Hereditary gene mutations in Korean patients with isolated erythrocytosis.

abstract：:We investigated whether human peripheral blood mononuclear cells (PBMC) express prothrombinase following stimulation with bacterial lipopolysaccharide (LPS). LPS-stimulated PBMC devoid of contaminating platelets failed to activate prothrombin directly. Addition of platelets did not result in expression of prothrombina...

journal_title：Annals of hematology

authors： Pejler G,Geczy CL

更新日期：2001-05-01 00:00:00

abstract：:To characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most co...

journal_title：Annals of hematology

authors： Kwong YL,Au WY,Leung AY,Tse EW

更新日期：2010-04-01 00:00:00

abstract：:Less toxic and more active treatments are needed for indolent lymphomas as there is no curative treatment, and patients eventually die due to complications related to their disease. The purpose of the present study was to assess the antitumour activity of the combination of low doses of Enzastaurin and Lenalidomide (R...

journal_title：Annals of hematology

authors： Cosenza M,Civallero M,Grisendi G,Marcheselli L,Roat E,Bari A,Sacchi S

更新日期：2012-10-01 00:00:00

abstract：:Haemoglobinopathies are the world's most frequently found monogenic disorders. In the cases with high oxygen affinity, the decrease in the liberation of the oxygen determines a secondary erythrocytosis. In this work, we present 17 unrelated families of Caucasian race and of Spanish origin, with ten variants of haemogl...

journal_title：Annals of hematology

authors： González Fernández FA,Villegas A,Ropero P,Carreño MD,Anguita E,Polo M,Pascual A,Henández A

更新日期：2009-03-01 00:00:00

abstract：:Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder which is clinically characterized by thrombocytopenia, microangiopathic hemolytic anemia, fever, neurologic symptoms, and cardiac and renal involvement. The pathogenic mechanisms of this disease are poorly understood. It is well known that TTP is asso...

journal_title：Annals of hematology

authors： Rozdzinski E,Hertenstein B,Schmeiser T,Seifried E,Kurrle E,Heimpel H

更新日期：1992-05-01 00:00:00

abstract：:We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concen...

journal_title：Annals of hematology

authors： Fest T,de Wazières B,Lamy B,Maskani M,Vuitton D,Dupond JL

更新日期：1994-09-01 00:00:00

abstract：:Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...

journal_title：Annals of hematology

authors： Patel K,Kelsey P

更新日期：1997-04-01 00:00:00

abstract：:To assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Co...

journal_title：Annals of hematology

authors： Ma SY,Tian XP,Cai J,Zhong GZ,Chen X,Huang HQ,Lin TY,Li ZM,Cai QQ

更新日期：2020-06-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a protein kinase involved in the phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway. It plays a pivotal role in the control of cell proliferation, survival, and angiogenesis with multiple and frequent dysregulations of this pathway in human tumors. Temsirolimus is a...

journal_title：Annals of hematology

authors： Zoellner AK,Weiglein T,Hutter G,Zimmermann Y,Cieplik HC,Hess G,Dreyling M

更新日期：2016-02-01 00:00:00

abstract：:Ninety patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis were reviewed to identify significant prognostic associations. At diagnosis of blast crisis the main clinical, laboratory, and cytogenetic data were recorded and evaluated for prognostic significance. At the time of the ...

journal_title：Annals of hematology

authors： Griesshammer M,Heinze B,Hellmann A,Popp C,Anger B,Heil G,Bangerter M,Heimpel H

更新日期：1996-11-01 00:00:00

abstract：:Multicentric Castleman's disease (MCD) is a rare systemic lymphoproliferative disorder with too few patient series reported in the literature to have a clear idea about the etiology, outcome and the best treatment available. Systemic reactive amyloidosis is a very rare complication of MCD and its presence worsens the ...

journal_title：Annals of hematology

authors： Gholam D,Vantelon JM,Al-Jijakli A,Bourhis JH

更新日期：2003-12-01 00:00:00

abstract：:Established risk factors for thrombosis in essential thrombocythemia (ET) include age (≥ 60 years) and previous vascular events. Recently, also leukocytosis has been proposed in risk stratification of ET patients. We report a retrospective study on 532 ET patients followed for a median of 7.6 years. Sixty-four patient...

journal_title：Annals of hematology

authors： Palandri F,Polverelli N,Catani L,Ottaviani E,Baccarani M,Vianelli N

更新日期：2011-08-01 00:00:00

abstract：:Primary myelofibrosis (PMF)-associated pruritus is often severe and requires treatment. Fifty-one patients with bone marrow-proven PMF with associated pruritus were identified from a primary cohort of patients with PMF (n = 566) seen at our institution. We conducted a retrospective review of the clinical characteristi...

journal_title：Annals of hematology

authors： Vaa BE,Tefferi A,Gangat N,Pardanani A,Lasho TL,Finke CM,Wolanskyj AP

更新日期：2016-06-01 00:00:00

abstract：:Acquired aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are interrelated ultra-rare diseases. Quality of life (QoL) evaluation tools used in studies for AA and PNH are unspecific and designed for cancer patients (e.g., the European Organization for Research and Treatment of Cancer Quality of Life Q...

journal_title：Annals of hematology

authors： Groth M,Singer S,Niedeggen C,Petermann-Meyer A,Röth A,Schrezenmeier H,Höchsmann B,Brümmendorf TH,Panse J

更新日期：2017-02-01 00:00:00

abstract：:Methods to estimate bone marrow plasma cells (BMPC) basically include histopathology, cytomorphology, and flow cytometry. The present study compares the outcomes of these methods with special focus on the impact of BMPC-specific characteristics on their recovery by either method. Laboratory reports of diagnostic sampl...

journal_title：Annals of hematology

authors： Demyanets S,Kaider A,Simonitsch-Klupp I,Bayer G,Subasic A,Thalhammer R,Esterbauer H,Krauth MT,Agis H,Reiter T,Schwarzinger I

更新日期：2020-11-01 00:00:00

abstract：:Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal condition with various underlying disorders in adult patients and is diagnosed based on the HLH-2004 criteria, which were established based on experience in pediatric patients. However, few studies have prospectively evaluated the treatment outcome...

journal_title：Annals of hematology

authors： Yoon SE,Eun Y,Huh K,Chung CR,Yoo IY,Cho J,Cho D,Ko YH,Park S,Kim WS,Kim SJ

更新日期：2020-09-01 00:00:00

abstract：:This study aimed to systematically review the prognostic value of interim and end-of-treatment (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in follicular lymphoma during and after first-line therapy. The PubMed/MEDLINE database was searched for relevant original studies. Included studies were ...

journal_title：Annals of hematology

authors： Adams HJA,Nievelstein RAJ,Kwee TC

更新日期：2016-01-01 00:00:00

abstract：:High-count monoclonal B cell lymphocytosis (MBL) with a chronic lymphocytic leukemia (CLL) phenotype is a well-known entity, featuring 1-4% annual risk of progression towards CLL requiring treatment. Lymphoma-like MBL (L-MBL), on the other hand, remains poorly defined and data regarding outcome are lacking. We retrosp...

journal_title：Annals of hematology

authors： Vander Meeren S,Heyrman B,Renmans W,Bakkus M,Maes B,De Raeve H,Schots R,Jochmans K

更新日期：2018-07-01 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) is an important complication after allogeneic hematopoietic stem cell transplantation (HSCT). To define the roles of T-cells and B-cells in cGVHD, a murine minor histocompatibility complex-mismatched HSCT model was used. Depletion of donor splenocyte CD4(+) T-cells and B220(+)...

journal_title：Annals of hematology

authors： Shao L,Lie AK,Zhang Y,Wong CH,Kwong YL

更新日期：2015-09-01 00:00:00

abstract：:A patient with painful peripheral neuropathy is presented, whose symptoms were thought to result from an infection with Borrelia burgdorferi sensu lato. Investigations of the cerebrospinal fluid for signs of inflammation and borrelial antibodies were negative, and the patient did not benefit from repeated antibiotic t...

journal_title：Annals of hematology

authors： Behringer D,Spyridonidis A,Fetscher S,Schmitt-Gräff A,Högerle S,Kaiser R

更新日期：2001-04-01 00:00:00

abstract：:Aplastic anaemia (AA) is a rare bone marrow failure syndrome treated either by immunosuppressive therapy or allogeneic stem cell transplantation (SCT). At present, no randomised clinical trials evaluating both treatment options, and in particular SCT from unrelated donors, are available. We here report the clinical co...

journal_title：Annals of hematology

authors： Buchholz S,Dammann E,Koenecke Ch,Stadler M,Franzke A,Blasczyk R,Bremer M,Krauter J,Hertenstein B,Ganser A,Eder M

更新日期：2008-07-01 00:00:00

abstract：:Many studies have confirmed that overexpressed WT1 exists in leukemic cells, especially in AML. However, the immunophenotypic features of this sort of leukemic cells remain to be unclarified. We retrospectively analyzed the immunophenotype of 283 newly diagnosed AML patients with intermediated and poor cytogenetic ris...

journal_title：Annals of hematology

authors： Wang XR,Chang Y,Yuan XY,Wang YZ,Qin YZ,Ruan GR,Lai YY,Liu YR

更新日期：2020-02-01 00:00:00

abstract：:The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory ...

journal_title：Annals of hematology

authors： Nybo M,Friis-Hansen L,Felding P,Milman N

更新日期：2007-09-01 00:00:00

abstract：:Since December 2019, a novel coronavirus has spread throughout China and across the world, causing a continuous increase in confirmed cases within a short period of time. Some studies reported cases of thrombocytopenia, but hardly any studies mentioned how the virus causes thrombocytopenia. We propose several mechanis...

journal_title：Annals of hematology

authors： Xu P,Zhou Q,Xu J

更新日期：2020-06-01 00:00:00

abstract：:Amifostine increases in vitro burst-forming unit-erythroid and colony-forming unit-granulocyte/granulcoyte-macrophage cultured from bone-marrow cells from patients with myelodysplastic syndrome (MDS). Several small clinical studies give divergent informations about the potential of amifostine as single agent to improv...

journal_title：Annals of hematology

authors： Hofmann WK,Seipelt G,Ottmann OG,Kalina U,Koschmieder S,Brücher J,Frickhofen N,Klausmann M,Mitrou PS,Hoelzer D

更新日期：2000-05-01 00:00:00

abstract：:Co-inheritance of triplicated α-genes can alter the clinical and hematological phenotypes of β-thalassemias. We evaluated the phenotypic diversity and transfusion requirements in β-thalassemia heterozygotes, homozygotes, and normal individuals with associated α-gene triplication. Clinical and hematological evaluation ...

journal_title：Annals of hematology

authors： Mehta PR,Upadhye DS,Sawant PM,Gorivale MS,Nadkarni AH,Shanmukhaiah C,Ghosh K,Colah RB

更新日期：2015-12-01 00:00:00

abstract：:Essential thrombocythemia (ET) is a heterogeneous disorder. For example, the growth of erythropoietin-independent erythroid colonies, termed "endogenous erythroid colonies (EECs)", has previously been observed in only 50% of ET patients. We have recently described the overexpression of a hematopoietic receptor, PRV-1 ...

journal_title：Annals of hematology

authors： Griesshammer M,Klippel S,Strunck E,Temerinac S,Mohr U,Heimpel H,Pahl HL

更新日期：2004-06-01 00:00:00

abstract：:Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in European adults. We aimed to evaluate time trends in CLL incidence and medical resource utilisation of CLL patients in the UK. We conducted a retrospective, observational cohort analysis using the UK Clinical Practice Research Datalink (CPRD) comprisi...

journal_title：Annals of hematology

authors： Pfeil AM,Imfeld P,Pettengell R,Jick SS,Szucs TD,Meier CR,Schwenkglenks M

更新日期：2015-03-01 00:00:00

abstract：:Acute Epstein-Barr virus (EBV) infection commonly induces hematological abnormalities, most notably atypical lymphocytosis ("infectious mononucleosis"). In addition, mild decreases in platelet counts are commonly encountered in uncomplicated cases; however, severe thrombocytopenia is exceedingly rare. Here, we describ...

journal_title：Annals of hematology

authors： Walter RB,Hong TC,Bachli EB

更新日期：2002-11-01 00:00:00

abstract：:In this prospective multicentric study, we investigated the contribution of positron emission tomography (PET) scanning to the staging of Hodgkin's lymphoma (HL) by computed tomography (CT) and attempted to determine whether it has any impact on therapeutic approach. One hundred eighty six consecutive patients with HL...

journal_title：Annals of hematology

authors： Rigacci L,Vitolo U,Nassi L,Merli F,Gallamini A,Pregno P,Alvarez I,Salvi F,Sancetta R,Castagnoli A,Versari A,Biggi A,Gregianin M,Pelosi E,Chisesi T,Bosi A,Levis A,Intergruppo Italiano Linfomi.

更新日期：2007-12-01 00:00:00