Impact of extramedullary plasmacytomas on outcomes according to treatment approach in newly diagnosed symptomatic multiple myeloma.

abstract：:Chronic hepatitis C (CHC) and iron overload are the main causes of liver disease in β-thalassemia major (βTM). There is limited data regarding the course of CHC in this population. All patients (n=144) from the thalassemia centre of the University Hospital of Patras were evaluated (January 1981 to June 2012). Patients...

journal_title：Annals of hematology

authors： Triantos C,Kourakli A,Kalafateli M,Giannakopoulou D,Koukias N,Thomopoulos K,Lampropoulou P,Bartzavali C,Fragopanagou H,Kagadis GC,Christofidou M,Tsamandas A,Nikolopoulou V,Karakantza M,Labropoulou-Karatza C

更新日期：2013-06-01 00:00:00

abstract：:In spite of their recognized risk of thrombosis, patients with myeloproliferative neoplasms (MPN) show little or no abnormalities of traditional coagulation tests, perhaps because these are unable to represent the balance between pro- and anticoagulants nor the effect of platelets and blood cells. We investigated whet...

journal_title：Annals of hematology

authors： Tripodi A,Chantarangkul V,Gianniello F,Clerici M,Lemma L,Padovan L,Gatti L,Mannucci PM,Peyvandi F

更新日期：2013-12-01 00:00:00

abstract：:Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is an atypical lympho-proliferative disorder with borderline features that often constitute a diagnostic challenge for the hematopathologist and a therapeutic dilemma for the treating clinician. Morphologically, the involved lymph nodes in this disorder are...

journal_title：Annals of hematology

authors： Sallah AS,Bernard S

更新日期：1996-12-01 00:00:00

abstract：:Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...

journal_title：Annals of hematology

authors： Görg C,Wollenberg B,Beyer J,Stolte MS,Neubauer A

更新日期：2005-01-01 00:00:00

abstract：:Second-generation azoles may be more effective than first-generation azoles in the prevention of fungal infections in hematology patients. We performed a systematic review with meta-analysis of randomized controlled trials comparing second- with first-generation azoles in hematology patients with respect to proven or ...

journal_title：Annals of hematology

authors： Ping B,Zhu Y,Gao Y,Yue C,Wu B

更新日期：2013-06-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disease with thrombosis as a major complication. The mechanism of thrombosis and related risk factors in PNH patients are still not well characterized. We retrospectively enrolled 99 patients with newly diagnosed PNH at our institute from 2011 to 2016....

journal_title：Annals of hematology

authors： Huang Y,Liu X,Chen F,Zhou W,Li H,Long Z,Yang C,Chen M,Han B

更新日期：2019-10-01 00:00:00

abstract：:Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the "unexplained" decrease in the number of circulating neutrophils. Serum inflammatory cytokines and chemokines are increased in CINA. In addition, cytokines gene polymorphisms are associated with increased levels of respectiv...

journal_title：Annals of hematology

authors： Addas-Carvalho M,de Paula EV,Lima CS,Saad ST

更新日期：2005-10-01 00:00:00

abstract：:Standard conditioning for allogeneic bone marrow transplantation induces high transplant-related mortality (TRM) in patients with a poor performance status. Less intensive regimens have been tested to reduce the TRM; our purpose was to evaluate the feasibility and tolerability of a new combination: thiotepa and fludar...

journal_title：Annals of hematology

authors： Alessandrino EP,Bernasconi P,Colombo AA,Caldera D,Bonfichi M,Pagnucco G,Malcovati L,Varettoni M,Lazzarino M,Bernasconi C

更新日期：2001-09-01 00:00:00

abstract：:Somatic mutations in the SF3B1 gene, a gene encoding the splicing factor 3B subunit 1, were recently reported in myelodysplastic syndromes (MDS), particularly in the presence of ring sideroblasts (RS). The authors investigated the prevalence and clinical significance of SF3B1 mutations in Korean patients with myeloid ...

journal_title：Annals of hematology

authors： Seo JY,Lee KO,Kim SH,Kim K,Jung CW,Jang JH,Kim HJ

更新日期：2014-04-01 00:00:00

abstract：:This study aimed to determine the clinical characteristics and prognostic significance of the meningioma 1 (MN1) gene and MN1-associated microRNA expression in Chinese adult de novo acute myeloid leukemia (AML) patients. The expression level of MN1, microRNA-20 (miR-20a), and microRNA-181b (miR-181b) in bone marrow mo...

journal_title：Annals of hematology

authors： Xiang L,Li M,Liu Y,Cen J,Chen Z,Zhen X,Xie X,Cao X,Gu W

更新日期：2013-08-01 00:00:00

abstract：:Although lenalidomide plus dexamethasone (RD) is a therapeutic option for relapsed/refractory multiple myeloma (RRMM), limited real-world clinical data exist. The purpose of this study was to estimate efficacy and safety of RD in RRMM patients of the clinical practice. Data from patients at 25 university hospitals in ...

journal_title：Annals of hematology

authors： Jo JC,Lee HS,Kim K,Lee JJ,Yoon SS,Bang SM,Kim JS,Eom HS,Yoon DH,Lee Y,Shin HJ,Park Y,Lee WS,Do YR,Mun YC,Lee MH,Kim HJ,Kim SH,Kim MK,Lim SN,Cho SH,Park SK,Yi JH,Lee JH,Kim J,Min CK,Korean Multiple Myel

更新日期：2020-02-01 00:00:00

abstract：:The hemoglobinopathies are a group of disorders passed down through families (inherited) in which there is abnormal production or structure of the hemoglobin molecule. They are among the most common inherited diseases around the world. Those that produce abnormal hemoglobin are called structural hemoglobinopathies whi...

journal_title：Annals of hematology

authors： de la Fuente-Gonzalo F,Nieto JM,Villegas A,González FA,Martínez R,Ropero P

更新日期：2019-07-01 00:00:00

abstract：:Eight patients who were carriers of beta-thalassemia induced by the cd121 (G-->T) mutation are described in four nonrelated Dutch families. This mutant, which is considered rare and inherited in a dominant manner, is expressed in a different way among each of the four families and even among carriers of the same famil...

journal_title：Annals of hematology

authors： Giordano PC,Harteveld CL,Michiels JJ,Terpstra W,Schelfhout LJ,Appel IM,Batelaan D,van Delft P,Plug RJ,Bernini LF

更新日期：1998-12-01 00:00:00

abstract：:Hydroxyurea is increasingly being used to control myeloproliferative disorders, in part because of its relative lack of side effects. We present a case of life-threatening alveolitis in a patient treated with hydroxyurea for myeloproliferative syndrome. Absence of exposure to other drugs and the clinical course sugges...

journal_title：Annals of hematology

authors： Hennemann B,Bross KJ,Reichle A,Andreesen R

更新日期：1993-09-01 00:00:00

abstract：:We retrospectively analyzed overall survival and survival after progression in 91 patients with low-grade follicular lymphoma (LGFL). Histological subtype was B in 75 patients and C in 16 patients. Twelve patients with localized disease received involved-field radiotherapy; seven patients without bulky disease had no ...

journal_title：Annals of hematology

authors： Morel P,Dupriez B,Plantier-Colcher I,Gosselin B,Declercq C,Pollet JP,Bauters F

更新日期：1993-06-01 00:00:00

abstract：:The present paper summarizes the results of the second German consensus meeting on immunogenetic donor search for allotransplantation of hematopoietic stem cells held in Essen in November 1999 under the auspices of the German Society for Immunogenetics (DGI) and the German Working Party for Blood and Marrow Transplant...

journal_title：Annals of hematology

authors： Ottinger HD,Müller CR,Goldmann SF,Albert E,Arnold R,Beelen DW,Blasczyk R,Bunjes D,Casper J,Ebell W,Ehninger G,Eiermann T,Einsele H,Fauser A,Ferencik S,Finke J,Hertenstein B,Heyll A,Klingebiel T,Knipper A,Kremens B

更新日期：2001-12-01 00:00:00

abstract：:In multiple myeloma, the polymerase chain reaction (PCR) of the Ig heavy chain with allele-specific oligonucleotide (ASO) primers is a common and well-described method of identifying the tumor clone in peripheral blood (PB), bone marrow (BM) or leukapheresis products (LA). A factor which is crucial to the detection of...

journal_title：Annals of hematology

authors： Draube A,Pfister R,Vockerodt M,Schuster S,Kube D,Diehl V,Tesch H

更新日期：2001-02-01 00:00:00

abstract：:Cytomegalovirus (CMV) can cause end-organ diseases including pneumonia, gastroenteritis, retinitis, and encephalitis in hematopoietic stem cell transplantation recipients. Potential differences among different CMV diseases remain uncertain. This study aimed to compare the clinical characteristics, risk factors, and mo...

journal_title：Annals of hematology

authors： Meng XY,Fu HX,Zhu XL,Wang JZ,Liu X,Yan CH,Zhang YY,Mo XD,Wang Y,Han W,Chen YH,Chen DB,Liu HX,Chang YJ,Xu LP,Liu KY,Huang XJ,Zhang XH

更新日期：2020-11-01 00:00:00

abstract：:Monoclonal immunoglobulin, as a marker for monoclonal gammopathy, is evaluated by protein electrophoresis (PEP) and immunofixation electrophoresis (IFE). However, PEP and IFE are not satisfactory in sensitivity, objectivity, and facility. Recently, a highly sensitive, automated immunoassay for measurement of free ligh...

journal_title：Annals of hematology

authors： Kang SY,Suh JT,Lee HJ,Yoon HJ,Lee WI

更新日期：2005-09-01 00:00:00

abstract：:MicroRNAs are short noncoding RNAs, known regulators of several signaling pathways cell differentiation and proliferation, development, and apoptosis, which are deregulated in acute leukemia. Mixed lineage leukemia (MLL) gene encodes a protein with histone methyltransferase activity, which is essential for the fine tu...

journal_title：Annals of hematology

authors： Benetatos L,Vartholomatos G

更新日期：2013-11-01 00:00:00

abstract：:Burkitt lymphoma (BL) is an aggressive B-cell lymphoma more common in children comprising one third of pediatric non-Hodgkin lymphoma cases. The recent discovery in BL pathogenesis highlighted the activation of PI3K pathway in cooperation with Myc in the development of BL. In this study, we demonstrated that PI3K/Akt ...

journal_title：Annals of hematology

authors： Ferreira AC,Robaina MC,Rezende LM,Severino P,Klumb CE

更新日期：2014-06-01 00:00:00

abstract：:Umbilical cord blood is capable of hematopoietic stem cell reconstitution in children. However, the major limitation of cord blood is a relatively low content of pluripotent progenitor cells. Thus, safe engraftment for adolescents and for adults is still not predictable and a technology for ex vivo expansion of umbili...

journal_title：Annals of hematology

authors： Schwinger W,Benesch M,Lackner H,Kerbl R,Walcher M,Urban C

更新日期：1999-08-01 00:00:00

abstract：:The possibility that human mesenchymal stromal cells (hMSC) may derive from the malignant clone in hematological malignancies (HM) is a controversial issue. In order to clarify hMSC origin and disclose possible cytogenetic heterogeneity in hMSC belonging to different patients, bone marrow (BM)-derived hMSC samples fro...

journal_title：Annals of hematology

authors： Campioni D,Bardi MA,Cavazzini F,Tammiso E,Pezzolo E,Pregnolato E,Volta E,Cuneo A,Lanza F

更新日期：2012-10-01 00:00:00

abstract：:Data are limited in developing countries regarding the clinicopathologic features and response to therapy of chronic myeloid leukemia (CML) in the era of imatinib (IM). The objective of this study is to report on the clinicoepidemiologic features of CML in Tunisia, to evaluate the long-term outcome of patients in chro...

journal_title：Annals of hematology

authors： Ben Lakhal R,Ghedira H,Bellaaj H,Ben Youssef Y,Menif S,Manai Z,Bedoui M,Lakhal A,M'Sadek F,Elloumi M,Khélif A,Ben Romdhane N,Laatiri MA,Ben Othmen T,Meddeb B

更新日期：2018-04-01 00:00:00

abstract：:This study retrospectively analyzed the clinical outcome of 172 children with newly diagnosed severe aplastic anemia (SAA) between January 2008 and April 2018, who received rabbit antithymocyte globulin (ATG) and cyclosporine (CsA) as first-line treatment. The median age at diagnosis was 5 years (range, 1-14). The ove...

journal_title：Annals of hematology

authors： Lan Y,Chang L,Yi M,Cai Y,Feng J,Ren Y,Liu C,Chen X,Wang S,Guo Y,Zhang A,Liu L,Zhang J,Zhu X

更新日期：2021-01-01 00:00:00

abstract：:Platelet concentrates were pretreated with a stable synthetic prostacyclin analogue (Iloprost) at two different concentrations before the second centrifugation step (pelleting step) of preparation. This resulted in loss of platelet sensitivity to aggregating agents. To mimic the situation after transfusion and to asse...

journal_title：Annals of hematology

authors： Elias M,Heethuis A,Weggemans M,Bom V,Blom N,McShine RL,Halie MR,Smit Sibinga CT

更新日期：1992-06-01 00:00:00

abstract：:Idarubicin belongs to a group of anthracyclines in which the methoxyl group in position 4 of the D ring in the aglycone moiety is replaced by a hydrogen atom. Lipophilicity is increased compared with other anthracyclines; as a result, idarubicin is the first anthracycline that can be administered orally while at the s...

journal_title：Annals of hematology

authors： Goebel M

更新日期：1993-01-01 00:00:00

abstract：:The clinical course of three patients with acute promyelocytic leukemia receiving all-trans retinoic acid (ATRA) as a single agent is reported. The first two patients were in first and second relapse of their leukemia that had occurred despite maintenance treatment with 13-cis retinoic acid after chemotherapy-induced ...

journal_title：Annals of hematology

authors： Runde V,Aul C,Südhoff T,Heyll A,Schneider W

更新日期：1992-06-01 00:00:00

abstract：:Autosomal recessive "malignant" osteopetrosis is a rare congenital disorder relating to bone resorption abnormalities. It is believed to arise due to the failure of osteoclasts to resorb immature bone. This leads to abnormal bone marrow cavity formation and, clinically, to the signs and symptoms of bone marrow failure...

journal_title：Annals of hematology

authors： Chen CJ,Lee MY,Hsu ML,Lien SH,Cheng SN

更新日期：2003-01-01 00:00:00

abstract：:The general objective of this study was to evaluate the risks of agranulocytosis and aplastic anemia in relation to drug use. Other potential risk factors, including history of infectious mononucleosis, were also evaluated. In an international population-based case-control study, cases of agranulocytosis and aplastic ...

journal_title：Annals of hematology

authors： Levy M,Kelly JP,Kaufman DW,Shapiro S

更新日期：1993-10-01 00:00:00