当前位置： SCI文献检索 > ANNALS OF HEMATOLOGY期刊下所有文献 > Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus antithymocyte globulin.

Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus antithymocyte globulin.

Abstract：

:We investigated the efficacy of an antithymocyte globulin/cyclophosphamide preparative regimen prior to allogeneic stem cell transplantation from HLA-identical siblings in patients with severe aplastic anemia. Since 1990, 21 patients, 6 males and 15 females, with a median age of 25 years (range: 7-43) have been enrolled in the protocol consisting of 200 mg/kg cyclophosphamide and 90-120 mg/kg antithymocyte globulin (ATG, rabbit, Fresenius, Bad Homburg, Germany). For further graft-versus-host disease (GVHD) prophylaxis all patients received cyclosporin A and a short course of methotrexate (MTX). Only one patient had a primary graft failure (5%). All other patients engrafted with a leukocyte count >1.0 x 10(9)/l and a platelet count >20 x 10(9)/l after a median of 19 (range: 11-28) and 26 days (range: 13-67), respectively. No late graft failure or relapse was observed. Two patients experienced mild acute GVHD grade I (10%), and one patient developed grade II GVHD (5%). No severe grade III/IV GVHD was observed; 17% of the patients developed limited chronic GVHD. The treatment-related mortality was 14% and mainly due to fungal infection. After a median follow-up of 70 months (range: 2-139), the estimated overall and event-free survival at 10 years for all patients is 86% (95% confidence interval: 70-100%). We conclude that ATG plus cyclophosphamide is an effective conditioning regimen in patients with aplastic anemia undergoing stem cell transplantation with a low treatment-related mortality, resulting in an excellent outcome.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Kröger N,Zabelina T,Renges H,Krüger W,Kordes U,Rischewski J,Schrum J,Horstmann M,Ayuk F,Erttmann R,Kabisch H,Zander AR

doi

10.1007/s00277-002-0566-0

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

627-31

issue

11

eissn

0939-5555

issn

1432-0584

journal_volume

81

pub_type

临床试验,杂志文章

相关文献

ANNALS OF HEMATOLOGY文献大全
  • Serologic response to meningococcal vaccination in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with the terminal complement inhibitor eculizumab.

    abstract：:Eculizumab is indicated for the therapy of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, patients on eculizumab are susceptible to Neisseria meningitidis infections. The two mainstays to reduce the risk of infection are vaccination and antibiotic...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-017-2924-y

    authors： Alashkar F,Vance C,Herich-Terhürne D,Preising N,Dührsen U,Röth A

    更新日期：2017-04-01 00:00:00

  • Severe bleeding in two patients due to increased sensitivity of factor IX activity to phenprocoumon therapy.

    abstract：:Two male patients with severe and recurrent bleeding episodes under phenprocoumon therapy are reported. Both patients exhibited a strong decrease of their factor IX activities below 1% of normal, whereas the activities of the vitamin K-dependent factors prothrombin, VII, and X were found to be within or above the expe...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050297

    authors： Quenzel EM,Hertfelder HJ,Oldenburg J

    更新日期：1997-06-01 00:00:00

  • Double-faced cell-mediated immunity in beta-thalassemia major: stimulated phenotype versus suppressed activity.

    abstract：:In this study, the immunologic abnormalities of Iranian beta-thalassemia major patients were characterized, considering their clinical parameters including splenectomy status and iron overload. Serum samples and peripheral blood mononuclear cells were collected from 28 patients and 30 age- and sex-matched healthy indi...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-008-0564-y

    authors： Gharagozloo M,Karimi M,Amirghofran Z

    更新日期：2009-01-01 00:00:00

  • The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women.

    abstract：:The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01714957

    authors： Milman N,Kirchhoff M

    更新日期：1991-07-01 00:00:00

  • Dynamics of circulating t(14;18)-positive cells during first-line and subsequent lines of treatment in follicular lymphoma.

    abstract：:In follicular lymphoma the t(14;18) might be useful as a tumor marker in predicting the quality of the response to treatment. We investigated whether analyzing numbers of t(14;18)-positive cells in peripheral blood correlated with remission status in individual patients receiving a variety of treatments. Numbers of ci...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0762-6

    authors： Mandigers CM,Meijerink JP,van 't Veer MB,Mensink EJ,Raemaekers JM

    更新日期：2003-12-01 00:00:00

  • Next-generation sequencing for JAK2 mutation testing: advantages and pitfalls.

    abstract：:The JAK2V617F mutation is part of the major criteria for diagnosis of myeloproliferative neoplasms (MPN). Allele-specific quantitative PCR (qPCR) is the most prevalent method used in laboratories but with the advent of next-generation sequencing (NGS) techniques, we felt necessary to evaluate this approach for JAK2 mu...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-018-3499-y

    authors： Maslah N,Verger E,Schlageter MH,Miclea JM,Kiladjian JJ,Giraudier S,Chomienne C,Cassinat B

    更新日期：2019-01-01 00:00:00

  • Acute leukemia with the phenotype of a natural killer/T cell bipotential precursor.

    abstract：:An acute leukemia with an unusual immunophenotype developed in a 17-year-old girl. At the initial presentation, extramedullary involvement was not evident, but with advancing disease, massive splenomegaly and an osteolytic rib tumor developed. The disease was aggressive and refractory to intensive chemotherapeutic reg...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050472

    authors： Ino T,Tsuzuki M,Okamoto M,Shamoto M,Hirano M

    更新日期：1999-01-01 00:00:00

  • Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.

    abstract：:Hydroxyurea is a drug widely used to control myeloproliferative disorders, due in part to its relative lack of severe side effects. We present a case of acute interstitial pneumonitis in a patient who was treated with hydroxyurea for essential thrombocythemia. The clinical course suggests that the interstitial pneumon...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050498

    authors： Quintás-Cardama A,Pérez-Encinas M,Gonzalez S,Bendaña A,Bello JL

    更新日期：1999-04-01 00:00:00

  • Rituximab therapy for hairy cell leukemia: a retrospective study of 41 cases.

    abstract：:The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 cente...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-014-2175-0

    authors： Leclerc M,Suarez F,Noël MP,Vekhoff A,Troussard X,Claisse JF,Thieblemont C,Maloisel F,Beguin Y,Tamburini J,Barbe C,Delmer A

    更新日期：2015-01-01 00:00:00

  • Granulocyte colony-stimulating factor shortens duration of critical neutropenia and prolongs disease-free survival after sequential high-dose cytosine arabinoside and mitoxantrone (S-HAM) salvage therapy for refractory and relapsed acute myeloid leukemia.

    abstract：:Patients with primary refractory or relapsed acute myeloid leukemia (AML) who undergo intensive salvage chemotherapy carry a high risk of treatment failure due to infectious complications and early relapses. The study presented here assessed the effect of granulocyte colony-stimulating factor (G-CSF) on the duration o...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002770050425

    authors： Kern W,Aul C,Maschmeyer G,Kuse R,Kerkhoff A,Grote-Metke A,Eimermacher H,Kubica U,Wörmann B,Büchner T,Hiddemann W

    更新日期：1998-09-01 00:00:00

  • Mosaicism in Fanconi anemia: concise review and evaluation of published cases with focus on clinical course of blood count normalization.

    abstract：:Fanconi anemia (FA) is a DNA repair disorder resulting from mutations in genes encoding for FA DNA repair complex components and is characterized by variable congenital abnormalities, bone marrow failure (BMF), and high incidences of malignancies. FA mosaicism arises from reversion or other compensatory mutations in h...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-03954-2

    authors： Nicoletti E,Rao G,Bueren JA,Río P,Navarro S,Surrallés J,Choi G,Schwartz JD

    更新日期：2020-05-01 00:00:00

  • DSMM XI study: dose definition for intravenous cyclophosphamide in combination with bortezomib/dexamethasone for remission induction in patients with newly diagnosed myeloma.

    abstract：:A clinical trial was initiated to evaluate the recommended dose of cyclophosphamide in combination with bortezomib and dexamethasone as induction treatment before stem cell transplantation for younger patients with newly diagnosed multiple myeloma (MM). Thirty patients were treated with three 21-day cycles of bortezom...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00277-009-0726-6

    authors： Kropff M,Liebisch P,Knop S,Weisel K,Wand H,Gann CN,Berdel WE,Einsele H,Deutsche Studiengruppe Multiples Myelom, DSMM.

    更新日期：2009-11-01 00:00:00

  • Comparison of prognostic models for patients with diffuse large B-cell lymphoma in the rituximab era.

    abstract：:Several revisions of International Prognostic Index (IPI) have been proposed for patients with diffuse large B-cell lymphoma (DLBCL) after the introduction of rituximab. Expanding evidence suggests that baseline absolute lymphocyte count (ALC) is also an independent factor for outcome prediction. We investigated the o...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-013-1807-0

    authors： Huang YC,Liu CY,Lu HJ,Liu HT,Hung MH,Hong YC,Hsiao LT,Gau JP,Liu JH,Hsu HC,Chiou TJ,Chen PM,Tzeng CH,Yu YB

    更新日期：2013-11-01 00:00:00

  • Switch from branded to generic imatinib: impact on molecular responses and safety in chronic-phase chronic myeloid leukemia patients.

    abstract：:Since July 2017, different generic imatinib formulations have been introduced in Italy for the treatment of patients with chronic myeloid leukemia (CML). We analyzed 168 chronic phase CML patients treated with branded imatinib for a median of 12 years (range 1-16) at a single institution who switched to a single gener...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04096-1

    authors： Scalzulli E,Colafigli G,Latagliata R,Pepe S,Diverio D,Stocchi F,Di Prima A,Efficace F,Martelli M,Foà R,Breccia M

    更新日期：2020-12-01 00:00:00

  • Plasma clot properties in patients with a mild-to-moderate bleeding tendency of unknown cause.

    abstract：:In a large proportion of patients with mild bleeding disorders (MBDs) no diagnosis can be established by routine coagulation tests. We investigated whether alterations in plasma clot properties account for MBDs of unknown cause. Ninety-five patients with MBDs of unknown origin and 98 age- and sex-matched healthy contr...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-015-2399-7

    authors： Gebhart J,Laczkovics C,Posch F,Ay C,Reitter-Pfoertner SE,Haslacher H,Muszbek L,Wolberg AS,Pabinger I

    更新日期：2015-08-01 00:00:00

  • Combination of low doses of enzastaurin and lenalidomide has synergistic activity in B-non-Hodgkin lymphoma cell lines.

    abstract：:Less toxic and more active treatments are needed for indolent lymphomas as there is no curative treatment, and patients eventually die due to complications related to their disease. The purpose of the present study was to assess the antitumour activity of the combination of low doses of Enzastaurin and Lenalidomide (R...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-012-1490-6

    authors： Cosenza M,Civallero M,Grisendi G,Marcheselli L,Roat E,Bari A,Sacchi S

    更新日期：2012-10-01 00:00:00

  • Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute leukemia: a comparative study between adults and pediatric MPAL patients.

    abstract：:Mixed phenotype acute leukemia (MPAL) is a rare type of leukemia with a limited number of studies conducted to characterize its clinical spectrum and most importantly the best treatment modality. MPAL blasts show more than one phenotype either myeloid/monocytic with T- or B-lymphoid or extremely rare triple lineage as...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-04354-2

    authors： Rasekh EO,Osman R,Ibraheem D,Madney Y,Radwan E,Gameel A,Abdelhafiz A,Kamel A,Elfishawi S

    更新日期：2020-11-23 00:00:00

  • Cationic lipid mediated transfer of c-abl and bcr antisense oligonucleotides to immature normal myeloid cells: uptake, biological effects and modulation of gene expression.

    abstract：:Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODN...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF00641311

    authors： Albrecht T,Schwab R,Peschel C,Engels HJ,Fischer T,Huber C,Aulitzky WE

    更新日期：1996-02-01 00:00:00

  • Ixazomib-based regimens for relapsed/refractory multiple myeloma: are real-world data compatible with clinical trial outcomes? A multi-site Israeli registry study.

    abstract：:Ixazomib, the first oral proteasome inhibitor (PI), has been approved for the treatment of relapsed refractory multiple myeloma (RRMM) in combination with lenalidomide and dexamethasone, based on the TOURMALINE-MM1 phase 3 trial, which demonstrated the efficacy and safety of this all-oral triplet, compared with lenali...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-020-03985-9

    authors： Cohen YC,Magen H,Lavi N,Gatt ME,Chubar E,Horowitz N,Kreiniz N,Tadmor T,Trestman S,Vitkon R,Rouvio O,Shvetz O,Shaulov A,Ziv-Baran T,Avivi I

    更新日期：2020-06-01 00:00:00

  • Prevalence of increased osmotic fragility of erythrocytes in German blood donors: screening using a modified glycerol lysis test.

    abstract：:We screened for increased osmotic fragility of erythrocytes in 1464 healthy German blood donors. The osmotic fragility was determined by an acidified glycerol lysis test (AGLT) using glycerol-sodium phosphate-buffered NaCl solution. Since the original test described by Zanella et al. [23] showed only low specificity f...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01715351

    authors： Eber SW,Pekrun A,Neufeldt A,Schröter W

    更新日期：1992-02-01 00:00:00

  • Modified ProMACE-MOPP hybrid regimen with moderate-dose methotrexate for patients with primary CNS lymphoma.

    abstract：:The object of this study was to assess the estimation of 2- and 5-year overall survival and tumor response and the frequency and severity of treatment morbidity with a modified ProMACE-MOPP hybrid protocol in patients with primary CNS lymphoma (PCNSL). Thirty-two immunocompetent patients were treated with a regimen of...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-005-1005-9

    authors： Yamanaka R,Morii K,Shinbo Y,Takeuchi S,Tamura T,Hondoh H,Takahashi H,Onda K,Takahashi H,Tanaka R

    更新日期：2005-07-01 00:00:00

  • von Willebrand disease: a clinical and laboratory study of sixty-five patients.

    abstract：:von Willebrand disease (VWD) is the commonest inherited bleeding disorder, yet it has not been well recognized in Southeast Asia. The aim of this prospective study was to report our experience of VWD diagnosis and to establish the clinical presentations of VWD in Taiwan. From October 2003 to April 2010, 863 patients w...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-011-1266-4

    authors： Chen YC,Yang L,Cheng SN,Hu SH,Chao TY

    更新日期：2011-10-01 00:00:00

  • Primary acquired sideroblastic anemia, thrombocytosis, and trisomy 8.

    abstract：:Myelodysplastic syndromes are usually associated with pancytopenia. Disorders involving deletion of the long arm of chromosome 5 (5q-syndrome) and, rarely, patients with karyotypic abnormalities involving chromosome 3 associated with abnormal thrombopoiesis may have a normal or even raised platelet count. Other cytoge...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050283

    authors： Patel K,Kelsey P

    更新日期：1997-04-01 00:00:00

  • Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia.

    abstract：:The frequency of apoptotic cells in bone marrow trephine biopsies and cytospins of immunomagnetically isolated myeloid progenitor cells was determined in 39 patients with chronic idiopathic neutropenia (CIN) and 12 hematologically normal individuals using the in situ end-labeling (ISEL) apoptosis detection method. We ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0709-y

    authors： Koumaki V,Papadaki HA,Stefanaki K,Damianaki A,Gemetzi C,Katonis P,Vrentzos G,Eliopoulos GD

    更新日期：2003-10-01 00:00:00

  • Maintenance with low-dose cytarabine for acute myeloid leukemia in complete remission.

    abstract：:Thirty-four patients with acute myeloid leukemia (AML) in complete remission (CR), 30 of them aged over 60, received maintenance therapy scheduling four courses of low-dose cytarabine (LDA) 20 mg/m2/day in two subcutaneous injections for 3 weeks every 6 weeks. Each course was stopped when hematologic toxicity occurred...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01698132

    authors： Archimbaud E,Anglaret B,Thomas X,Jaubert J,Sebban C,Guyotat D,Fiere D

    更新日期：1992-08-01 00:00:00

  • Allogeneic bone marrow transplantation compared to peripheral blood stem cell transplantation for the treatment of hematologic malignancies: a meta-analysis based on time-to-event data from randomized controlled trials.

    abstract：:Controversy remains regarding the transplant outcomes of human leukocyte antigen-identical related bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) for the treatment of patients with hematological malignancies. To provide an estimate of the effect of BMT and PBSCT on clinical ou...

    journal_title：Annals of hematology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00277-011-1299-8

    authors： Chang YJ,Weng CL,Sun LX,Zhao YT

    更新日期：2012-03-01 00:00:00

  • High leukemia-free survival after TBI-based conditioning and mycophenolate mofetil-containing immunosuppression in patients allografted for chronic myelomonocytic leukemia: a single-center experience.

    abstract：:This retrospective single-center analysis studied the impact of the conditioning and the graft-versus-host disease (GVHD) prophylaxis on outcome in unselected patients allografted for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) secondary to documented prior CMML. A total of 44 patients (med...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-020-03952-4

    authors： Radujkovic A,Hegenbart U,Müller-Tidow C,Herfarth K,Dreger P,Luft T

    更新日期：2020-04-01 00:00:00

  • Risk for cytomegalovirus infection following reduced intensity allogeneic stem cell transplantation.

    abstract：:Preliminary data suggest a faster immune recovery following non-myeloablative stem cell transplantation because of the persistence of recipient T cells, but the real impact on post-transplant infectious complications remains unknown. We retrospectively analysed the incidence of cytomegalovirus (CMV) infection in twent...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0706-1

    authors： Nachbaur D,Larcher C,Kircher B,Eibl G,Nussbaumer W,Gunsilius E,Haun M,Grünewald K,Gastl G

    更新日期：2003-10-01 00:00:00

  • Fine needle aspiration and core needle biopsy in the diagnosis of lymphadenopathy of unknown aetiology.

    abstract：:The clarification of enlarged lymph nodes is a common issue in clinical routine. By now, open surgery with complete lymph node extirpation, followed by histopathology, is considered as standard. We investigated the value of fine needle aspiration (FNA) and core needle biopsy (CNB) when supporting the conventional morp...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-012-1476-4

    authors： Metzgeroth G,Schneider S,Walz C,Reiter S,Hofmann WK,Marx A,Hastka J

    更新日期：2012-09-01 00:00:00

  • Developmental regulation of granulocyte-macrophage colony-stimulating factor production during human monocyte-to-macrophage maturation.

    abstract：:Cells of the macrophage lineage are a major source of various cytokines and hematopoietic growth factors. With regard to the growth factors acting on cells of their own lineage, macrophage colony-stimulating factor (M-CSF) has been proven to be secreted by monocytes (MO) and macrophages (MAC), whereas the production o...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/BF01696222

    authors： Krause SW,Kreutz M,Zenke G,Andreesen R

    更新日期：1992-04-01 00:00:00