当前位置： SCI文献检索 > ANNALS OF HEMATOLOGY期刊下所有文献 > Central nervous system involvement in adults with haemophagocytic lymphohistiocytosis: a single-center study.

Central nervous system involvement in adults with haemophagocytic lymphohistiocytosis: a single-center study.

Abstract：

:Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystem disorder characterized by proliferation and diffuse infiltration multiple organs with histiocytes, including the central nervous system (CNS). Neurological manifestations of HLH have been recognized in different studies with children, but they remain relatively ill-defined in adults with HLH. From March 2008 to October 2014, 289 adult patients with HLH were admitted to our center. Clinical, radiological, and cerebral spinal fluid (CSF) data of the patients with CNS involvement were reviewed, and a retrospective study in our single-center was carried out. CNS involvement was observed in 29 patients (10%) either in their diagnosis process or during disease course. CNS symptoms included disturbance of consciousness, cranial nerve palsies, seizures, headache, limb paralysis, irritability, meningism, and memory loss. CSF analysis was conducted in 17 patients (59%). Among them, 11 patients (65%) were reported as having abnormal CSF. Neuroradiological studies were performed in 25 patients (86%). Among the 13 cases that underwent CT scan, one patient hemorrhaged. Single or multiple hypodense foci were detected in the other 2 patients. Magnetic resonance imaging (MRI) abnormalities were found in 15 patients, including focal lesions in cortical and adjacent subcortical regions with or without variable nodular or ring contrast-enhancement, multiple lesions in white matter, diffuse white matter signal changes, and meningeal enhancement. Basal ganglia, cerebellum, and brainstem lesions were also observed. CNS involvement could also be found in adult patients with HLH, but not as frequent as it was in children. The clinical manifestations could be diversified. By carrying out rigorous CNS examinations, an early diagnosis could be made and it was of the utmost importance for the prevention of further lesions.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Cai G,Wang Y,Liu X,Han Y,Wang Z

doi

10.1007/s00277-017-3035-5

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

1279-1285

issue

8

eissn

0939-5555

issn

1432-0584

pii

10.1007/s00277-017-3035-5

journal_volume

96

pub_type

杂志文章

相关文献

ANNALS OF HEMATOLOGY文献大全
  • Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean patients.

    abstract：:To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seroposi...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2222-x

    authors： Park M,Lee YH,Lee SH,Yoo KH,Sung KW,Koo HH,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Lee JW,Chung NG,Cho B,Kim HK,Koh KN,Im HJ,Seo JJ,Baek HJ,Kook H,Hwang TJ,Lee JM,Hah JO,Lim YJ,Park JE,Lyu CJ,Lim YT,Ch

    更新日期：2015-03-01 00:00:00

  • Clinical features and survival of extranodal natural killer/T cell lymphoma with and without hemophagocytic syndrome.

    abstract：:Extranodal natural killer (NK)/T cell lymphoma-associated hemophagocytic syndrome (HPS) (NK/T-LAHS) is a heterogeneous and life-threatening disease, which warrants investigation of its risk factors and clinical features. We retrospectively analyzed the clinical records of 202 patients with extranodal NK/T cell lymphom...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-016-2805-9

    authors： Jia J,Song Y,Lin N,Liu W,Ping L,Zheng W,Wang X,Xie Y,Tu M,Zhang C,Ying Z,Deng L,Ding N,Zhu J

    更新日期：2016-12-01 00:00:00

  • Predictors for splenectomy among patients with primary chronic immune thrombocytopenia: a population-based cohort study from Denmark.

    abstract：:We conducted a nationwide cohort study of adult Danish patients with primary chronic immune thrombocytopenia (cITP) to examine selected patient and clinical characteristics as predictors for splenectomy. We analyzed data from the Danish National Patient Registry and patient medical records from 1996 to 2007. Using Cox...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-010-1047-5

    authors： Jensen AO,Nørgaard M,Engebjerg MC,Farkas DK,Fryzek JP,Zhao S,Sørensen HT

    更新日期：2011-02-01 00:00:00

  • Fine needle aspiration and core needle biopsy in the diagnosis of lymphadenopathy of unknown aetiology.

    abstract：:The clarification of enlarged lymph nodes is a common issue in clinical routine. By now, open surgery with complete lymph node extirpation, followed by histopathology, is considered as standard. We investigated the value of fine needle aspiration (FNA) and core needle biopsy (CNB) when supporting the conventional morp...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-012-1476-4

    authors： Metzgeroth G,Schneider S,Walz C,Reiter S,Hofmann WK,Marx A,Hastka J

    更新日期：2012-09-01 00:00:00

  • Establishment of serum-free pre-colony forming unit assays for differentiation of primitive hematopoietic progenitors: serum induces early macrophage differentiation and inhibits early erythroid differentiation of CD34++CD38- cells.

    abstract：:In this report we show that serum has differentiation-inducing effects on primitive hematopoietic progenitor cells with the CD34++CD38- immunophenotype. Using the pre-colony forming unit (pre-CFU) assay as a model for early myelopoiesis, we compared the effects of serum-containing and serum-free media and evaluated di...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770000227

    authors： Willems R,Henckaerts E,Lenjou M,Nijs G,Rodrigus I,Moulijn AC,Slegers H,Berneman ZN,Van Bockstaele DR

    更新日期：2001-01-01 00:00:00

  • Reduced dose of post-transplantation cyclophosphamide compared to ATG for graft-versus-host disease prophylaxis in recipients of mismatched unrelated donor hematopoietic cell transplantation: a single-center study.

    abstract：:Post-transplantation cyclophosphamide (PTCy) demonstrated effectiveness to prevent GVHD after haploidentical hematopoietic cell transplantation (HCT). Reducing toxicities with a maximized efficacy is still challenging in HCT. In this retrospective study, we analyzed the safety and efficacy of transplantation from a 1-...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-019-03673-3

    authors： Soltermann Y,Heim D,Medinger M,Baldomero H,Halter JP,Gerull S,Arranto C,Passweg JR,Kleber M

    更新日期：2019-06-01 00:00:00

  • MCNU in the treatment of essential thrombocythemia--a pilot study.

    abstract：:The efficacy of a single dose of MCNU 150 mg was evaluated in nine symptomatic patients with essential thrombocythemia (ET). As the platelet counts increased during the following 4 weeks, an extra dose of 100 mg of MCNU was administered to three patients. All patients had thrombotic or hemorrhagic complications. Seven...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01738474

    authors： Murakami H,Tamura J,Sawamura M

    更新日期：1993-05-01 00:00:00

  • Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors: G-CSF, GM-CSF, IL-1, IL-2, M-CSF.

    abstract：:Hematopoietic recovery in 115 patients with metastatic breast cancer or metastatic melanoma, enrolled in phase-I studies of recombinant growth factors while undergoing treatment with high-dose chemotherapy with autologous bone marrow support, was examined with assays of bone marrow progenitor cells and peripheral bloo...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01696346

    authors： Laughlin MJ,Kirkpatrick G,Sabiston N,Peters W,Kurtzberg J

    更新日期：1993-12-01 00:00:00

  • Failure of combination therapy with recombinant granulocyte colony-stimulating factor and erythropoietin in myelodysplastic syndromes.

    abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) and erythropoietin (rhE-PO) were used to treat ten patients with myelodysplastic syndromes (MDS). None of the patients showed a favorable response in erythrocyte and platelet counts following 10 weeks' treatment, although favorable responses in neutroph...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01834360

    authors： Imamura M,Kobayashi M,Kobayashi S,Yoshida K,Mikuni C,Ishikawa Y,Matsumoto S,Sakamaki S,Niitsu Y,Hinoda Y

    更新日期：1994-04-01 00:00:00

  • Myeloproliferative disorders: complications, survival and causes of death.

    abstract：:This retrospective single-center study compared thromboembolic and hemorrhagic complications, survival and causes of death in a cohort of 102 consecutive patients with myeloproliferative disorders (MPD). We included 17 patients with essential thrombocythemia (ET), 59 with polycythemia vera (PV), and 26 with osteomyelo...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002779900136

    authors： Brodmann S,Passweg JR,Gratwohl A,Tichelli A,Skoda RC

    更新日期：2000-06-01 00:00:00

  • Mesenchymal stem cells for the treatment and prevention of graft-versus-host disease: experiments and practice.

    abstract：:Mesenchymal stem cells (MSCs) have emerged as a therapeutic approach in a range of medical fields, including regenerative medicine, cancer, autoimmune diseases, and inflammatory diseases, because of their unique properties of tissue repair and major histocompatibility complex-unmatched immunosuppression. Because both ...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-013-1796-z

    authors： Kim N,Im KI,Lim JY,Jeon EJ,Nam YS,Kim EJ,Cho SG

    更新日期：2013-10-01 00:00:00

  • PD-L1, LAG3, and HLA-DR are increasingly expressed during smoldering myeloma progression.

    abstract：:Symptomatic multiple myeloma (MM) is a plasma cell neoplasm that represents the final stage of a continuum of clinical conditions that start from monoclonal gammopathy of unknown significance (MGUS), then transits in the more advance, but still asymptomatic, smoldering MM (SMM), with a final evolution in symptomatic M...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-019-03648-4

    authors： Mussetti A,Pellegrinelli A,Cieri N,Garzone G,Dominoni F,Cabras A,Montefusco V

    更新日期：2019-07-01 00:00:00

  • Ixazomib-based regimens for relapsed/refractory multiple myeloma: are real-world data compatible with clinical trial outcomes? A multi-site Israeli registry study.

    abstract：:Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-020-03985-9

    authors： Cohen YC,Magen H,Lavi N,Gatt ME,Chubar E,Horowitz N,Kreiniz N,Tadmor T,Trestman S,Vitkon R,Rouvio O,Shvetz O,Shaulov A,Ziv-Baran T,Avivi I

    更新日期：2020-06-01 00:00:00

  • Second line azacitidine for elderly or infirmed patients with acute myeloid leukemia (AML) not eligible for allogeneic hematopoietic cell transplantation-a retrospective national multicenter study.

    abstract：:Elderly and infirm patients with acute myeloid leukemia (AML) with either induction refractory or relapse disease may benefit from treatment with azacitidine. We retrospectively reviewed the data from five tertiary centers in Israel, treated between 2009 and 2015. Thirty-four patients (median age 74 years) were identi...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-016-2914-5

    authors： Ram R,Gatt M,Merkel D,Helman I,Inbar T,Nagler A,Avivi I,Ofran Y

    更新日期：2017-04-01 00:00:00

  • Mucocutaneous autoimmune syndrome following fludarabine therapy for low-grade non-Hodgkin's lymphoma of B-cell type (B-NHL).

    abstract：:A 40-year-old patient with low-grade B-NHL developed a generalized macular-papular rash following the first cycle of fludarabine treatment which progressed to a complete epidermal necrolysis following the second cycle. Clinical symptoms and the results of the direct and indirect immunofluorescence were consistent with...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050347

    authors： Braess J,Reich K,Willert S,Strutz F,Neumann C,Hiddemann W,Wörmann B

    更新日期：1997-11-01 00:00:00

  • New prognostic model for extranodal natural killer/T cell lymphoma, nasal type.

    abstract：:Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 pa...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2089-x

    authors： Cai Q,Luo X,Zhang G,Huang H,Huang H,Lin T,Jiang W,Xia Z,Young KH

    更新日期：2014-09-01 00:00:00

  • Iron status in Danes 1994. II: Prevalence of iron deficiency and iron overload in 1319 Danish women aged 40-70 years. Influence of blood donation, alcohol intake and iron supplementation.

    abstract：:Iron status, i.e. serum ferritin and haemoglobin (Hb) levels, was assessed in a population survey in 1994 (Dan-Monica 10) comprising 1319 Caucasian Danish women in age cohorts of 40, 50, 60 and 70 years. In the entire series, ferritin levels increased significantly from 40 years to 60 years of age. The prevalence of s...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770000209

    authors： Milman N,Byg KE,Ovesen L

    更新日期：2000-11-01 00:00:00

  • Blood B, T, CD4+ and CD8+ lymphocytes in female Wistar rats.

    abstract：:We have established reference values of peripheral blood lymphocyte subsets in healthy female Wistar rats under highly standardized conditions. Using monoclonal antibodies and flow cytometry, T lymphocytes (OX19+), B lymphocytes (OX6+ and anti-Ig+), T-helper/inducer (W3/25+), and T-suppressor/cytotoxic subsets (OX8+) ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01701732

    authors： Franch A,Castellote C,Pelegrí C,Tolosa E,Castell M

    更新日期：1993-09-01 00:00:00

  • Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial.

    abstract：:Obesity is a well-known risk factor for the development of cancer, but its influence on the course of disease is still controversial. We investigated the influence of body mass index (BMI) on overall survival (OS) in 502 patients with indolent non-Hodgkin's lymphoma or mantle cell lymphoma in a subgroup analysis of th...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-017-3003-0

    authors： Weiss L,Melchardt T,Egle A,Hopfinger G,Hackl H,Greil R,Barth J,Rummel M

    更新日期：2017-07-01 00:00:00

  • Low-density lipoprotein cholesterol suppresses apoptosis in human multiple myeloma cells.

    abstract：:Multiple myeloma (MM) is an incurable disease accompanied by low plasma levels of low-density lipoprotein cholesterol (LDL-c). The significance of altered cholesterol metabolism in the pathophysiology of MM remains elusive. Although it has been hypothesized that myeloma cells depend on exogenous cholesterol for its su...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-011-1246-8

    authors： Tirado-Vélez JM,Benítez-Rondán A,Cózar-Castellano I,Medina F,Perdomo G

    更新日期：2012-01-01 00:00:00

  • Activation-induced deaminase and its splice variants associate with trisomy 12 in chronic lymphocytic leukemia.

    abstract：:Activation-induced cytidine deaminase (AID) is a mutator enzyme essential for somatic hypermutation (SHM) and class switch recombination (CSR) during effective adaptive immune responses. Its aberrant expression and activity have been detected in lymphomas, leukemias, and solid tumors. In chronic lymphocytic leukemia (...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-018-3520-5

    authors： Zaprazna K,Reblova K,Svobodova V,Radova L,Bystry V,Baloun J,Durechova K,Tom N,Loja T,Buresova M,Stranska K,Oltova A,Doubek M,Atchison ML,Trbusek M,Malcikova J,Pospisilova S

    更新日期：2019-02-01 00:00:00

  • Modified BEAM with triple autologous stem cell transplantation for patients with relapsed aggressive non-Hodgkin lymphoma.

    abstract：:Treatment of relapse and primary progression in aggressive lymphoma remains unsatisfactory; outcome is still poor. Better treatment strategies are much needed for this patient population. The R1 study is a prospective multi-center phase I/II study evaluating a dose finding approach with a triple transplant regimen in ...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-016-2671-5

    authors： Hohloch K,Zeynalova S,Chapuy B,Pfreundschuh M,Loeffler M,Ziepert M,Feller AC,Trümper L,Hasenclever D,Wulf G,Schmitz N

    更新日期：2016-06-01 00:00:00

  • Oral high-dose sucrosomial iron vs intravenous iron in sideropenic anemia patients intolerant/refractory to iron sulfate: a multicentric randomized study.

    abstract：:Iron deficiency anemia is among the most frequent causes of disability. Intravenous iron is the quickest way to correct iron deficiency, bypassing the bottleneck of iron intestinal absorption, the only true mechanism of iron balance regulation in human body. Intravenous iron administration is suggested in patients who...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04361-3

    authors： Giordano G,Napolitano M,Di Battista V,Lucchesi A

    更新日期：2020-12-02 00:00:00

  • Selective expansion of the CD14(+)/CD16(bright) subpopulation of circulating monocytes in patients with hemophagocytic syndrome.

    abstract：:Overproduction of proinflammatory cytokines is characteristic of hemophagocytic syndrome (HPS), a highly lethal inflammatory disease. Peripheral blood monocytes include two distinct subpopulations according to surface antigen expression: a major type, CD14(+)/CD16(-) (classical monocytes), and a minor type, CD14(+)/CD...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-007-0332-4

    authors： Takeyama N,Yabuki T,Kumagai T,Takagi S,Takamoto S,Noguchi H

    更新日期：2007-11-01 00:00:00

  • High-resolution ultrasonography in gastrointestinal graft-versus-host disease.

    abstract：:Gastrointestinal graft-versus-host disease (GVHD) is one of the main causes of therapy-related death after allogeneic hemopoietic stem cell transplantation. Early diagnosis and immediate treatment are probably essential for improving clinical outcome. High-resolution sonography allows the evaluation of single bowel wa...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-004-0893-4

    authors： Görg C,Wollenberg B,Beyer J,Stolte MS,Neubauer A

    更新日期：2005-01-01 00:00:00

  • L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia.

    abstract：:A female patient presenting with B-CLL and coincident eosinophilia-myalgia syndrome (EMS) after ingestion of L-tryptophan is described. The manifestations of EMS disappeared completely during treatment with cyclophosphamide/prednisone. and there was an intermittent clinical remission of CLL with absence of the monoclo...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050449

    authors： Böhme A,Wolter M,Hoelzer D

    更新日期：1998-11-01 00:00:00

  • Autologous peripheral blood stem cell transplant in patients previously diagnosed with invasive aspergillosis.

    abstract：:Patients previously diagnosed with invasive aspergillosis (IA) have been considered to be at risk for relapse of mycosis during subsequent hematopoietic transplant. Even with prophylactic measures, reactivation of the infection occurs in 29% of patients undergoing bone marrow transplantation (BMT). A period of neutrop...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770100311

    authors： Sevilla J,Hernandez-Maraver D,Aguado MJ,Ojeda E,Morado M,Hernandez-Navarro F

    更新日期：2001-08-01 00:00:00

  • Hereditary gene mutations in Korean patients with isolated erythrocytosis.

    abstract：:Most cases of erythrocytosis occur secondary to chronic tissue hypoxia or as a clonal disease such as polycythemia vera with somatic mutations in the Janus kinase 2 (JAK2) gene. Rarely, erythrocytosis is caused by hereditary gene mutations. This study investigated hereditary gene mutations in 38 unrelated Korean patie...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2006-3

    authors： Jang JH,Seo JY,Jang J,Jung CW,Lee KO,Kim SH,Kim HJ

    更新日期：2014-06-01 00:00:00

  • Bloodstream infections with gram-negative organisms and the impact of multidrug resistance in patients with hematological malignancies.

    abstract：:Infections and especially blood stream infections (BSI) with gram-negative bacteria (GNB) represent a major threat for patients with hematological diseases undergoing chemotherapy and mainly contribute to morbidity and mortality. In this retrospective single-center study, we analyzed the impact of BSI with different g...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-018-3423-5

    authors： Scheich S,Weber S,Reinheimer C,Wichelhaus TA,Hogardt M,Kempf VAJ,Kessel J,Serve H,Steffen B

    更新日期：2018-11-01 00:00:00

  • PRV-1 mRNA expression discriminates two types of essential thrombocythemia.

    abstract：:Essential thrombocythemia (ET) is a heterogeneous disorder. For example, the growth of erythropoietin-independent erythroid colonies, termed "endogenous erythroid colonies (EECs)", has previously been observed in only 50% of ET patients. We have recently described the overexpression of a hematopoietic receptor, PRV-1 ...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00277-004-0864-9

    authors： Griesshammer M,Klippel S,Strunck E,Temerinac S,Mohr U,Heimpel H,Pahl HL

    更新日期：2004-06-01 00:00:00