Abstract：
:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disease with thrombosis as a major complication. The mechanism of thrombosis and related risk factors in PNH patients are still not well characterized. We retrospectively enrolled 99 patients with newly diagnosed PNH at our institute from 2011 to 2016. According to binary logistic regression model analysis, we first identified four baseline clinical risk factors which may be associated with incidence of thrombosis in the PNH cohort, including PNH clone sizes (fluorescent aerolysin of neutrophil) ≤ 80 (OR 1.056, 95%CI 1.016-1.097, P = 0.005), hemoglobin ≤ 75 g/L (OR 4.202, 95%CI 0.984-17.954, P = 0.053), platelet > 100 × 109/L (OR 6.547, 95%CI 1.490-28.767, P = 0.013) and rs495828 = G (OR 5.243, 95%CI 1.314-20.916, P = 0.019). These independent risk factors were combined together to develop a risk model to evaluate thrombosis risk (AUC = 0.756, 95%CI 0.607-0.905, P < 0.001). Our risk model revealed a higher cumulative incidence of thrombosis and an earlier thrombosis events in PNH patients with high risk (risk score ≥ 23) compared with those with low risk (risk score < 23, P < 0.001 and P = 0.043, respectively). Although with some limitations, we set up a prediction model for thrombosis risk in patients with PNH for the first time, but it needed to be verified in a prospective study with larger patients and longer follow-up time in the future.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Huang Y,Liu X,Chen F,Zhou W,Li H,Long Z,Yang C,Chen M,Han Bdoi
10.1007/s00277-019-03770-3subject
Has Abstractpub_date
2019-10-01 00:00:00pages
2283-2291issue
10eissn
0939-5555issn
1432-0584pii
10.1007/s00277-019-03770-3journal_volume
98pub_type
临床试验,杂志文章abstract：:Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression t...
journal_title：Annals of hematology
pub_type： 共识发展会议,杂志文章,实务指引,评审
doi：10.1007/s00277-016-2621-2
更新日期：2016-04-01 00:00:00
abstract：:Follicular lymphoma (FL) is a low-grade lymphoma that is usually characterized by generalized lymphadenopathy. Extranodal invasion by FL generally involves the bone marrow, skin, and duodenum; splenic infiltration often occurs in the advanced stages. However, primary splenic FL is very rare. Hence, few studies have be...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-017-3139-y
更新日期：2017-12-01 00:00:00
abstract：:Previous studies have suggested that adherence to imatinib therapy can be an obstacle among patients with chronic myeloid leukemia (CML). We studied adherence to imatinib therapy among CML patients treated at the Sahlgrenska University Hospital. We identified all CML patients that were alive at the 1st of January 2010...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1359-0
更新日期：2012-05-01 00:00:00
abstract：:Anthracyclines are a major component in the therapy of non-Hodgkin's lymphoma. However, due to their cardiac toxicity potential, curative and palliative treatment is often limited in patients with preexisting cardiac dysfunction. Liposomal doxorubicin formulations have been described to be less cardiotoxic than conven...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1308-y
更新日期：2012-03-01 00:00:00
abstract：:Approximately 10% of patients with polycythemia vera (PV) transform to acute leukemia (blast phase) at 10 years after initial diagnosis of PV. The bone marrow pathologic, cytogenetic, and molecular features of blast phase have not been well characterized. In this study, we reviewed 422 PV patients over a period of 11 ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-3211-7
更新日期：2018-03-01 00:00:00
abstract：:Hodgkin lymphoma (HL), a disease of mostly young patients, also peaks in the elderly. Despite the profound improvement in the outcome of young patients, in the elderly, 5-year progression-free survival (PFS) rates are under 70%. Interim PET-CT (iPET) is known to be highly predictive for PFS in young HL patients, but i...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00277-019-03686-y
更新日期：2019-07-01 00:00:00
abstract：:In contrast to adult medicine, specific scoring systems predicting the treatment response for an individual pediatric patient (pt) with chronic myeloid leukemia (CML) have not yet been defined. We evaluated to what extend prognostic scores as described for adults (e.g., Sokal, Hasford, EUTOS score) resulted in compara...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2367-2
更新日期：2015-08-01 00:00:00
abstract：:The clinical experience of the significant difference in iron metabolism between multiple myeloma and myelodysplasia prompted us to analyse patients according to mutation frequency in the hemochromatosis gene (HFE) known to participate in the regulation of iron metabolism. HFE genotyping results were also evaluated in...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-006-0178-1
更新日期：2006-12-01 00:00:00
abstract：:The severity of thalassemia is currently classified based on clinical manifestations and multiple tests. In the present study, we performed a plasma proteome analysis to identify differentially expressed proteins compared between normal subjects and patients with mild and severe forms of β-thalassemia/hemoglobin E (Hb...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1629-5
更新日期：2013-03-01 00:00:00
abstract：:The impact of intraocular involvement (IOL) in primary CNS lymphoma (PCNSL) has not been sufficiently evaluated. Here, we present the analysis of IOL in the only completed randomized phase III trial in PCNSL. The G-PCNSL-SG1 study evaluated the role of whole-brain radiotherapy in primary therapy of PCNSL. Data of the ...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00277-014-2212-z
更新日期：2015-03-01 00:00:00
abstract：:Gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B cell lymphoma (DLBCL) show a spectrum of disease characterized by varying proportions of low-grade and high-grade components. While the natural history and optimum treatment for low-grade gastric MALT lymphoma and DLBCL is well established, ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0604-7
更新日期：2009-05-01 00:00:00
abstract：:Impact of FLT3 receptor tyrosine kinase activation via internal tandem duplication (ITD) of the juxtamembrane region on outcome of acute myeloid leukemia (AML) is still controversial. Recent researches reveal a role of FLT3 in monocyte differentiation in hematopoiesis. We analyzed the clinical impact of FLT3 alteratio...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-009-0733-7
更新日期：2009-11-01 00:00:00
abstract：:A 64-year-old woman with adult T cell leukemia (ATL) was admitted to our hospital with severe hypercalcemia. The serum calcium level was elevated to 14.9 mg/dl. Biochemical parameters for bone formation including serum osteocalcin (bone Gla protein, BGP) and alkaline phosphatase (ALP) were normal. The serum levels of ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770100305
更新日期：2001-07-01 00:00:00
abstract：:Paul Kaznelson is credited with describing the first case of pure red cell aplasia. He was also known for his contribution to the discovery of the therapeutic role of splenectomy in idiopathic thrombocytopenic purpura. Most of his academic works appeared in 1910s and 1920s, when he used to work in Karl-Ferdinand Unive...
journal_title：Annals of hematology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s00277-008-0553-1
更新日期：2008-11-01 00:00:00
abstract：:Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the "unexplained" decrease in the number of circulating neutrophils. Serum inflammatory cytokines and chemokines are increased in CINA. In addition, cytokines gene polymorphisms are associated with increased levels of respectiv...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-005-1066-9
更新日期：2005-10-01 00:00:00
abstract：:The objective of this study is to compare and evaluate the diagnostic value of hereditary spherocytosis (HS) by three screening tests, comparing mean spherical corpuscular volume (MSCV) to mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and flow cytometric osmotic fragility test. Perip...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2270-2
更新日期：2015-05-01 00:00:00
abstract：:A 72-year-old-man with night sweats and a low-grade fever was found to have bilateral adrenal enlargement associated with incipient adrenal insufficiency. Without any intervention, these adrenal lesions regressed spontaneously, accompanied by disappearance of clinical symptoms. Seven months later, however, the lesions...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770100335
更新日期：2001-09-01 00:00:00
abstract：:Two immunocompetent patients with cat-scratch disease due to infection with Bartonella henselae developed monoclonal and biclonal gammopathy. Neither patient had evidence of any other known cause of plasma cell dyscrasia, and antibiotic eradication of Bartonella henselae infection resulted in the prompt disappearance ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0675-4
更新日期：2003-07-01 00:00:00
abstract：:Haemoglobinopathies are the world's most frequently found monogenic disorders. In the cases with high oxygen affinity, the decrease in the liberation of the oxygen determines a secondary erythrocytosis. In this work, we present 17 unrelated families of Caucasian race and of Spanish origin, with ten variants of haemogl...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-008-0581-x
更新日期：2009-03-01 00:00:00
abstract：:Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-009-0896-2
更新日期：2010-07-01 00:00:00
abstract：:Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few ...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-003-0815-x
更新日期：2004-08-01 00:00:00
abstract：:The laboratory diagnosis of hereditary spherocytosis (HS) is based on several screening and confirmatory tests; our algorithm includes clinical features, red blood cell morphology analysis and cryohaemolysis test, and, in case of positive screening, sodium dodecyl sulphate polyacrylamide gel electrophoresis as a diagn...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2127-8
更新日期：2014-11-01 00:00:00
abstract：:Sickle cell disease (SCD) is a relatively common inherited hemolytic anemia among individuals of African descent. Genetic factors might clarify clinical diversity of the disease and variations in treatment response. Some researchers investigated heme oxygenase-1 (HMOX1) or chemokine receptor 5 (CCR5Δ32) genotypes amon...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-019-03697-9
更新日期：2019-08-01 00:00:00
abstract：:Although lenalidomide plus dexamethasone (RD) is a therapeutic option for relapsed/refractory multiple myeloma (RRMM), limited real-world clinical data exist. The purpose of this study was to estimate efficacy and safety of RD in RRMM patients of the clinical practice. Data from patients at 25 university hospitals in ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00277-019-03904-7
更新日期：2020-02-01 00:00:00
abstract：:The purpose of this report is to provide long-term follow-up of 38 patients diagnosed of post-transplant lymphoproliferative disease (PTLD) included in a phase 2 clinical trial of first line therapy with rituximab and to evaluate the same therapy in a real world cohort of 21 consecutive patients treated once the trial...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04056-9
更新日期：2020-05-04 00:00:00
abstract：:Cancer incidence in patients with recurrent unprovoked venous thromboembolism (VTE) is much higher than after a first event, but the incidence of myeloproliferative neoplasms (MPN) in this situation is still unknown. We tested for JAK2V617F and calreticulin mutants, 372 DNA samples of patients treated for (VTR). Among...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2853-1
更新日期：2017-03-01 00:00:00
abstract：:In the attempt to induce graft-vs-host disease (GVHD) in patients undergoing autologous bone marrow transplantation (ABMT) or blood stem cell transplantation (BSCT), 12 consecutive patients received cyclosporin A (CyA) post transplant. CyA was given at a dose of 1.5 mg/kg/day intravenously for 28 days, starting on the...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01703140
更新日期：1991-05-01 00:00:00
abstract：:MicroRNAs are short noncoding RNAs, known regulators of several signaling pathways cell differentiation and proliferation, development, and apoptosis, which are deregulated in acute leukemia. Mixed lineage leukemia (MLL) gene encodes a protein with histone methyltransferase activity, which is essential for the fine tu...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-013-1803-4
更新日期：2013-11-01 00:00:00
abstract：:Chronic idiopathic neutropenia (CIN) has been well recognized as a granulocytic disorder not associated with increased risk to malignant transformation. Four cases, however, of acute myeloid leukemia have been recently reported in patients with CIN. In the current paper, we report on a CIN patient who developed acute ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-004-0862-y
更新日期：2004-06-01 00:00:00
abstract：:The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2580-z
更新日期：2016-03-01 00:00:00
