Platelet activation and function during eltrombopag treatment in immune thrombocytopenia.

Abstract:

:We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombopag. Overall, platelet activation and function normalized with increasing platelet counts. However, P-selectin, which was already elevated before treatment, and PMA increased further transiently during the first weeks. The increases in P-selectin and in PMA indicate ongoing platelet activation during the early period of treatment.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Haselboeck J,Pabinger I,Ay C,Koder S,Panzer S

doi

10.1007/s00277-011-1249-5

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

109-13

issue

1

eissn

0939-5555

issn

1432-0584

journal_volume

91

pub_type

杂志文章,随机对照试验
  • The association of venous thromboembolism with survival in pediatric cancer patients: a population-based cohort study.

    abstract::Venous thromboembolism (VTE) is a well-recognized complication in pediatric oncology patients. Studies in adult oncology patients have suggested a potential negative association between VTE and survival, but this association has not been examined in pediatric patients yet. The aim of this study was to assess the assoc...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-018-3371-0

    authors: Forbrigger Z,Kuhle S,Brown MM,Moorehead PC,Digout C,Kulkarni K

    更新日期:2018-10-01 00:00:00

  • Identification of CD318 (CDCP1) as novel prognostic marker in AML.

    abstract::Genetic and morphological markers are well-established prognostic factors in acute myeloid leukemia (AML). However, further reliable markers are urgently needed to improve risk stratification in AML. CD318 (CDCP1) is a transmembrane protein which in solid tumors promotes formation of metastasis and correlates with poo...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-03907-9

    authors: Heitmann JS,Hagelstein I,Hinterleitner C,Roerden M,Jung G,Salih HR,Märklin M,Kauer J

    更新日期:2020-03-01 00:00:00

  • Transient spontaneous regression of aggressive non-Hodgkin's lymphoma confined to the adrenal glands.

    abstract::A 72-year-old-man with night sweats and a low-grade fever was found to have bilateral adrenal enlargement associated with incipient adrenal insufficiency. Without any intervention, these adrenal lesions regressed spontaneously, accompanied by disappearance of clinical symptoms. Seven months later, however, the lesions...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s002770100335

    authors: Fujiwara T,Kawamura M,Sasaki A,Asahi H,Sasou S,Itoh S,Hiramori K

    更新日期:2001-09-01 00:00:00

  • Treatment of primary mediastinal large B cell lymphoma with an alternating chemotherapy regimen based on high-dose methotrexate.

    abstract::Primary mediastinal large B cell lymphomas (MLCL) differ from other diffuse large cell lymphomas, leading to a description as a separate entity in the current World Health Organization classification. Dose intensification improves long-term results, but no standard therapy has been established so far. We investigated ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s00277-008-0625-2

    authors: Fietz T,Knauf WU,Hänel M,Franke A,Freund M,Thiel E,East German Study Group on Hematology and Oncology-OSHO.

    更新日期:2009-05-01 00:00:00

  • Flow cytometric immunophenotyping is of great value to diagnosis of natural killer cell neoplasms involving bone marrow and peripheral blood.

    abstract::Natural killer (NK) cell neoplasms are unusual disorders. In this study we compared results of flow cytometric immunophenotype (FCI) with cytomorphology, histopathology and clinical findings in a series of patients with NK cell neoplasms with peripheral blood and/or bone marrow involvement, and the FCI of neoplastic a...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1574-3

    authors: Jiang NG,Jin YM,Niu Q,Zeng TT,Su J,Zhu HL

    更新日期:2013-01-01 00:00:00

  • Predictors for splenectomy among patients with primary chronic immune thrombocytopenia: a population-based cohort study from Denmark.

    abstract::We conducted a nationwide cohort study of adult Danish patients with primary chronic immune thrombocytopenia (cITP) to examine selected patient and clinical characteristics as predictors for splenectomy. We analyzed data from the Danish National Patient Registry and patient medical records from 1996 to 2007. Using Cox...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-010-1047-5

    authors: Jensen AO,Nørgaard M,Engebjerg MC,Farkas DK,Fryzek JP,Zhao S,Sørensen HT

    更新日期:2011-02-01 00:00:00

  • Blood leukocyte subsets and cytokine profile after autologous peripheral blood stem cell transplantation.

    abstract::High-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) includes the risk of infectious complications due to neutropenia and therapy-induced immune deviation. In order to understand early immune recovery in this situation, we analyzed the distribution of cell subsets by flow cytometry...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-003-0716-z

    authors: Krause SW,Rothe G,Gnad M,Reichle A,Andreesen R

    更新日期:2003-10-01 00:00:00

  • Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms.

    abstract::The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive. To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed t...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-009-0706-x

    authors: Caramazza D,Caracciolo C,Barone R,Malato A,Saccullo G,Cigna V,Berretta S,Schinocca L,Quintini G,Abbadessa V,Di Raimondo F,Siragusa S

    更新日期:2009-10-01 00:00:00

  • Prognostic impact of intraocular involvement in primary CNS lymphoma: experience from the G-PCNSL-SG1 trial.

    abstract::The impact of intraocular involvement (IOL) in primary CNS lymphoma (PCNSL) has not been sufficiently evaluated. Here, we present the analysis of IOL in the only completed randomized phase III trial in PCNSL. The G-PCNSL-SG1 study evaluated the role of whole-brain radiotherapy in primary therapy of PCNSL. Data of the ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00277-014-2212-z

    authors: Kreher S,Strehlow F,Martus P,Roth P,Hertenstein B,Röth A,Birnbaum T,Griesinger F,Rauch M,Kanz L,Thiel E,Weller M,Korfel A

    更新日期:2015-03-01 00:00:00

  • Geriatric nutritional risk index as a useful prognostic factor in second allogeneic hematopoietic stem cell transplantation.

    abstract::Second allogeneic hematopoietic stem cell transplantation (allo-HSCT) has a low survival outcome and a high non-relapse mortality (NRM) rate which is a major obstacle to this treatment. We hypothesized that the status of malnourishment after first allo-HSCT as represented by the geriatric nutritional risk index (GNRI)...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04089-0

    authors: Kaito S,Wada A,Adachi H,Konuma R,Kishida Y,Nagata A,Konishi T,Yamada Y,Kumagai T,Yoshifuji K,Mukae J,Akiyama M,Inamoto K,Toya T,Igarashi A,Najima Y,Muto H,Kobayashi T,Kakihana K,Ohashi K,Sakamaki H,Doki N

    更新日期:2020-07-01 00:00:00

  • Nitric oxide metabolites and arginase I levels in β-thalassemic patients: an Egyptian study.

    abstract::Stored red blood cells become deficient in nitric oxide that limits their ability to transfer oxygen to tissues that need it. The aims of this study are to assess the endogenous nitric oxide metabolites (NOx) and arginase I levels in transfusion-dependent β-thalassemic patients; to compare these levels in patients tra...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-012-1427-0

    authors: El-Hady SB,Farahat MH,Atfy M,Elhady MA

    更新日期:2012-08-01 00:00:00

  • Phase IV study evaluating efficacy of escalated dose of imatinib in chronic myeloid leukemia patients showing suboptimal response to standard dose imatinib.

    abstract::The aim of this phase IV study was to (1) to define efficacy of escalating dose imatinib in chronic myeloid leukemia (CML) patients showing suboptimal response to standard dose imatinib and (2) to find markers that predict the response to escalating doses of imatinib. CML patients in chronic phase (CP) who failed to a...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-010-0910-8

    authors: Koh Y,Kim I,Yoon SS,Kim BK,Kim DY,Lee JH,Lee KH,Park E,Kim HJ,Sohn SK,Joo YD,Kim SJ,Chung J,Shin HJ,Kim SH,Kim CS,Song HS,Kim MK,Hyun MS,Ahn JS,Jung CW,Park S,Korean Society of Hematology CML working party.

    更新日期:2010-07-01 00:00:00

  • Does mRNA level of microsomal carnitine palmitoyltransferase predict yield of peripheral blood stem cell apheresis?

    abstract::Transplantation of autologous hematopoietic stem cells is a well established therapeutic procedure. Despite advances in efficacy of the stem cell mobilization and apheresis process until now a predictive factor for the expected stem cell yield before initiation of mobilization therapy could not be identified. The main...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-005-0074-0

    authors: Fillitz M,Karlic H,Tüchler H,Zeibig J,Spiegel W,Wihlidal P,Varga F,Pittermann E,Pfeilstöcker M

    更新日期:2006-06-01 00:00:00

  • Central nervous system involvement in adults with haemophagocytic lymphohistiocytosis: a single-center study.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a rare multisystem disorder characterized by proliferation and diffuse infiltration multiple organs with histiocytes, including the central nervous system (CNS). Neurological manifestations of HLH have been recognized in different studies with children, but they remain relat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-017-3035-5

    authors: Cai G,Wang Y,Liu X,Han Y,Wang Z

    更新日期:2017-08-01 00:00:00

  • Busulfan, cyclophosphamide, and etoposide as high-dose conditioning regimen in patients with malignant lymphoma.

    abstract::We investigated the efficacy and toxicity of the combination of busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP-16) as a preparative regimen prior to autologous hematopoietic stem cell transplantation (ASCT) in patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL). Fifty-three patients with recurren...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-001-0413-8

    authors: Hänel M,Kröger N,Sonnenberg S,Bornhäuser M,Krüger W,Kroschinsky F,Hänel A,Metzner B,Birkmann J,Schmid B,Hoffknecht MM,Fiedler F,Ehninger G,Zander AR

    更新日期:2002-02-01 00:00:00

  • Overexpressed WT1 exhibits a specific immunophenotype in intermediate and poor cytogenetic risk acute myeloid leukemia.

    abstract::Many studies have confirmed that overexpressed WT1 exists in leukemic cells, especially in AML. However, the immunophenotypic features of this sort of leukemic cells remain to be unclarified. We retrospectively analyzed the immunophenotype of 283 newly diagnosed AML patients with intermediated and poor cytogenetic ris...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-019-03808-6

    authors: Wang XR,Chang Y,Yuan XY,Wang YZ,Qin YZ,Ruan GR,Lai YY,Liu YR

    更新日期:2020-02-01 00:00:00

  • Rituximab in the treatment of idiopathic thrombocytopenic purpura (ITP).

    abstract::The objective of this study was to evaluate the efficacy and safety of rituximab in the treatment of patients with idiopathic thrombocytopenic purpura (ITP). A prospective study was performed at Mubarak Al-Kabeer University Hospital involving the use of rituximab in 14 patients who had previously been treated with ste...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0574-9

    authors: Alasfoor K,Alrasheed M,Alsayegh F,Mousa SA

    更新日期:2009-03-01 00:00:00

  • IDEC-C2B8 (Rituximab) anti-CD20 antibody treatment in relapsed advanced-stage follicular lymphomas: results of a phase-II study of the German Low-Grade Lymphoma Study Group.

    abstract:PURPOSE:The current study was initiated to assess the clinical efficacy and side effects of rituximab in patients with relapsed advanced stage follicular lymphoma. PATIENTS AND METHODS:The study was performed as an open-label non-randomized multicenter phase-II trial and included patients older than 18 years of age wi...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002770000163

    authors: Feuring-Buske M,Kneba M,Unterhalt M,Engert A,Gramatzki M,Hiller E,Trümper L,Brugger W,Ostermann H,Atzpodien J,Hallek M,Aulitzky E,Hiddemann W

    更新日期:2000-09-01 00:00:00

  • Neutropenic enterocolitis: a serious complication during the treatment of acute leukemias.

    abstract::Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy. It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum. The serious clinical state of NE patients requires very frequent surgical consultations; however, in a few ...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-003-0815-x

    authors: Wach M,Dmoszynska A,Wasik-Szczepanek E,Pozarowski A,Drop A,Szczepanek D

    更新日期:2004-08-01 00:00:00

  • The prognostic value of serum erythropoietin in patients with lower-risk myelodysplastic syndromes: a review of the literature and expert opinion.

    abstract::Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies associated with an erythroid maturation defect, resulting in anemia. Treatments for MDS include erythropoiesis-stimulating agents (ESAs). The identification of prognostic markers is important to help predict response and improve outcomes. Various...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s00277-019-03799-4

    authors: Park S,Kelaidi C,Meunier M,Casadevall N,Gerds AT,Platzbecker U

    更新日期:2020-01-01 00:00:00

  • Cytogenetic profiles of 2806 patients with acute myeloid leukemia-a retrospective multicenter nationwide study.

    abstract::The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-016-2691-1

    authors: Byun JM,Kim YJ,Yoon HJ,Kim SY,Kim HJ,Yoon J,Min YH,Cheong JW,Park J,Lee JH,Hong DS,Park SK,Kim HJ,Ahn JS,Shin HJ,Chung JS,Lee WS,Lee SM,Park Y,Kim BS,Lee JH,Lee KH,Jung CW,Jang JH,Min WS,Park TS,AML\/M

    更新日期:2016-08-01 00:00:00

  • Factor V HR2 haplotype: a risk factor for venous thromboembolism in individuals with absence of Factor V Leiden.

    abstract::Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), occurs secondary to a number of hereditary and acquired disorders of hemostasis. A recently recognized polymorphism in Factor V (FV) gene H1299R (also named HR2) has been reported to be a possible risk factor for the deve...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-008-0543-3

    authors: Otrock ZK,Taher AT,Shamseddeen WA,Zaatari G,Bazarbachi A,Mahfouz RA

    更新日期:2008-12-01 00:00:00

  • Perinatal management of idiopathic thrombocytopenic purpura in pregnancy: risk factors for passive immune thrombocytopenia.

    abstract::Thirty-nine pregnant women with idiopathic thrombocytopenic purpura (ITP) were studied in order to evaluate the influence of therapies for maternal ITP on fetal passive immune thrombocytopenia (PIT). Neonatal platelet counts were also compared with platelet counts, amount of PAIgG, and presence of circulating antiplat...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01695918

    authors: Yamada H,Fujimoto S

    更新日期:1994-01-01 00:00:00

  • Upfront autologous stem cell transplantation for untreated diffuse large B cell lymphoma patients in rituximab era: a systematic review and meta-analysis.

    abstract::To assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Co...

    journal_title:Annals of hematology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00277-020-04016-3

    authors: Ma SY,Tian XP,Cai J,Zhong GZ,Chen X,Huang HQ,Lin TY,Li ZM,Cai QQ

    更新日期:2020-06-01 00:00:00

  • Acute lymphoblastic leukemia-like treatment regimen provides better response in mixed phenotype acute leukemia: a comparative study between adults and pediatric MPAL patients.

    abstract::Mixed phenotype acute leukemia (MPAL) is a rare type of leukemia with a limited number of studies conducted to characterize its clinical spectrum and most importantly the best treatment modality. MPAL blasts show more than one phenotype either myeloid/monocytic with T- or B-lymphoid or extremely rare triple lineage as...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-020-04354-2

    authors: Rasekh EO,Osman R,Ibraheem D,Madney Y,Radwan E,Gameel A,Abdelhafiz A,Kamel A,Elfishawi S

    更新日期:2020-11-23 00:00:00

  • Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "Watch and wait" strategy after complete resection.

    abstract::Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), olde...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/s00277-013-1785-2

    authors: Attarbaschi A,Beishuizen A,Mann G,Rosolen A,Mori T,Uyttebroeck A,Niggli F,Csoka M,Krenova Z,Mellgren K,Kabickova E,Chiang AK,Reiter A,Williams D,Burkhardt B,European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) an

    更新日期:2013-11-01 00:00:00

  • Prognostic significance of diagnosed WT1 level in acute myeloid leukemia: a meta-analysis.

    abstract::The Wilms' tumor 1 (WT1) expression has been recognized in a substantial number of acute myeloid leukemia (AML) patients. Some studies indicated the association of diagnosed WT1 higher expression (WT1(H)) and poor outcome in the AML patients, while other studies had different opinions. Therefore, we performed a meta-a...

    journal_title:Annals of hematology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00277-014-2295-6

    authors: Yi-Ning Y,Xiao-rui W,Chu-xian Z,Chun W,You-wen Q

    更新日期:2015-06-01 00:00:00

  • 2-Chlorodeoxyadenosine with or without daunorubicin in relapsed or refractory acute myeloid leukemia.

    abstract::2-Chlorodeoxyadenosine (2-CdA) is a purine analogue which has proved to be active in acute myeloid leukemia (AML), especially in children. In adults, results yielded by 2-CdA alone or with ara-C were less encouraging. Here we report on the efficacy of 2-CdA with or without daunorubicin (DNR) in 19 relapsing or refract...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s002770050355

    authors: Van Den Neste E,Martiat P,Mineur P,Delannoy A,Doyen C,Zenebergh A,Michaux JL,Ferrant A

    更新日期:1998-01-01 00:00:00

  • Stabilization of standard platelet concentrates and minimization of the platelet storage lesion by a prostacyclin analogue.

    abstract::Platelet concentrates were pretreated with a stable synthetic prostacyclin analogue (Iloprost) at two different concentrations before the second centrifugation step (pelleting step) of preparation. This resulted in loss of platelet sensitivity to aggregating agents. To mimic the situation after transfusion and to asse...

    journal_title:Annals of hematology

    pub_type: 杂志文章

    doi:10.1007/BF01695474

    authors: Elias M,Heethuis A,Weggemans M,Bom V,Blom N,McShine RL,Halie MR,Smit Sibinga CT

    更新日期:1992-06-01 00:00:00

  • Bortezomib, doxorubicin, and dexamethasone combination therapy followed by thalidomide and dexamethasone consolidation as a salvage treatment for relapsed or refractory multiple myeloma: analysis of efficacy and safety.

    abstract::We conducted a phase 2 study with bortezomib, doxorubicin, and dexamethasone (PAD) followed by thalidomide and dexamethasone (TD) in patients with relapsed multiple myeloma (MM). Forty patients were enrolled between November 2005 and October 2007, with follow-up continuing until January 2009. Efficacy could be assesse...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00277-010-0943-z

    authors: Lee SS,Suh C,Kim BS,Chung J,Joo YD,Ryoo HM,Do YR,Jin JY,Kang HJ,Lee GW,Lee MH,Shim H,Kim K,Yoon SS,Bang SM,Kim HY,Lee JJ,Park J,Lee DS,Lee JH,Korean Multiple Myeloma Working Party.

    更新日期:2010-09-01 00:00:00