Abstract:
:A 72-year-old-man with night sweats and a low-grade fever was found to have bilateral adrenal enlargement associated with incipient adrenal insufficiency. Without any intervention, these adrenal lesions regressed spontaneously, accompanied by disappearance of clinical symptoms. Seven months later, however, the lesions became enlarged and exceeded their initial size while remaining confined to the adrenals, associated with reappearance of nights sweats and overt adrenal insufficiency. Upon unilateral laparoscopic adrenalectomy, the lesion proved histopathologically to be diffuse large B cell non-Hodgkin's lymphoma (NHL). After contralateral laparoscopic adrenalectomy and adjuvant chemotherapy, the patient remains alive with no recurrence at 26 months. Treatment with bilateral adrenalectomy and chemotherapy is effective for aggressive NHL confined to bilateral adrenal glands. A transient clinical improvement without treatment was considered to be due to a spontaneous regression of NHL, although we could not confirm the histological results before the regression. Such tumor behavior showing spontaneous regression in spite of aggressive histology may also be related to the favorable outcome, even though regression was transient.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Fujiwara T,Kawamura M,Sasaki A,Asahi H,Sasou S,Itoh S,Hiramori Kdoi
10.1007/s002770100335subject
Has Abstractpub_date
2001-09-01 00:00:00pages
561-4issue
9eissn
0939-5555issn
1432-0584journal_volume
80pub_type
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-012-1561-8
更新日期:2013-01-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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更新日期:2007-09-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:1991-08-01 00:00:00
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s00277-003-0815-x
更新日期:2004-08-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-016-2779-7
更新日期:2016-10-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000267
更新日期:2001-04-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,评审
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2020-12-02 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770050209
更新日期:1996-08-01 00:00:00