Evaluation of mixed chimerism by two-step polymerase chain reaction amplification of hypervariable region MCT118 after allogeneic bone marrow transplantation.

Abstract:

:We assessed the origin of peripheral blood cells and bone marrow cells of 92 samples obtained from 19 patients after allo BMT by two-step polymerase chain reaction (PCR) amplification of MCT118, one of the variable number of tandem repeat regions (VNTR) which has a different length in 19 of 32 sibling pairs examined, that can detect the DNA pattern of a minor cell population of only 1% without using radioisotopes. Mixed chimerism (MC) was detected in the hematopoietic cells of four patients. Two patients who showed progressive MC developed relapse of leukemia 3 months and 4 months after the detection of MC, and two patients died with bone marrow hypoplasia 61 days and 7 months after BMT. These data suggest the clinical importance of analyzing the correlation of MC and clinical complications after BMT by this method, which can be used to monitor MC in about two thirds of allo BMT patients with an adequate sensitivity.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Tanaka J,Kasai M,Imamura M,Higa T,Kobayashi S,Hashino S,Sakurada K,Miyazaki T

doi

10.1007/BF01834365

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

189-93

issue

4

eissn

0939-5555

issn

1432-0584

journal_volume

68

pub_type

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