemia intermedia were enrolled to assess response to HU therapy. Major response was defined as transfu...
journal_title:Annals of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s00277-005-1026-4
更新日期:2005-07-01 00:00:00