Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101.


:Burkitt lymphoma (BL) is an aggressive B-cell lymphoma more common in children comprising one third of pediatric non-Hodgkin lymphoma cases. The recent discovery in BL pathogenesis highlighted the activation of PI3K pathway in cooperation with Myc in the development of BL. In this study, we demonstrated that PI3K/Akt pathway is a target to histone deacetylase inhibitor (HDACi) in BL cells. The combination of HDACi (sodium butyrate, NaB) and chemotherapy (VP-16) inhibited 51 % of the proliferation and enhanced the blockage of the cell cycle progression at G2/M with a concurrent decrease in the S phase. Microarray profiling showed a synergistic action of NaB/VP-16 combination through the differential regulation of 1,413 genes. Comparing VP-16 treatment with the NaB/VP-16 combination, 318 genes were deregulated: 250 genes were downregulated, and 68 were upregulated when compared with untreated cells. Among these genes, six (CDKN1A, CCND1, FAS, CHEK2, MDM4, and SESN2) belong to the p53-signaling pathway. The activation of this signaling pathway is usually induced by stress signals and ultimately leads to cell cycle arrest. Besides, the inhibition of the cell growth was related to reduced Akt phosphorylation, and decrease of c-Myc protein expression by about 60 % (p ≤ 0.005). Moreover, HDACi enhanced miR-101, miR-143, and miR-145 levels in BL cell line, which were inversely associated with the levels of miR-101, miR-143, and miR-145 found to be extremely downregulated in the sample of BL patients. We highlight the fact that effective combinations of HDACis with other target drugs could improve BL therapy in the future.


Ann Hematol


Annals of hematology


Ferreira AC,Robaina MC,Rezende LM,Severino P,Klumb CE




Has Abstract


2014-06-01 00:00:00












  • A comprehensive analysis of adult patients with secondary hemophagocytic lymphohistiocytosis: a prospective cohort study.

    abstract::Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal condition with various underlying disorders in adult patients and is diagnosed based on the HLH-2004 criteria, which were established based on experience in pediatric patients. However, few studies have prospectively evaluated the treatment outcome...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Yoon SE,Eun Y,Huh K,Chung CR,Yoo IY,Cho J,Cho D,Ko YH,Park S,Kim WS,Kim SJ

    更新日期:2020-09-01 00:00:00

  • Influence of conditioning regimens and stem cell sources on donor-type chimerism early after stem cell transplantation.

    abstract::We retrospectively analyzed very early chimerism before and ongoing neutrophil engraftment (days 7, 14, 21, 28) and investigated the influence of conditioning regimens and stem cell sources on donor-type chimerism in 59 Japanese patients who had received allogeneic hematopoietic stem cell transplantation. The percenta...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Sugita J,Tanaka J,Hashimoto A,Shiratori S,Yasumoto A,Wakasa K,Kikuchi M,Shigematsu A,Miura Y,Tsutsumi Y,Kondo T,Asaka M,Imamura M

    更新日期:2008-12-01 00:00:00

  • Epidemiology of chronic myeloid leukaemia: an update.

    abstract::National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Höglund M,Sandin F,Simonsson B

    更新日期:2015-04-01 00:00:00

  • A review of the European LeukemiaNet recommendations for the management of CML.

    abstract::Several guidelines and recommendations on the management of chronic myeloid leukemia (CML) have been prepared by several scientific societies. The European LeukemiaNet (ELN) appointed a panel of experts who submitted their recommendations to peer-reviewed scientific journals in 2006, 2009, and 2013. Here, we make a cr...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Baccarani M,Castagnetti F,Gugliotta G,Rosti G

    更新日期:2015-04-01 00:00:00

  • Long-term outcome after allogeneic bone marrow transplantation for hematological malignancies with non-remission status. Results of a single-center study of 24 patients.

    abstract::To investigate the problem of allogeneic bone marrow transplantation (allo-BMT) for advanced stage patients, we retrospectively analyzed 24 consecutive patients who underwent allo-BMT in the non-remission stage. Twenty-four patients (19 males and 5 females) with acute leukemia, chronic myelogenous leukemia, and malign...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Tabata M,Satake A,Okura N,Yamazaki Y,Toda A,Nishioka K,Tanaka H,Chin M,Itsukuma T,Yamaguchi M,Misawa M,Kai S,Hara H

    更新日期:2002-10-01 00:00:00

  • Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia.

    abstract::We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concen...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Fest T,de Wazières B,Lamy B,Maskani M,Vuitton D,Dupond JL

    更新日期:1994-09-01 00:00:00

  • Can prognostic scoring systems for chronic myeloid leukemia as established in adults be applied to pediatric patients?

    abstract::In contrast to adult medicine, specific scoring systems predicting the treatment response for an individual pediatric patient (pt) with chronic myeloid leukemia (CML) have not yet been defined. We evaluated to what extend prognostic scores as described for adults (e.g., Sokal, Hasford, EUTOS score) resulted in compara...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Gurrea Salas D,Glauche I,Tauer JT,Thiede C,Suttorp M

    更新日期:2015-08-01 00:00:00

  • Immune thrombocytopenia: epidemiological and clinical features of 216 patients in northwestern Turkey.

    abstract::We evaluated the clinical features, treatment modalities, treatment responses, and prognosis of our patients with immune thrombocytopenia (ITP). Furthermore, we estimated the frequency of ITP in the Thrace region of Turkey. Two hundred sixteen patients diagnosed with ITP between 2000 and 2012 at our center were retros...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Koylu A,Pamuk GE,Uyanik MS,Demir M,Pamuk ON

    更新日期:2015-03-01 00:00:00

  • Allogeneic peripheral blood stem cell transplantation following fludarabine-based conditioning in six children with advanced Hodgkin's disease.

    abstract::Despite high-dose chemotherapy and autografting, the outcome for patients with primary refractory Hodgkin's disease (HD) or multiple relapses remains unsatisfactory. Six pediatric patients (median age: 16 years, range: 11-19) received reduced intensity conditioning and allogeneic peripheral blood stem cell transplanta...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Claviez A,Klingebiel T,Beyer J,Nürnberger W,Ehninger G,Suttorp M,Dreger P,Dörffel W,Schmitz N

    更新日期:2004-04-01 00:00:00

  • Establishment of serum-free pre-colony forming unit assays for differentiation of primitive hematopoietic progenitors: serum induces early macrophage differentiation and inhibits early erythroid differentiation of CD34++CD38- cells.

    abstract::In this report we show that serum has differentiation-inducing effects on primitive hematopoietic progenitor cells with the CD34++CD38- immunophenotype. Using the pre-colony forming unit (pre-CFU) assay as a model for early myelopoiesis, we compared the effects of serum-containing and serum-free media and evaluated di...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Willems R,Henckaerts E,Lenjou M,Nijs G,Rodrigus I,Moulijn AC,Slegers H,Berneman ZN,Van Bockstaele DR

    更新日期:2001-01-01 00:00:00

  • The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women.

    abstract::The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Milman N,Kirchhoff M

    更新日期:1991-07-01 00:00:00

  • Notch1 signaling is irresponsible to the anti-leukemic effect of HDACis in B-ALL Nalm-6 cells.

    abstract::B cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy with limited treatment strategies. Histone deacetylases inhibitors (HDACis) are promising novel tools for cancer therapy, whose anti-tumor effects and the underlying mechanisms on B-ALL remain to be elucidated. Recently, Notch1 signali...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Shao N,Ma D,Wang J,Lu T,Guo Y,Ji C

    更新日期:2013-01-01 00:00:00

  • CT-guided needle biopsy performed with modified coaxial technique in patients with refractory or recurrent lymphomas.

    abstract::The aim of this study was to evaluate the role of computed tomography (CT)-guided core needle biopsy (CNB) performed by modified coaxial technique as an alternative tool to surgical biopsy in patients with refractory or recurrent lymphomas. Between May 2005 and May 2012, 57 CT-guided CNB of deep lesions were performed...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Gaudio F,Pedote P,Ferrante A,Perrone T,Ingravallo G,Ianora AA,Angelelli G,Specchia G

    更新日期:2014-09-01 00:00:00

  • Effect of treatment with amifostine used as a single agent in patients with refractory anemia on clinical outcome and serum tumor necrosis factor alpha levels.

    abstract::Amifostine increases in vitro burst-forming unit-erythroid and colony-forming unit-granulocyte/granulcoyte-macrophage cultured from bone-marrow cells from patients with myelodysplastic syndrome (MDS). Several small clinical studies give divergent informations about the potential of amifostine as single agent to improv...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Hofmann WK,Seipelt G,Ottmann OG,Kalina U,Koschmieder S,Brücher J,Frickhofen N,Klausmann M,Mitrou PS,Hoelzer D

    更新日期:2000-05-01 00:00:00

  • Recombinant human thrombopoietin promotes platelet engraftment after haploidentical hematopoietic stem cell transplantation: a prospective randomized controlled trial.

    abstract::Delayed platelet engraftment (DPE) is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This phenomenon is also a predictor of increased treatment-related mortality and poor survival. Therefore, therapies that promote platelet engraftment to prevent DPE are needed. This pr...

    journal_title:Annals of hematology

    pub_type: 杂志文章,随机对照试验


    authors: Han TT,Xu LP,Liu DH,Liu KY,Wang FR,Wang Y,Yan CH,Chen YH,Sun YQ,Ji Y,Wang JZ,Zhang XH,Huang XJ

    更新日期:2015-01-01 00:00:00

  • Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia.

    abstract::Along with their immunogenic role, dendritic cells (DCs) are also critical in maintaining tolerance to self-antigens by inducing regulatory T cells (Tregs) via the expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In turn, Tregs modulate the maturation and/or function of DCs. In immune th...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Catani L,Sollazzo D,Trabanelli S,Curti A,Evangelisti C,Polverelli N,Palandri F,Baccarani M,Vianelli N,Lemoli RM

    更新日期:2013-01-01 00:00:00

  • Spectrum of Von Willebrand disease and inherited platelet function disorders amongst Indian bleeders.

    abstract::Platelet function disorders (PFD) and Von Willebrand disease (VWD) are among the uncommon causes of bleeding in haematological practice. The inherited variety of PFD includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. VWD is classified into three major categories-type 1 ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Gupta PK,Charan VD,Saxena R

    更新日期:2007-06-01 00:00:00

  • Five theses concerning the clinical consequences of pathology and prognostic factors.

    abstract::We discuss possible justifications to split study populations from a biometrical point of view. The existence of prognostic differences between subgroups are neither a sufficient nor a necessary reason to justify a splitting decision. There are essentially two separate types of relevant arguments to justify a split of...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Hasenclever D,Loeffler M

    更新日期:2001-01-01 00:00:00

  • Good adherence to imatinib therapy among patients with chronic myeloid leukemia--a single-center observational study.

    abstract::Previous studies have suggested that adherence to imatinib therapy can be an obstacle among patients with chronic myeloid leukemia (CML). We studied adherence to imatinib therapy among CML patients treated at the Sahlgrenska University Hospital. We identified all CML patients that were alive at the 1st of January 2010...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Jönsson S,Olsson B,Söderberg J,Wadenvik H

    更新日期:2012-05-01 00:00:00

  • The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion.

    abstract::The absence of researches about autophagy in multiple myeloma promoted us to explore the biological characteristics and role of autophagy induced by nutrient depletion in multiple myeloma (MM) cell line RPMI8226 cells. Both autophagic and apoptotic morphology were observed by TUNEL, transmission electron microscopy (T...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Zeng R,He J,Peng J,Chen Y,Yi S,Zhao F,Cui G

    更新日期:2012-03-01 00:00:00

  • Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults.

    abstract::Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the "unexplained" decrease in the number of circulating neutrophils. Serum inflammatory cytokines and chemokines are increased in CINA. In addition, cytokines gene polymorphisms are associated with increased levels of respectiv...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Addas-Carvalho M,de Paula EV,Lima CS,Saad ST

    更新日期:2005-10-01 00:00:00

  • Chronic myeloid leukemia patients in Tunisia: epidemiology and outcome in the imatinib era (a multicentric experience).

    abstract::Data are limited in developing countries regarding the clinicopathologic features and response to therapy of chronic myeloid leukemia (CML) in the era of imatinib (IM). The objective of this study is to report on the clinicoepidemiologic features of CML in Tunisia, to evaluate the long-term outcome of patients in chro...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究


    authors: Ben Lakhal R,Ghedira H,Bellaaj H,Ben Youssef Y,Menif S,Manai Z,Bedoui M,Lakhal A,M'Sadek F,Elloumi M,Khélif A,Ben Romdhane N,Laatiri MA,Ben Othmen T,Meddeb B

    更新日期:2018-04-01 00:00:00

  • Thromboembolic events as an emerging adverse effect during high-dose intravenous immunoglobulin therapy in elderly patients: a case report and discussion of the relevant literature.

    abstract::A case of an 82-year-old man who suffered an acute ST-elevation myocardial infarction while receiving treatment with intravenous immunoglobulin (IVIg) for thrombocytopenia is discussed. A total of 29 other cases of thromboembolism related to IVIg therapy have been reported, and the incidence seems to be especially hig...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Hefer D,Jaloudi M

    更新日期:2004-10-01 00:00:00

  • Dynamics of circulating t(14;18)-positive cells during first-line and subsequent lines of treatment in follicular lymphoma.

    abstract::In follicular lymphoma the t(14;18) might be useful as a tumor marker in predicting the quality of the response to treatment. We investigated whether analyzing numbers of t(14;18)-positive cells in peripheral blood correlated with remission status in individual patients receiving a variety of treatments. Numbers of ci...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Mandigers CM,Meijerink JP,van 't Veer MB,Mensink EJ,Raemaekers JM

    更新日期:2003-12-01 00:00:00

  • Immunomagnetic enrichment of CD138 positive cells from weakly infiltrated myeloma patients samples enables the determination of the tumor clone specific IgH rearrangement.

    abstract::In multiple myeloma, the polymerase chain reaction (PCR) of the Ig heavy chain with allele-specific oligonucleotide (ASO) primers is a common and well-described method of identifying the tumor clone in peripheral blood (PB), bone marrow (BM) or leukapheresis products (LA). A factor which is crucial to the detection of...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Draube A,Pfister R,Vockerodt M,Schuster S,Kube D,Diehl V,Tesch H

    更新日期:2001-02-01 00:00:00

  • Successful alemtuzumab retreatment in progressive B-cell chronic lymphocytic leukemia: a multicenter survey in 30 patients.

    abstract::Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究


    authors: Fiegl M,Falkner F,Steurer M,Zojer N,Hopfinger G,Haslbauer F,Winder G,Voskova D,Andel J,Lang A,Brychtova Y,Mayer J,Greil R,Gastl G,Austrian Collaborative Study Group on Alemtuzumab in Chronic Lymphocytic Leukemia.,Czech Leuk

    更新日期:2011-09-01 00:00:00

  • Stroke prevention in the young child with sickle cell anaemia.

    abstract::Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Roberts L,O'Driscoll S,Dick MC,Height SE,Deane C,Goss DE,Pohl K,Rees DC

    更新日期:2009-10-01 00:00:00

  • Higher prevalence of anemia among pregnant immigrant women compared to pregnant ethnic Danish women.

    abstract::The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Nybo M,Friis-Hansen L,Felding P,Milman N

    更新日期:2007-09-01 00:00:00

  • sIL2R ratio as early marker for response in hairy cell leukemia and the prognostic relevance of IL28B genotype to interferon-α therapy.

    abstract::Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Jud S,Goede JS,Senn O,Spanaus K,Manz MG,Benz R

    更新日期:2017-05-01 00:00:00

  • Haplo-identical allografting with post-transplant cyclophosphamide in high-risk patients.

    abstract::Haplo-identical transplants (Haplo-Tx) are an important alternative for patients with hematological malignancies who lack a HLA-identical donor. Seventy-one T-replete Haplo-Tx were performed in 70 high-risk patients at our center; 22/70 (31%) patients with refractory/relapsed leukemia received sequential salvage thera...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Brunello L,Passera R,Dellacasa CM,Giaccone L,Audisio E,Ferrero D,D'Ardia S,Allione B,Aydin S,Festuccia M,Lia G,Crisà E,Maffini E,Butera S,Busca A,Bruno B

    更新日期:2018-11-01 00:00:00