Transient spontaneous regression of aggressive non-Hodgkin's lymphoma confined to the adrenal glands.

Abstract:

:A 72-year-old-man with night sweats and a low-grade fever was found to have bilateral adrenal enlargement associated with incipient adrenal insufficiency. Without any intervention, these adrenal lesions regressed spontaneously, accompanied by disappearance of clinical symptoms. Seven months later, however, the lesions became enlarged and exceeded their initial size while remaining confined to the adrenals, associated with reappearance of nights sweats and overt adrenal insufficiency. Upon unilateral laparoscopic adrenalectomy, the lesion proved histopathologically to be diffuse large B cell non-Hodgkin's lymphoma (NHL). After contralateral laparoscopic adrenalectomy and adjuvant chemotherapy, the patient remains alive with no recurrence at 26 months. Treatment with bilateral adrenalectomy and chemotherapy is effective for aggressive NHL confined to bilateral adrenal glands. A transient clinical improvement without treatment was considered to be due to a spontaneous regression of NHL, although we could not confirm the histological results before the regression. Such tumor behavior showing spontaneous regression in spite of aggressive histology may also be related to the favorable outcome, even though regression was transient.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Fujiwara T,Kawamura M,Sasaki A,Asahi H,Sasou S,Itoh S,Hiramori K

doi

10.1007/s002770100335

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

561-4

issue

9

eissn

0939-5555

issn

1432-0584

journal_volume

80

pub_type

杂志文章
  • Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia.

    abstract::Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and non-relapse mortality. The FLAMSA-RIC protocol for high-risk patients with acute myeloid leukemia (AML) and myel...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-011-1253-9

    authors: Chemnitz JM,von Lilienfeld-Toal M,Holtick U,Theurich S,Shimabukuro-Vornhagen A,Krause A,Brossart P,Hallek M,Scheid C

    更新日期:2012-01-01 00:00:00

  • Epstein-Barr virus infection in allogeneic marrow grafting: lessons for transplant physicians and virologists.

    abstract::The relationship between Epstein-Barr virus (EBV) and the host is profoundly disturbed by allogeneic bone marrow transplantation (BMT) because EBV resides in the recipient's hematopoietic system, which has to be destroyed in the majority of cases, and in the donor's hematopoietic system, i.e., the marrow graft. We hav...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01715373

    authors: Gratama JW,Oosterveer MA,Lepoutre J,Fibbe WE,Ringdén O,Vossen JM,Willemze R,Bolhuis RL,van Rood JJ,Ernberg I

    更新日期:1992-06-01 00:00:00

  • Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial.

    abstract::Obesity is a well-known risk factor for the development of cancer, but its influence on the course of disease is still controversial. We investigated the influence of body mass index (BMI) on overall survival (OS) in 502 patients with indolent non-Hodgkin's lymphoma or mantle cell lymphoma in a subgroup analysis of th...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-3003-0

    authors: Weiss L,Melchardt T,Egle A,Hopfinger G,Hackl H,Greil R,Barth J,Rummel M

    更新日期:2017-07-01 00:00:00

  • Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangements.

    abstract::Although the outcome of patients with acute myeloid leukemia (AML) has improved by optimized chemotherapy regimens and bone marrow transplantation, leukemia relapse remains one of the most challenging problems during therapy. Sustained existence of AML blasts is a fundamental determinant for the development of leukemi...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2913-6

    authors: Liu J,Qin YZ,Yang S,Wang Y,Chang YJ,Zhao T,Jiang Q,Huang XJ

    更新日期:2017-04-01 00:00:00

  • Bloodstream infections with gram-negative organisms and the impact of multidrug resistance in patients with hematological malignancies.

    abstract::Infections and especially blood stream infections (BSI) with gram-negative bacteria (GNB) represent a major threat for patients with hematological diseases undergoing chemotherapy and mainly contribute to morbidity and mortality. In this retrospective single-center study, we analyzed the impact of BSI with different g...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00277-018-3423-5

    authors: Scheich S,Weber S,Reinheimer C,Wichelhaus TA,Hogardt M,Kempf VAJ,Kessel J,Serve H,Steffen B

    更新日期:2018-11-01 00:00:00

  • Quality-adjusted survival analysis shows differences in outcome after immunosuppression or bone marrow transplantation in aplastic anemia.

    abstract::Bone marrow transplantation (BMT) and immunosuppression (IS) have improved the prognosis of aplastic anemia; both treatments have specific advantages and drawbacks but similar survival rates. Analysis of additional endpoints may help in treatment decisions. In a single-center study, patients with aplastic anemia treat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-004-0930-3

    authors: Viollier R,Passweg J,Gregor M,Favre G,Kühne T,Nissen C,Gratwohl A,Tichelli A

    更新日期:2005-01-01 00:00:00

  • Improved clinical outcomes for multiple myeloma patients treated at a single specialty clinic.

    abstract::Despite recent advances made in its treatment, multiple myeloma (MM) remains an incurable B cell malignancy. Thus, the objective for treating these patients is to prolong overall survival (OS) and preserve patients' quality of life. We have analyzed data from 264 consecutive MM patients who had their initial visit bet...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2888-3

    authors: Berenson A,Vardanyan S,David M,Wang J,Harutyunyan NM,Gottlieb J,Halleluyan R,Spektor TM,Udd KA,Eshaghian S,Nassir Y,Eades B,Swift R,Berenson JR

    更新日期:2017-03-01 00:00:00

  • Notch1 signaling is irresponsible to the anti-leukemic effect of HDACis in B-ALL Nalm-6 cells.

    abstract::B cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy with limited treatment strategies. Histone deacetylases inhibitors (HDACis) are promising novel tools for cancer therapy, whose anti-tumor effects and the underlying mechanisms on B-ALL remain to be elucidated. Recently, Notch1 signali...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1561-8

    authors: Shao N,Ma D,Wang J,Lu T,Guo Y,Ji C

    更新日期:2013-01-01 00:00:00

  • Efficacy of Helicobacter pylori eradication for the 1st line treatment of immune thrombocytopenia patients with moderate thrombocytopenia.

    abstract::The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities of H. pylori eradication ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-014-2268-9

    authors: Kim H,Lee WS,Lee KH,Bae SH,Kim MK,Joo YD,Zang DY,Jo JC,Lee SM,Lee JH,Lee JH,Kim DY,Ryoo HM,Hyun MS,Kim HJ,CoOperative Study Group A for Hematology (COSAH).

    更新日期:2015-05-01 00:00:00

  • Automated reticulocyte parameters for hereditary spherocytosis screening.

    abstract::The laboratory diagnosis of hereditary spherocytosis (HS) is based on several screening and confirmatory tests; our algorithm includes clinical features, red blood cell morphology analysis and cryohaemolysis test, and, in case of positive screening, sodium dodecyl sulphate polyacrylamide gel electrophoresis as a diagn...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2127-8

    authors: Lazarova E,Pradier O,Cotton F,Gulbis B

    更新日期:2014-11-01 00:00:00

  • Higher prevalence of anemia among pregnant immigrant women compared to pregnant ethnic Danish women.

    abstract::The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-007-0305-7

    authors: Nybo M,Friis-Hansen L,Felding P,Milman N

    更新日期:2007-09-01 00:00:00

  • X-linked thrombocytopenia and Wiskott-Aldrich syndrome: similar regional assignment but distinct X-inactivation pattern in carriers.

    abstract::While inherited X-linked (XL) isolated thrombocytopenia is a mild condition, the Wiskott-Aldrich syndrome (WAS) associates severe thrombocytopenia with an immunodeficiency component and has a poor prognosis. Whether these conditions correspond to separate genetic entities or to different mutations of the same gene(s) ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01707282

    authors: De Saint-Basile G,Schlegel N,Caniglia M,Le Deist F,Kaplan C,Lecompte T,Piller F,Fischer A,Griscelli C

    更新日期:1991-08-01 00:00:00

  • Prognostic impact of bleomycin-induced pneumonitis on the outcome of Hodgkin's lymphoma.

    abstract::Bleomycin-induced pneumonitis (BIP) has been well described in Hodgkin's lymphoma (HL) patients. The impact of BIP on patients uniformly treated with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) is not clear; previous studies have included patients treated with both ABVD and hybrid regimens. We reviewed ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-010-1032-z

    authors: Ngeow J,Tan IB,Kanesvaran R,Tan HC,Tao M,Quek R,Lim ST

    更新日期:2011-01-01 00:00:00

  • Bernard-Soulier syndrome: novel nonsense mutation in GPIbbeta gene affecting GPIb-IX complex expression.

    abstract::Bernard-Soulier syndrome (BSS) is a rare autosomal recessive genetic disorder characterized by thrombocytopenia, circulating giant platelets, and prolonged bleeding time. BSS is explained by a defect in primary hemostasis owing to quantitative or qualitative defect in the GPIb-IX-V complex, composed of four subunits: ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0611-8

    authors: Hadjkacem B,Elleuch H,Gargouri J,Gargouri A

    更新日期:2009-05-01 00:00:00

  • Identification of CD318 (CDCP1) as novel prognostic marker in AML.

    abstract::Genetic and morphological markers are well-established prognostic factors in acute myeloid leukemia (AML). However, further reliable markers are urgently needed to improve risk stratification in AML. CD318 (CDCP1) is a transmembrane protein which in solid tumors promotes formation of metastasis and correlates with poo...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-03907-9

    authors: Heitmann JS,Hagelstein I,Hinterleitner C,Roerden M,Jung G,Salih HR,Märklin M,Kauer J

    更新日期:2020-03-01 00:00:00

  • Neutropenic enterocolitis: a serious complication during the treatment of acute leukemias.

    abstract::Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-003-0815-x

    authors: Wach M,Dmoszynska A,Wasik-Szczepanek E,Pozarowski A,Drop A,Szczepanek D

    更新日期:2004-08-01 00:00:00

  • Evaluation of neutrophil-lymphocyte ratio in patients with early-stage mycosis fungoides.

    abstract::Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-016-2779-7

    authors: Eren R,Nizam N,Doğu MH,Mercan S,Erdemir AV,Suyanı E

    更新日期:2016-10-01 00:00:00

  • Genetic polymorphisms of HbE/beta thalassemia related to clinical presentation: implications for clinical diversity.

    abstract::HbE/Beta thalassemia (HbE/β-thalassemia) is one of the common genetic disorders in South East Asia. It is heterogeneous in its clinical presentation and molecular defects. There are genetic modifiers which have been reported to influence the disease severity of this disorder. The aim of this study was to determine the...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-03927-5

    authors: Azman NF,Abdullah WZ,Hanafi S,Diana R,Bahar R,Johan MF,Zilfalil BA,Hassan R

    更新日期:2020-04-01 00:00:00

  • Treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: the role of corticosteroids.

    abstract::We aimed to evaluate the treatments, particularly the role of corticosteroids, in patients with late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). One hundred and sixty-three consecutive patients who underwent non-T-cell-depleted allo-HSCT and met the criterion...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-018-3290-0

    authors: Mo XD,Zhang XH,Xu LP,Wang Y,Yan CH,Chen H,Chen YH,Han W,Wang FR,Wang JZ,Liu KY,Huang XJ

    更新日期:2018-07-01 00:00:00

  • Central nervous system involvement in adults with haemophagocytic lymphohistiocytosis: a single-center study.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystem disorder characterized by proliferation and diffuse infiltration multiple organs with histiocytes, including the central nervous system (CNS). Neurological manifestations of HLH have been recognized in different studies with children, but they remain relat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-3035-5

    authors: Cai G,Wang Y,Liu X,Han Y,Wang Z

    更新日期:2017-08-01 00:00:00

  • Genetic research and clinical analysis of deletional Chinese Gγ+(Aγδβ)0 -thalassemia and Southeast Asian HPFH in South China.

    abstract::Chinese Gγ+(Aγδβ)0-thalassemia and SEA-HPFH are the most common types of β-globin gene cluster deletion in Chinese population. The aim of the study was to analyze clinical features of deletional Chinese Gγ+(Aγδβ)0-thalassemia and Southeast Asian hereditary persistence of fetal hemoglobin (SEA-HPFH) in South China. A t...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04252-7

    authors: Wu Y,Yao Q,Zhong M,Wu J,Xie L,Su L,Yu F

    更新日期:2020-12-01 00:00:00

  • The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.

    abstract::Nondeletional hereditary persistence of fetal hemoglobin (nd-HPFH), a rare hereditary condition resulting in elevated levels of fetal hemoglobin (Hb F) in adults, is associated with promoter mutations in the human fetal globin (HBG1 and HBG2) genes. In this paper, we report a novel type of nd-HPFH due to a HBG2 gene p...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0643-0

    authors: Chassanidis C,Kalamaras A,Phylactides M,Pourfarzad F,Likousi S,Maroulis V,Papadakis MN,Vamvakopoulos NK,Aleporou-Marinou V,Patrinos GP,Kollia P

    更新日期:2009-06-01 00:00:00

  • Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia.

    abstract::Indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells (DCs) can induce or maintain peripheral immune tolerance. Impaired IDO-mediated tryptophan catabolism has been observed in autoimmune diseases. In order to investigate the effects of IDO-mediated tryptophan catabolism and IDO-expressing DCs in immune thro...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1451-0

    authors: Xu SQ,Wang CY,Zhu XJ,Dong XY,Shi Y,Peng J,Qin P,Sun JZ,Guo C,Ni H,Hou M

    更新日期:2012-10-01 00:00:00

  • Primary non-Hodgkin's lymphoma of bone: three cases and a short review of the literature.

    abstract::Primary non-Hodgkin's lymphoma of bone (PLB) is a rare entity. We present three new cases and a review of the literature. If PLB is suspected radiologically, the diagnosis must be confirmed by open biopsy. Histopathologically, PLB usually represents diffuse large B-cell lymphoma or lymphoma of the follicular center ty...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-003-0674-5

    authors: Misgeld E,Wehmeier A,Krömeke O,Gattermann N

    更新日期:2003-07-01 00:00:00

  • Ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) plus L-asparaginase as a first-line therapy improves outcomes in stage III/IV NK/T cell-lymphoma, nasal type (NTCL).

    abstract::The prognosis of patients with stage III/IV NK/T-cell lymphoma (NTCL) is extremely poor. Although L-asparaginase (L-asp) is effective for NTCL, its significance has not been clearly demonstrated. In addition, there are few studies comparing treatment outcomes in stage III/IV NTCL. This study evaluated the efficacy of ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-014-2228-4

    authors: Kim M,Kim TM,Kim KH,Keam B,Lee SH,Kim DW,Lee JS,Jeon YK,Kim CW,Heo DS

    更新日期:2015-03-01 00:00:00

  • Hereditary protein C deficiency in Indian patients with venous thrombosis.

    abstract::Approximately, 4-11 % of the patients with idiopathic venous thrombosis (VT) show protein C (PC) deficiency. The molecular pathology of PC deficiency was analyzed in 102 patients; 98 healthy controls were also studied to assess the association of various polymorphisms with reduced PC levels. PROC gene mutations were d...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1483-5

    authors: Pai N,Ghosh K,Shetty S

    更新日期:2012-09-01 00:00:00

  • Paraneoplastic polyneuropathy preceding the diagnosis of Hodgkin's disease and non-small cell lung cancer in a patient with concomitant Borrelia burgdorferi infection.

    abstract::A patient with painful peripheral neuropathy is presented, whose symptoms were thought to result from an infection with Borrelia burgdorferi sensu lato. Investigations of the cerebrospinal fluid for signs of inflammation and borrelial antibodies were negative, and the patient did not benefit from repeated antibiotic t...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770000267

    authors: Behringer D,Spyridonidis A,Fetscher S,Schmitt-Gräff A,Högerle S,Kaiser R

    更新日期:2001-04-01 00:00:00

  • The prognostic value of serum erythropoietin in patients with lower-risk myelodysplastic syndromes: a review of the literature and expert opinion.

    abstract::Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies associated with an erythroid maturation defect, resulting in anemia. Treatments for MDS include erythropoiesis-stimulating agents (ESAs). The identification of prognostic markers is important to help predict response and improve outcomes. Various...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-019-03799-4

    authors: Park S,Kelaidi C,Meunier M,Casadevall N,Gerds AT,Platzbecker U

    更新日期:2020-01-01 00:00:00

  • Oral high-dose sucrosomial iron vs intravenous iron in sideropenic anemia patients intolerant/refractory to iron sulfate: a multicentric randomized study.

    abstract::Iron deficiency anemia is among the most frequent causes of disability. Intravenous iron is the quickest way to correct iron deficiency, bypassing the bottleneck of iron intestinal absorption, the only true mechanism of iron balance regulation in human body. Intravenous iron administration is suggested in patients who...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04361-3

    authors: Giordano G,Napolitano M,Di Battista V,Lucchesi A

    更新日期:2020-12-02 00:00:00

  • Refractory thrombocytopenia with chromosome 11q23 abnormality.

    abstract::Although cytopenia is a common manifestation of myelodysplastic syndrome (MDS), isolated thrombocytopenia is rare. The term "refractory thrombocytopenia" (RTC) has been proposed as a counterpart of refractory anemia. We describe here a case of RTC associated with chromosome abnormality on 11q23. A 59-year-old man was ...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770050209

    authors: Imoto S,Hayashi Y,Matsui T,Murayama T,Iwata N,Matsuoka H,Nagata A,Itoh H,Chihara K

    更新日期:1996-08-01 00:00:00